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Synthesis and Characterization of PVP/CaCO3-Ag Blend Hydrogel by Gamma Irradiation: Study of Drug Delivery System and Antimicrobial Activity

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Characterization of Minerals, Metals, and Materials 2019

Part of the book series: The Minerals, Metals & Materials Series ((MMMS))

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Abstract

Chronic wounds are skin injuries with failed healing. They have become a public health problem that affects more than 2% of the population and the presence of bacteria resistances difficult of treatment. Pseudomonas aeruginosa is opportunist pathogens and the treatment is difficult and requires a long period of treatment. Hydrogels are structure polymeric tridimensional and biocompatible. They have been used as a controlled delivery system for treatment of topic infection. Studies have reported calcium carbonate and silver ion can improve the mechanical properties and biocide activity of hydrogel . Here in this study, hydrogels loaded CaCO3-Ag were prepared using poly (N-vinyl-2-pyrrolidone), poly (ethylene glycol), agar, calcium carbonate , silver nitrate followed gamma irradiation with 25 kGy dose. The gel fraction, behavior swelling and biocide action against P. aeruginosa was investigated. The degree of swelling of the hydrogel loaded CaCO3-Ag was 12% higher than the unloaded and exhibited antibacterial effects against P. aeruginosa and biofilm.

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Acknowledgements

The authors would like to thank Coordination for the Improvement of Higher Education Personnel (CAPES, process n° 88881.134341/2016-01), Foundation for Research Support of the State of São Paulo (FAPESP, process n° 2016/19254-0), and Nuclear and Energy Research Institute (IPEN-CNEN/SP, Brazil). Dr. T. Samuel Lab is supported by NIH SC3GM109314.

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Authors and Affiliations

  1. Nuclear and Energy Research Institute, IPEN, CNEN/SP, Av. Prof. Lineu Prestes, 2242, São Paulo, SP, 05508-000, Brazil

    Angelica Tamiao Zafalon, Vinícius dos Santos Juvino, Luiz Gustavo Hiroki Komatsu, Duclerc Fernandes Parra & Ademar Lugao

  2. College of Veterinary Medicine, Tuskegee University, Tuskegee, AL, 36088, USA

    Temesgen Samuel

  3. Department of Materials Science and Engineering, Tuskegee University, Tuskegee, AL, 36088, USA

    Vijaya Rangari

Authors
  1. Angelica Tamiao Zafalon
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  2. Vinícius dos Santos Juvino
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  3. Luiz Gustavo Hiroki Komatsu
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  4. Duclerc Fernandes Parra
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  5. Ademar Lugao
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  6. Temesgen Samuel
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  7. Vijaya Rangari
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Corresponding author

Correspondence to Angelica Tamiao Zafalon .

Editor information

Editors and Affiliations

  1. Michigan Technological University, Houghton, MI, USA

    Bowen Li

  2. CanmetMATERIALS, Hamilton, ON, Canada

    Jian Li

  3. Al-Isra University, Amman, Jordan

    Shadia Ikhmayies

  4. ArcelorMittal Global R&D, East Chicago, IN, USA

    Mingming Zhang

  5. Middle East Technical University, Ankara, Turkey

    Yunus Eren Kalay

  6. Los Alamos National Laboratory, Los Alamos, NM, USA

    John S. Carpenter

  7. Michigan Technological University, Houghton, MI, USA

    Jiann-Yang Hwang

  8. Military Institute of Engineering, Rio de Janeiro, Brazil

    Sergio Neves Monteiro

  9. Chongqing University, Chongqing, China

    Chenguang Bai

  10. UNSW Canberra, Campbell, ACT, Australia

    Juan P. Escobedo-Diaz

  11. Free University of Bozen-Bolzano, Bolzano, Italy

    Pasquale Russo Spena

  12. Naval Research Laboratory, Washington, DC, USA

    Ramasis Goswami

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Zafalon, A.T. et al. (2019). Synthesis and Characterization of PVP/CaCO3-Ag Blend Hydrogel by Gamma Irradiation: Study of Drug Delivery System and Antimicrobial Activity. In: Li, B., et al. Characterization of Minerals, Metals, and Materials 2019. The Minerals, Metals & Materials Series. Springer, Cham. https://doi.org/10.1007/978-3-030-05749-7_26

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