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A Review of Acute Viral Hepatitides Including Hepatitis E

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Book cover Viral Hepatitis: Acute Hepatitis

Abstract

Acute viral hepatitis (AVH) is a systemic infection, caused by a group of viruses, which have special affliction and primary site of replication in the liver [1]. As of today, five unelated hepatotropic pathogens have been identified to cause AVH. These include the hepatitis A virus (HAV), the hepatitis B virus (HBV), the hepatitis C virus (HCV), the hepatitis D virus (HDV), and the hepatitis E virus (HEV). However, varying proportion of AVH cases fall in to the non-A-E group and are in search of putative agent/s. This includes 2–30% cases of sporadic AVH [2], 30–55% cases of acute liver failure [3], and most cases of giant-cell hepatitis (postviral hepatitis) aplastic anemia [4]. Over the years, several viruses have been identified and all are in search of disease. Transfusion-transmitted agents, namely human pegivirus (HPgV) (formerly known as GBV-C/HGV), TT virus, and other TTV-related viruses (SANYAN, YONBON, SEN viruses, and TTV-like Mini virus), have been identified but do not cause AVH [5]. There have been new kids on the block of whom we must learn more about in future. Two more novel agents in the pegivirus genera of the family Flaviviridae have been identified and named as human hepegivirus 1 (HHpgV-1) [6] and human pegivirus 2 (HPgV-2) [7]. A number of systemic viral infections that may involve liver and cause hepatitis include Epstein-Barr virus infection, cytomegalovirus infection, herpes simplex virus infection, Varicella-Zoster virus infection, and severe acute respiratory syndrome [8].

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References

  1. Dienstag JL. Acute viral hepatitis. In: Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors. Principles of internal medicine. 17th ed. New York: McGraw Hill Medical; 2008. p. 1932–49.

    Google Scholar 

  2. Chu CM, Lin DY, Yeh CT, Sheen IS, Liaw YF. Epidemiological characteristics, risk factors, and clinical manifestations of acute non-A-E hepatitis. J Med Virol. 2001;65(2):296–300.

    CAS  PubMed  Google Scholar 

  3. Kuwada SK, Patel VM, Hollinger FB, Lin HJ, Yarbough PO, Wiesner RH, et al. Non-A, non-B fulminant hepatitis is also non-E and non-C. Am J Gastroenterol. 1994;89(1):57–61.

    CAS  PubMed  Google Scholar 

  4. Gonzalez-Casas R, Garcia-Buey L, Jones EA, Gisbert JP, Moreno-Otero R. Systematic review: hepatitis-associated aplastic anaemia--a syndrome associated with abnormal immunological function. Aliment Pharmacol Ther. 2009;30(5):436–43.

    CAS  PubMed  Google Scholar 

  5. Khuroo MS. Discovery of hepatitis G virus. Ann Saudi Med. 1997;17(2):209–16.

    CAS  PubMed  Google Scholar 

  6. Kapoor A, Kumar A, Simmonds P, Bhuva N, Singh Chauhan L, Lee B, et al. Virome analysis of transfusion recipients reveals a novel human virus that shares genomic features with hepaciviruses and pegiviruses. MBio. 2015;6(5):e01466–15.

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Berg MG, Lee D, Coller K, Frankel M, Aronsohn A, Cheng K, et al. Discovery of a novel human pegivirus in blood associated with hepatitis C virus co-infection. PLoS Pathog. 2015;11(12):e1005325.

    PubMed  PubMed Central  Google Scholar 

  8. Heathcote E, Feld J. Hepatitis caused by other viruses. In: Feldman M, Friedman LS, Brandt LJ, editors. Sleisinger & Fordtran’s Gastrointestinal and liver disease. 8th ed. Philadelphia: Saunders; 2006. p. 1719–29.

    Google Scholar 

  9. Mokdad AA, Lopez AD, Shahraz S, Lozano R, Mokdad AH, Stanaway J, et al. Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis. BMC Med. 2014;12:145.

    PubMed  PubMed Central  Google Scholar 

  10. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2095–128.

    PubMed  Google Scholar 

  11. Jacobsen KH, Wiersma ST. Hepatitis A virus seroprevalence by age and world region, 1990 and 2005. Vaccine. 2010;28(41):6653–7.

    PubMed  Google Scholar 

  12. Rein DB, Stevens GA, Theaker J, Wittenborn JS, Wiersma ST. The global burden of hepatitis E virus genotypes 1 and 2 in 2005. Hepatology. 2012;55(4):988–97.

    PubMed  Google Scholar 

  13. Hu MD. Isolation of HAV and HAV RNA from hairy clams in Qidong region by using cell culture and RNA hybridization technique. Shanghai Med J. 1989;12:72–3.

    Google Scholar 

  14. Khuroo MS, Khuroo MS. Hepatitis E: an emerging global disease—from discovery towards control and cure. J Viral Hepat. 2016;23(2):68–79.

    CAS  PubMed  Google Scholar 

  15. Ott JJ, Stevens GA, Groeger J, Wiersma ST. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine. 2012;30(12):2212–9.

    CAS  PubMed  Google Scholar 

  16. Lavanchy D. The global burden of hepatitis C. Liver Int. 2009;29(Suppl 1):74–81.

    PubMed  Google Scholar 

  17. WHO. Prevention and Control of Viral Hepatitis Infection: Framework for Global Action. WHO reference number: WHO/HSE/PED/HIP/GHP 20121. 2012:1–28.

    Google Scholar 

  18. Lin HH, Lee SS, Yu ML, Chang TT, Su CW, Hu BS, et al. Changing hepatitis D virus epidemiology in a hepatitis B virus endemic area with a national vaccination program. Hepatology. 2015;61(6):1870–9.

    CAS  PubMed  Google Scholar 

  19. Lemon SN. Type A viral hepatitis: epidemiology, diagnosis, and Prevention. Clin Chem. 1997;43(8(B)):1494–9.

    CAS  PubMed  Google Scholar 

  20. Zuckerman AJ. Hepatitis viruses. In: Baron S, editor. Medical microbiology. 4th ed. Galveston, TX: University of Texas Medical Branch at Galveston; 1996. p. 1–169.

    Google Scholar 

  21. Tahaei SM, Mohebbi SR, Zali MR. Enteric hepatitis viruses. Gastroenterol Hepatol Bed Bench. 2012;5(1):7–15.

    PubMed  PubMed Central  Google Scholar 

  22. Purcell RH. Hepatitis viruses: changing patterns of human disease. Proc Natl Acad Sci U S A. 1994;91(7):2401–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Nainan OV, Xia G, Vaughan G, Margolis HS. Diagnosis of hepatitis a virus infection: a molecular approach. Clin Microbiol Rev. 2006;19(1):63–79.

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Gust ID. Epidemiological patterns of hepatitis A in different parts of the world. Vaccine. 1992;10(Suppl 1):S56–8.

    PubMed  Google Scholar 

  25. WHO. WHO Position Papers on HAV Vaccines-June 2012. Weekly Epidemiological Record 2012.

    Google Scholar 

  26. Kim YJ, Lee HS. Increasing incidence of hepatitis A in Korean adults. Intervirology. 2010;53(1):10–4.

    PubMed  Google Scholar 

  27. Munne MS, Vladimirsky S, Moreiro R, Ciocca M, Cuarterolo M, Otegui L, et al. Molecular characterization of hepatitis A virus in children with fulminant hepatic failure in Argentina. Liver Int. 2008;28(1):47–53.

    CAS  PubMed  Google Scholar 

  28. Santos DC, Martinho JM, Pacheco-Moreira LF, Araujo CC, Oliveira BC, Lago BV, et al. Fulminant hepatitis failure in adults and children from a Public Hospital in Rio de Janeiro. Brazil Braz J Infect Dis. 2009;13(5):323–9.

    PubMed  Google Scholar 

  29. Collier MG, Khudyakov YE, Selvage D, Adams-Cameron M, Epson E, Cronquist A, et al. Outbreak of hepatitis A in the USA associated with frozen pomegranate arils imported from Turkey: an epidemiological case study. Lancet Infect Dis. 2014;14(10):976–81.

    PubMed  Google Scholar 

  30. Wheeler C, Vogt TM, Armstrong GL, Vaughan G, Weltman A, Nainan OV, et al. An outbreak of hepatitis A associated with green onions. N Engl J Med. 2005;353(9):890–7.

    CAS  PubMed  Google Scholar 

  31. Centers for Disease C, Prevention. Hepatitis A outbreak associated with green onions at a restaurant--Monaca, Pennsylvania, 2003. MMWR Morb Mortal Wkly Rep. 2003;52(47):1155–7.

    Google Scholar 

  32. Centers for Disease C, Prevention. Foodborne transmission of hepatitis A--Massachusetts, 2001. MMWR Morb Mortal Wkly Rep. 2003;52(24):565–7.

    Google Scholar 

  33. Provost PJ, Wolanski BS, Miller WJ, Ittensohn OL, McAleer WJ, Hilleman MR. Physical, chemical and morphologic dimensions of human hepatitis A virus strain CR326 (38578). Proc Soc Exp Biol Med. 1975;148(2):532–9.

    CAS  PubMed  Google Scholar 

  34. Fiore AE. Hepatitis A transmitted by food. Clin Infect Dis. 2004;38(5):705–15.

    PubMed  Google Scholar 

  35. Behrens RH, Collins M, Botto B, Heptonstall J. Risk for British travellers of acquiring hepatitis A. BMJ. 1995;311(6998):193.

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Chironna M, Lopalco P, Prato R, Germinario C, Barbuti S, Quarto M. Outbreak of infection with hepatitis A virus (HAV) associated with a food handler and confirmed by sequence analysis reveals a new HAV genotype IB variant. J Clin Microbiol. 2004;42(6):2825–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  37. Halliday ML, Kang LY, Zhou TK, Hu MD, Pan QC, Fu TY, et al. An epidemic of hepatitis A attributable to the ingestion of raw clams in Shanghai. China J Infect Dis. 1991;164(5):852–9.

    CAS  PubMed  Google Scholar 

  38. Hansman GS, Oka T, Li TC, Nishio O, Noda M, Takeda N. Detection of human enteric viruses in Japanese clams. J Food Prot. 2008;71(8):1689–95.

    PubMed  Google Scholar 

  39. Amri I, Hmaied F, Loisy F, Lebeau B, Barkallah I, Saidi M, et al. Hepatitis A virus detection in shellfish from Tunisia by reverse transcription-nested PCR--investigation of a correlation between viral and bacterial contamination. Pathol Biol (Paris). 2011;59(4):217–21.

    CAS  Google Scholar 

  40. Cooksley WG. What did we learn from the Shanghai hepatitis A epidemic? J Viral Hepat. 2000;7(Suppl 1):1–3.

    PubMed  Google Scholar 

  41. Hollinger FB, Khan NC, Oefinger PE, Yawn DH, Schmulen AC, Dreesman GR, et al. Posttransfusion hepatitis type A. JAMA. 1983;250(17):2313–7.

    CAS  PubMed  Google Scholar 

  42. O'Donovan D, Cooke RP, Joce R, Eastbury A, Waite J, Stene-Johansen K. An outbreak of hepatitis A amongst injecting drug users. Epidemiol Infect. 2001;127(3):469–73.

    CAS  PubMed  PubMed Central  Google Scholar 

  43. Corey L, Holmes KK. Sexual transmission of hepatitis A in homosexual men: incidence and mechanism. N Engl J Med. 1980;302(8):435–8.

    CAS  PubMed  Google Scholar 

  44. Dane DS, Cameron CH, Briggs M. Virus-like particles in serum of patients with Australia-antigen-associated hepatitis. Lancet. 1970;1(7649):695–8.

    CAS  PubMed  Google Scholar 

  45. Dienstag JL. Hepatitis B virus infection. N Engl J Med. 2008;359(14):1486–500.

    CAS  PubMed  Google Scholar 

  46. Chu JJ, Wormann T, Popp J, Patzelt G, Akmatov MK, Kramer A, et al. Changing epidemiology of hepatitis B and migration—a comparison of six Northern and North-Western European countries. Eur J Pub Health. 2013;23(4):642–7.

    Google Scholar 

  47. Nelson NP, Easterbrook PJ, McMahon BJ. Epidemiology of Hepatitis B Virus infection and impact of vaccination on disease. Clin Liver Dis. 2016;20(4):607–28.

    PubMed  PubMed Central  Google Scholar 

  48. Choo QL, Richman KH, Han JH, Berger K, Lee C, Dong C, et al. Genetic organization and diversity of the hepatitis C virus. Proc Natl Acad Sci U S A. 1991;88(6):2451–5.

    CAS  PubMed  PubMed Central  Google Scholar 

  49. Houghton M, Weiner A, Han J, Kuo G, Choo QL. Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral disease. Hepatology. 1991;14(2):381–8.

    CAS  PubMed  Google Scholar 

  50. Petruzziello A, Marigliano S, Loquercio G, Cozzolino A, Cacciapuoti C. Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes. World J Gastroenterol. 2016;22(34):7824–40.

    PubMed  PubMed Central  Google Scholar 

  51. Tibbs CJ. Methods of transmission of hepatitis C. J Viral Hepat. 1995;2(3):113–9.

    CAS  PubMed  Google Scholar 

  52. Rizzetto M, Ponzetto A, Forzani I. Hepatitis delta virus as a global health problem. Vaccine. 1990;8(Suppl):S10–4; discussion S21-3.

    PubMed  Google Scholar 

  53. Rizzetto M, Hepatitis D. Virus: Introduction and Epidemiology. Cold Spring Harb Perspect Med. 2015;5(7):a021576.

    PubMed  PubMed Central  Google Scholar 

  54. Crispim MA, Fraiji NA, Campello SC, Schriefer NA, Stefani MM, Kiesslich D. Molecular epidemiology of hepatitis B and hepatitis delta viruses circulating in the Western Amazon region, North Brazil. BMC Infect Dis. 2014;14:94.

    PubMed  PubMed Central  Google Scholar 

  55. Pavio N, Meng XJ, Renou C. Zoonotic hepatitis E: animal reservoirs and emerging risks. Vet Res. 2010;41(6):46.

    PubMed  PubMed Central  Google Scholar 

  56. Smith DB, Simmonds P, Jameel S, Emerson SU, Harrison TJ, International Committee on Taxonomy of Viruses Hepeviridae Study G, et al. Consensus proposals for classification of the family Hepeviridae. J Gen Virol. 2014;95(Pt 10):2223–32.

    PubMed  PubMed Central  Google Scholar 

  57. Ahmad I, Holla RP, Jameel S. Molecular virology of hepatitis E virus. Virus Res. 2011;161(1):47–58.

    CAS  PubMed  PubMed Central  Google Scholar 

  58. Aggarwal R, Naik S. Epidemiology of hepatitis E: current status. J Gastroenterol Hepatol. 2009;24(9):1484–93.

    PubMed  Google Scholar 

  59. Khuroo MS. Hepatitis E: the enterically transmitted non-A, non-B hepatitis. Indian J Gastroenterol. 1991;10(3):96–100.

    CAS  PubMed  Google Scholar 

  60. Arankalle VA, Paranjape S, Emerson SU, Purcell RH, Walimbe AM. Phylogenetic analysis of hepatitis E virus isolates from India (1976-1993). J Gen Virol. 1999;80(Pt 7):1691–700.

    CAS  PubMed  Google Scholar 

  61. Panda SK, Thakral D, Rehman S. Hepatitis E virus. Rev Med Virol. 2007;17(3):151–80.

    CAS  PubMed  Google Scholar 

  62. Ghabrah TM, Stickland GT, Tsarev S, Yarbough P, Farci P, Engle R, et al. Acute viral hepatitis in Saudi Arabia: seroepidemiological analysis, risk factors, clinical manifestations, and evidence for a sixth hepatitis agent. Clin Infect Dis. 1995;21(3):621–7.

    CAS  PubMed  Google Scholar 

  63. Dai X, Dong C, Zhou Z, Liang J, Dong M, Yang Y, et al. Hepatitis E virus genotype 4, Nanjing, China, 2001-2011. Emerg Infect Dis. 2013;19(9):1528–30.

    PubMed  PubMed Central  Google Scholar 

  64. Delarocque-Astagneau E, Abravanel F, Moshen A, Le Fouler L, Gad RR, El-Daly M, et al. Epidemiological and virological characteristics of symptomatic acute hepatitis E in Greater Cairo, Egypt. Clin Microbiol Infect. 2012;18(10):982–8.

    CAS  PubMed  Google Scholar 

  65. Blackard JT, Rouster SD, Nady S, Galal G, Marzuuk N, Rafaat MM, et al. Genotypic characterization of symptomatic hepatitis E virus (HEV) infections in Egypt. J Clin Virol. 2009;46(2):140–4.

    CAS  PubMed  PubMed Central  Google Scholar 

  66. Pischke S, Heim A, Bremer B, Raupach R, Horn-Wichmann R, Ganzenmueller T, et al. Hepatitis E: an emerging infectious disease in Germany? Z Gastroenterol. 2011;49(9):1255–7.

    CAS  PubMed  Google Scholar 

  67. Kamar N, Izopet J, Rostaing L. Hepatitis E virus infection. Curr Opin Gastroenterol. 2013;29(3):271–8.

    CAS  PubMed  Google Scholar 

  68. Mansuy JM, Peron JM, Abravanel F, Poirson H, Dubois M, Miedouge M, et al. Hepatitis E in the south west of France in individuals who have never visited an endemic area. J Med Virol. 2004;74(3):419–24.

    PubMed  Google Scholar 

  69. Meng XJ. From barnyard to food table: the omnipresence of hepatitis E virus and risk for zoonotic infection and food safety. Virus Res. 2011;161(1):23–30.

    CAS  PubMed  PubMed Central  Google Scholar 

  70. Naik SR, Aggarwal R, Salunke PN, Mehrotra NN. A large waterborne viral hepatitis E epidemic in Kanpur, India. Bull World Health Organ. 1992;70(5):597–604.

    CAS  PubMed  PubMed Central  Google Scholar 

  71. Tandon BN, Gandhi BM, Joshi YK, Irshad M, Gupta H. Hepatitis virus non-A, non-B: the cause of a major public health problem in India. Bull World Health Organ. 1985;63(5):931–4.

    CAS  PubMed  PubMed Central  Google Scholar 

  72. Kane MA, Bradley DW, Shrestha SM, Maynard JE, Cook EH, Mishra RP, et al. Epidemic non-A, non-B hepatitis in Nepal. Recovery of a possible etiologic agent and transmission studies in marmosets. JAMA. 1984;252(22):3140–5.

    CAS  PubMed  Google Scholar 

  73. Teshale EH, Grytdal SP, Howard C, Barry V, Kamili S, Drobeniuc J, et al. Evidence of person-to-person transmission of hepatitis E virus during a large outbreak in Northern Uganda. Clin Infect Dis. 2010;50(7):1006–10.

    PubMed  Google Scholar 

  74. Khuroo MS, Duermeyer W, Zargar SA, Ahanger MA, Shah MA. Acute sporadic non-A, non-B hepatitis in India. Am J Epidemiol. 1983;118(3):360–4.

    CAS  PubMed  Google Scholar 

  75. Khuroo MS, Kamili S. Aetiology, clinical course and outcome of sporadic acute viral hepatitis in pregnancy. J Viral Hepat. 2003;10(1):61–9.

    CAS  PubMed  Google Scholar 

  76. Aggarwal R. Hepatitis E virus and person-to-person transmission. Clin Infect Dis. 2010;51(4):477–8; author reply 8–9.

    PubMed  Google Scholar 

  77. Yugo DM, Meng XJ. Hepatitis E virus: foodborne, waterborne and zoonotic transmission. Int J Environ Res Public Health. 2013;10(10):4507–33.

    PubMed  PubMed Central  Google Scholar 

  78. Miyashita K, Kang JH, Saga A, Takahashi K, Shimamura T, Yasumoto A, et al. Three cases of acute or fulminant hepatitis E caused by ingestion of pork meat and entrails in Hokkaido, Japan: Zoonotic food-borne transmission of hepatitis E virus and public health concerns. Hepatol Res. 2012;42(9):870–8.

    CAS  PubMed  Google Scholar 

  79. Colson P, Borentain P, Queyriaux B, Kaba M, Moal V, Gallian P, et al. Pig liver sausage as a source of hepatitis E virus transmission to humans. J Infect Dis. 2010;202(6):825–34.

    PubMed  Google Scholar 

  80. Garbuglia AR, Alessandrini AI, Pavio N, Tesse S, Grignolo S, Viscoli C, et al. Male patient with acute hepatitis E in Genoa, Italy: figatelli (pork liver sausage) as probable source of the infection. Clin Microbiol Infect. 2015;21(1):e4–6.

    CAS  PubMed  Google Scholar 

  81. Khuroo MS, Kamili S, Yattoo GN. Hepatitis E virus infection may be transmitted through blood transfusions in an endemic area. J Gastroenterol Hepatol. 2004;19(7):778–84.

    PubMed  Google Scholar 

  82. Matsubayashi K, Nagaoka Y, Sakata H, Sato S, Fukai K, Kato T, et al. Transfusion-transmitted hepatitis E caused by apparently indigenous hepatitis E virus strain in Hokkaido, Japan. Transfusion. 2004;44(6):934–40.

    PubMed  Google Scholar 

  83. Matsubayashi K, Kang JH, Sakata H, Takahashi K, Shindo M, Kato M, et al. A case of transfusion-transmitted hepatitis E caused by blood from a donor infected with hepatitis E virus via zoonotic food-borne route. Transfusion. 2008;48(7):1368–75.

    CAS  PubMed  Google Scholar 

  84. Hewitt PE, Ijaz S, Brailsford SR, Brett R, Dicks S, Haywood B, et al. Hepatitis E virus in blood components: a prevalence and transmission study in southeast England. Lancet. 2014;384(9956):1766–73.

    PubMed  Google Scholar 

  85. Fukuda S, Sunaga J, Saito N, Fujimura K, Itoh Y, Sasaki M, et al. Prevalence of antibodies to hepatitis E virus among Japanese blood donors: identification of three blood donors infected with a genotype 3 hepatitis E virus. J Med Virol. 2004;73(4):554–61.

    CAS  PubMed  Google Scholar 

  86. Vollmer T, Diekmann J, Johne R, Eberhardt M, Knabbe C, Dreier J. Novel approach for detection of hepatitis E virus infection in German blood donors. J Clin Microbiol. 2012;50(8):2708–13.

    PubMed  PubMed Central  Google Scholar 

  87. Holm DK, Moessner BK, Engle RE, Zaaijer HL, Georgsen J, Purcell RH, et al. Declining prevalence of hepatitis E antibodies among Danish blood donors. Transfusion. 2015;55(7):1662–7.

    CAS  PubMed  Google Scholar 

  88. Juhl D, Baylis SA, Blumel J, Gorg S, Hennig H. Seroprevalence and incidence of hepatitis E virus infection in German blood donors. Transfusion. 2014;54(1):49–56.

    CAS  PubMed  Google Scholar 

  89. Khuroo MS, Kamili S, Jameel S. Vertical transmission of hepatitis E virus. Lancet. 1995;345(8956):1025–6.

    CAS  PubMed  Google Scholar 

  90. Khuroo MS, Kamili S, Khuroo MS. Clinical course and duration of viremia in vertically transmitted hepatitis E virus (HEV) infection in babies born to HEV-infected mothers. J Viral Hepat. 2009;16(7):519–23.

    CAS  PubMed  Google Scholar 

  91. Khuroo MS. Association of severity of hepatitis E virus infection in the mother and vertically transmitted infection in the fetus. JK-Practitioner. 2006;13(2):70–4.

    Google Scholar 

  92. Bose PD, Das BC, Hazam RK, Kumar A, Medhi S, Kar P. Evidence of extrahepatic replication of hepatitis E virus in human placenta. J Gen Virol. 2014;95(Pt 6):1266–71.

    CAS  PubMed  Google Scholar 

  93. Chibber RM, Usmani MA, Al-Sibai MH. Should HEV infected mothers breast feed? Arch Gynecol Obstet. 2004;270(1):15–20.

    PubMed  Google Scholar 

  94. Lee GH, Tan BH, Teo EC, Lim SG, Dan YY, Wee A, et al. Chronic infection with Camelid Hepatitis E virus in a liver transplant recipient who regularly consumes camel meat and milk. Gastroenterology. 2016;150(2):355–7 e3.

    PubMed  Google Scholar 

  95. Ghany MG, Liang TK. Acute viral hepatitis. In: Podolsky DK, Camilleri M, Fitz JG, Kallo AN, Shanahan F, Wang TC, editors. Yamada’s textbook of gastroenterology, vol. Vol. 2. 6th ed. Hoboken, NJ: Wiley Blackwell; 2016. p. 1886–915.

    Google Scholar 

  96. Lankarani KB, Mahmoodi M, Honarvar B, Nematollahi P, Zamiri N, Ghaffarpasand F. Determinants of poor outcome in patients with hepatitis A infection: a four-year retrospective study in Shiraz, Southern Iran. Arch Virol. 2014;159(8):1901–7.

    CAS  PubMed  Google Scholar 

  97. Gordon SC, Reddy KR, Schiff L, Schiff ER. Prolonged intrahepatic cholestasis secondary to acute hepatitis A. Ann Intern Med. 1984;101(5):635–7.

    CAS  PubMed  Google Scholar 

  98. Glikson M, Galun E, Oren R, Tur-Kaspa R, Shouval D. Relapsing hepatitis A. Review of 14 cases and literature survey. Medicine (Baltimore). 1992;71(1):14–23.

    CAS  Google Scholar 

  99. Sjogren MH, Tanno H, Fay O, Sileoni S, Cohen BD, Burke DS, et al. Hepatitis A virus in stool during clinical relapse. Ann Intern Med. 1987;106(2):221–6.

    CAS  PubMed  Google Scholar 

  100. Khuroo MS. Acute liver failure in India. Hepatology. 1997;26(1):244–6.

    CAS  PubMed  Google Scholar 

  101. Brown GR, Persley K. Hepatitis A epidemic in the elderly. South Med J. 2002;95(8):826–33.

    PubMed  Google Scholar 

  102. Vento S, Garofano T, Renzini C, Cainelli F, Casali F, Ghironzi G, et al. Fulminant hepatitis associated with hepatitis A virus superinfection in patients with chronic hepatitis C. N Engl J Med. 1998;338(5):286–90.

    CAS  PubMed  Google Scholar 

  103. Willner IR, Uhl MD, Howard SC, Williams EQ, Riely CA, Waters B. Serious hepatitis A: an analysis of patients hospitalized during an urban epidemic in the United States. Ann Intern Med. 1998;128(2):111–4.

    CAS  PubMed  Google Scholar 

  104. Ilan Y, Hillman M, Oren R, Zlotogorski A, Shouval D. Vasculitis and cryoglobulinemia associated with persisting cholestatic hepatitis A virus infection. Am J Gastroenterol. 1990;85(5):586–7.

    CAS  PubMed  Google Scholar 

  105. Tagle Arrospide M, Leon Barua R. Viral hepatitis A as a triggering agent of autoimmune hepatitis report of a case and review of literature. Rev Gastroenterol Peru. 2003;23(2):134–7.

    PubMed  Google Scholar 

  106. Liaw YF, Brunetto MR, Hadziyannis S. The natural history of chronic HBV infection and geographical differences. Antivir Ther. 2010;15(Suppl 3):25–33.

    PubMed  Google Scholar 

  107. Kappus MR, Sterling RK. Extrahepatic manifestations of acute hepatitis B virus infection. Gastroenterol Hepatol (N Y). 2013;9(2):123–6.

    Google Scholar 

  108. Cacoub P, Comarmond C, Domont F, Savey L, Desbois AC, Saadoun D. Extrahepatic manifestations of chronic hepatitis C virus infection. Ther Adv Infect Dis. 2016;3(1):3–14.

    CAS  PubMed  PubMed Central  Google Scholar 

  109. Khuroo MS, Zargar SA, Mahajan R, Javid G, Lal R. An epidemic of hepatitis D in the foothills of the Himalayas in south Kashmir. J Hepatol. 1988;7(2):151–6.

    CAS  PubMed  Google Scholar 

  110. Khuroo MS. Study of an epidemic of non-A, non-B hepatitis. Possibility of another human hepatitis virus distinct from post-transfusion non-A, non-B type. Am J Med. 1980;68(6):818–24.

    CAS  PubMed  Google Scholar 

  111. Chauhan A, Jameel S, Dilawari JB, Chawla YK, Kaur U, Ganguly NK. Hepatitis E virus transmission to a volunteer. Lancet. 1993;341(8838):149–50.

    CAS  PubMed  Google Scholar 

  112. Khuroo MS, Rustgi VK, Dawson GJ, Mushahwar IK, Yattoo GN, Kamili S, et al. Spectrum of hepatitis E virus infection in India. J Med Virol. 1994;43(3):281–6.

    CAS  PubMed  Google Scholar 

  113. Khuroo MS, Kamili S. Aetiology and prognostic factors in acute liver failure in India. J Viral Hepat. 2003;10(3):224–31.

    CAS  PubMed  Google Scholar 

  114. Khuroo MS, Teli MR, Skidmore S, Sofi MA, Khuroo MI. Incidence and severity of viral hepatitis in pregnancy. Am J Med. 1981;70(2):252–5.

    CAS  PubMed  Google Scholar 

  115. Hamid SS, Atiq M, Shehzad F, Yasmeen A, Nissa T, Salam A, et al. Hepatitis E virus superinfection in patients with chronic liver disease. Hepatology. 2002;36(2):474–8.

    PubMed  Google Scholar 

  116. Kumar Acharya S, Kumar Sharma P, Singh R, Kumar Mohanty S, Madan K, Kumar Jha J, et al. Hepatitis E virus (HEV) infection in patients with cirrhosis is associated with rapid decompensation and death. J Hepatol. 2007;46(3):387–94.

    PubMed  Google Scholar 

  117. Ramachandran J, Eapen CE, Kang G, Abraham P, Hubert DD, Kurian G, et al. Hepatitis E superinfection produces severe decompensation in patients with chronic liver disease. J Gastroenterol Hepatol. 2004;19(2):134–8.

    PubMed  Google Scholar 

  118. Radha Krishna Y, Saraswat VA, Das K, Himanshu G, Yachha SK, Aggarwal R, et al. Clinical features and predictors of outcome in acute hepatitis A and hepatitis E virus hepatitis on cirrhosis. Liver Int. 2009;29(3):392–8.

    PubMed  Google Scholar 

  119. Khuroo MS. Discovery of hepatitis E: the epidemic non-A, non-B hepatitis 30 years down the memory lane. Virus Res. 2011;161(1):3–14.

    CAS  PubMed  Google Scholar 

  120. Izopet J, Kamar N. Hepatitis E: from zoonotic transmission to chronic infection in immunosuppressed patients. Med Sci (Paris). 2008;24(12):1023–5.

    Google Scholar 

  121. Yamamoto T, Suzuki H, Toyota T, Takahashi M, Okamoto H. Three male patients with sporadic acute hepatitis E in Sendai, Japan, who were domestically infected with hepatitis E virus of genotype III or IV. J Gastroenterol. 2004;39(3):292–8.

    PubMed  Google Scholar 

  122. Khuroo MS, Khuroo MS. Hepatitis E virus. Curr Opin Infect Dis. 2008;21(5):539–43.

    PubMed  Google Scholar 

  123. Kamar N, Selves J, Mansuy JM, Ouezzani L, Peron JM, Guitard J, et al. Hepatitis E virus and chronic hepatitis in organ-transplant recipients. N Engl J Med. 2008;358(8):811–7.

    CAS  PubMed  Google Scholar 

  124. Kamar N, Mansuy JM, Cointault O, Selves J, Abravanel F, Danjoux M, et al. Hepatitis E virus-related cirrhosis in kidney- and kidney-pancreas-transplant recipients. Am J Transplant. 2008;8(8):1744–8.

    CAS  PubMed  Google Scholar 

  125. Kamar N, Garrouste C, Haagsma EB, Garrigue V, Pischke S, Chauvet C, et al. Factors associated with chronic hepatitis in patients with hepatitis E virus infection who have received solid organ transplants. Gastroenterology. 2011;140(5):1481–9.

    PubMed  Google Scholar 

  126. Dalton HR, Kamar N, van Eijk JJ, McLean BN, Cintas P, Bendall RP, et al. Hepatitis E virus and neurological injury. Nat Rev Neurol. 2016;12(2):77–85.

    CAS  PubMed  Google Scholar 

  127. Abid S, Khan AH. Severe hemolysis and renal failure in glucose-6-phosphate dehydrogenase deficient patients with hepatitis E. Am J Gastroenterol. 2002;97(6):1544–7.

    CAS  PubMed  Google Scholar 

  128. Au WY, Ngai CW, Chan WM, Leung RY, Chan SC. Hemolysis and methemoglobinemia due to hepatitis E virus infection in patient with G6PD deficiency. Ann Hematol. 2011;90(10):1237–8.

    PubMed  PubMed Central  Google Scholar 

  129. Bhagat S, Wadhawan M, Sud R, Arora A. Hepatitis viruses causing pancreatitis and hepatitis: a case series and review of literature. Pancreas. 2008;36(4):424–7.

    PubMed  Google Scholar 

  130. Haffar S, Bazerbachi F, Lake JR. HEV-associated cryoglobulinaemia and extrahepatic manifestations of hepatitis E. Lancet Infect Dis. 2015;15(3):268.

    PubMed  Google Scholar 

  131. Mishra A, Saigal S, Gupta R, Sarin SK. Acute pancreatitis associated with viral hepatitis: a report of six cases with review of literature. Am J Gastroenterol. 1999;94(8):2292–5.

    CAS  PubMed  Google Scholar 

  132. Cheung MC, Maguire J, Carey I, Wendon J, Agarwal K. Review of the neurological manifestations of hepatitis E infection. Ann Hepatol. 2012;11(5):618–22.

    PubMed  Google Scholar 

  133. Scharn N, Ganzenmueller T, Wenzel JJ, Dengler R, Heim A, Wegner F. Guillain-Barre syndrome associated with autochthonous infection by hepatitis E virus subgenotype 3c. Infection. 2014;42(1):171–3.

    CAS  PubMed  Google Scholar 

  134. Bruffaerts R, Yuki N, Damme PV, Moortele MV, Wautier M, Lagrou K, et al. Acute ataxic neuropathy associated with hepatitis E virus infection. Muscle Nerve. 2015;52(3):464–5.

    PubMed  Google Scholar 

  135. Wu X, Liu K, Zhang HL. Guillain-Barre syndrome and encephalitis/encephalopathy associated with acute severe hepatitis E infection. Neurol Sci. 2015;36(1):165–6.

    CAS  PubMed  Google Scholar 

  136. Cronin S, McNicholas R, Kavanagh E, Reid V, O'Rourke K. Anti-glycolipid GM2-positive Guillain-Barre syndrome due to hepatitis E infection. Ir J Med Sci. 2011;180(1):255–7.

    CAS  PubMed  Google Scholar 

  137. Dienstag JL. Acute viral hepatitis. In: Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo JL, editors. Harrison’s principles of internal medicine. 17th ed. New York, NY: McGraw-Hill Companies Inc.; 2008. p. 1932–49.

    Google Scholar 

  138. Kao HW, Ashcavai M, Redeker AG. The persistence of hepatitis A IgM antibody after acute clinical hepatitis A. Hepatology. 1984;4(5):933–6.

    CAS  PubMed  Google Scholar 

  139. Liaw YF, Yang CY, Chu CM, Huang MJ. Appearance and persistence of hepatitis A IgM antibody in acute clinical hepatitis A observed in an outbreak. Infection. 1986;14(4):156–8.

    CAS  PubMed  Google Scholar 

  140. Hoofnagle JH, Di Bisceglie AM. Serologic diagnosis of acute and chronic viral hepatitis. Semin Liver Dis. 1991;11(2):73–83.

    CAS  PubMed  Google Scholar 

  141. Yotsuyanagi H, Iino S, Koike K, Yasuda K, Hino K, Kurokawa K. Duration of viremia in human hepatitis A viral infection as determined by polymerase chain reaction. J Med Virol. 1993;40(1):35–8.

    CAS  PubMed  Google Scholar 

  142. Pas SD, Streefkerk RH, Pronk M, de Man RA, Beersma MF, Osterhaus AD, et al. Diagnostic performance of selected commercial HEV IgM and IgG ELISAs for immunocompromised and immunocompetent patients. J Clin Virol. 2013;58(4):629–34.

    CAS  PubMed  Google Scholar 

  143. Zhao ZY, Ruan B, Shao H, Chen ZJ, Liu SL. Detection of hepatitis E virus RNA in sera of patients with hepatitis E by polymerase chain reaction. Hepatobiliary Pancreat Dis Int. 2007;6(1):38–42.

    PubMed  Google Scholar 

  144. Pischke S, Wedemeyer H. Chronic hepatitis E in liver transplant recipients: a significant clinical problem? Minerva Gastroenterol Dietol. 2010;56(2):121–8.

    CAS  PubMed  Google Scholar 

  145. Kamar N, Rostaing L, Abravanel F, Garrouste C, Lhomme S, Esposito L, et al. Ribavirin therapy inhibits viral replication on patients with chronic hepatitis e virus infection. Gastroenterology. 2010;139(5):1612–8.

    CAS  PubMed  Google Scholar 

  146. Brochot E, Choukroun G, Duverlie G. Ribavirin for chronic hepatitis E virus infection. N Engl J Med. 2014;370(25):2446–7.

    CAS  PubMed  Google Scholar 

  147. Coppola N, Genovese D, Pisaturo M, Taffon S, Argentini C, Pasquale G, et al. Acute hepatitis with severe cholestasis and prolonged clinical course due to hepatitis A virus Ia and Ib coinfection. Clin Infect Dis. 2007;44(9):e73–7.

    PubMed  Google Scholar 

  148. William R. Classification, etiology and considerations of outcome in acute liver failure. Semin Liver Dis. 1996;16:343.

    Google Scholar 

  149. European Association for the Study of the Liver. Electronic address eee, European Association for the Study of the L. EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection. J Hepatol. 2017;67(2):370–98.

    Google Scholar 

  150. Bethea ED, Chen Q, Hur C, Chung RT, Chhatwal J. Should we treat acute hepatitis C? A decision and cost-effectiveness analysis. Hepatology. 2018;67(3):837–46.

    PubMed  PubMed Central  Google Scholar 

  151. Goyal R, Kumar A, Panda SK, Paul SB, Acharya SK. Ribavirin therapy for hepatitis E virus-induced acute on chronic liver failure: a preliminary report. Antivir Ther. 2012;17(6):1091–6.

    CAS  PubMed  Google Scholar 

  152. Wang Y, Zhou X, Debing Y, Chen K, Van Der Laan LJ, Neyts J, et al. Calcineurin inhibitors stimulate and mycophenolic acid inhibits replication of hepatitis E virus. Gastroenterology. 2014;146(7):1775–83.

    CAS  PubMed  Google Scholar 

  153. Dao Thi VL, Debing Y, Wu X, Rice CM, Neyts J, Moradpour D, et al. Sofosbuvir inhibits hepatitis E virus replication in vitro and results in an additive effect when combined with ribavirin. Gastroenterology. 2016;150(1):82–5 e4.

    CAS  PubMed  Google Scholar 

  154. Fiore A, Baxter LC, Bell BP, Hershow R, Passaro D, Twiddy S, et al. Hepatitis A 2004 vaccination in children: methods and findings of a survey in two states. Am J Prev Med. 2007;33(4):346–52.

    PubMed  Google Scholar 

  155. Advisory Committee on Immunization P, Fiore AE, Wasley A, Bell BP. Prevention of hepatitis A through active or passive immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2006;55(RR-7):1–23.

    Google Scholar 

  156. Abarca K, Ibanez I, Perret C, Vial P, Zinsou JA. Immunogenicity, safety, and interchangeability of two inactivated hepatitis A vaccines in Chilean children. Int J Infect Dis. 2008;12(3):270–7.

    CAS  PubMed  Google Scholar 

  157. Demicheli V, Tiberti D. The effectiveness and safety of hepatitis A vaccine: a systematic review. Vaccine. 2003;21(19–20):2242–5.

    CAS  PubMed  Google Scholar 

  158. Aristegui J, Morales JL, Dal-Re R, Gonzalez A, Gallego MS, Garrote E. Safety and immunogenicity of an inactivated hepatitis A vaccine in children 2 to 5 years old. Infection. 1995;23(5):334–8.

    CAS  PubMed  Google Scholar 

  159. Belmaker I, Dukhan L, Yosef Y, Leventhal A, Dagan R. Elimination of hepatitis a infection outbreaks in day care and school settings in southern Israel after introduction of the national universal toddler hepatitis a immunization program. Pediatr Infect Dis J. 2007;26(1):36–40.

    PubMed  Google Scholar 

  160. Fangcheng Z, Xuanyi W, Mingding C, Liming J, Jie W, Qi J, et al. Era of vaccination heralds a decline in incidence of hepatitis A in high-risk groups in China. Hepat Mon. 2012;12(2):100–5.

    PubMed  PubMed Central  Google Scholar 

  161. Dagan R, Leventhal A, Anis E, Slater P, Ashur Y, Shouval D. Incidence of hepatitis A in Israel following universal immunization of toddlers. JAMA. 2005;294(2):202–10.

    CAS  PubMed  Google Scholar 

  162. Hanna JN, Warnock TH, Shepherd RW, Selvey LA. Fulminant hepatitis A in indigenous children in north Queensland. Med J Aust. 2000;172(1):19–21.

    CAS  PubMed  Google Scholar 

  163. Victor JC, Monto AS, Surdina TY, Suleimenova SZ, Vaughan G, Nainan OV, et al. Hepatitis A vaccine versus immune globulin for postexposure prophylaxis. N Engl J Med. 2007;357(17):1685–94.

    CAS  PubMed  Google Scholar 

  164. Kane M. Global programme for control of hepatitis B infection. Vaccine. 1995;13(Suppl 1):S47–9.

    PubMed  Google Scholar 

  165. Boccalini S, Pellegrino E, Tiscione E, Pesavento G, Bechini A, Levi M, et al. Sero-epidemiology of hepatitis B markers in the population of Tuscany, Central Italy, 20 years after the implementation of universal vaccination. Hum Vaccin Immunother. 2013;9(3):636–41.

    PubMed  PubMed Central  Google Scholar 

  166. Hagan LM, Wolpe PR, Schinazi RF. Treatment as prevention and cure towards global eradication of hepatitis C virus. Trends Microbiol. 2013;21(12):625–33.

    CAS  PubMed  Google Scholar 

  167. Khuroo MS. Sanitation and sewage disposal in India. http://www.researchgate.net/publication/2694115842014.

  168. Khuroo MS. Viral hepatitis in international travellers: risks and prevention. Int J Antimicrob Agents. 2003;21(2):143–52.

    CAS  PubMed  Google Scholar 

  169. Kamar N, Legrand-Abravanel F, Izopet J, Rostaing L. Hepatitis E virus: what transplant physicians should know. Am J Transplant. 2012;12(9):2281–7.

    CAS  PubMed  Google Scholar 

  170. Zhu FC, Zhang J, Zhang XF, Zhou C, Wang ZZ, Huang SJ, et al. Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial. Lancet. 2010;376(9744):895–902.

    CAS  PubMed  Google Scholar 

  171. Zhang J, Shih JW, Xia NS. Long-term efficacy of a hepatitis E vaccine. N Engl J Med. 2015;372(23):2265–6.

    CAS  PubMed  Google Scholar 

  172. Azman AS, Luquero FJ, Ciglenecki I. Long-term efficacy of a hepatitis E vaccine. N Engl J Med. 2015;372(23):2265.

    CAS  PubMed  Google Scholar 

  173. Hepatitis E vaccine: why wait? Lancet. 2010;376(9744):845.

    Google Scholar 

  174. Hepatitis E vaccine: WHO position paper, May 2015. Wkly Epidemiol Rec. 2015;90(18):185–200.

    Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India

    Mohammad Sultan Khuroo

  2. King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

    Mohammad Sultan Khuroo

  3. Digestive Diseases Centre, Dr. Khuroo’s Medical Clinic, Srinagar, Kashmir, India

    Mohammad Sultan Khuroo

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  1. Cerrahasa Medical School, Istanbul University Cerrahasa Medical School, Istanbul, Turkey

    Resat Ozaras

  2. University Medical Center Utrecht, GA Utrecht, Utrecht, The Netherlands

    Joop E. Arends

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Khuroo, M.S. (2019). A Review of Acute Viral Hepatitides Including Hepatitis E. In: Ozaras, R., Arends, J. (eds) Viral Hepatitis: Acute Hepatitis. Springer, Cham. https://doi.org/10.1007/978-3-030-03535-8_6

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