Skip to main content

Laryngopharyngeal Reflux

  • Chapter
  • First Online:
Laryngopharyngeal Reflux Disease

Abstract

Laryngopharyngeal reflux is used to describe laryngeal irritation resulting from contact with gastric secretions. This condition usually presents with vague symptoms including globus (“lump-in-the-throat” sensation), throat clearing, voice alterations, cough, and sore throat. The anatomical structures involved include the larynx, esophagus, and stomach.

The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, the Department of Defense, or the US Government.

We are military service members. This work was prepared as part of our official duties. Title 17 U.S.C. 105 provides that “Copyright protection under this title is not available for any work of the US Government.” Title 17 U.S.C. 101 defines a US Government work as a work prepared by a military service member or employee of the US Government as part of that person’s official duties.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2013;108:308–28. https://doi.org/10.1038/ajg.2012.444; published online 19 February 2013.

    Article  PubMed  Google Scholar 

  2. Irwin RS, Curley FJ, French CL. Chronic cough. The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy. Am Rev Respir Dis. 1990;141:640–7.

    Article  CAS  Google Scholar 

  3. el-Serag HB, Sonnenberg A. Comorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans. Gastroenterology. 1997;113(3):755–60, ISSN 0016-5085.

    Article  CAS  Google Scholar 

  4. Olson NR. Laryngopharyngeal manifestations of gastroesophageal reflux disease. Otolaryngol Clin N Am. 1991;24(5):1201–13. PubMed PMID: 1754220.

    CAS  Google Scholar 

  5. Ford CN. Evaluation and management of laryngopharyngeal reflux. JAMA. 2005;294(12):1534–40. https://doi.org/10.1001/jama.294.12.1534.

    Article  CAS  PubMed  Google Scholar 

  6. Klinkenberg-Knol EC. Otolaryngologic manifestations of gastro-oesophageal reflux disease. Scand J Gastroenterol Suppl. 1998;225:24–8. Review. PubMed PMID: 9515748.

    Article  CAS  Google Scholar 

  7. Khan AM, Hashmi SR, Elahi F, Tariq M, Ingrams DR. Laryngopharyngeal reflux: a literature review. Surgeon. 2006;4(4):221–5. Review. PubMed PMID: 16892839.

    Article  CAS  Google Scholar 

  8. Modlin IM, Moss SF, Kidd M, Lye KD. Gastroesophageal reflux disease: then and now. J Clin Gastroenterol. 2004;38(5):390–402. Review. PubMed PMID: 15100517.

    Article  Google Scholar 

  9. Stephen J, Sontag MD. Gastroesophageal reflux and asthma. Am J Med. 1997;103(5, Suppl 1):84S–90S, ISSN 0002-9343.

    Google Scholar 

  10. Bray GW. The treatment of asthma. Postgrad Med J. 1935;11(120):339–45.

    Article  CAS  Google Scholar 

  11. PubMed PMID: 21312974; PubMed Central PMCID: PMC2476505.

    Google Scholar 

  12. Winkelstein A. Peptic esophagitis. J Am Med Assoc. 1935;104(11):906–9.

    Article  Google Scholar 

  13. Cherry J, Margulies SI. Contact ulcer of the larynx. Laryngoscope. 1968;78(11):1937–40.

    Article  CAS  Google Scholar 

  14. Malcomson KG. Radiological findings in globus hystericus. Br J Radiol. 1966;39(464):583–6.

    Article  CAS  Google Scholar 

  15. Lee BE, Kim GH. Globus pharyngeus: a review of its etiology, diagnosis and treatment. World J Gastroenterol: WJG. 2012;18(20):2462–71. https://doi.org/10.3748/wjg.v18.i20.2462.

    Article  PubMed  Google Scholar 

  16. Malcomson K. Globus hystericus vel pharyngis: a reconnaissance of proximal vagal modalities. J Laryngol Otol. 1968;82(3):219–30. https://doi.org/10.1017/S0022215100068687.

    Article  CAS  PubMed  Google Scholar 

  17. Delahunty JE, Cherry J. Experimentally produced vocal cord granulomas. Laryngoscope. 1968;78(11):1941–7. PubMed PMID: 5722897.

    Article  CAS  Google Scholar 

  18. Little FB, Koufman JA, Kohut RI, Marshall RB. Effect of gastric acid on the pathogenesis of subglottic stenosis. Ann Otol Rhinol Laryngol. 1985;94(5 Pt 1):516–9. PubMed PMID: 4051410.

    Article  CAS  Google Scholar 

  19. Adhami T, Goldblum JR, Richter JE, Vaezi MF. The role of gastric and duodenal agents in laryngeal injury: an experimental canine model. Am J Gastroenterol. 2004;99(11):2098–106. PubMed PMID: 15554987.

    Article  Google Scholar 

  20. Johnson LF, Demeester TR. Twenty-four-hour pH monitoring of the distal esophagus. A quantitative measure of gastroesophageal reflux. Am J Gastroenterol. 1974;62(4):325–32. PubMed PMID: 4432845.

    CAS  PubMed  Google Scholar 

  21. Wiener GJ, Koufman JA, Wu WC, Cooper JB, Richter JE, Castell DO. Chronic hoarseness secondary to gastroesophageal reflux disease: documentation with 24-h ambulatory pH monitoring. Am J Gastroenterol. 1989;84(12):1503–8. PubMed PMID: 2596451.

    CAS  PubMed  Google Scholar 

  22. DeMeester TR, Bonavina L, Iascone C, Courtney JV, Skinner DB. Chronic respiratory symptoms and occult gastroesophageal reflux. A prospective clinical study and results of surgical therapy. Ann Surg. 1990;211(3):337–45. PubMed PMID: 2310240; PubMed Central PMCID: PMC1358440.

    Article  CAS  Google Scholar 

  23. Kamel PL, Hanson D, Kahrilas PJ. Omeprazole for the treatment of posterior laryngitis. Am J Med. 1994;96(4):321–6, ISSN 0002-9343. https://doi.org/10.1016/0002-9343(94)90061-2.

    Article  CAS  Google Scholar 

  24. Little JP, Matthews BL, Glock MS, Koufman JA, Reboussin DM, Loughlin CJ, McGuirt WF Jr. Extraesophageal pediatric reflux: 24-hour double-probe pH monitoring of 222 children. Ann Otol Rhinol Laryngol Suppl. 1997;169:1–16. PubMed PMID: 9228867.

    CAS  PubMed  Google Scholar 

  25. Hawkins BL. Laryngopharyngeal reflux: a modern day “great masquerader”. J Ky Med Assoc. 1997;95(9):379–85. Review. PubMed PMID: 9322411

    CAS  PubMed  Google Scholar 

  26. Koufman J, Sataloff RT, Toohill R. Laryngopharyngeal reflux: consensus conference report. J Voice. 1996;10(3):215–6. PubMed PMID: 8865091.

    Article  CAS  Google Scholar 

  27. Johnson J. Bailey’s head and neck surgery: otolaryngology. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2013.

    Google Scholar 

  28. Marieb EN, Hoehn K. Human anatomy & physiology. San Francisco: Benjamin Cummings; 2010. ISBN 0-8053-9591-1.

    Google Scholar 

  29. Czinn SJ, Blanchard SS. 25 – developmental anatomy and physiology of the stomach. In: Wyllie R, Hyams JS, editors. Pediatric gastrointestinal and liver disease (fourth edition). Saint Louis: W.B. Saunders; 2011. p. 262–268.e1. https://doi.org/10.1016/B978-1-4377-0774-8.10025-9. ISBN 9781437707748.

    Google Scholar 

  30. Samloff IM. Peptic ulcer: the many proteinases of aggression. Gastroenterology. 1989;96(2 Pt 2 Suppl):586–95. Review. PubMed PMID: 2642445.

    Article  CAS  Google Scholar 

  31. Lu W, Liu X, Liu Y-l, Zeng F-f, Wu T, Yang C-l, Shen H-y, Li X-p. Correlation of pepsin-measured laryngopharyngeal reflux disease with symptoms and signs. Otolaryngol Head Neck Surg. 2010;143(6):765–71, ISSN 0194-5998.

    Article  Google Scholar 

  32. Park D, Lee HH, Lee ST, Oh Y, Lee JC, Nam KW, Ryu JS. Normal contractile algorithm of swallowing related muscles revealed by needle EMG and its comparison to videofluoroscopic swallowing study and high resolution manometry studies: a preliminary study. J Electromyogr Kinesiol. 2017;36:81–9. https://doi.org/10.1016/j.jelekin.2017.07.007. [Epub ahead of print] PubMed PMID: 28763682.

    Article  PubMed  Google Scholar 

  33. Kahrilas PJ, Dodds WJ, Dent J, Haeberle B, Hogan WJ, Arndorfer RC. Effect of sleep, spontaneous gastroesophageal reflux, and a meal on upper esophageal sphincter pressure in normal human volunteers. Gastroenterology. 1987;92(2):466–71, ISSN 0016-5085.

    Article  CAS  Google Scholar 

  34. Naito Y, Uchiyama K, Kuroda M, Takagi T, Kokura S, Yoshida N, Ichikawa H, Yoshikawa T. Role of pancreatic trypsin in chronic esophagitis induced bygastroduodenal reflux in rats. J Gastroenterol. 2006;41(3):198–208. PubMedPMID: 16699853.

    Article  CAS  Google Scholar 

  35. Fitzgerald RC, Onwuegbusi BA, Bajaj-Elliott M, Saeed IT, Burnham WR, Farthing MJ. Diversity in the oesophageal phenotypic response to gastro-oesophageal reflux: immunological determinants. Gut. 2002;50(4):451–9. PubMed PMID: 11889061; PubMed Central PMCID: PMC1773186.

    Article  CAS  Google Scholar 

  36. Sasaki CT, Marotta J, Hundal J, Chow J, Eisen RN. Bile-induced laryngitis: is there a basis in evidence? Ann Otol Rhinol Laryngol. 2005;114(3):192–7. PubMed PMID: 15825567.

    Article  Google Scholar 

  37. Cobeta I, Pacheco A, Mora E. The role of the larynx in chronic cough. Acta Otorrinolaringol Esp. 2013;64:363.

    Article  Google Scholar 

  38. Bucca CB, Bugiani M, Culla B, et al. Chronic cough and irritable larynx. J Allergy Clin Immunol. 2011;127:412.

    Article  Google Scholar 

  39. Cook IJ, Dent J, Shannon S, Collins SM. Measurement of upper esophageal sphincter pressure. Effect of acute emotional stress. Gastroenterology. 1987;93(3):526–32. PubMed PMID: 3609662.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Morrison, M.P., Anderson, D.C. (2019). Laryngopharyngeal Reflux. In: Jamal, N., Wang, M. (eds) Laryngopharyngeal Reflux Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-12318-5_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-12318-5_1

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-12317-8

  • Online ISBN: 978-3-030-12318-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics