Abstract
Recently, significant advancement has achieved in the field of bone tissue engineering for the preparation of artificial bone in order to treat defects or bone loss. Biomaterials mainly used to construct devices that are associated with the biological system to co-exist for long-lasting use with limited chance of failures. Most well-known biomaterials used for bone implants include metals, ceramics, and polymers. At present carbon nanomaterials, particularly carbon nanotubes are promising biomaterials for artificial bone due to their remarkable mechanical, electrical and thermal strength. However, in biomedical applications, carbon nanotubes are restricted to use alone due to issues like toxicity, abacas sheets formation and aggregation. Functionalization techniques help to avoid such issues. Functionalization techniques are categorized into covalent and non-covalent approaches. Covalent approach primarily focuses on tailoring the sidewalls to proceed with the modification, whereas non-covalent are constrained to alter the structure. Furthermore, CNTs are among remarkable biomaterials, and immense successful studies have been conducted to analyse the effects of CNTs with/without polymers in both vivo and in vitro experiments. The purpose of this chapter is to use functionalized carbon nanomaterial, mainly CNTs as filler material for artificial bone replacement. Therefore, this chapter reviewed the bones structure and mechanics, artificial bone history, carbon nanotubes synthesis and functionalization techniques.
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References
Bawa R, Audette GF, Rubinstein I (2016) Handbook of clinical nanomedicine: nanoparticles, imaging, therapy, and clinical applications. CRC Press, Boca Raton
Adlakha-Hutcheon G, Khaydarov R, Korenstein R, Varma R, Vaseashta A, Stamm H et al (2009) Nanomaterials, nanotechnology. Nanomaterials: Risks and Benefits. Springer, Berlin, pp 195–207
Schaefer H-E (2010) Nanoscience: the science of the small in physics, engineering, chemistry, biology and medicine. Springer, Berlin Heidelberg, pp 615–735
Yang Y, Yang X, Yang Y, Yuan Q (2018) Aptamer-functionalized carbon nanomaterials electrochemical sensors for detecting cancer relevant biomolecules. Carbon 129:380–395
Liu Y, Dong X, Chen P (2012) Biological and chemical sensors based on graphene materials. Chem Soc Rev 41(6):2283–2307
Trung TQ, Lee NE (2016) Flexible and stretchable physical sensor integrated platforms for wearable human-activity monitoring and personal healthcare. Adv Mater 28(22):4338–4372
Yang W, Ratinac KR, Ringer SP, Thordarson P, Gooding JJ, Braet F (2010) Carbon nanomaterials in biosensors: should you use nanotubes or graphene? Angew Chem Int Ed 49(12):2114–2138
Weiss NO, Zhou H, Liao L, Liu Y, Jiang S, Huang Y et al (2012) Graphene: an emerging electronic material. Adv Mater 24(43):5782–5825
Backes C (2012) Introduction: noncovalent functionalization of carbon nanotubes: fundamental aspects of dispersion and separation in water. Springer, Berlin Heidelberg, pp 1–37
Zamolo VA, Vazquez E, Prato M (2013) Carbon nanotubes: synthesis, structure, functionalization, and characterization. In: Siegel JS, Wu Y-T (eds) Polyarenes II. 350, pp 65–109, Springer, Cham
Yadav Y, Kunduru V, Prasad S (2008) Carbon nanotubes: synthesis and characterization. In: Morris JE (ed) Nanopackaging: nanotechnologies and electronics packaging. Springer US, Boston, MA, pp 325–344
Rezakazemi M, Amooghin AE, Montazer-Rahmati MM, Ismail AF, Matsuura T (2014) State-of-the-art membrane based CO2 separation using mixed matrix membranes (MMMs): an overview on current status and future directions. Prog Polym Sci 39(5):817–861
Kong J, Zhou C, Morpurgo A, Soh HT, Quate CF, Marcus C et al (1999) Synthesis, integration, and electrical properties of individual single-walled carbon nanotubes. Appl Phys A 69(3):305–308
Sun H, She P, Lu G, Xu K, Zhang W, Liu Z (2014) Recent advances in the development of functionalized carbon nanotubes: a versatile vector for drug delivery. J Mater Sci 49(20):6845–6854
Liu Y, Zhao Y, Sun B, Chen C (2012) Understanding the toxicity of carbon nanotubes. Acc Chem Res 46(3):702–713
Schafer FQ, Qian SY, Buettner GR (2000) Iron and free radical oxidations in cell membranes. Cellular and molecular biology (Noisy-le-Grand, France) 46(3):657
Basiuk EV, Basiuk VA (2015) Solvent-free functionalization of carbon nanomaterials. In: Basiuk VA, Basiuk EV (eds) Green processes for nanotechnology: from inorganic to bioinspired nanomaterials. Springer, Cham, pp 163–205
Krishna V, Stevens N, Koopman B, Moudgil B (2010) Optical heating and rapid transformation of functionalized fullerenes. Nat Nanotechnol 5(5):330
Bai RG, Ninan N, Muthoosamy K, Manickam S (2017) Graphene: a versatile platform for nanotheranostics and tissue engineering. Progress in Materials Science
Egli RJ, Luginbuehl R (2012) Tissue engineering-nanomaterials in the musculoskeletal system. Swiss Med Wkly 142:w13647
Cowin SC (2001) Bone mechanics handbook. CRC Press, Boca Roton
Currey J (2002) Bones: structure and mechanics. Princeton University Press, Princeton, NJ
Behari J (1991) Solid state bone behaviour. Prog Biophys Mol Biol 56(1):1–41
Rouhi G (2006) Theoretical aspects of bone remodeling and resorption processes. Ph.D. Thesis, University of Calgary
Bartel D, Davy D, Keaveny T (2006) Orthopaedic biomechanics mechanics and design in musculoskeletal systems. Pearson Education Inc., Upper Saddle River
Lakes R, Saha S (1979) Cement line motion in bone. Science 204(4392):501–503
van der Meulen MC (2000) Mechanics in skeletal development, adaptation and disease. Philos Trans Royal Soc Lond A Math Phys Eng Sci 358(1766):565–578
Guldberg R, Caldwell N, Guo X, Goulet R, Hollister S, Goldstein S (1997) Mechanical stimulation of tissue repair in the hydraulic bone chamber. J Bone Miner Res 12(8):1295–1302
Burger EH, Klein-Nulend J (1999) Mechanotransduction in bone—role of the lacuno-canalicular network. FASEB J 13(9001):S101–S12
Parfitt A (1995) Problems in the application of in vitro systems to the study of human bone remodeling. Calcif Tissue Int 56(1):S5–S7
Standring S (2015) Gray’s anatomy e-book: the anatomical basis of clinical practice. Elsevier, Amsterdam
Patka P, Haarman HJTM, van der Elst M, Bakker FC (2000) Artificial bone. In: Wise DL, Trantolo DJ, Lewandrowski K-U, Gresser JD, Cattaneo MV, Yaszemski MJ (eds) Biomaterials engineering and devices: human applications, vol 2, Orthopedic, Dental, and Bone Graft Applications, pp 95–109. 2 Totowa, Humana Press, NJ
Autograft (2001) In: Schwab M (ed) Encyclopedic reference of cancer, p 83. Springer, Berlin, Heidelberg
Isograft (2001) In: Schwab M (ed). Encyclopedic reference of cancer, p 468. Springer, Berlin, Heidelberg
Allograft (2001) In: Schwab M (ed) Encyclopedic reference of cancer, p 38. Springer, Berlin Heidelberg
Kabbashi N, Jamal Ibrahim D, Rosli NF (2011) Statistical analysis for removal of cadmium from aqueous solution at high pH. Aust J Basic Appl Sci 5(6):440–446
Syahrom A, Kadir MRA, Abdullah J, Öchsner A (2013) Permeability studies of artificial and natural cancellous bone structures. Med Eng Phys 35(6):792–799
Saijo H, Kanno Y, Mori Y, Suzuki S, Ohkubo K, Chikazu D et al (2011) A novel method for designing and fabricating custom-made artificial bones. Int J Oral Maxillofac Surg 40(9):955–960
Kamachimudali U, Sridhar T, Raj B (2003) Corrosion of bio implants. Sadhana 28(3–4):601–637
Trebše R (2012) Biomaterials in artificial joint replacements. Infected total joint arthroplasty. Springer, Berlin, pp 13–21
Virtanen S, Milošev I, Gomez-Barrena E, Trebše R, Salo J, Konttinen Y (2008) Special modes of corrosion under physiological and simulated physiological conditions. Acta Biomater 4(3):468–476
De Volder MF, Tawfick SH, Baughman RH, Hart AJ (2013) Carbon nanotubes: present and future commercial applications. Science 339(6119):535–539
Grace T (2003) An introduction to carbon nanotubes. Summer, Stanford University
Pénicaud A (2014) Solubilization of fullerenes, carbon nanotubes, and graphene. Making and exploiting fullerenes, graphene, and carbon nanotubes. Springer, Berlin, pp 1–35
Rao CK, Rao L (2017) Critical velocities in fluid-conveying single-walled carbon nanotubes embedded in an elastic foundation. J Appl Mech Tech Phys 58(4):743–752
Yu O, Daoyong L, Weiran C, Shaohua S, Li C (2009) A temperature window for the synthesis of single-walled carbon nanotubes by catalytic chemical vapor deposition of CH 4 over Mo 2-Fe 10/MgO catalyst. Nanoscale Res Lett 4(6):574
Qingwen L, Hao Y, Yan C, Jin Z, Zhongfan L (2002) A scalable CVD synthesis of high-purity single-walled carbon nanotubes with porous MgO as support material. J Mater Chem 12(4):1179–1183
Ahmed W, Jackson MJ (2016) Surgical tools and medical devices. Springer, Berlin
Radushkevich L, Lukyanovich V (1952) Carbon structure formed under thermal decomposition of carbon monoxide on iron. Zh Fiz Khim 26(1):88–95
Shin Y-H, Song J-W, Lee E-S, Han C-S (2007) Imaging characterization of carbon nanotube tips modified using a focused ion beam. Appl Surf Sci 253(16):6872–6877
Vajtai R (2013) Springer handbook of nanomaterials. Springer Science & Business Media, Berlin
Huczko A (2002) Synthesis of aligned carbon nanotubes. Appl Phys A 74(5):617–638
Chauhan SK, Shukla A, Dutta S, Gangopadhyay S, Bharadwaj LM (2012) Carbon nanotubes for environmental protection. Springer, Environmental Chemistry for a Sustainable World, pp 83–98
Syrgiannis Z, Melchionna M, Prato M (2015) Covalent carbon nanotube functionalization. In: Kobayashi S, Müllen K (eds) Encyclopedia of polymeric nanomaterials. Springer, Berlin Heidelberg, pp 480–487
Yang Y, Qiu S, Xie X, Wang X, Li RKY (2010) A facile, green, and tunable method to functionalize carbon nanotubes with water-soluble azo initiators by one-step free radical addition. Appl Surf Sci 256(10):3286–3292
Mananghaya MR, Santos GN, Yu DN (2017) Solubility of amide functionalized single wall carbon nanotubes: a quantum mechanical study. J Mol Liq 242:1208–1214
Giliopoulos DJ, Triantafyllidis KS, Gournis D (2013) Chemical functionalization of carbon nanotubes for dispersion in epoxy matrices. In: Paipetis A, Kostopoulos V (eds) Carbon nanotube enhanced aerospace composite materials: a new generation of multifunctional hybrid structural composites, pp 155–183. Springer: Dordrecht, Netherlands
Erol O, Uyan I, Hatip M, Yilmaz C, Tekinay AB, Guler MO (2017) Recent advances in bioactive 1D and 2D carbon nanomaterials for biomedical applications. Nanomedicine: Nanotechnology, Biology and Medicine
Liang S, Li G, Tian R (2016) Multi-walled carbon nanotubes functionalized with a ultrahigh fraction of carboxyl and hydroxyl groups by ultrasound-assisted oxidation. J Mater Sci 51(7):3513–3524
Battigelli A, Ménard-Moyon C, Da Ros T, Prato M, Bianco A (2013) Endowing carbon nanotubes with biological and biomedical properties by chemical modifications. Adv Drug Deliv Rev 65(15):1899–1920
Zhao Z, Yang Z, Hu Y, Li J, Fan X (2013) Multiple functionalization of multi-walled carbon nanotubes with carboxyl and amino groups. Appl Surf Sci 276:476–481
Khani H, Moradi O (2013) Influence of surface oxidation on the morphological and crystallographic structure of multi-walled carbon nanotubes via different oxidants. J Nanostruct Chem 3(1):73
Martín O, Gutierrez HR, Maroto-Valiente A, Terrones M, Blanco T, Baselga J (2013) An efficient method for the carboxylation of few-wall carbon nanotubes with little damage to their sidewalls. Mater Chem Phys 140(2–3):499–507
Zschoerper NP, Katzenmaier V, Vohrer U, Haupt M, Oehr C, Hirth T (2009) Analytical investigation of the composition of plasma-induced functional groups on carbon nanotube sheets. Carbon 47(9):2174–2185
Saito T, Matsushige K, Tanaka K (2002) Chemical treatment and modification of multi-walled carbon nanotubes. Physica B 323(1–4):280–283
Dillon AC, Gennett T, Jones KM, Alleman JL, Parilla PA, Heben MJ (1999) A simple and complete purification of single-walled carbon nanotube materials. Adv Mater 11(16):1354–1358
Morelos-Gómez A, Tristán López F, Cruz-Silva R, Vega DÃ-az SM, Terrones M (2013) Modified carbon nanotubes. In: Vajtai R (ed) Springer Handbook of Nanomaterials, pp 189–232. Springer, Berlin Heidelberg
Hirsch A, Vostrowsky O (2005) Functionalization of carbon nanotubes. Functional molecular nanostructures. Springer, Berlin, pp 193–237
Trusova ME, Kutonova KV, Kurtukov VV, Filimonov VD, Postnikov PS (2016) Arenediazonium salts transformations in water media: coming round to origins. Resour Efficient Technol 2(1):36–42
Mohamed AA, Salmi Z, Dahoumane SA, Mekki A, Carbonnier B, Chehimi MM (2015) Functionalization of nanomaterials with aryldiazonium salts. Adv Coll Interface Sci 225:16–36
Backes C, Hirsch A (2010) Noncovalent functionalization of carbon nanotubes. Wiley, Chichester, UK, pp 1–48
Composites C. Functionalization of CNTs 2018 (cited 11 Mar 2018). Available from: https://sites.google.com/site/cntcomposites/functionalization-of-cnts
Ferreira FV, Cividanes LDS, Brito FS, de Menezes BRC, Franceschi W, Simonetti EAN et al (2016) Functionalization of carbon nanotube and applications. Functionalizing Graphene and carbon nanotubes: A review. Springer, Cham, pp 31–61
Bianco A, Sainz R, Li S, Dumortier H, Lacerda L, Kostarelos K et al (2008) Biomedical applications of functionalised carbon nanotubes. In: Cataldo F, Da Ros T (eds) Medicinal chemistry and pharmacological potential of fullerenes and carbon nanotubes. Springer, Dordrecht, Netherlands, pp 23–50
Kasperski A, Weibel A, Estournès C, Laurent C, Peigney A (2014) Multi-walled carbon nanotube–Al2O3 composites: covalent or non-covalent functionalization for mechanical reinforcement. Scripta Mater 75:46–49
Behnam B, Shier WT, Nia AH, Abnous K, Ramezani M (2013) Non-covalent functionalization of single-walled carbon nanotubes with modified polyethyleneimines for efficient gene delivery. Int J Pharm 454(1):204–215
Sanz V, Borowiak E, Lukanov P, Galibert AM, Flahaut E, Coley HM et al (2011) Optimising DNA binding to carbon nanotubes by non-covalent methods. Carbon 49(5):1775–1781
Jeon I-Y, Chang DW, Kumar NA, Baek J-B (2011) Functionalization of carbon nanotubes. Carbon nanotubes-Polymer nanocomposites: InTech
Eatemadi A, Daraee H, Karimkhanloo H, Kouhi M, Zarghami N, Akbarzadeh A et al (2014) Carbon nanotubes: properties, synthesis, purification, and medical applications. Nanoscale Res Lett 9(1):393
Pal S (2014) Biomaterials and its characterization. Design of artificial human joints & organs. Springer US, Boston, MA, pp 51–73
Tibbetts GG (2001) Vapor-grown carbon fiber research and applications: achievements and barriers. Carbon filaments and nanotubes: common origins, differing applications?. Springer, Berlin, pp 1–9
Ci L, Wei J, Wei B, Xu C, Liang J, Wu D (2000) Novel carbon filaments with carbon beads grown on their surface. J Mater Sci Lett 19(1):21–22
Ren Z, Lan Y, Wang Y (2012) Aligned carbon nanotubes: physics, concepts, fabrication and devices. Springer Science & Business Media, Berlin
Ko FK, Kuznetsov V, Flahaut E, Peigney A, Laurent C, Prinz VY, et al (2004) Formation of nanofibers and nanotubes production. Nanoeng Nanofibrous Mater. 169:1–129. Springer, Berlin
Oberlin A, Endo M, Koyama T (1976) Filamentous growth of carbon through benzene decomposition. J Cryst Growth 32(3):335–349
Demoncy N, Stephan O, Brun N, Colliex C, Loiseau A, Pascard H (1998) Filling carbon nanotubes with metals by the arc-discharge method: the key role of sulfur. Eur Phys J B-Condens Matter Complex Syst 4(2):147–157
Fonseca A, Nagy J (2001) Carbon nanotubes formation in the arc discharge process: carbon filaments and nanotubes: common origins, differing applications? p 75–84. Springer, Berlin
Hu J, Bando Y, Xu F, Li Y, Zhan J, Xu J et al (2004) Growth and field-emission properties of crystalline, thin-walled carbon microtubes. Adv Mater 16(2):153–156
Ren Z, Lan Y, Wang Y (2013) Carbon nanotubes: Aligned carbon nanotubes: physics, concepts, fabrication and devices. Springer, Berlin Heidelberg, pp 7–43
Iijima S, Ichihashi T (1993) Single-shell carbon nanotubes of 1-nm diameter. Nature 363(6430):603
Joselevich E, Dai H, Liu J, Hata K, Windle AH (2008) Carbon nanotube synthesis and organization. Carbon nanotubes. Springer, Berlin, Heidelberg, pp 101–165
Lyskawa J, Grondein A, Bélanger D (2010) Chemical modifications of carbon powders with aminophenyl and cyanophenyl groups and a study of their reactivity. Carbon 48(4):1271–1278
Leinonen H, Lajunen M (2012) Direct functionalization of pristine single-walled carbon nanotubes by diazonium-based method with various five-membered S-or N-heteroaromatic amines. J Nanopart Res 14(9):1064
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Khan, F.S.A., Mubarak, N.M., Khalid, M., Abdullah, E.C. (2019). Functionalized Carbon Nanomaterial for Artificial Bone Replacement as Filler Material. In: Inamuddin, Thomas, S., Kumar Mishra, R., Asiri, A. (eds) Sustainable Polymer Composites and Nanocomposites. Springer, Cham. https://doi.org/10.1007/978-3-030-05399-4_27
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