Abstract
Since 1960s, lipids are broadly explored as fundamental models to understand and study the cell membranes, as carriers for delivering and protecting bioactive agents. Lipids and lipid-based polymer composites have been utilized in various fields of research including imaging, diagnosis, cosmetics, vaccines, drug delivery and tissue engineering. This provides a strategy that involves the application of specified cell types and structured scaffold biomaterials to produce living biological structures. To develop a new tissue, well-controlled stimulation of cultured cells is required through organized combination of mechanical signals and bioactive agents. In this chapter, we highlight the potential use of lipid and lipid-based biopolymer composites as a platform for the in vivo imaging, tissue engineering, cell rejuvenation and theranostic applications.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abugoch LE, Tapia C, Villamán MC et al (2011) Characterization of quinoa protein-chitosan blend edible films. Food Hydrocolloids 25:879–886. https://doi.org/10.1016/j.foodhyd.2010.08.008
Akbarzadeh A, Rezaei-Sadabady R, Davaran S et al (2013) Liposome: classification, preparation, and applications. Nanoscale Res Lett 8:1–8. https://doi.org/10.1186/1556-276X-8-102
An SY, Bui MPN, Nam YJ et al (2009) Preparation of monodisperse and size-controlled poly(ethylene glycol) hydrogel nanoparticles using liposome templates. J Colloid Interface Sci 331:98–103. https://doi.org/10.1016/j.jcis.2008.11.022
Antimisiaris SG, Kallinteri P, Fatouros DG (2007) Liposomes and drug delivery. Pharmaceutical manufacturing handbook: production and processes. Wiley, Hoboken, NJ, USA, pp 443–533
Auad ML, Mosiewicki MA, Richardson T et al (2010) Nanocomposites made from cellulose nanocrystals and tailored segmented polyurethanes. J Appl Polym Sci 115:1215–1225. https://doi.org/10.1002/app.31218
Barauskas J, Johnsson M, Joabsson F, Tiberg F (2005) Cubic phase nanoparticles (cubosome): principles for controlling size, structure, and stability. Langmuir 21:2569–2577. https://doi.org/10.1021/la047590p
Baru M, Axelrod JH, Nur I (1995) Liposome-encapsulated DNA-mediated gene transfer and synthesis of human factor IX in mice. Gene 161:143–150. https://doi.org/10.1016/0378-1119(95)00281-A
Boerman OC, Laverman P, Oyen WJG et al (2000) Radiolabeled liposomes for scintigraphic imaging. Prog Lipid Res 39:461–475
Chang C-M, Lan K-L, Huang W-S et al (2017) 188Re-liposome can induce mitochondrial autophagy and reverse drug resistance for ovarian cancer: from bench evidence to preliminary clinical proof-of-concept. Int J Mol Sci 18:903. https://doi.org/10.3390/ijms18050903
Coleman RA, Lee DP (2004) Enzymes of triacylglycerol synthesis and their regulation. Prog Lipid Res 43:134–176
Collier JH, Messersmith PB (2001) Phospholipid strategies in biomineralization and biomaterials research. Annu Rev Mater Res 31:237–263. https://doi.org/10.1146/annurev.matsci.31.1.237
Cudd A, Nicolau C (1985) Intracellular fate of liposome-encapsulated DNA in mouse liver. Analysis using electron microscope autoradiography and subcellular fractionation. BBA—Mol Cell Res 845:477–491. https://doi.org/10.1016/0167-4889(85)90214-9
Drummond DC, Meyer O, Hong K et al (1999) Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors. Pharmacol Rev 51:691–743. doi: VL–51
Eibl H, Kaufmann-Kolle P (1995) Medical application of synthetic phospholipids as liposomes and drugs. J Liposome Res 5:131–148. https://doi.org/10.3109/08982109509039914
Ewert KK, Evans HM, Zidovska A et al (2006) A columnar phase of dendritic lipid-based cationic liposome-DNA complexes for gene delivery: hexagonally ordered cylindrical micelles embedded in a DNA honeycomb lattice. J Am Chem Soc 128:3998–4006. https://doi.org/10.1021/ja055907h
Fahy E, Subramaniam S, Murphy RC et al (2009) Update of the LIPID MAPS comprehensive classification system for lipids. J Lipid Res 50:S9–S14. https://doi.org/10.1194/jlr.R800095-JLR200
Farooqui AA, Horrocks LA, Farooqui T (2000) Glycerophospholipids in brain: Their metabolism, incorporation into membranes, functions, and involvement in neurological disorders. Chem Phys Lipid 106:1–29
Ferrara KW, Borden MA, Zhang H (2009) Lipid-shelled vehicles: engineering for ultrasound molecular imaging and drug delivery. Acc Chem Res 42:881–892. https://doi.org/10.1021/ar8002442
Fraley R, Subramani S, Berg P, Papahadjopoulos D (1980) Introduction of liposome-encapsulated SV40 DNA into cells. J Biol Chem 255:10431–10435
Gomez-Hens A, Manuel Fernandez-Romero J (2005) The role of liposomes in analytical processes. TrAC—Trends in Anal Chem 24:9–19
Horzinek M, Mussgay M (1971) Studies on the substructure of togaviruses—I. Effect of urea, deoxycholate, and saponin on the sindbis virion. Archiv fur die gesamte Virusforschung 33:296–305. https://doi.org/10.1007/bf01254686
Huang Z, Li X, Zhang T et al (2014) Progress involving new techniques for liposome preparation. Asian J Pharm Sci 9:176–182
Ishii M, Shibata R, Numaguchi Y et al (2011) Enhanced angiogenesis by transplantation of mesenchymal stem cell sheet created by a novel magnetic tissue engineering method. Arterioscler Thromb Vasc Biol 31:2210–2215. https://doi.org/10.1161/ATVBAHA.111.231100
Issa JPM, Spadaro ACC, Bentley MVLB et al (2008) Monoolein and chitosan gels as potential carriers of the rhBMP-2, using decortication surgical technique in Wistar rats as experimental model. Micron 39:952–959. https://doi.org/10.1016/j.micron.2007.11.001
Jain A, Kim YT, McKeon RJ, Bellamkonda RV (2006) In situ gelling hydrogels for conformal repair of spinal cord defects, and local delivery of BDNF after spinal cord injury. Biomaterials 27:497–504. https://doi.org/10.1016/j.biomaterials.2005.07.008
Kawakami S, Sato A, Yamada M et al (2001) The effect of lipid composition on receptor-mediated in vivo gene transfection using mannosylated cationic liposomes in mice. STP Pharma Sci 11
Kleusch C, Hersch N, Hoffmann B et al (2012) Fluorescent lipids: functional parts of fusogenic liposomes and tools for cell membrane labeling and visualization. Molecules 17:1055–1073. https://doi.org/10.3390/molecules17011055
Kodama T, Tomita N, Yagishita Y et al (2011) Volumetric and angiogenic evaluation of antitumor effects with acoustic liposome and high-frequency ultrasound. Can Res 71:6957–6964. https://doi.org/10.1158/0008-5472.CAN-11-2389
Konikoff FM, Chung DS, Donovan JM et al (1992) Filamentous, helical, and tubular microstructures during cholesterol crystallization from bile. Evidence that cholesterol does not nucleate classic monohydrate plates. J Clinical Investigation 90:1155–1160. https://doi.org/10.1172/JCI115935
Konrad Sandhoff AHM Jr, Alfred H Jr, Merrill KS (2002) Sphingolipids: metabolism and cell signaling. In: Biochemistry of lipids, lipoproteins and membranes, pp 373–406
Koynova R, Tihova M (2010) Nanosized self-emulsifying lipid vesicles of diacylglycerol-PEG lipid conjugates: biophysical characterization and inclusion of lipophilic dietary supplements. Biochim et Biophys Acta—Biomembr 1798:646–653. https://doi.org/10.1016/j.bbamem.2009.12.022
Kulkarni M, Greiser U, O’Brien T, Pandit A (2010) Liposomal gene delivery mediated by tissue-engineered scaffolds. Trends Biotechnol 28:28–36
Kuzuyama T, Seto H (2003) Diversity of the biosynthesis of the isoprene units. Nat Prod Rep 20:171–183
Laouini A, Jaafar-Maalej C, Limayem-Blouza I et al (2012) Preparation, characterization and applications of liposomes: state of the art. J Colloid Sci Biotechnol 1:147–168. https://doi.org/10.1166/jcsb.2012.1020
Liakos I, Rizzello L, Scurr DJ et al (2014) All-natural composite wound dressing films of essential oils encapsulated in sodium alginate with antimicrobial properties. Int J Pharm 463:137–145. https://doi.org/10.1016/j.ijpharm.2013.10.046
Liu PY, Tong W, Liu K et al (2004) Liposome-mediated transfer of vascular endothelial growth factor cDNA augments survival of random-pattern skin flaps in the rat. Wound Repair and Regeneration 12:80–85. https://doi.org/10.1111/j.1067-1927.2004.012114.x-1
Maurer N, Wong KF, Stark H et al (2001) Spontaneous entrapment of polynucleotides upon electrostatic interaction with ethanol-destabilized cationic liposomes. Biophys J 80:2310–2326. https://doi.org/10.1016/S0006-3495(01)76202-9
McNaught AD, Wilkinson A (2009) IUPAC compendium of chemical terminology. IUPAC. Research Triagle Park, NC
Meilander NJ, Yu X, Ziats NP, Bellamkonda RV (2001) Lipid-based microtubular drug delivery vehicles. J Controlled Release 71:141–152. https://doi.org/10.1016/S0168-3659(01)00214-0
Messias MCF, Mecatti GC, Priolli DG, De Oliveira Carvalho P (2018) Plasmalogen lipids: Functional mechanism and their involvement in gastrointestinal cancer. Lipids Health Disease 17:41. https://doi.org/10.1186/s12944-018-0685-9
Michlits W, Mittermayr R, Schäfer R et al (2007) Fibrin-embedded administration of VEGF plasmid enhances skin flap survival. Wound Repair and Regeneration 15:360–367. https://doi.org/10.1111/j.1524-475X.2007.00238.x
Monfregola L, Leone M, Vittoria V et al (2011) Chemical modification of pectin: Environmental friendly process for new potential material development. Polym Chem 2:800–804. https://doi.org/10.1039/c0py00341g
Monteiro N, Martins A, Reis RL, Neves NM (2014a) Liposomes in tissue engineering and regenerative medicine. J R Soc Interface 11:20140459–20140459. https://doi.org/10.1098/rsif.2014.0459
Monteiro N, Ribeiro D, Martins A et al (2014b) Instructive nanofibrous scaffold comprising runt-related transcription factor 2 gene delivery for bone tissue engineering. ACS Nano 8:8082–8094. https://doi.org/10.1021/nn5021049
Monteiro N, Martins M, Martins A et al (2015) Antibacterial activity of chitosan nanofiber meshes with liposomes immobilized releasing gentamicin. Acta Biomater 18:196–205. https://doi.org/10.1016/j.actbio.2015.02.018
Morishita R, Kaneda Y (2002) HVJ (hemagglutinating virus of Japan; Sendai virus)-liposome method. In: Methods in Enzymology, pp 619–627
Mowat a M, Reid G (2001) Preparation of immune stimulating complexes (ISCOMs) as adjuvants. Current protocols in immunology/ edited by John E Coligan. [et al] Chapter 2: Unit 2.11. https://doi.org/10.1002/0471142735.im0211s16
Mozafari MR (2005) Liposomes: an overview of manufacturing techniques. Cell Mol Biol Lett 10:711–719
Mufamadi MS, Pillay V, Choonara YE et al (2011) A review on composite liposomal technologies for specialized drug delivery. J Drug Delivery 2011:1–19. https://doi.org/10.1155/2011/939851
Murao A, Nishikawa M, Managit C et al (2002) Targeting efficiency of galactosylated liposomes to hepatocytes in vivo: effect of lipid composition. Pharm Res 19:1808–1814. https://doi.org/10.1023/A:1021433206081
Myschik J, Lendemans DG, McBurney WT et al (2006) On the preparation, microscopic investigation and application of ISCOMs. Micron 37:724–734. https://doi.org/10.1016/j.micron.2006.03.016
Nanjwade BK, Yallappamaharaj R (2014) Development of cuboidal nanomedicine by nanotechnology. Austin J Nanomed Nanotechnol 2:1–8
Nikalje AP (2015) Nanotechnology and its applications in medicine. Med. Chem. 5: https://doi.org/10.4172/2161-0444.1000247
Perdones Á, Chiralt A, Vargas M (2016) Properties of film-forming dispersions and films based on chitosan containing basil or thyme essential oil. Food Hydrocolloids 57:271–279. https://doi.org/10.1016/j.foodhyd.2016.02.006
Pornpattananangkul D, Olson S, Aryal S et al (2010) Stimuli-responsive liposome fusion mediated by gold nanoparticles. ACS Nano 4:1935–1942. https://doi.org/10.1021/nn9018587
Quaglia F (2008) Bioinspired tissue engineering: the great promise of protein delivery technologies. Int J Pharm 364:281–297
Raetz CRH, Garrett TA, Reynolds CM et al (2006) Kdo 2 -Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. J Lipid Res 47:1097–1111. https://doi.org/10.1194/jlr.M600027-JLR200
Rahmim A, Zaidi H (2008) Pet versus spect: Strengths, limitations and challenges. Nucl Med Commun 29:193–207
Rambhia KJ, Ma PX (2015) Controlled drug release for tissue engineering. J Control Release 219:119–128. https://doi.org/10.1016/j.jconrel.2015.08.049
Rampichová M, Martinová L, Košťáková E et al (2012) A simple drug anchoring microfiber scaffold for chondrocyte seeding and proliferation. J Mater Sci—Mater Med 23:555–563. https://doi.org/10.1007/s10856-011-4518-x
Reineccius GA (1995) Liposomes for controlled release in the food industry, pp 113–131
Russell DW (2003) The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem 72:137–174. https://doi.org/10.1146/annurev.biochem.72.121801.161712
Samal SK, Dash M, Van Vlierberghe S et al (2012) Cationic polymers and their therapeutic potential. Chem Soc Rev 41:7147–7194
Santo VE, Gomes ME, Mano JF, Reis RL (2012) From nano-to macro-scale: nanotechnology approaches for spatially controlled delivery of bioactive factors for bone and cartilage engineering. Nanomedicine 7:1045–1066
Shimizu T, Masuda M, Minamikawa H (2005) Supramolecular nanotube architectures based on amphiphilic molecules. Chem Rev 105:1401–1443
Siekmann B, Bunjes H, Koch MHJ, Westesen K (2002) Preparation and structural investigations of colloidal dispersions prepared from cubic monoglyceride-water phases. Int J Pharm 244:33–43. https://doi.org/10.1016/S0378-5173(02)00298-3
Singh AK, Cummings EB, Throckmorton DJ (2001) Fluorescent liposome flow markers for microscale particle-image velocimetry. Anal Chem 73:1057–1061. https://doi.org/10.1021/ac001159x
Spicer PT, Hayden KL, Lynch ML et al (2001) Novel process for producing cubic liquid crystalline nanoparticles (cubosomes). Langmuir 17:5748–5756. https://doi.org/10.1021/la010161w
Tsukanova V, Salesse C (2004) On the nature of conformational transition in poly(ethylene glycol) chains grafted onto phospholipid monolayers. J. Phys Chem B 108:10754–10764. https://doi.org/10.1021/jp036992n
Valencia PM, Basto PA, Zhang L et al (2010) Single-step assembly of homogenous lipid-polymeric and lipid-quantum dot nanoparticles enabled by microfluidic rapid mixing. ACS Nano 4:1671–1679. https://doi.org/10.1021/nn901433u
Vance JE, Vance DE (2008) Biochemistry of lipids. Elsevier, Lipoproteins and Membranes
Vargas R, Mariani P, Gulik A, Luzzati V (1992) Cubic phases of lipid-containing systems. The structure of phase Q223 (Space group Pm3n). An X-ray scattering study. J Mol Biol 225:137–145. https://doi.org/10.1016/0022-2836(92)91031-J
Vemuri S, Rhodes CT (1995) Preparation and characterization of liposomes as therapeutic delivery systems: a review. Pharm Acta Helv 70:95–111
Voinea M, Simionescu M (2002) Designing of “intelligent” liposomes for efficient delivery of drugs. J Cell Mol Med 6:465–474
Wagner A, Vorauer-Uhl K (2011) Liposome technology for industrial purposes. J. Drug Delivery 2011:1–9. https://doi.org/10.1155/2011/591325
Wang G, Mostafa NZ, Incani V et al (2012) Bisphosphonate-decorated lipid nanoparticles designed as drug carriers for bone diseases. J Biomed Mater Res—Part A 100 A:684–693. https://doi.org/10.1002/jbm.a.34002
Westhaus E, Messersmith PB (2001) Triggered release of calcium from lipid vesicles: a bioinspired strategy for rapid gelation of polysaccharide and protein hydrogels. Biomaterials 22:453–462. https://doi.org/10.1016/S0142-9612(00)00200-3
Winkler H, Vorwerg W, Rihm R (2014) Thermal and mechanical properties of fatty acid starch esters. Carbohyd Polym 102:941–949. https://doi.org/10.1016/j.carbpol.2013.10.040
Winn S, Chen J, Gong X et al (2005) Non-viral-mediated gene therapy approaches for bone repair. Orthod Craniofac Res 8:183–190. https://doi.org/10.1111/j.1601-6343.2005.00332.x
Woodle MC, Lasic DD (1992) Sterically stabilized liposomes. BBA—Rev Biomembr 1113:171–199
Woodle MC, Scaria P (2001) Cationic liposomes and nucleic acids. Curr Opin Colloid Interface Sci 6:78–84. https://doi.org/10.1016/S1359-0294(00)00091-1
Xia S, Xu S (2005) Ferrous sulfate liposomes: preparation, stability and application in fluid milk. Food Res Int 289–296
Yager P, Schoen PE, Davies C et al (1985) Structure of lipid tubules formed from a polymerizable lecithin. Biophys J 48:899–906. https://doi.org/10.1016/S0006-3495(85)83852-2
Yau WWY, Rujitanaroj P, Lam L, Chew SY (2012) Directing stem cell fate by controlled RNA interference. Biomaterials 33:2608–2628
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Raj, V., Priya, P. (2019). Multi-functional Lipid-Based Polymer Composites for In Vivo Imaging, Tissue Healing, Cell Rejuvenation and Theranostic Applications. In: Sadasivuni, K., Ponnamma, D., Rajan, M., Ahmed, B., Al-Maadeed, M. (eds) Polymer Nanocomposites in Biomedical Engineering . Lecture Notes in Bioengineering. Springer, Cham. https://doi.org/10.1007/978-3-030-04741-2_4
Download citation
DOI: https://doi.org/10.1007/978-3-030-04741-2_4
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-04740-5
Online ISBN: 978-3-030-04741-2
eBook Packages: EngineeringEngineering (R0)