Abstract
Besides their use in human treatments, antibiotics have been extensively used to control animal diseases and, in some countries, still used to promote animal growth in livestock industry. To attempt human diet necessities, concentrated animal feeding operations (CAFOs) are necessary, increasing antibiotics consumption and manure production. Once antibiotic active agents and its metabolites are excreted in urine and feces, these substances are present in manure and can reach the environment. Around the world, especially in rural areas, manure is the main substrate for biogas production. This chapter presents a review about fate of antibiotics, with special focus on livestock by-products, and effects during the anaerobic digestion (AD). The antibiotic interaction has two important emphases addressed: (a) inhibition on the biogas and methane production process by the presence and action of these compounds and metabolites in the digester and (b) the ability of AD to degrade the molecules of antibiotics and thereby reduce the adverse effect caused by these compounds on the environment.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Aga DS, Goldfish R, Kulshrestha P (2003) Application of ELISA in determining the fate of tetracyclines in land-applied livestock wastes. Analyst 128:658. https://doi.org/10.1039/b301630g
Alexy R, Schöll A, Kümpel T, Kümmerer K (2004) What do we know about antibiotics in the environment? Pharmaceuticals in the environment. Springer, Berlin, pp 209–221
Angelidaki I, Alves M, Bolzonella D et al (2009) Defining the biomethane potential (BMP) of solid organic wastes and energy crops: a proposed protocol for batch assays. Water Sci Technol 59:927. https://doi.org/10.2166/wst.2009.040
Bbosa GS, Mwebaza N (2013) Global irrational antibiotics/antibacterial drugs use: a current and future health and environmental consequences. In: Méndez-Vilas A (ed) Microbial pathogens and strategies for combating them: science, technology and education, Formatex Research Center, pp 1645–1655
Bressan CR, Airton K, Schmidell W, Soares HM (2013) Effects of long-term exposure to antimicrobial colistin sulfate (polymyxin E) over mixed cultures of nitrifiers and methanogens. In: RAMIRAN, p 4
Brown KD, Kulis J, Thomson B et al (2006) Occurrence of antibiotics in hospital, residential, and dairy effluent, municipal wastewater, and the Rio Grande in New Mexico. Sci Total Environ 366:772–783. https://doi.org/10.1016/j.scitotenv.2005.10.007
CDDEP (2015) The state of the world’s antibiotics
Cetecioglu Z, Ince B, Orhon D, Ince O (2012) Acute inhibitory impact of antimicrobials on acetoclastic methanogenic activity. Bioresour Technol 114:109–116. https://doi.org/10.1016/j.biortech.2012.03.020
Chen Y, Zhang H, Luo Y, Song J (2012a) Occurrence and dissipation of veterinary antibiotics in two typical swine wastewater treatment systems in East China. Environ Monit Assess 184:2205–2217. https://doi.org/10.1007/s10661-011-2110-y
Chen Y, Zhang H, Luo Y, Song J (2012b) Occurrence and assessment of veterinary antibiotics in swine manures: a case study in East China. Chin Sci Bull 57:606–614. https://doi.org/10.1007/s11434-011-4830-3
Chenxi W, Spongberg AL, Witter JD (2008) Determination of the persistence of pharmaceuticals in biosolids using liquid-chromatography tandem mass spectrometry. Chemosphere 73:511–518. https://doi.org/10.1016/j.chemosphere.2008.06.026
De Briyne N, Atkinson J, Borriello SP, Pokludová L (2014) Antibiotics used most commonly to treat animals in Europe. Vet Rec 175:325. https://doi.org/10.1136/vr.102462
ESVAC (2017) Sales of veterinary antimicrobial agents in 30 European countries in 2015 trends from 2010 to 2015. In: Seventh ESVAC report
Etebu E, Arikekpar I (2016) Antibiotics: classification and mechanisms of action with emphasis on molecular perspectives. Ijambr 4:90–101
FDA (2017) Antimicrobials sold or distributed for use in food-producing animals
Federation of Veterinarians of Europe—FVE (2016) Antimicrobial use in food-producing animals—replies to EFSA/EMA questions on the use of antimicrobials in food-producing animals in EU and possible measures to reduce antimicrobial use
Fischer JR, Iannotti EL, Sievers DM (1981) Anaerobic digestion of manure from swine fed on various diets. Agric Wastes 3:201–214
Gartiser S, Urich E, Alexy R, Kümmerer K (2007) Anaerobic inhibition and biodegradation of antibiotics in ISO test schemes. Chemosphere 66:1839–1848. https://doi.org/10.1016/j.chemosphere.2006.08.040
Gonzalez Ronquillo M, Angeles Hernandez JC (2017) Antibiotic and synthetic growth promoters in animal diets: review of impact and analytical methods. Food Control 72:255–267. https://doi.org/10.1016/j.foodcont.2016.03.001
Haller MY, Müller SR, McArdell CS et al (2002) Quantification of veterinary antibiotics (sulfonamides and trimethoprim) in animal manure by liquid chromatography–mass spectrometry. J Chromatogr A 952:111–120. https://doi.org/10.1016/S0021-9673(02)00083-3
Hao H, Cheng G, Iqbal Z, et al (2014) Benefits and risks of antimicrobial use in food-producing animals. Front Microbiol 5. https://doi.org/10.3389/fmicb.2014.00288
He Z, Pagliari PH, Waldrip HM (2016) Applied and environmental chemistry of animal manure: a review. Pedosphere 26:779–816. https://doi.org/10.1016/S1002-0160(15)60087-X
Hu XG, Luo Y, Zhou QX, Xu L (2008) Determination of thirteen antibiotics residues in manure by solid phase extraction and high performance liquid chromatography. Chin J Anal Chem 36:1162–1166. https://doi.org/10.1016/s1872-2040(08)60063-8
International Organization for Standardization (2003) ISO 13641-1 water quality—determination of inhibition of gas production of anaerobic bacteria. General test. 16
Jacobsen AM, Halling-Sørensen B (2006) Multi-component analysis of tetracyclines, sulfonamides and tylosin in swine manure by liquid chromatography–tandem mass spectrometry. Anal Bioanal Chem 384:1164–1174. https://doi.org/10.1007/s00216-005-0261-9
Jarvis A, Leather J, Shembavnekar N, Linh T (2011) Assessment of the impact of the revision of veterinary pharmaceutical legislation. London, UK
Ji JY, Xing YJ, Ma ZT et al (2013) Acute toxicity of pharmaceutical wastewaters containing antibiotics to anaerobic digestion treatment. Chemosphere 91:1094–1098. https://doi.org/10.1016/j.chemosphere.2013.01.009
Koch BJ, Hungate BA, Price LB (2017) Food-animal production and the spread of antibiotic resistance: the role of ecology. Front Ecol Environ 15:309–318. https://doi.org/10.1002/fee.1505
Kunz A, Miele M, Steinmetz RLR (2009) Advanced swine manure treatment and utilization in Brazil. Bioresour Technol 100:5485–5489
Lambert T (2012) Antibiotics that affect the ribosome. Rev Sci Tech 31:57–64
Landers TF, Cohen B, Wittum TE, Larson EL (2012) A review of antibiotic use in food animals: perspective, policy, and potential. Public Health Rep 127:4–22. https://doi.org/10.1177/003335491212700103
Leal RMP, Figueira RF, Tornisielo VL, Regitano JB (2012) Occurrence and sorption of fluoroquinolones in poultry litters and soils from São Paulo State, Brazil. Sci Total Environ 432:344–349. https://doi.org/10.1016/j.scitotenv.2012.06.002
Li Y, Liu H, Li G et al (2018) Manure digestate storage under different conditions: chemical characteristics and contaminant residuals. Sci Total Environ 639:19–25. https://doi.org/10.1016/j.scitotenv.2018.05.128
Loftin KA, Henny C, Adams CD et al (2005) Inhibition of microbial metabolism in anaerobic lagoons by selected sulfonamides, tetracyclines, lincomycin, and tylosin tartrate. Environ Toxicol Chem 24:782–788. https://doi.org/10.1897/04-093R.1
Martínez-Carballo E, González-Barreiro C, Scharf S, Gans O (2007) Environmental monitoring study of selected veterinary antibiotics in animal manure and soils in Austria. Environ Pollut 148:570–579. https://doi.org/10.1016/j.envpol.2006.11.035
Massé DI, Lu D, Masse L, Droste RL (2000) Effect of antibiotics on psychrophilic anaerobic digestion of swine manure slurry in sequencing batch reactors. Bioresour Technol 75:205–211. https://doi.org/10.1016/S0960-8524(00)00046-8
O’Neill J (2015) The review on antimicrobial resistance. London
Pan X, Qiang Z, Ben W, Chen M (2011) Residual veterinary antibiotics in swine manure from concentrated animal feeding operations in Shandong Province, China. Chemosphere 84:695–700. https://doi.org/10.1016/j.chemosphere.2011.03.022
Poels J, Van Assche P, Verstraete W (1984) Effects of disinfectants and antibiotics on the anaerobic digestion of piggery waste. Agric Wastes 9:239–247. https://doi.org/10.1016/0141-4607(84)90083-0
Sanz JL, Rodríguez N, Amils R (1996) The action of antibiotics on the anaerobic digestion process. Appl Microbiol Biotechnol 46:587–592. https://doi.org/10.1007/s002530050865
Scheeren MB, Kunz A, Steinmetz RLR, Dressler VL (2011) The ANAMMOX process as an alternative for treatment of water with high containing nitrogen. Rev Bras Eng Agric e Ambient 15
Schlüsener MP, Bester K, Spiteller M (2003) Determination of antibiotics such as macrolides, ionophores and tiamulin in liquid manure by HPLC-MS/MS. Anal Bioanal Chem 375:942–947. https://doi.org/10.1007/s00216-003-1838-9
Schlüsener MP, Von Arb MA, Bester K (2006) Elimination of macrolides, tiamulin, and salinomycin during manure storage. Arch Environ Contam Toxicol 51:21–28. https://doi.org/10.1007/s00244-004-0240-8
Seganfredo MA, Girotto AF (2004) Custos de armazenamento e transporte de dejetos suínos usados como fertilizante do solo. Concórdia/Brazil
Shi JC, Liao XD, Wu YB, Liang JB (2011) Effect of antibiotics on methane arising from anaerobic digestion of pig manure. Anim Feed Sci Technol 166–167:457–463. https://doi.org/10.1016/j.anifeedsci.2011.04.033
Shimada T, Zilles JL, Morgenroth E, Raskin L (2008) Inhibitory effects of the macrolide antimicrobial tylosin on anaerobic treatment. Biotechnol Bioeng 101:73–82. https://doi.org/10.1002/bit.21864
Shimada T, Li X, Zilles JL et al (2011) Effects of the antimicrobial tylosin on the microbial community structure of an anaerobic sequencing batch reactor. Biotechnol Bioeng 108:296–305. https://doi.org/10.1002/bit.22934
Silva M, Lidon FC (2016) Food preservatives—an overview on applications and side effects. Emirates J Food Agric 28:366–373. https://doi.org/10.9755/ejfa.2016-04-351
Sneeringer S, MacDonald J, Key N et al (2015) Economics of antibiotic use in U.S. Livestock production
Sperelakis N (2012) Cell physiology sourcebook: essentials of membrane biophysics, 4th edn. Elsevier
Steinmetz RLR, Gressler V, Kunz A, Soares HM (2016) Tetracycline compounds interference and persistence in co-digestion of animal manure and cellulosic wastes. In: XIII Latin American workshop and symposium on anaerobic digestion. IWA—International Water Association, Cusco/Peru, p 4
Tagiri-Endo M, Suzuki S, Nakamura T et al (2009) Rapid determination of five antibiotic residues in swine wastewater by online solid-phase extraction–high performance liquid chromatography–tandem mass spectrometry. Anal Bioanal Chem 393:1367–1375. https://doi.org/10.1007/s00216-008-2543-5
Tilman D, Cassman KG, Matson PA et al (2002) Agricultural sustainability and intensive production practices. Nature 418:671–677. https://doi.org/10.1038/nature01014
Tong Z-L, Liu Y-L, Hu Z-H, Yuan S-J (2012) Anaerobic digestion of animal manure contaminated by tetracyclines. Huan Jing Ke Xue 33:1028–1032
Turker G, Ince O, Ertekin E et al (2013) Changes in performance and active microbial communities due to single and multiple effects of mixing and solid content in anaerobic digestion process of OTC medicated cattle manure. Int J Renew Energ Res 3:144–148
Van Boeckel TP, Brower C, Gilbert M et al (2015) Global trends in antimicrobial use in food animals. In: Proceedings of national academy sciences, USA, pp 1–6. https://doi.org/10.1073/pnas.1503141112
Venglovsky J, Sasakova N, Placha I (2009) Pathogens and antibiotic residues in animal manures and hygienic and ecological risks related to subsequent land application. Bioresour Technol 100:5386–5391. https://doi.org/10.1016/j.biortech.2009.03.068
World Health Organization W (2018) Antibiotic resistance. http://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance. Accessed on 8 Oct 2018
Yan DY, Lam FL (2015) Development of a novel photocatalyst for the advanced antibiotic oxidation of wastewater. Springerplus 4:O7. https://doi.org/10.1186/2193-1801-4-S2-O7
Zhao L, Dong YH, Wang H (2010) Residues of veterinary antibiotics in manures from feedlot livestock in eight provinces of China. Sci Total Environ 408:1069–1075. https://doi.org/10.1016/j.scitotenv.2009.11.014
Zhou L-J, Ying G-G, Liu S et al (2012) Simultaneous determination of human and veterinary antibiotics in various environmental matrices by rapid resolution liquid chromatography–electrospray ionization tandem mass spectrometry. J Chromatogr A 1244:123–138. https://doi.org/10.1016/j.chroma.2012.04.076
Zhou L-J, Ying G-G, Liu S et al (2013) Excretion masses and environmental occurrence of antibiotics in typical swine and dairy cattle farms in China. Sci Total Environ 444:183–195. https://doi.org/10.1016/j.scitotenv.2012.11.087
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Steinmetz, R.L.R., Gressler, V. (2019). Impact of Antibiotics on Biogas Production. In: Treichel, H., Fongaro, G. (eds) Improving Biogas Production. Biofuel and Biorefinery Technologies, vol 9. Springer, Cham. https://doi.org/10.1007/978-3-030-10516-7_8
Download citation
DOI: https://doi.org/10.1007/978-3-030-10516-7_8
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-10515-0
Online ISBN: 978-3-030-10516-7
eBook Packages: EnergyEnergy (R0)