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Sex Hormones and CGRP

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Gender and Migraine

Part of the book series: Headache ((HEAD))

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Abstract

Migraine is three times more prevalent in women than in men. The mechanisms behind the sex disparity in migraine are not completely understood, but it is thought to be mediated through changes in ovarian steroid hormones. Migraine pathophysiology is considered to involve an activation of the trigeminovascular system and the subsequent release of calcitonin gene-related peptide (CGRP); therefore, an interaction between ovarian steroid hormones, the trigeminovascular system, and CGRP has been suggested. Although studies are scarce, it has been shown that indeed there is a cross talk and that further studies could lead to the development of sex-specific treatments.

This chapter provides a summary of the studies that have evaluated the sex differences in CGRP, in both preclinical and clinical models of migraine and their possible implications for migraine pathophysiology and treatment.

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  1. Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

    Eloísa Rubio-Beltrán & Alejandro Labastida-Ramírez

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  1. Eloísa Rubio-Beltrán
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  2. Alejandro Labastida-Ramírez
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Correspondence to Eloísa Rubio-Beltrán .

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  1. Division of Pharmacology and Vascular Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands

    Antoinette Maassen van den Brink

  2. Barts Health NHS Trust, London, UK

    E. Anne MacGregor

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Rubio-Beltrán, E., Labastida-Ramírez, A. (2019). Sex Hormones and CGRP. In: Maassen van den Brink, A., MacGregor, E. (eds) Gender and Migraine. Headache. Springer, Cham. https://doi.org/10.1007/978-3-030-02988-3_7

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