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Muscle Gene Therapy pp 227–237Cite as

Optical Polarization Tractography Imaging of Structural Changes in the Skeletal and Cardiac Muscles of the mdx4cv Mice

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Abstract

Optical polarization tractography (OPT) is a recently developed imaging technology that can quantitatively evaluate the three-dimensional fiber organization in tissue with microscopic resolution. In this chapter, we first introduce the basic principle and system design of this technology. We then show its applications for imaging skeletal muscle damage and heart structural remodeling in the mdx4cv mice, a mouse model for Duchenne muscular dystrophy. Because of its relatively low system cost, high imaging speed, and cellular-level resolution, OPT may become an effective tool for phenotype assessment in the research of neuromuscular diseases.

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Acknowledgment

The results presented in this chapter were obtained in close collaboration with Dr. Dongsheng Duan. We thank Yuanbo Wang, Keqing Zhang, Chuanmao Fan, and many other students and colleagues’ valuable contributions to this project.

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Authors and Affiliations

  1. Department of Bioengineering, University of Missouri, Columbia, MO, USA

    Gang Yao

Authors
  1. Gang Yao
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Correspondence to Gang Yao .

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Editors and Affiliations

  1. Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, MO, USA; Department of Neurology, School of Medicine, University of Missouri, Columbia, MO, USA, Department of Biomedical Sciences College of Veterinary Medicine, University of Missouri, Columbia, MO, USA; Department of Bioengineering, University of Missouri, Columbia, MO, USA

    Dongsheng Duan

  2. Department of Pediatrics Nationwide Children’s Hospital and Research Institute, Department of Neurology Nationwide Children’s Hospital and Research Institute, The Ohio State University, Columbus, OH, USA

    Jerry R. Mendell

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Yao, G. (2019). Optical Polarization Tractography Imaging of Structural Changes in the Skeletal and Cardiac Muscles of the mdx4cv Mice. In: Duan, D., Mendell, J. (eds) Muscle Gene Therapy. Springer, Cham. https://doi.org/10.1007/978-3-030-03095-7_13

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