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Sodium-Glucose Cotransporter 2 Inhibitors

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Abstract

Sodium-glucose cotransporter 2 inhibitors are the latest medications to be approved and released for treatment of patients with type 2 diabetes. These include canagliflozin, dapagliflozin, and empagliflozin. Their mechanism of action is characterized by permissive glucosuria which has significant effects on lowering hemoglobin A1c by up to 1%. These drugs are also beneficial for blood pressure control mainly due to its diuretic-like effects as well as weight loss secondary to caloric loss via glucosuria. Most impressive to these medications are the marked potential benefits observed in cardiovascular and renal outcomes noted with empagliflozin but yet to be assessed with canagliflozin and dapagliflozin. Use of these medications has introduced to the scientific and medical world the concept of ketones as a superfuel as well. Sodium-glucose cotransporter 2 inhibitors are promising drugs to the diabetic community, and use of these is expected to rise.

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Author information

Authors and Affiliations

  1. The Scripps Whittier Diabetes Institute, La Jolla, CA, USA

    George Dailey III

  2. Scripps Green Hospital, San Diego, CA, USA

    Lauren H. S. Clarine

  3. Diabetes and Endocrinology Training Program, Scripps Clinic/Scripps Green Hospital, San Diego, CA, USA

    Renil Marie Rodriguez-Martinez

Authors
  1. George Dailey III
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  2. Lauren H. S. Clarine
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  3. Renil Marie Rodriguez-Martinez
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Corresponding author

Correspondence to George Dailey III .

Editor information

Editors and Affiliations

  1. Multidisciplinary Diabetes Center, Mexico City, Mexico

    Joel Rodriguez-Saldana

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Dailey, G., Clarine, L.H.S., Rodriguez-Martinez, R.M. (2019). Sodium-Glucose Cotransporter 2 Inhibitors. In: Rodriguez-Saldana, J. (eds) The Diabetes Textbook. Springer, Cham. https://doi.org/10.1007/978-3-030-11815-0_34

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  • DOI: https://doi.org/10.1007/978-3-030-11815-0_34

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-11814-3

  • Online ISBN: 978-3-030-11815-0

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