Abstract
Lymphoid follicles are not native to the skin, and their presence in the dermis is a pathologic finding. They can be reactive (benign) or neoplastic (malignant) and can be present in several types of pseudolymphoma and in low-grade cutaneous B-cell lymphomas. The distinguishing histomorphologic features include their distribution, mantle zone preservation, mitotic activity, tingible body macrophages, and polarization.
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Leinweber B, Colli C, Chott A, Kerl H, Cerroni L. Differential diagnosis of cutaneous infiltrates of B lymphocytes with follicular growth pattern. Am J Dermatopathol. 2004;26(1):4–13.
Subtil A. A general approach to the diagnosis of cutaneous lymphomas and pseudolymphomas. Cutaneous lymphomas (Subtil, ed.). Surg Pathol Clin. 2014;7(2):135–42. Elsevier: Philadelphia.
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Subtil, A. (2019). Lymphoid Follicles: Reactive vs. Neoplastic. In: Diagnosis of Cutaneous Lymphoid Infiltrates. Springer, Cham. https://doi.org/10.1007/978-3-030-11654-5_5
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DOI: https://doi.org/10.1007/978-3-030-11654-5_5
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