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Pericytes in Tissue Engineering

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Pericyte Biology - Novel Concepts

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1109))

Abstract

Pericytes have crucial roles in blood-brain barrier function, blood vessel function/stability, angiogenesis, endothelial cell proliferation/differentiation, wound healing, and hematopoietic stem cells maintenance. They can be isolated from fetal and adult tissues and have multipotential differentiation capacity as mesenchymal stem cells (MSCs). All of these properties make pericytes as preferred cells in the field of tissue engineering. Current developments have shown that tissue-engineered three-dimensional (3D) systems including multiple cell layers (or types) and a supporting biological matrix represent the in vivo environment better than those monolayers on plastic dishes. Tissue-engineered models are also more ethical and cheaper systems than animal models. This chapter describes the role of pericytes in tissue engineering for regenerative medicine.

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Conflict of Interest Statement

The author declares that she has no conflicts of interest concerning this work.

Ethical Approval

This article does not contain any studies with human participants or animals performed by the author.

Informed Consent

This article does not contain any studies with human participants or animals performed by the author.

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Authors and Affiliations

  1. Department of Stem Cell Sciences, Hacettepe University Graduate School of Health Sciences, Ankara, Turkey

    Betül Çelebi-Saltik

  2. Center for Stem Cell Research and Development, Hacettepe University, Ankara, Turkey

    Betül Çelebi-Saltik

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  1. Betül Çelebi-Saltik
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Correspondence to Betül Çelebi-Saltik .

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  1. Department of Radiology, Columbia University Medical Center, New York, NY, USA

    Alexander Birbrair

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Çelebi-Saltik, B. (2018). Pericytes in Tissue Engineering. In: Birbrair, A. (eds) Pericyte Biology - Novel Concepts. Advances in Experimental Medicine and Biology, vol 1109. Springer, Cham. https://doi.org/10.1007/978-3-030-02601-1_10

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