Skip to main content
SpringerLink
Log in

Proteases from Endophytic Fungi with Potential Industrial Applications

  • Chapter
  • First Online:
Book cover Recent Advancement in White Biotechnology Through Fungi

Part of the book series: Fungal Biology ((FUNGBIO))

Abstract

Proteases are enzymes that hydrolyse proteins and polypeptides into smaller constituents. Holding two-thirds of the global enzyme market, proteases are used to execute unique functions in industries of food, textile, detergent, therapeutics and environmental remediation. Fungi have emerged as the most dominant source of proteases due to several cultivational advantages over other sources. Expeditious industrial growth and emerging environment problems necessitate search for novel enzymes from more efficient fungal sources. Endophytic fungi form an uncharted ecological group of fungi with assorted synthesizing potential. Their efficacy has been proven within a short amount of time, as distinguished bioactive secondary metabolites have already been obtained from them. Commercial hydrolases are customarily isolated from soil-borne genera of fungi, but their endophytic counterparts offer a potential alternative, owing to recent findings that endophytes too display the same array of enzymes as do the soil fungi. Prospecting of endophytic fungi for protease production is not only promising, but there also exists the possibility of isolating and characterizing novel proteases that might be suitable alternatives for specialized industries. Several researchers have endorsed this postulate as they have discovered endophytic fungi with optimum protease producing capabilities and novel proteases with projected industrial applications prima facie.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abdennabi R, Triki MA, Salah RB, Gharsallah N (2017) Antifungal activity of Endophytic fungi isolated from date palm sap (Phoenix dactylifera L.). EC Microbiol 13(4):123–131

    Google Scholar 

  • Ahmad MS, Noor ZM, Ariffin ZZ (2014) Isolation and identification fibrinolytic protease endophytic fungi from Hibiscus leaves in Shah Alam. Int J Agri Biosyst Eng 8(10):1104–1107

    Google Scholar 

  • Alberto RN, Costa AT, Polonio JC, Santos MS, Rhoden SA, Azevedo JL, Pamphile JA (2016) Extracellular enzymatic profiles and taxonomic identification of endophytic fungi isolated from four plant species. Genet Mol Res. https://doi.org/10.4238/gmr15049016

  • Amirita A, Sindhu P, Swetha J, Vasanthi NS, Kannan KP (2012) Enumeration of endophytic fungi from medicinal plants and screening of extracellular enzymes. World J Sci Technol 2:13–19

    Google Scholar 

  • Anbu P, Gopinath SCB, Cihan AC, Chaulagain BP (2013) Microbial enzymes and their applications in industries and medicine. Biomed Res Int 204014. https://doi.org/10.1155/2013/204014

  • Anwar A, Saleemuddin M (1998) Alkaline proteases: a review. Bioresour Technol 64:175–183

    Google Scholar 

  • Arnold AE (2007) Understanding the diversity of foliar endophytic fungi: progress, challenges and practise. Fungal Biol Rev 21:51–56

    Google Scholar 

  • Bensaci OA, Daoud H, Lombarkia N, Rouabah K (2015) Formulation of the endophytic fungus Cladosporium oxysporum Berk. & M.A. Curtis, isolated from Euphorbia bupleuroides subsp. luteola, as a new biocontrol tool against the black bean aphid (Aphis fabae Scop.). J Plant Prot Res 55(1):80–87

    Google Scholar 

  • Bezerra JD, Santos MG, Svedese VM, Lima DM, Fernandes MJ, Paiva LM, Souza-Motta CM (2012) Richness of endophytic fungi isolated from Opuntia ficus-indica Mill. (Cactaceae) and preliminary screening for enzyme production. World J Microbiol Biotechnol 28:1989–1995

    Google Scholar 

  • Bhagobaty RK, Joshi SR (2012) Enzymatic activity of fungi endophytic on five medicinal plant species of the pristine sacred forests of Meghalaya, India. Biotechnol Bioprocess Eng 17:33–40

    Google Scholar 

  • Bhargav S, Panda BP, Ali M, Javed S (2008) Solid-state fermentation: an overview. Chem Biochem Eng Q 22:49–70

    Google Scholar 

  • Birrane G, Bhyravbhatla B, Navia MA (2014) Synthesis of aspartame by thermolysin: an X-ray structural study. ACS Med Chem Lett 5:706–710

    Google Scholar 

  • Borges WS, Borges KB, Bonato PS, Said S, Pupo MT (2009) Endophytic fungi: natural products, enzymes and biotransformation reactions. Curr Org Chem 13:1137–1163

    Google Scholar 

  • Brandelli A, Daroit DJ, Riffel A (2010) Biochemical features of microbial keratinases and their production and applications. Appl Microbiol Biotechnol 85:1735–1750

    Google Scholar 

  • Bryant MK, Schardl CL, Hesse U, Scott B (2009) Evolution of subtilisin–like protease gene family in the grass endophytic fungus Epichloë festucae. BMC Evol Biol 9:168

    Google Scholar 

  • Budiarto BR, Mustopa AZ, Tarman K (2015) Isolation, purification and characterization of extracellular protease produced by marine-derived endophytic fungus Xylaria psidii KT30. J Coast Life Med 3(1):56–63

    Google Scholar 

  • Caldwell BA, Jumpponen A, Trappe JM (2000) Utilization of major detrital substrates by dark-septate, root endophytes. Mycologia 92:230–232

    Google Scholar 

  • Canavan HE, Cheng X, Graham DJ, Ratner BD, Castner DG (2005) Cell sheet detachment affects the extracellular matrix: a surface science study comparing thermal liftoff, enzymatic, and mechanical methods. J Biomed Mater Res A 75(1):1–13

    Google Scholar 

  • Carroll G (1988) Fungal endophytes in stems and leaves: from latent pathogen to mutualistic symbiont. Ecology 69(1):2–9

    Google Scholar 

  • Chathurdevi G, Gowrie SU (2016) Endophytic fungi isolated from medicinal plant – a promising source of potential bioactive metabolites. Int J Curr Pharm Res 8(1):50–56

    Google Scholar 

  • Choi YW, Hodgkiss IJ, Hyde KD (2005) Enzyme production by endophytes of Brucea javanica. J Agric Technol 1:55–56

    Google Scholar 

  • Correa RCG, Rhoden SA, Mota TR, Azevedo JL, Pamphile JA, de Souza CGM, Polizeli MLTM, Bracht A, Peralta RM (2014) Endophytic fungi: expanding arsenal of industrial enzyme producers. J Ind Microbiol Biotechnol 41:1467–1478

    Google Scholar 

  • Craik CS, Page MJ, Madison EL (2011) Proteases as therapeutics. Biochem J 435(1):1–16

    Google Scholar 

  • dos Santos Aguilar JG, Sato HH (2018) Microbial proteases: production and application in obtaining protein hydrolysates. Food Res Int 103:253–262

    Google Scholar 

  • Ebeling W, Hennrich N, Klockow M, Metz H, Orth HD, Lang H (1974) Proteinase K from Tritirachium album limber. Eur J Biochem 47:91–97

    Google Scholar 

  • Fareed S, Jadoon UN, Ullah I, Jadoon MA, Rehman MU, Bibi Z, Waqas M (2017) Isolation and biological evaluation of endophytic fungus from Ziziphus nummularia. J Entomol Zool Stud 5(3):32–38

    Google Scholar 

  • Fouda AH, Hassan SED, Eid AH, Ewais EED (2015) Biotechnological applications of fungal endophytes associated with medicinal plant Asclepias sinaica (Bioss.). Ann Agric Sci 60(1):95–104

    Google Scholar 

  • Gabres CA, Undan JR, Valentino MJG (2016) Proteolytic enzyme like activity of fungal endophytes and their effects in the proximate composition of dried bamboo leaves. Int J Biol Pharm Allied Sci 5(6):1298–1306

    Google Scholar 

  • Gulrajani ML, Gupta SV (1996) Degumming of silk with different protease enzymes. Indian J Fibre Text Res 21:270–275

    Google Scholar 

  • Gupta R, Beg QK, Chauhan B (2002a) An overview on fermentation, downstream processing and properties of microbial proteases. Applied Microbiol Biotechnol 60:381–395

    Google Scholar 

  • Gupta R, Beg QK, Larenz P (2002b) Bacterial alkaline proteases: molecular approaches and industrial applications. Appl Microbiol Biotechnol 59:15–32

    Google Scholar 

  • Harrison RL, Bonning BC (2010) Proteases as insecticidal agents. Toxins 2:935–953

    Google Scholar 

  • Hasan S, Ahmad A, Purwar A, Khan N, Kundan R, Gupta G (2013) Production of extracellular enzymes in the entomopathogenic fungus Verticillium lecanii. Bioinformation 9:238–242

    Google Scholar 

  • Hawksworth DL (1991) The fungal dimension of biodiversity: magnitude, significance, and conservation. Mycol Res 95:641–655

    Google Scholar 

  • Hinton DM, Bacon CW (1985) The distribution and ultrastructure of the endophyte of toxic tall fescue. Can J Bot 63:36–42

    Google Scholar 

  • Holliger P, Hudson PJ (2005) Engineered antibody fragments and the rise of single domains. Nature Biotechnol 23:1126–1136

    Google Scholar 

  • Huang HL, Hsing HW, Lai TC, Chen YW, Lee TR, Chan HT, Lyu PC, Wu CL, Lu YC, Lin ST, Lin CW, Lai CH, Chang HT, Chou HC, Chan HL (2012) Trypsin-induced proteome alteration during cell subculture in mammalian cells. J Biomed Sci 17(1):36

    Google Scholar 

  • Hyde KD (2001) Increasing the likelihood of novel compound discovery from filamentous fungi. In: Pointing SB, Hyde KD (eds) Bio-Exploitation of filamentous fungi, Fungal Diversity Research Series 6, Fungal Diversity Press, Hong Kong, pp 77–91

    Google Scholar 

  • Katoch M, Salgotra A, Singh G (2014) Endophytic fungi found in association with Bacopa monnieri as potential producers of industrial enzyme and antimicrobial bioactive compounds. Braz Arch Biol Technol 57(5):714–722

    Google Scholar 

  • Katoch M, Singh A, Singh G, Wazir P, Kumar R (2017) Phylogeny, antimicrobial, antioxidant and enzyme-producing potential of fungal endophytes found in Viola odorata. Ann Microbiol 67:529–540

    Google Scholar 

  • Kirk O, Borchert TV, Fuglsan CC (2002) Industrial enzyme applications. Curr Opin Biotechnol 13:345–351

    Google Scholar 

  • Kour D, Rana KL, Verma P, Yadav AN, Kumar V, Singh DH (2017) Biofertilizers: eco-friendly technologies and bioresources for sustainable agriculture. In: Proceeding of International Conference on Innovative Research in Engineering Science and Technology IREST/PP/014

    Google Scholar 

  • Kühn D, Dürrschmidt P, Mansfeld J, Ulbrich-Hofmann R (2002) Biolysin and thermolysin in dipeptide synthesis: a comparative study. Biotechnol Appl Biochem 36:71–76

    Google Scholar 

  • Kumar CG, Takagi H (1999) Microbial alkaline proteases: from a bioindustrial viewpoint. Biotechnol Adv 17:561–594

    Google Scholar 

  • Kumaresan V, Suryanarayanan TS (2002) Endophyte assemblages in young, mature and senescent leaves of Rhizophora apiculata: evidence for the role endophytes in mangrove litter degradation. Fungal Divers 9:81–91

    Google Scholar 

  • Kunitz MJ (1947) Crystalline soybean trypsins inhibitor II. General properties. J Gen Physiol 30:291–310

    Google Scholar 

  • Ladenburger WU, Richter W, Moeller P, Boehm BO (1997) Protease treatment delays diabetes onset in diabetes-prone nonobese diabetic (NOD) mice. Int J Immunother 13(3/4):75–78

    Google Scholar 

  • Lee JM, Tan WS, Ting ASY (2014) Revealing the antimicrobial and enzymatic potentials of culturable fungal endophytes from tropical pitcher plants (Nepenthes sp.). Mycosphere 5(2):364–377

    Google Scholar 

  • Li Y, Shuang JL, Yuam WW, Huang WY, Tan RX (2007) Verticase: a fibrinolytic enzyme produced by Verticillium sp. Tj33, an endophyte of Trachelospermum jasminoides. J Integr Plant Biol 49:1548–1554

    Google Scholar 

  • Li HY, Shen M, Zhou ZP, Li T, Wei Y-I, Lin L-B (2012a) Diversity and cold adaptation of endophytic fungi from five dominant plant species collected from the Baima Snow Mountain, Southwest China. Fungal Divers 53:1–8

    Google Scholar 

  • Li S, Yang X, Yang S, Zhu M, Wang X (2012b) Technology prospecting on enzymes: application, marketing and engineering. Comput Struct Biotechnol J 2:1–11

    Google Scholar 

  • Lindstrom JT, Belanger FC (1994) Purification and characterization of an endophytic fungal proteinase that is abundantly expressed in the infected host grass. Plant Physiol 106:7–16

    Google Scholar 

  • Littlewood JM, Wolfe SP, Conway SP (2006) Diagnosis and treatment of intestinal malabsorption in cystic fibrosis. Pediatr Pulmonol 41:35–49

    Google Scholar 

  • Mani VM, Soundari AJPG, Preethi K (2018) Enzymatic and phytochemical analysis of endophytic fungi on Aegle marmelos from Western Ghats of Tamil Nadu, India. Int J Life Sci Pharma Res 8(1):1–8

    Google Scholar 

  • Maria GL, Sridhar KR, Raviraja NS (2005) Antimicrobial and enzyme activity of mangrove endophytic fungi of southwest coast of India. J Agr Tech 1:67–80

    Google Scholar 

  • Mayerhofer MS, Fraser E, Kernaghan G (2015) Acid protease production in fungal root endophytes. Mycologia 107(1):1–11

    Google Scholar 

  • Meijer M, Houbraken JAMP, Dalhuijsen S, Samson RA, Vries RO (2011) Growth and hydrolase profiles can be used as characteristics to distinguish Aspergillus niger and other black aspergilla. Stud Mycol 69:19–30

    Google Scholar 

  • Meshram V, Saxena S, Paul K (2016) Xylarinase: a novel clot busting enzyme from an endophytic fungus Xylaria curta. J Enzyme Inhib Med Chem 31(6):1502–1511

    Google Scholar 

  • Mótyán JA, Tóth F, Tőzsér J (2013) Research applications of proteolytic enzymes in molecular biology. Biomol Ther 3:923–942

    Google Scholar 

  • Najafi MF, Deobagkar D, Deobagkar D (2005) Potential application of protease isolated from Pseudomonas aeruginosa PD100. Electron J Biotechnol 8:197–203

    Google Scholar 

  • Ng’ang’a MP, Kahangi EM, Onguso JM, Losenge T, Mwaura P (2011) Analyses of extra-cellular enzymes production by endophytic fungi isolated from bananas in Kenya. Afr J Hortic Sci 5:1–8

    Google Scholar 

  • Nielsen RI, Oxenboll K (1998) Enzymes from fungi: their technology and uses. Mycologist 12:69–71

    Google Scholar 

  • Ningthoujam DS, Kshetri P, Sanasam S, Nimaichand S (2009) Screening, identification of best producers and optimization of extracellular proteases from moderately halophilic alkali thermotolerant indigenous actinomycetes. World Appl Sci J 7:907–916

    Google Scholar 

  • Okumura H, Watanabe R, Kotoura Y, Nakane Y, Tangiku O (1997) Effects of a proteolytic enzyme preparations used concomitantly with an antibiotic in Osteroarticular infections. Jpn J Antibiot 30(3):223–227

    Google Scholar 

  • Orlandelli RC, de Almeida TT, Alberto RN, Polonio JC, Azevedo JL, Pamphile JA (2015) Antifungal and proteolytic activities of endophytic fungi isolated from Piper hispidum Sw. Braz J Microbiol 46(2):359–366

    Google Scholar 

  • Østergaard LH, Olsen HS (2010) Industrial applications of fungal enzymes. In: Hofrichter XM (ed) The mycota. Springer, Berlin, pp 269–290

    Google Scholar 

  • Patel C, Yadav S, Rahi S, Dave A (2013) Studies on biodiversity of fungal endophytes of indigenous monocotaceous and dicotaceous plants and evaluation of their enzymatic potentialities. Int J Sci Res Publ 3(7):1–4

    Google Scholar 

  • Patil MG, Pagare J, Patil SN, Sidhu AK (2015) Extracellular enzymatic activities of endophytic fungi isolated from various medicinal plants. Int J Curr Microbiol App Sci 4(3):1035–1042

    Google Scholar 

  • Pavithra N, Sathish L, Ananda K (2012) Antimicrobial and enzyme activity of endophytic fungi isolated from Tulsi. J Pharm Biomed Sci 16(12):1–5

    Google Scholar 

  • Peterson R, Grinyer J, Nevalainen H (2011) Extracellular hydrolase profiles of fungi isolated from koala faeces invite biotechnological interest. Mycol Progr 10:207–218

    Google Scholar 

  • Potshangbam M, Indira Devi S, Sahoo D, Strobel GA (2017) Functional characterization of endophytic fungal community associated with Oryza sativa L. and Zea mays L. Front Microbiol 8:325

    Google Scholar 

  • Prathyusha P, Rajitha Sri AB, Satya Prasad K (2015) Diversity and enzymatic activity of foliar endophytic fungi isolated from medicinal plants of Indian dry deciduous forest. Pharm Lett 7(8):244–251

    Google Scholar 

  • Priest FG (1984) Extracellular enzymes. In: Aspects of microbiology, Volume 9. Van Nostrand Reinhold, Wokingham, UK

    Google Scholar 

  • Promputtha I, Lumyong S, Dhanasekaran V, McKenzie EHC, Hyde KD, Jeewon R (2007) A phylogenetic evaluation of whether endophytes become saprotrophs at host senescence. Microb Ecol 53:579–590

    Google Scholar 

  • Rajput K, Chanyal S, Agrawal PK (2016) Optimization of protease production by endophytic fungus, Alternaria alternata isolated from gymnosperm tree- Cupressus torulosa D.Don. World J Pharm Pharm Sci 5(7):1034–1054

    Google Scholar 

  • Raju DC, Thomas SM, Thomas SE (2015) Screening for extracellular enzyme production in endophytic fungi isolation from Calophyllum inophyllum L. leaves. J Chem Pharm Res 7:900–904

    Google Scholar 

  • Rana KL, Kour D, Yadav AN, Kumar V, Dhaliwal HS (2016a) Biotechnological applications of endophytic microbes associated with barley (Hordeum vulgare L.) growing in Indian Himalayan regions. In: Proceeding of 86th Annual Session of NASI & Symposium on “Science, Technology and Entrepreneurship for Human Welfare in The Himalayan Region”, p 80

    Google Scholar 

  • Rana KL, Kour D, Yadav AN, Kumar V, Dhaliwal HS (2016b) Endophytic microbes from wheat: diversity and biotechnological applications for sustainable agriculture. In: Proceeding of 57th Association of Microbiologist of India & International symposium on “Microbes and Biosphere: What’s New What’s Next”, p 453

    Google Scholar 

  • Rana KL, Kour D, Verma P, Yadav AN, Kumar V, Singh DH (2017) Diversity and biotechnological applications of endophytic microbes associated with maize (Zea mays L.) growing in Indian Himalayan regions. In: Proceeding of National Conference on Advances in Food Science and Technology, pp 41

    Google Scholar 

  • Rao MB, Tanskale AM, Ghatger MS, Deshpande VV (1998) Molecular and biotechnological aspects of microbial proteases. Microbiol Mol Biol Rev 62(3):597–635

    Google Scholar 

  • Rawlings ND, Tolle DP, Barrett AJ (2004) MEROPS: the peptidase database. Nucleic Acids Res 32:D160–D164

    Google Scholar 

  • Russell JR, Huang J, Anand P, Kucera K, Sandoval AG, Dantzler KW, Hickman DS, Jee J, Kimovec FM, Koppstein D, Marks DH, Mittermiller PA, Núñez SJ, Santiago M, Townes MA, Vishnevetsky M, Williams NE, Vargas MPN, Boulanger L-A, Bascom-Slack C, Strobel SA (2011) Biodegradation of polyester polyurethane by endophytic fungi. J Appl Environ Microbiol 77(17):6076–6084

    Google Scholar 

  • Sahay H, Yadav AN, Singh AK, Singh S, Kaushik R, Saxena AK (2017) Hot springs of Indian Himalayas: potential sources of microbial diversity and thermostable hydrolytic enzymes. 3 Biotech 7:1–11

    Google Scholar 

  • Samal BB, Karan B, Stabinsky Y (1990) Stability of two novel serine proteinases in commercial laundry detergent formulations. Biotechnol Bioeng 35:650–652

    Google Scholar 

  • Saran S, Isar J, Saxena RK (2007) A modified method for the detection of microbial proteases on agar plates using tannic acid. J Biochem Bioph Meth 70:697–699

    Google Scholar 

  • Sawant R, Nagendran S (2014) Protease: an enzyme with multiple industrial applications. World J Pharm Pharm Sci 3(6):568–579

    Google Scholar 

  • Saxena AK, Yadav AN, Kaushik R, Tyagi S, Kumar M, Prasanna R, Shukla L (2014) Use of microbes from extreme environments for the benefits of agriculture. In: Afro-Asian Congress on microbes for human & environmental health. https://doi.org/10.13140/RG.2.1.3479.1841

    Google Scholar 

  • Saxena AK, Yadav AN, Kaushik R, Tyagi SP, Shukla L (2015) Biotechnological applications of microbes isolated from cold environments in agriculture and allied sectors. In: International conference on “low temperature science and biotechnological advances”, society of low temperature biology, p 104. https://doi.org/10.13140/RG.2.1.2853.5202

  • Saxena AK, Yadav AN, Rajawat M, Kaushik R, Kumar R, Kumar M, Prasanna R, Shukla L (2016) Microbial diversity of extreme regions: an unseen heritage and wealth. Indian J Plant Genet Resour 29:246–248

    Google Scholar 

  • Schulz B, Boyle C, Draeger S, Römmert AK, Krohn K (2002) Endophytic fungi: a source of novel biologically active secondary metabolites. Mycol Res 106(9):996–1004

    Google Scholar 

  • Sharma KM, Kumar R, Vats S, Gupta A (2014) Production, partial purification and characterization of alkaline protease from Bacillus aryabhattai K3. Int J Adv Pharm Biol Chem 3(2):290–298

    Google Scholar 

  • Sharma KM, Kumar R, Panwar S, Kumar A (2017) Microbial alkaline proteases: optimization of production parameters and their properties. J Genet Eng Biotechnol 15:115–126

    Google Scholar 

  • Shubha J, Srinivas C (2017) Diversity and extracellular enzymes of endophytic fungi associated with Cymbidium aloifolium L. Afr J Biotechnol 16(48):2248–2258

    Google Scholar 

  • Sim YC, Lee SG, Lee DC, Kang BY, Park KM, Lee JY, Kim MS, Chang IS, Rhee JS (2000) Stabilization of papain and lysozyme for application to cosmetic products. Biotechnol Lett 22:137–140

    Google Scholar 

  • Strobel GA, Daisy B (2003) Bioprospecting for microbial endophytes and their natural products. Microbiol Mol Biol Rev 67:491–502

    Google Scholar 

  • Strobel GA, Daisy B, Castillo U, Harper J (2004) Natural products from endophytic microorganisms. J Nat Prod 67:257–268

    Google Scholar 

  • Suman A, Verma P, Yadav AN, Saxena AK (2015) Bioprospecting for extracellular hydrolytic enzymes from culturable thermotolerant bacteria isolated from Manikaran thermal springs. Res J Biotechnol 10:33–42

    Google Scholar 

  • Suman A, Yadav AN, Verma P (2016) Endophytic microbes in crops: diversity and beneficial impact for sustainable agriculture. In: Singh D, Abhilash P, Prabha R (eds) Microbial inoculants in sustainable agricultural productivity, research perspectives. Springer, India, pp 117–143. https://doi.org/10.1007/978-81-322-2647-5_7

    Google Scholar 

  • Sumantha A, Larroche C, Pandey A (2006) Microbiology and industrial biotechnology of food-grade proteases: a perspective. Food Technol Biotechnol 44(2):211–220

    Google Scholar 

  • Sun X, Guo L, Hyde KD (2011) Community composition of endophytic fungi in Acer truncatum and their role in decomposition. Fungal Divers 47:85–95

    Google Scholar 

  • Sunitha VH, Nirmala Devi D, Srinivas C (2013) Extracellular enzymatic activity of endophytic fungal strains isolated from medicinal plants. World J Agric Sci 9:01–09

    Google Scholar 

  • Suryanarayanan TS, Thirunavukkarasu N, Govindarajulu MB, Gopalan V (2012) Fungal endophytes: an untapped source of biocatalysts. Fungal Divers 54:19–30

    Google Scholar 

  • Tan RX, Zou WX (2001) Endophytes: a rich source of natural metabolites. Nat Prod Rep 8:448–459

    Google Scholar 

  • Tavano OL (2013) Protein hydrolysis using proteases: an important tool for food biotechnology. J Mol Catal B Enzym 90:1–11

    Google Scholar 

  • Tehran MM, Shahnavaz B, Birjandi RG, Mashreghi M, Fooladi J (2016) Optimization of protease production by psychrotrophic Rheinheimera sp. with response surface methodology. Appl Food Biotechnol 3(4):236–245

    Google Scholar 

  • Tenguria RK, Khan FN, Quereshi S (2011) Endophytes- mines of pharmacological therapeutics. World J Sci Technol 1(5):127–149

    Google Scholar 

  • Thirunavukkarasu N, Suryanarayanan TS, Rajamani T, Paranetharan MS (2017) A rapid and simple method for screening fungi for extracellular protease enzymes. Mycosphere 8(1):131–136

    Google Scholar 

  • Valls C, Pujadas G, Garcia-Vallve S, Mulero M (2011) Characterization of the protease activity of detergents laboratory practicals for studying the protease profile and activity of various commercial detergents. Biochem Mol Biol Educ 39(4):280–290

    Google Scholar 

  • Vasundhara M, Kumar A, Reddy MS (2016) Molecular approaches to screen bioactive compounds from endophytic fungi. Front Microbiol 7:1774

    Google Scholar 

  • Verma P, Yadav AN, Kumar V, Singh DP, Saxena AK (2017) Beneficial plant-microbes interactions: biodiversity of microbes from diverse extreme environments and its impact for crops improvement. In: Singh DP, Singh HB, Prabha R (eds) Plant-microbe interactions in agro-ecological perspectives. Springer Nature, Singapore, pp 543–580. https://doi.org/10.1007/978-981-10-6593-4_22

    Google Scholar 

  • Vignardet C, Guillaume YC, Michel L, Friedrich J, Millet J (2001) Comparison of two hard keratinous substrates submitted to the action of a keratinase using an experimental design. Int J Pharm 224:115–122

    Google Scholar 

  • Ward OP, Qin WM, Dhanjoon J, Ye J, Singh A (2005) Physiology and biotechnology of Aspergillus. Adv Appl Microbiol 58:1–75

    Google Scholar 

  • Ward OP, Rao MB, Kulkarni A (2009) Proteases, production. In: Schaechter M (ed) Encyclopaedia of microbiology, 3rd edn. Elsevier, New York, pp 495–511

    Google Scholar 

  • Whitaker JR (1994) Principles of enzymology for the food science, 2nd edn, Marcel Dekker, New York, pp 469–497

    Google Scholar 

  • Wilson AD, Clement SL, Kiaser WJ (1991) Survey and detection of endophytic fungi in Lolium germplasm by direct staining and aphid assays. Plant Dis 75:169–173

    Google Scholar 

  • Wooldridge JL, Heubi JE, Amaro-Galvez R, Boas SR, Blake KV, Nasr SZ, Chatfield B, McColley SA, Woo MS, Hardy KA, Kravitz RM, Straforini C, Anelli M, Lee C (2009) EUR-1008 pancreatic enzyme replacement is safe and effective in patients with cystic fibrosis and pancreatic insufficiency. J Cystic Fibrosis 8:405–417

    Google Scholar 

  • Wu B, Wu L, Chen D, Yang Z, Luo M (2009) Purification and characterization of a novel fibrinolytic protease from Fusarium sp. CPCC 480097. J Ind Microb Biotechnol 36:451–459

    Google Scholar 

  • Yadav AN, Sachan SG, Verma P, Kaushik R, Saxena AK (2016) Cold active hydrolytic enzymes production by psychrotrophic Bacilli isolated from three sub-glacial lakes of NW Indian Himalayas. J Basic Microbiol 56:294–307

    Google Scholar 

  • Yadav AN, Kumar R, Kumar S, Kumar V, Sugitha T, Singh B, Chauhan VS, Dhaliwal HS, Saxena AK (2017a) Beneficial microbiomes: biodiversity and potential biotechnological applications for sustainable agriculture and human health. J App Biol Biotech 5:1–13

    Google Scholar 

  • Yadav AN, Verma P, Kumar R, Kumar V, Kumar K (2017b) Current applications and future prospects of eco-friendly microbes. EU Voice 3:1–3

    Google Scholar 

  • Zaferanloo B, Virkar A, Mahon PJ, Palombo EA (2013) Endophytes from an Australian native plant are a promising source of industrially useful enzymes. World J Microbiol Biotechnol 29:335–345

    Google Scholar 

  • Zaferanloo B, Quang TD, Daumoo S, Ghorbani MM, Mahon PJ, Palombo EA (2014) Optimization of protease production by endophytic fungus, Alternaria alternata, isolated from Australian native plant. World J Microbiol Biotechnol 30:1755–1762

    Google Scholar 

  • Zhang XQ, Liu QH, Zhang GQ, Wang HX, Ng TB (2010) Purification and molecular cloning of a serine protease from mushroom Hypsizigus marmoreus. Process Biochem 45:724–730

    Google Scholar 

Download references

Acknowledgments

Authors are thankful to the Council of Scientific and Industrial Research (CSIR), Government of India, for financial support in the form of Junior Research Fellowship to SM and Department of Biotechnology (DBT), New Delhi for financial support.

Author information

Authors and Affiliations

  1. Microbiology and Microbial Biotechnology Laboratory, Department of Botany and Forestry, Vidyasagar University, Midnapore, West Bengal, India

    Suchandra Mandal & Debdulal Banerjee

Authors
  1. Suchandra Mandal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Debdulal Banerjee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Debdulal Banerjee .

Editor information

Editors and Affiliations

  1. Department of Biotechnology, Akal College of Agriculture, Eternal University, Himachal Pradesh, India

    Ajar Nath Yadav

  2. QCQA Laboratory, Biotech Park, Lucknow, Uttar Pradesh, India

    Shashank Mishra

  3. Department of Biochemistry, Dr. Ram Manohar Lohia Avadh University, Faizabad, Uttar Pradesh, India

    Sangram Singh

  4. Department of Biology, Sri Avadh Raj Singh Smarak Degree College, Gonda, Uttar Pradesh, India

    Arti Gupta

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Mandal, S., Banerjee, D. (2019). Proteases from Endophytic Fungi with Potential Industrial Applications. In: Yadav, A., Mishra, S., Singh, S., Gupta, A. (eds) Recent Advancement in White Biotechnology Through Fungi. Fungal Biology. Springer, Cham. https://doi.org/10.1007/978-3-030-10480-1_10

Download citation

Publish with us

Policies and ethics

Search

Navigation