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Pathogenesis of B-Cell Lymphoma

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Non-Hodgkin's Lymphoma in Childhood and Adolescence

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Abstract

B-cell lymphomas are hematological malignancies, which develop from B-cells at different maturation stages by the acquisition of genetic changes. These genetic changes are at least in part introduced through somatic mutation machineries which B-cells need to fulfill their physiologic tasks in adaptive immunity. The transformed malignant B-cells are frozen at distinct maturation stages, a feature which aids to their classification based on morphologic, immunophenotypic, transcriptional, and epigenetic characteristics. Overall, the pathogenesis of B-cell lymphomas is assumed to be a multifactorial process to which components of germline predisposition, environmental factors (e.g. viruses), physiological processes, microenvironmental stimuli, and somatic alterations interactively can contribute and which ultimately lead to a clonal evolution of tumor-initiating cells. The present chapter will outline key principles and general mechanisms underlying the pathogenesis of B-cell non-Hodgkin lymphomas in children and adolescents.

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Acknowledgment

The author’s own work on B-cell lymphomas is supported by the BMBF, the Deutsche Krebshilfe, the Medical Faculty of the Ulm University, and the KinderKrebsInitiative Buchholz Holm-Seppensen. The authors want to acknowledge and excuse to all colleagues, whose seminal contributions to the topic could not be quoted appropriately due to space constraints.

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  1. Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany

    Rabea Wagener, Cristina López & Reiner Siebert

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  1. Rabea Wagener
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  2. Cristina López
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  3. Reiner Siebert
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Correspondence to Reiner Siebert .

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  1. University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada

    Oussama Abla

  2. Medical University of Vienna, St. Anna Children’s Hospital, Vienna, Wein, Austria

    Andishe Attarbaschi

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Wagener, R., López, C., Siebert, R. (2019). Pathogenesis of B-Cell Lymphoma. In: Abla, O., Attarbaschi, A. (eds) Non-Hodgkin's Lymphoma in Childhood and Adolescence. Springer, Cham. https://doi.org/10.1007/978-3-030-11769-6_4

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