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Addressing Key Knowledge Gaps in Nutrition Research and the Impact of Funding Priorities in Human Nutrition

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Book cover Vitamin E in Human Health

Part of the book series: Nutrition and Health ((NH))

Abstract

An improved nutritional status is believed to be a cost-effective strategy for reducing mortality, morbidity, and risks of chronic diseases. However, much of the scientific evidence to support the benefits of nutrients for health maintenance lack consistency and validity. Study designs, methodologies, tools, and funding priorities for nutrition research are evolving to better address key knowledge gaps impacting the science. Some examples include (1) development of new tools to improve assessments of dietary intake, (2) identification and validation of improved biomarkers for determining nutrition status, (3) enhancement of omics technologies to better map the interrelationships between intake (via supplement or food) and true nutrient bioavailability, and (4) improved study designs to better address phenotypic variations in nutrient requirements. To adequately address these and other knowledge gaps, funding opportunities have expanded beyond isolated federal agency initiatives to include more interagency collaborations, public-private partnerships, and international collaborations. The broader scope of collaborations is expected to promote greater opportunities for nutrition researchers to participate in the sharing and analysis of biomedical big data. Capitalizing on access to and the use of biomedical big data may facilitate investigations of the full complexities of the human ecosystem with respect to the nutrition sciences. Provided here is an overview of the funding priorities and trends as they relate to the key knowledge gaps impacting nutrition sciences to date.

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References

  1. World Health Organization. Nutrition; 2017. Available from: http://www.who.int/topics/nutrition/en/. Cited 04 Dec 2017.

  2. Heaney RP. Nutrients, endpoints, and the problem of proof. J Nutr. 2008;138(9):1591–5.

    Article  CAS  Google Scholar 

  3. Blumberg J, et al. Evidence-based criteria in the nutritional context. Nutr Rev. 2010;68(8):478–84.

    Article  Google Scholar 

  4. Ohlhorst SD, et al. Nutrition research to affect food and a healthy life span. Am J Clin Nutr. 2013;98(2):620–5.

    Article  CAS  Google Scholar 

  5. Allison DB, et al. Goals in nutrition science 2015–2020. Front Nutr. 2015;2(26):1–13.

    Google Scholar 

  6. Jackson AA, Wootton SA, Wiseman M. Nature, purpose and implications of research in nutrition. In: Lovegrove JA, Hodson L, Sharma S, Lanham-New SA, editors. Nutrition research methodologies. Chichester: John Wiley & Sons, Ltd; 2015. p. 1–12.

    Google Scholar 

  7. Institute of Medicine. Dietary reference intakes for vitamin C, vitamin D, selenium, and carotenoids. Washington, DC: National Academy Press; 2000.

    Google Scholar 

  8. Horwitt MK. Vitamin E and lipid metabolism in man. Am J Clin Nutr. 1960;8:451–61.

    Article  CAS  Google Scholar 

  9. Program, N.I.o.H.A.o.U.R. The future of health begins with all of us; 2017. Available from: https://allofus.nih.gov/. Cited 04 Dec 2017.

  10. Kaput J, et al. Propelling the paradigm shift from reductionism to systems nutrition. Genes Nutr. 2017;12(1):3.

    Article  Google Scholar 

  11. Schork NJ. Time for one-person trials. Nature. 2015;520:609–11.

    Article  CAS  Google Scholar 

  12. Jiang Q. Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy. Free Radic Biol Med. 2014;72:76–90.

    Article  CAS  Google Scholar 

  13. Rizvi S, et al. The role of vitamin E in human health and some diseases. Sultan Qaboos Univ Med J. 2014;14(2):e157–65.

    PubMed  PubMed Central  Google Scholar 

  14. Seifried HE, et al. The antioxidant conundrum in cancer. Cancer Res. 2003;63(15):4295–8.

    CAS  PubMed  Google Scholar 

  15. Zingg JM, Azzi A. Non-antioxidant activities of vitamin E. Curr Med Chem. 2004;11(9):1113–33.

    Article  CAS  Google Scholar 

  16. Cook NR, et al. A randomized factorial trial of vitamins C, E, and Beta-Carotene in the secondary prevention of cardiovascular events in women: results from the women’s antioxidant cardiovascular study (WACS). Arch Intern Med. 2007;167(15):1610–8.

    Article  CAS  Google Scholar 

  17. Wolf G. How an increased intake of alpha-tocopherol can suppress the bioavailability of gamma-tocopherol. Nutr Rev. 2006;64(6):295–9.

    Article  Google Scholar 

  18. Galli F, et al. Vitamin E: emerging aspects and new directions. Free Radic Biol Med. 2017;102(Supplement C):16–36.

    Article  CAS  Google Scholar 

  19. Borel P, Preveraud D, Desmarchelier C. Bioavailability of vitamin E in humans: an update. Nutr Rev. 2013;71(6):319–31.

    Article  Google Scholar 

  20. Péter S, et al. Nutrient status assessment in individuals and populations for healthy aging—statement from an expert workshop. Nutrients. 2015;7(12):10491–500.

    Article  Google Scholar 

  21. Raubenheimer D, Simpson SJ. Nutritional ecology and human health. Annu Rev Nutr. 2016;36(1):603–26.

    Article  CAS  Google Scholar 

  22. Pandey G, Pandey AK. Nutrition research perspectives in immune-mediated inflammatory disorders. Indian J Rheumatol. 2013;8(1):30–6.

    Article  Google Scholar 

  23. Svetkey LP, et al. Effect of the dietary approaches to stop hypertension diet and reduced sodium intake on blood pressure control. J Clin Hypertens (Greenwich). 2004;6(7):373–81.

    Article  Google Scholar 

  24. Ard JD, et al. One-year follow-up study of blood pressure and dietary patterns in dietary approaches to stop hypertension (DASH)-sodium participants. Am J Hypertens. 2004;17(12 Pt 1):1156–62.

    Article  Google Scholar 

  25. NIH- National Heart, L., and Blood Institue. DASH eating plan. September 16, 2015. Available from: https://www.nhlbi.nih.gov/health/health-topics/topics/dash/. Cited 04 Dec 2017.

  26. NIH-Office of Dietary Supplements. Vitamin E: fact sheet for health professionals; November 3, 2016. Available from: https://ods.od.nih.gov/factsheets/VitaminE-HealthProfessional/. Cited 5 Dec 2017.

  27. Hercberg S, et al. The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med. 2004;164(21):2335–42.

    Article  CAS  Google Scholar 

  28. Brigelius-Flohé R, et al. The European perspective on vitamin E: current knowledge and future research. Am J Clin Nutr. 2002;76(4):703–16.

    Article  Google Scholar 

  29. Fleischhacker SE, et al. Developmental process and early phases of implementation for the US interagency committee on human nutrition research national nutrition research roadmap 2016–2021. J Nutr. 2017;147(10):1833–8.

    Article  CAS  Google Scholar 

  30. NIH-Office of Disease Prevention. National nutrition research roadmap. Available from: https://prevention.nih.gov/resources-for-researchers/prevention-research-needs-gaps/national-nutrition-research-roadmap. Cited 4 Dec 2017.

  31. Klein EA, et al. Vitamin e and the risk of prostate cancer: The selenium and vitamin e cancer prevention trial (select). JAMA. 2011;306(14):1549–56.

    Article  CAS  Google Scholar 

  32. Pittas AG, et al. Rationale and design of the vitamin D and type 2 diabetes (D2d) study: a diabetes prevention trial. Diabetes Care. 2014;37(12):3227–34.

    Article  Google Scholar 

  33. Manson JE, et al. The vitamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and Marine Omega-3 Fatty Acid supplements for the primary prevention of cancer and cardiovascular disease. Contemp Clin Trials. 2012;33(1):159–71.

    Article  CAS  Google Scholar 

  34. Bassuk SS, et al. Baseline characteristics of participants in the vitamin D and OmegA-3 TriaL (VITAL). Contemp Clin Trials. 2016;47:235–43.

    Article  Google Scholar 

  35. US Department of Health and Human Services. Accelerating medicines partnership (AMP). Available from: https://www.nih.gov/research-training/accelerating-medicines-partnership-amp. Cited 23 Apr 2018.

  36. Foundation for the National Institutes of Health. Biomarkers consortium, 1996–2017. Available from: https://fnih.org/what-we-do/biomarkers-consortium. Cited 23 Apr 2018.

  37. European Commission. European research area, coordination of research programmes,. Joint programming initiatives, 4/22/2013. Available from: http://ec.europa.eu/research/era/joint-programming-initiatives_en.html. Cited 23 Apr 2018.

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Authors and Affiliations

  1. Office of Dietary Supplements, National Institutes of Health, Bethesda, MD, USA

    La Verne L. Brown & Paul M. Coates

Authors
  1. La Verne L. Brown
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  2. Paul M. Coates
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Correspondence to La Verne L. Brown .

Editor information

Editors and Affiliations

  1. University of Hohenheim, Institute of Nutritional Sciences, Stuttgart , Germany

    Peter Weber

  2. University of Applied Sciences Fulda, Nutritional, Food and Consumer Sciences, Fulda, Germany

    Marc Birringer

  3. Friedman School of Nutrition Science and Policy, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA

    Jeffrey B. Blumberg

  4. University Medical Center Groningen, Hanzeplain 1, Groningen, The Netherlands

    Manfred Eggersdorfer

  5. University of Hohenheim, Institute of Nutritional Sciences, Stuttgart , Germany

    Jan Frank

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Brown, L.V.L., Coates, P.M. (2019). Addressing Key Knowledge Gaps in Nutrition Research and the Impact of Funding Priorities in Human Nutrition. In: Weber, P., Birringer, M., Blumberg, J., Eggersdorfer, M., Frank, J. (eds) Vitamin E in Human Health. Nutrition and Health. Humana Press, Cham. https://doi.org/10.1007/978-3-030-05315-4_31

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  • DOI: https://doi.org/10.1007/978-3-030-05315-4_31

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  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-030-05314-7

  • Online ISBN: 978-3-030-05315-4

  • eBook Packages: MedicineMedicine (R0)

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