Abstract
Mushroom has been broadly used and appreciated for nutraceutical values and healthy properties in oriental countries for over 2000 years. More and more health conscious consumers come to realize that added attention should be given to the mushroom as functional foods and complementary medicinal agents. Various bioactive substances existed in mushrooms, such as polysaccharides, proteins, vitamins and minerals, apart from low caloric content and low level of lipids. Fungi are abundant sources of polysaccharides, mostly homo-polysaccharides. They are normally not digested by human enzymes, being considered as fibres, which could not only improve stool bulk and promote intestinal motility, but also decrease absorption of carcinogenic substances and harmful toxic. Polysaccharides extracted from mushroom have been extensively studied as dietary supplements and therapeutics for the treatment of some diseases over the past decades. This chapter is aimed at the suitable utilization of mushroom polysaccharides as bioactive prebiotics, taking into view the high development for application in nutritional and pharmaceuticals industry.
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References
Bhunia SK, Dey B, Maity KK, Patra S, Mandal S, Maiti S, Maiti TK, Sikdar SR, Islam SS (2010) Structural characterization of an immunoenhancing heteroglycan isolated from an aqueous extract of an edible mushroom, Lentinus squarrosulus (Mont.) Singer. Carbohydr Res 345(17):2542–2549
Bi H, Gao T, Li Z, Ji L, Yang W, Jeff Iteku B, Liu E, Zhou Y (2013) Structural elucidation and antioxidant activity of a water-soluble polysaccharide from the fruit bodies of Bulgaria inquinans (Fries). Food Chem 138(2–3):1470–1475
Bi H, Han H, Li Z, Ni W, Chen Y, Zhu J, Gao T, Hao M, Zhou Y (2011) A Water-Soluble Polysaccharide from the fruit bodies of Bulgaria inquinans (Fries) and its anti-malarial activity. Evid Based Complement Alternat Med 2011:1–12
Campelo-Felix PH, Souza HJB, Figueiredo JDA, Fernandes RVDB, Botrel DA, de Oliveira CR, Yoshida Ml Borges SV (2017) Prebiotic carbohydrates: effect on reconstitution, storage, release, and antioxidant properties of lime essential oil microparticles. J Agric Food Chem 65(2):445–453
Carbonero ER, Gracher AHP, Komura DL, Marcon R, Freitas CS, Baggio CH, Santos ARS, Torri G, Gorin PAJ, Lacomini M (2008) Lentinus edodes heterogalactan: antinociceptive and anti-inflammatory effects. Food Chem 111(3):531–537
Chang CJ, Lin CS, Lu CC, Martel J, Ko YF, Ojcius DM, Tseng SF, Wu TR, Chen YYM, Young JD, Lai HC (2015) Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota. Nat Commun 6:7489–7506
Chen AW, Huang NL (2001) Production of the medicinal mushroom Tremella fuciformis Berk by mixed-culture cultivation on synthetic logs. Int J Med Mushrooms 32(2–3):1
Chou WT, Sheih IC, Fang TJ (2013) The applications of polysaccharides from various mushroom wastes as prebiotics in different systems. J Food Sci 78(7):1041–1048
De Silva DD, Rapior S, Fons F, Bahkali AH, Hyde KD (2012) Medicinal mushrooms in supportive cancer therapies: an approach to anti-cancer effects and putative mechanisms of action. Fungal Divers 55(1):1–35
Delzenne NM, Bindels LB (2015) Gut microbiota: Ganoderma lucidum, a new prebiotic agent to treat obesity? Nat Rev Gastroenterol Hepatol 12(10):553–554
Ding X, Hou Y, Hou W (2012) Structure elucidation and antioxidant activity of a novel polysaccharide isolated from Boletus speciosus forst. Int J Biol Macromol 50(3):613–618
Douglas LC, Sanders ME (2008) Probiotics and prebiotics in dietetics practice. J Am Diet Assoc 108(3):510–521
Duncan CJG, Pugh N, Pasco DS, Ross SA (2002) Isolation of a galactomannan that enhances macrophage activation from the edible fungus Morchella esculenta. J Agric Food Chem 50(20):5683–5685
Duncan SH, Scott KP, Ramsay AG, Harmsen HJ, Welling GW (2003) Effects of alternative dietary substrates on competition between human colonic bacteria in an anaerobic fermentor system. Appl Environ Microbiol 69(2):1136–1142
Ferrão J, Bell V, Calabrese V, Pimentel L, Pintado M, Fernandes TH (2017) Impact of mushroom nutrition on microbiota and potential for preventative health. J Food Nutr Res 5(4):226–233
Gibson GR (2004) From probiotics to prebiotics and a healthy digestive system. J Food Sci 69(5):141–143
Gibson GR, Beatty ER, Wang X, Cummings JH (1995) Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 108(4):975–982
Gibson GR, Probert HM, Loo JV, Rastall RA, Roberfroid MB (2004) Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutr Res Rev 17(2):259–275
Gibson GR, Roberfroid MB (1995) Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 125(6):1401–1412
Hara C, Kumazawa Y, Inagaki K, Kaneko M, Kiho T, Ukai S (1991) Mitogenic and colony-stimulating factor-inducing activities of polysaccharide fractions from the fruit bodies of Dictyophora indusiata fisch. Chem Pharm Bull 39(6):1615–1616
Hardy ML (2008) Dietary supplement use in cancer care: help or harm. Hematol Oncol Clin North Am 22(4):581–617
Huebner J, Wehling RL, Parkhurst A, Hutkins RW (2008) Effect of processing conditions on the prebiotic activity of commercial prebiotics. Int Dairy J 18(3):287–293
Khan I, Huang G, Li X, Leong W, Xia W, Hsiao WLW (2017) Polysaccharides from two medicinal mushrooms Ganoderma lucidum and Poria cocos reveal prebiotic effects in mice. The Functional Food Center's 22nd International Conference, Boston
Khan I, Huang G, Li X, Leong W, Xia W, Hsiao WLW (2018) Mushroom polysaccharides from Ganoderma lucidum and Poria cocos reveal prebiotic functions. J Funct Foods 41:191–201
Kiho T, Shiose Y, Nagai K, Ukai S (1992) Polysaccharides in fungi. xxx. antitumor and immunomodulating activities of two polysaccharides from the fruiting bodies of Armillariella tabescens. Chem Pharma Bulletin 40(8):2110–2114
Kim GY, Choi GS, Lee SH, Park YM (2004) Acidic polysaccharide isolated from Phellinus linteus, enhances through the up-regulation of nitric oxide and tumor necrosis factor-α from peritoneal macrophages. J Ethnopharmacol 95(1):69–76
Kim YO, Han SB, Lee HW, Ahn HJ, Yoon YD (2005) Immuno-stimulating effect of the endo-polysaccharide produced by submerged culture of Inonotus obliquus. Life Sci 77(19):2438–2456
Kim YO, Park HW, Kim JH, Lee JY, Moon SH (2006) Anti-cancer effect and structural characterization of endo-polysaccharide from cultivated mycelia of Inonotus obliquus. Life Sci 79:72–80
Kozarski M, Klaus A, Niksic M, Jakovljevic D, Jpfg H, Ljld VG (2011) Antioxidative and immunomodulating activities of polysaccharide extracts of the medicinal mushrooms Agaricus bisporus. Food Chem 129(4):1667–1675
Langlands SJ, Hopskin MJ, Coleman N, Cummings JH (2004) Prebiotic carbohydrates modify the mucosa-associated microflora of the human large bowel. Gut 53(11):1610–1616
Lee JW, Park JW (2010) Changes of fatty acid composition and oxidation stability of edible oils with frying number of french fried potatoes. J Korean Soc Food Sci Nutr 39(7):1011–1017
Leung MY, Fung KP, Choy YM (1997) The isolation and characterization of an immunomodulatory and anti-tumor polysaccharide preparation from flammulina velutipes. Immunopharmacol 35(3), 255–263.
Liang Z, Miao C, Zhang Y (1996) Influence of chemical-modified structures on antitumour activity of polysaccharides from Clitopilus caespitosus. Chin Pharm J 31(10):613–615
Liao W, Yu Z, Lin Z, Lei Z, Ning Z, Regenstein JM, Yang J, Ren J (2015) Biofunctionalization of selenium nanoparticle with Dictyophora indusiata polysaccharide and its antiproliferative activity through death-receptor and mitochondria-mediated apoptotic pathways. Sci Rep 5:18629
Liu Y, Sun J, Rao S, Su Y, Li J, Li C, Xu S, Yang Y (2013) Antidiabetic activity of mycelia selenium-polysaccharide from Catathelasma ventricosum in STZ-induced diabetic mice. Food Chem Toxicol 62:285–291
Luo Q, Sun Q, Wu L, Yang Z (2012) Structural characterization of an immunoregulatory polysaccharide from the fruiting bodies of Lepista sordida. Carbohyd Polym 88(3):820–824
Ma Z, Wang J, Zhang L (2008) Structure and chain Conformation of β-Glucan Isolated from Auricularia auricula-judae. Biopolymers 87(7):614–622
Ma Z, Wang J, Zhang L, Zhang Y, Ding K (2010) Evaluation of water soluble β-d-glucan from Auricularia auricular-judae as potential anti-tumor agent. Carbohydr Polym 80(3):977–983
Macfarlane GT, Steed H, Macfarlane S (2008) Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebiotics. J Appl Microbiol 104(2):305–344
Macfarlane S, Macfarlane GT, Cummings JH (2006) Review article: prebiotics in the gastrointestinal tract. Aliment Pharm Ther 24(5):701–714
Maity KK, Patra S, Dey B, Bhunia SK, Mandal S, Das D, Majumdar DK, Maiti S, Maiti TK, Islam SS (2011) A heteropolysaccharide from aqueous extract of an edible mushroom, Pleurotus ostreatus cultivar: structural and biological studies. Carbohydr Res 346(2):366–372
Mandal EK, Maity K, Maity S, Gantait SK, Maiti S, Maiti TK, Sikdar SR, Islam SS (2011) Structural characterization of an immunoenhancing cytotoxic heteroglycan isolated from an edible mushroom Calocybe indicavar. APK2. Carbohydr Res 346(14):2237–2243
Mandal V, Sen SK, Mandal NC (2009) Effect of prebiotics on bacteriocin production and cholesterol lowering activity of Pediococcus acidilactici LAB 5. World J Microbiol Biotechnol 25(10):1837–1847
Manning T, Gibson G (2004) Microbial-gut interactions in health and disease Prebiotics. Best Pract Res Clin Gastroenterol 18(2):287–298
Masuda Y, Inoue M, Miyata A, Mizuno S, Nanba H (2009) Maitake beta-glucan enhances therapeutic effect and reduces myelosupression and nephrotoxicity of cisplatin in mice. Int Immunopharmacol 9(4):620–629
Mizuno T (1995) Yamabushitake: bioactive substances and medicinal utilization. Food Rev Int 11(1):173–178
Mizuna T (1999) Bioactive substances in Hericium erinaceus (bull.: fr.) pers. (yamabushitake), and its medicinal utilization. Int J Med Mushrooms 1(2):105–119
Mizuno T, Inagaki R, Kanao T, Hagiwara T, Nakamura T, Ito H, Shimura K, Sumiya T, Asakura A (1990) Antitumor activity and some properties of water-insoluble hetero-glycans from “Himematsutake”, the fruiting body of Agaricus blazei Murill. Agric Biol Chem 54(11):2897–2905
Mizuno T, Wasa T, Ito H, Suzuki C, Ukai N (1992) Antitumor-active polysaccharides isolated from the fruiting body of Hericium erinaceum, an edible and medicinal mushroom called yamabushitake or houtou. Biosci Biotechnol Biochem 56(2):347–348
Nakashima S, Umeda Y, Kanada T (2013) Effect of polysaccharides from ganoderma applanatum on immune responses. i. enhancing effect on the induction of delayed hypersensitivity in mice. Microbiol Immunol 23(6):501–513
Nanba H, Hamaguchi A, Kuroda H (1987) The chemical structure of an antitumor polysaccharide in fruit bodies of Grifola frondosa (maitake). Chem Pharm Bull 35(3):1162–1168
Nandan CK, Sarkar R, Bhanja SK, Sikdar SR, Islam SS (2011) Isolation and characterization of polysaccharides of a hybrid mushroom (backcross mating between PfloVv12 and Volvariella volvacea). Carbohydr Res 346(15):2451–2456
Nosál'Ová V, Bobek P, Cerná S, Galbavý S, Stvrtina S (2001) Effects of pleuran (ß-Glucan isolated from Pleurotus ostreatus) on experimental colitis in rats. Physiol Res 50(6):575–581
Nowak R, Nowacka-Jechalke N, Juda M, Malm A (2018) The preliminary study of prebiotic potential of polish wild mushroom polysaccharides: the stimulation effect on Lactobacillus strains growth. Eur J Nutr 57:1511–1521
Ojha AK, Chandra K, Ghosh K, Islam SS (2010) Glucans from the alkaline extract of an edible mushroom, Pleurotus florida, Assam Florida: isolation, purification, and characterization. Carbohydr Res 345(15):2157–2163
Palframan R, Gibson GR, Rastall RA (2003) Development of a quantitative tool for the comparison of the prebiotic effect of dietary oligosaccharides. Lett Appl Microbiol 37(44):281–284
Patra P, Bhanja SK, Sen IK, Nandi AK, Samanta S, Das D, Devi KS, Maiti TK, Acharya K, Islam SS (2012) Structural and immunological studies of hetero polysaccharide isolated from the alkaline extract of Tricholoma crassum (Berk.) Sacc. Carbohydr Res 362:1–7
Rathore H, Prasad S, Sharma S (2017) Mushroom nutraceuticals for improved nutrition and better human health: a review. Pharma Nutr 5(2):35–46
Roncero-Ramos I, Delgado-Andrade C (2017) The beneficial role of edible mushrooms in human health. Curr Opin Food Sci 14:122–128
Rout D, Mondal S, Chakraborty I, Pramanik M, Islam SS (2004) Structural characterisation of an immunomodulating polysaccharide isolated from aqueous extract of Pleurotus florida, fruit-bodies. Med Chem Res 13(6–7):509–517
Sasaki T, Takasuka N (1976) Further study of the structure of lentinan, an anti-tumor polysaccharide from Lentinus edodes. Carbohydr Res 47(1):99–104
Stowell J (2007) Sweeteners and sugar alternatives in food technology. In: Mitchell H (ed) Calorie Control and Weight Management, pp 54–64. https://doi.org/10.1002/9780470996003.ch4
Sun YX, Liang HT, Zhang XT, Tong HB, Liu JC (2009) Structural elucidation and immunological activity of a polysaccharide from the fruiting body of Armillaria mellea. Bioresour Technol 100(5):1860–1863
Synytsya A, Míčková K, Synytsya A, Jablonský I, Spěváček J, Erban V, Kovarikova E, Copikova J (2009) Glucans from fruit bodies of cultivated mushrooms Pleurotus ostreatus and Pleurotus eryngii: structure and potential prebiotic activity. Carbohydr Polym 76(4):548–556
Tuohy KM, Probert HM, Smejkal CW, Gibson GR (2003) Using probiotics and prebiotics to improve gut health. Drug Discov Today 8(15):692–700
Ukai S, Kiho T, Hara C, Morita M, Goto A, Imaizumi N, Hasegawa Y (1983) Polysaccharides in fungi. xiii. antitumor activity of various polysaccharides isolated from Dictyophora indusiata, Ganoderma japonicum, Cordyceps cicadae, Auricularia auricula-judae and Auricularia species. Chem Pharm Bull 31(2):741–744
Ukai S, Morisaki S, Goto M, Kiho T, Hara C, Hirose K (2008) Polysaccharides in fungi. vii. acidic heteroglycans from the fruit bodies of Auricularia auricula-judae quel. Chem Pharm Bulletin 30(2):635–643
Vamanu E, Vamanu A (2010) The influence of prebiotics on bacteriocin synthesis using the strain Lactobacillus paracasei CMGB16. Afr J Microbiol Res 4(7):534–537
Wang D, Sun S, Wu W, Yang S, Tan J (2014) Characterization of a water-soluble polysaccharide from Boletus edulis and its antitumor and immunomodulatory activities on renal cancer in mice. Carbohydr Polym 105:127–134
Wang J, Hu S, Liang Z, Yeh C (2005) Optimization for the production of water-soluble polysaccharide from Pleurotus citrinopileatus in submerged culture and its antitumor effect. Appl Microbiol Biotechnol 67(6):759–766
Wang SY, Hsu ML, Hsu HC, Tzeng CH, Lee SS (1997) The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. Int J Cancer 70(6):699–705
Wang Y (2009) Prebiotics: present and future in food science and technology. Food Res Int 42(1):8–12
Wasser S (2002) Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol 60(3):258–274
Wasser SP (2011) Current findings, future trends, and unsolved problems in studies of medicinal mushrooms. Appl Microbiol Biotechnol 89(5):1323–1332
Wong KH, Wong KY, Kwan HS, Cheung PC (2005) Dietary fibers from mushroom sclerotia: 3. in vitro fermentability using human fecal microflora. J Agric Food Chem 53(24):9407–9412
Xu S, Xu X, Zhang L (2012) Branching structure and chain conformation of water-soluble glucan extracted from Auricularia auricula-judae. J Agric Food Chem 60(13):3498–3506
Xu X, Yang J, Ning Z, Zhang X (2015) Lentinula edodes-derived polysaccharide rejuvenates mice in terms of immune responses and gut microbiota. Food Funct 6(8):2653–2663
Yamanaka D, Tada R, Adachi Y, Ishibashi K, Motoi M, Iwakura Y, Ohno N (2012) Agaricus brasiliensis-derived β-glucans exert immunoenhancing effects via a dectin-1-dependent pathway. Int Immunopharmacol 14(3):311–319
Yan LL, Han JC (2008) Effect of Agarcus blazei murill polysaccharides on lactic acid bacteria. China Dairy Ind 36(12):7–10
Yang LJ, Wang RT, Liu JS, Tong H, Deng YQ, Li QH (2004) The effect of polyporus umbellatus polysaccharide on the immunosuppression property of culture supernatant of S180 cells. J Cell Mol Immunol 20(2):234–237
Yoneda K, Ueta E, Yamamoto T, Osaki T (1991) Immunoregulatory effects of Sizofiran (SPG) on lymphocytes and polymorphonuclear leukocytes. Clin Exp Immunol 86(2):229–235
Yu R, Yang W, Song L, Yan C, Zhang Z, Zhao Y (2007) Structural characterization and antioxidant activity of a polysaccharide from the fruiting bodies of cultured Cordyceps militaris. Carbohydr Polym 70(4):430–436
Zhang J, Tang Q, Zhou C, Jia W, Da Silva L, Nguyen LD, Reutter W, Fan H (2010) GLIS, a bioactive proteoglycan fraction from Ganoderma lucidum, displays anti-tumour activity by increasing both humoral and cellular immune response. Life Sci 87(19–22):628–637
Zhang L, Li CG, Liang H, Reddy N (2017) Bioactive mushroom polysaccharides: immunoceuticals to anticancer agents. J Nutraceuticals Food Sci 2(6(2)):1–6
Zheng R, Su J, Dai H, Wu M (2005) Characterization and immunomodulating activities of polysaccharide from Lentinus edodes. Int Immunopharmacol 5(5):811–820
Zhou BL, Liang Q, Zou Y, Ming J, Zhao GH (2011) Research progress in prebiotic properties of edible mushroom. Food Sci 32(15):303–307
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Wang, Y., Huang, X., Nie, S. (2018). Novel Prospective of Wild Mushroom Polysaccharides as Potential Prebiotics. In: Singh, B., Lallawmsanga, Passari, A. (eds) Biology of Macrofungi. Fungal Biology. Springer, Cham. https://doi.org/10.1007/978-3-030-02622-6_10
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