Skip to main content
SpringerLink
Log in

Stem Cells

  • Chapter
  • First Online:
Deer's Treatment of Pain

  • 109 Accesses

Abstract

There has been a growing and sustained interest in the advancement in stem cell technology in pain medicine due to limitations in medical and surgical interventions in treating common chronic pain conditions such as low back pain, osteoarthritis, and various tendinopathies. In this chapter, we will outline the basic mechanisms, application, and current evidence supporting stem cell therapeutics.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Recommended Reading

  1. Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D. Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician. 2008;11(3):343–53.

    PubMed  Google Scholar 

  2. Centeno CJ, Schultz JR, Cheever M, et al. Safety and complications reporting update on the re-implantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique. Curr Stem Cell Res Ther. 2011;6(4):368–78.

    Article  CAS  Google Scholar 

  3. Centeno CJ, Pitts JA, Al-Sayegh H, Freeman MD. Efficacy and safety of bone marrow concentrate for osteoarthritis of the hip; treatment registry results for 196 patients. J Stem Cell Res Ther. 2014;4(242):2.

    Google Scholar 

  4. Dragoo JL, Carlson G, McCormick F, et al. Healing full-thickness cartilage defects using adipose-derived stem cells. Tissue Eng. 2007;13(7):1615–21.

    Article  CAS  Google Scholar 

  5. Hernigou P, Flouzat Lachaniette CH, Delambre J, et al. Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study. Int Orthop. 2014;38(9):1811–8.

    Article  Google Scholar 

  6. Karahuseyinoglu S, Cinar O, Kilic E, et al. Biology of stem cells in human umbilical cord stroma: in situ and in vitro surveys. Stem Cells. 2007;25(2):319–31.

    Article  CAS  Google Scholar 

  7. Mishra A, Tummala P, King A, et al. Buffered platelet-rich plasma enhances mesenchymal stem cell proliferation and chondrogenic differentiation. Tissue Eng Part C Methods. 2009;15(3):431–5.

    Article  CAS  Google Scholar 

  8. Mochida J, Sakai D, Nakamura Y, Watanabe T, Yamamoto Y, Kato S. Intervertebral disc repair with activated nucleus pulposus cell transplantation: a three-year, prospective clinical study of its safety. Eur Cell Mater. 2015;29:202–12; discussion 212

    Article  CAS  Google Scholar 

  9. Nelson L, Fairclough J, Archer CW. Use of stem cells in the biological repair of articular cartilage. Expert Opin Biol Ther. 2010;10(1):43–55.

    Article  CAS  Google Scholar 

  10. Orozco L, Soler R, Morera C, Alberca M, Sánchez A, García-Sancho J. Intervertebral disc repair by autologous mesenchymal bone marrow cells: a pilot study. Transplantation. 2011;92(7):822–8.

    Article  Google Scholar 

  11. Pang X, Yang H, Peng B. Human umbilical cord mesenchymal stem cell transplantation for the treatment of chronic discogenic low back pain. Pain Physician. 2014;17(4):E525–30.

    PubMed  Google Scholar 

  12. Pantalone A, Antonucci I, Guelfi M, et al. Amniotic fluid stem cells: an ideal resource for therapeutic application in bone tissue engineering. Eur Rev Med Pharmacol Sci. 2016;20(13):2884–90.

    CAS  PubMed  Google Scholar 

  13. Petrie Aronin CE, Tuan RS. Therapeutic potential of the immunomodulatory activities of adult mesenchymal stem cells. Birth Defects Res C Embryo Today. 2010;90(1):67–74.

    Article  CAS  Google Scholar 

  14. Pettine K, Suzuki R, Sand T, Murphy M. Treatment of discogenic back pain with autologous bone marrow concentrate injection with minimum two year follow-up. Int Orthop. 2016;40(1):135–40.

    Article  Google Scholar 

  15. Richter M, Zech S. Matrix-associated stem cell transplantation (MAST) in chondral defects of foot and ankle is effective. Foot Ankle Surg. 2013;19(2):84–90.

    Article  Google Scholar 

  16. Sakai D, Mochida J, Iwashina T, et al. Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc. Biomaterials. 2006;27(3):335–45.

    Article  CAS  Google Scholar 

  17. Sen B, Xie Z, Case N, Ma M, Rubin C, Rubin J. Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal. Endocrinology. 2008;149(12):6065–75.

    Article  CAS  Google Scholar 

  18. Stanco D, Viganò M, Perucca Orfei C, et al. Multidifferentiation potential of human mesenchymal stem cells from adipose tissue and hamstring tendons for musculoskeletal cell-based therapy. Regen Med. 2015;10(6):729–43.

    Article  CAS  Google Scholar 

  19. Tremolada C, Beltrami G, Magri A, et al. Adipose mesenchymal stem cells and “regenerative adipose tissue graft”(Lipogems®) for musculoskeletal regeneration. Eur J Musculoskelet Dis. 2014;3(2):57–67.

    Google Scholar 

  20. Vangsness CT Jr, Farr J 2nd, Boyd J, Dellaero DT, Mills CR, LeRoux-Williams M. Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study. J Bone Joint Surg Am. 2014;96(2):90–8.

    Article  Google Scholar 

  21. Vega A, Martín-Ferrero MA, Del Canto F, et al. Treatment of Knee Osteoarthritis With Allogeneic Bone Marrow Mesenchymal Stem Cells: A Randomized Controlled Trial. Transplantation. 2015;99(8):1681–90.

    Article  CAS  Google Scholar 

  22. Voleti PB, Buckley MR, Soslowsky LJ. Tendon healing: repair and regeneration. Annu Rev Biomed Eng. 2012;14:47–71.

    Article  CAS  Google Scholar 

  23. Vora A, Borg-Stein J, Nguyen RT. Regenerative injection therapy for osteoarthritis: fundamental concepts and evidence-based review. PM R. 2012;4(5 Suppl):S104–9.

    Article  Google Scholar 

  24. Westminster CO, Westminister CO, Vail CO, Busse D. Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician. 2008;11(3):343–53.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Ajax Yang & Corey W. Hunter

  2. Ainsworth Institute of Pain Management, New York, NY, USA

    Corey W. Hunter

  3. Arizona Pain Specialists, Scottsdale, AZ, USA

    Tory L. McJunkin, Paul J. Lynch & Edward L. Swing

Authors
  1. Ajax Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Corey W. Hunter
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tory L. McJunkin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Paul J. Lynch
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Edward L. Swing
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The Spine and Nerve Center of the Virginias, Charleston, WV, USA

    Timothy R. Deer

  2. Evolve Restorative Center, Santa Rosa, CA, USA

    Jason E. Pope

  3. Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA

    Tim J. Lamer

  4. Pain Diagnostics and Interventional Care, Sewickley, PA, USA

    David Provenzano

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Yang, A., Hunter, C.W., McJunkin, T.L., Lynch, P.J., Swing, E.L. (2019). Stem Cells. In: Deer, T., Pope, J., Lamer, T., Provenzano, D. (eds) Deer's Treatment of Pain. Springer, Cham. https://doi.org/10.1007/978-3-030-12281-2_89

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-12281-2_89

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-12280-5

  • Online ISBN: 978-3-030-12281-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation