Skip to main content

Solid Dose Formulations

  • Chapter
  • First Online:
Solid Oral Dose Process Validation

Abstract

Among the solid dosage forms, tablets and capsules take by far the largest fraction of drug products taken by oral route. The chapter discusses tablet and capsule formulations and the traditional manufacturing processes. New technologies such as 3D printing are currently emerging as an alternate manufacturing process. Continuous solid dose manufacturing utilizes technology such as process analytical technology (PAT), process modeling to enhance pharmaceutical solid dose manufacturing processes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Lachman L, Lieberman HA, Kanig JL. The theory and practice of industrial pharmacy. Philadelphia: Lea & Febiger; 1970.

    Google Scholar 

  2. Hasegawa M. Direct compression microcrystalline cellulose grade 12 versus classic grade 102. Pharm Technol. 2002;26:50–61.

    Google Scholar 

  3. Block LH, Morreton A, Apte SP, Wendt RH, Munson EJ, Creekmore JR, Persaud IV, Sheehan C, Wang H. Excipients for direct compaction—an update. Pharm Dev Technol. 2009;11:111–24.

    Google Scholar 

  4. Shanmugham S. Granulation techniques and technologies: recent progresses. Bioimpacts. 2015;5(1):55–63.

    Article  Google Scholar 

  5. Acevedo D, Muliadi A, Giridhar A, Litster JD, Romañach RJ. Evaluation of three approaches for real-time monitoring of roller compaction with near-infrared spectroscopy. AAPS PharmSciTech. 2012;13(3):1005–12.

    Article  CAS  PubMed  Google Scholar 

  6. Patil H, Tiwari RV, Repka MA. Hot-melt extrusion: from theory to application in pharmaceutical formulation. AAPS PharmSciTech. 2016;17(1):20–42.

    Article  CAS  Google Scholar 

  7. Teunou RE, Poncelet D. Batch and continuous fluid bed coating—review and state of the art. J Food Eng. 2002;53(4):325–40.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2018 American Association of Pharmaceutical Scientists

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Pazhayattil, A.B., Sayeed-Desta, N., Fredro-Kumbaradzi, E., Collins, J. (2018). Solid Dose Formulations. In: Solid Oral Dose Process Validation. AAPS Introductions in the Pharmaceutical Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-02472-7_2

Download citation

Publish with us

Policies and ethics