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Tumor Response Assessment: RECIST and Beyond

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Imaging in Pediatric Oncology

Part of the book series: Pediatric Oncology ((PEDIATRICO))

Abstract

The Response Evaluation Criteria in Solid Tumors (RECIST) guidance was introduced in 2000 and revised as RECIST 1.1 in 2009. RECIST was put together with the goal of standardising and simplifying tumor response criteria. The important role of imaging in response assessment was recognised, and specific imaging guidelines were included. The significant imaging-related changes in RECIST 1.1 in comparison to RECIST 1.0 included a reduction in the number of lesions to be addressed, from a maximum of 10 to a maximum of 5 and from 5 to 2 lesions per organ; assessment of lymph node size; and clarification of what constituted disease progression. The definitions of response within the RECIST guidance are addressed within this chapter in addition to the limitations of using tumor size alone as a biomarker for tumor response. Other methods of assessing tumor response such as response to immunotherapy (iRECIST) and response on PET-CT (PERCIST) are also included.

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Author information

Authors and Affiliations

  1. Radiology Department, Great Ormond Street Hospital for Children, London, UK

    Kieran McHugh

  2. Department of Radiology, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA

    Simon Kao

Authors
  1. Kieran McHugh
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  2. Simon Kao
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Correspondence to Kieran McHugh .

Editor information

Editors and Affiliations

  1. Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA

    Stephan D. Voss

  2. Department of Radiology, Great Ormond Street Hospital for Children, London, UK

    Kieran McHugh

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McHugh, K., Kao, S. (2019). Tumor Response Assessment: RECIST and Beyond. In: Voss, S., McHugh, K. (eds) Imaging in Pediatric Oncology. Pediatric Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-03777-2_9

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  • DOI: https://doi.org/10.1007/978-3-030-03777-2_9

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-030-03777-2

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