Skip to main content

Peritoneal Carcinomatosis and Other Emergencies Not Related to Primary Colorectal Cancer

  • Chapter
  • First Online:
  • 755 Accesses

Part of the book series: Hot Topics in Acute Care Surgery and Trauma ((HTACST))

Abstract

Synchronous peritoneal carcinomatosis occurs in approximately 5% of patients with colorectal cancer, whereas metachronous carcinomatosis is reported in 5–19% of cases. It requires medical and, in selected cases, surgical management that most of the times occurs in an emergency setting. Malignant bowel obstruction is a frequent complication of peritoneal carcinomatosis, with potentially severe complications and the need of a complex multidisciplinary management, ranging from medical therapy to interventional endoscopic or radiological procedures to emergency surgery. Careful evaluation of patients’ status, cancer disease history, and expected prognosis is required, if possible by a multidisciplinary team, to establish the optimal treatment. In this chapter, disease presentation, diagnosis, and treatment strategies for peritoneal carcinomatosis presenting in emergency setting are discussed in the light of the recent literature. Furthermore, colitis that may be associated with colorectal cancer or with chemotherapy regimens is discussed, including ischemic, neutropenic, and pseudomembranous colitis. Differential diagnosis of colitis is crucial to establish a prompt and appropriate treatment in these patients. The possibility of incidental diagnosis of colorectal cancer in patients treated for other emergency conditions is also discussed.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Lemoine L, Sugarbaker P, Van der Speeten K. Pathophysiology of colorectal peritoneal carcinomatosis: role of the peritoneum. World J Gastroenterol. 2016;22:7692–707.

    Article  CAS  Google Scholar 

  2. Koppe MJ, Boerman OC, Oyen WJ, Bleichrodt RP. Peritoneal carcinomatosis of colorectal origin: incidence and current treatment strategies. Ann Surg. 2006;243:212–22.

    Article  Google Scholar 

  3. Lemmens VE, Klaver YL, Verwaal VJ, Rutten HJ, Coebergh JW, de Hingh IH. Predictors and survival of synchronous peritoneal carcinomatosis of colorectal origin: a population-based study. Int J Cancer. 2011;128:2717–25.

    Article  CAS  Google Scholar 

  4. Segelman J, Granath F, Holm T, Machado M, Mahteme H, Martling A. Incidence, prevalence and risk factors for peritoneal carcinomatosis from colorectal cancer. Br J Surg. 2012;99:699–705.

    Article  CAS  Google Scholar 

  5. Klaver CE, Groenen H, Morton DG, Laurberg S, Bemelman WA, Tanis PJ. Recommendations and consensus on the treatment of peritoneal metastases of colorectal origin: a systematic review of national and international guidelines. Colorectal Dis. 2017;19:224–36.

    Article  CAS  Google Scholar 

  6. Sadahiro S, Suzuki T, Maeda Y, Tanaka A, Makuuchi H, Kamijo A, Haruki Y, Murayama C. Prognostic factors in patients with synchronous peritoneal carcinomatosis (PC) caused by a primary cancer of the colon. J Gastrointest Surg. 2009;13:1593–8.

    Article  Google Scholar 

  7. Segelman J, Akre O, Gustafsson UO, Bottai M, Martling A. External validation of models predicting the individual risk of metachronous peritoneal carcinomatosis from colon and rectal cancer. Colorectal Dis. 2016;18:378–85.

    Article  CAS  Google Scholar 

  8. Sugarbaker PH. Peritoneal surface oncology: review of a personal experience with colorectal and appendiceal malignancy. Tech Coloproctol. 2005;9:95–103.

    Article  CAS  Google Scholar 

  9. Faron M, Macovei R, Goéré D, Honoré C, Benhaim L, Elias D. Linear relationship of peritoneal cancer index and survival in patients with peritoneal metastases from colorectal cancer. Ann Surg Oncol. 2016;23:114–9.

    Article  Google Scholar 

  10. Goéré D, Malka D, Tzanis D, et al. Is there a possibility of a cure in patients with colorectal peritoneal carcinomatosis amenable to complete cytoreductive surgery and intraperitoneal chemotherapy? Ann Surg. 2013;257:1065–71.

    Article  Google Scholar 

  11. Elias D, Mariani A, Cloutier AS, et al. Modified selection criteria for complete cytoreductive surgery plus HIPEC based on peritoneal cancer index and small bowel involvement for peritoneal carcinomatosis of colorectal origin. Eur J Surg Oncol. 2014;40:1467–73.

    Article  CAS  Google Scholar 

  12. Glehen O, Kwiatkowski F, Sugarbaker PH, et al. Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for the management of peritoneal carcinomatosis from colorectal cancer: a multi-institutional study. J Clin Oncol. 2004;22:3284–92.

    Article  CAS  Google Scholar 

  13. Mo S, Cai G. Multidisciplinary treatment for colorectal peritoneal metastases: review of the literature. Gastroenterol Res Pract. 2016;2016:1516259.

    Article  Google Scholar 

  14. Wu W, Yan S, Liao X, et al. Curative versus palliative treatments for colorectal cancer with peritoneal carcinomatosis: a systematic review and meta-analysis. Oncotarget. 2017;8:113202–12.

    PubMed  PubMed Central  Google Scholar 

  15. Arjona-Sánchez A, Barrios P, Boldo-Roda E, et al. HIPECT4: multicentre, randomized clinical trial to evaluate safety and efficacy of Hyperthermic intra-peritoneal chemotherapy (HIPEC) with Mitomycin C used during surgery for treatment of locally advanced colorectal carcinoma. BMC Cancer. 2018;18:183.

    Article  Google Scholar 

  16. Avital I, Brücher BL, Nissan A, Stojadinovic A. Randomized clinical trials for colorectal cancer peritoneal surface malignancy. Surg Oncol Clin N Am. 2012;21:665–88.

    Article  Google Scholar 

  17. NCCN. Clinical Practice Guidelines in Oncology, Colon Cancer, version 2.18, March 2018. https://www.nccn.org/professionals/physician_gls/pdf/colon.pdf. Accessed April 25, 2018.

  18. Sadeghi B, Arvieux C, Glehen O, et al. Peritoneal carcinomatosis from non-gynecologic malignancies: results of the EVOCAPE 1 multicentric prospective study. Cancer. 2000;88:358–63.

    Article  CAS  Google Scholar 

  19. Klaver YL, Leenders BJ, Creemers GJ, et al. Addition of biological therapies to palliative chemotherapy prolongs survival in patients with peritoneal carcinomatosis of colorectal origin. Am J Clin Oncol. 2013;36:157–61.

    Article  CAS  Google Scholar 

  20. Verwaal VJ, Bruin S, Boot H, van Slooten G, van Tinteren H. 8-year follow-up of randomized trial: cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy in patients with peritoneal carcinomatosis of colorectal cancer. Ann Surg Oncol. 2008;15:2426–32.

    Article  Google Scholar 

  21. Arakawa K, Kawai K, Ishihara S, et al. Prognostic significance of peritoneal metastasis in stage IV colorectal cancer patients with R0 resection: a multicenter, retrospective study. Dis Colon Rectum. 2017;60:1041–9.

    Article  Google Scholar 

  22. Quere P, Facy O, Manfredi S, Jooste V, Faivre J, Lepage C, Bouvier AM. Epidemiology, management, and survival of peritoneal carcinomatosis from colorectal cancer: a population-based study. Dis Colon Rectum. 2015;58:743–52.

    Article  CAS  Google Scholar 

  23. Laval G, Marcelin-Benazech B, Guirimand F, et al. Recommendations for bowel obstruction with peritoneal carcinomatosis. J Pain Symptom Manage. 2014;48:75–91.

    Article  Google Scholar 

  24. Silva AC, Pimenta M, Guimarães LS. Small bowel obstruction: what to look for. Radiographics. 2009;29:423–39.

    Article  Google Scholar 

  25. Woolfson RG, Jennings K, Whalen GF. Management of bowel obstruction in patients with abdominal cancer. Arch Surg. 1997;132:1093–7.

    Article  CAS  Google Scholar 

  26. Legendre H, Vanhuyse F, Caroli-Bosc FX, Pector JC. Survival and quality of life after palliative surgery for neoplastic gastrointestinal obstruction. Eur J Surg Oncol. 2001;27:364–7.

    Article  CAS  Google Scholar 

  27. Dalal KM, Gollub MJ, Miner TJ, et al. Management of patients with malignant bowel obstruction and stage IV colorectal cancer. J Palliat Med. 2011;14:822–8.

    Article  Google Scholar 

  28. Clark K, Lam L, Currow D. Reducing gastric secretions--a role for histamine 2 antagonists or proton pump inhibitors in malignant bowel obstruction? Support Care Cancer. 2009;17:1463–8.

    Article  CAS  Google Scholar 

  29. Ripamonti CI, Easson AM, Gerdes H. Management of malignant bowel obstruction. Eur J Cancer. 2008;44:1105–15.

    Article  Google Scholar 

  30. Murray-Brown F, Dorman S. Haloperidol for the treatment of nausea and vomiting in palliative care patients. Cochrane Database Syst Rev. 2015;11(2):CD006271.

    Google Scholar 

  31. Obita GP, Boland EG, Currow DC, Johnson MJ, Boland JW. Somatostatin analogues compared with placebo and other pharmacologic agents in the management of symptoms of inoperable malignant bowel obstruction: a systematic review. J Pain Symptom Manage. 2016;52:901–919.e1.

    Article  Google Scholar 

  32. Caceres A, Zhou Q, Iasonos A, Gerdes H, Chi DS, Barakat RR. Colorectal stents for palliation of large-bowel obstructions in recurrent gynecologic cancer: an updated series. Gynecol Oncol. 2008;108:482–5.

    Article  Google Scholar 

  33. Mendelsohn RB, Gerdes H, Markowitz AJ, DiMaio CJ, Schattner MA. Carcinomatosis is not a contraindication to enteral stenting in selected patients with malignant gastric outlet obstruction. Gastrointest Endosc. 2011;73:1135–40.

    Article  Google Scholar 

  34. Brooksbank MA, Game PA, Ashby MA. Palliative venting gastrostomy in malignant intestinal obstruction. Palliat Med. 2002;16:520–6.

    Article  CAS  Google Scholar 

  35. Paul Olson TJ, Pinkerton C, Brasel KJ, Schwarze ML. Palliative surgery for malignant bowel obstruction from carcinomatosis: a systematic review. JAMA Surg. 2014;149:383–92.

    Article  Google Scholar 

  36. Shariat-Madar B, Jayakrishnan TT, Gamblin TC, Turaga KK. Surgical management of bowel obstruction in patients with peritoneal carcinomatosis. J Surg Oncol. 2014;110:666–9.

    Article  Google Scholar 

  37. Ko GY, Ha HK, Lee HJ, et al. Usefulness of CT in patients with ischemic colitis proximal to colonic cancer. AJR Am J Roentgenol. 1997;168:951–6.

    Article  CAS  Google Scholar 

  38. Xiong L, Chintapalli KN, Dodd GD, et al. Frequency and CT patterns of bowel wall thickening proximal to cancer of the colon. AJR Am J Roentgenol. 2004;182:905–9.

    Article  Google Scholar 

  39. Jang HJ, Lim HK, Park CK, Kim SH, Park JM, Choi YL. Segmental wall thickening in the colonic loop distal to colonic carcinoma at CT: importance and histopathologic correlation. Radiology. 2000;216:712–7.

    Article  CAS  Google Scholar 

  40. Chiu HH, Chen CM, Mo LR, Chao TJ. Gastrointestinal: ischemic colitis associated with colon cancer. J Gastroenterol Hepatol. 2005;20:1458.

    Article  Google Scholar 

  41. Rodrigues FG, Dasilva G, Wexner SD. Neutropenic enterocolitis. World J Gastroenterol. 2017;23:42–7.

    Article  Google Scholar 

  42. Gorschlüter M, Mey U, Strehl J, et al. Neutropenic enterocolitis in adults: systematic analysis of evidence quality. Eur J Haematol. 2005;75:1–13.

    Article  Google Scholar 

  43. Ong GK, Reidy TJ, Huk MD, Lane FR. Clostridium difficile colitis: a clinical review. Am J Surg. 2017;213:565–71.

    Article  Google Scholar 

  44. Morales Chamorro R, Serrano Blanch R, Méndez Vidal MJ, Gómez España MA, Rubio Pérez MJ, de la Haba Rodríguez JR, Aranda Aguilar E. Pseudomembranous colitis associated with chemotherapy with 5-fluorouracil. Clin Transl Oncol. 2005;7:258–61.

    Article  Google Scholar 

  45. GLOBOCAN 2012. Estimated cancer incidence, mortality and prevalence worldwide in 2012. http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx. Accessed April 25, 2018.

  46. Mangat S, Kozoriz MG, Bicknell S, Spielmann A. The accuracy of colorectal cancer detection by computed tomography in the unprepared large bowel in a community-based hospital. Can Assoc Radiol J. 2018;69:92–6.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Petrucciani, N., Laurent, A., Brunetti, F., de’Angelis, N. (2019). Peritoneal Carcinomatosis and Other Emergencies Not Related to Primary Colorectal Cancer. In: de'Angelis, N., Di Saverio, S., Brunetti, F. (eds) Emergency Surgical Management of Colorectal Cancer. Hot Topics in Acute Care Surgery and Trauma. Springer, Cham. https://doi.org/10.1007/978-3-030-06225-5_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-06225-5_10

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-06224-8

  • Online ISBN: 978-3-030-06225-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics