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Role of Chaperone Mediated Autophagy in Viral Infections

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Chaperokine Activity of Heat Shock Proteins

Part of the book series: Heat Shock Proteins ((HESP,volume 16))

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Abstract

Chaperone-mediated autophagy (CMA) is a selective mechanism for degradation of soluble cytosolic proteins is responsible for the timed degradation of 30% of cytosolic proteins under conditions of prolonged nutrient deprivation and stress. Molecular chaperones in the lysosomal lumen and in the cytosol and induce this proteolytic pathway. A central molecule for CMA is a receptor in the lysosomal membrane is known as the lysosome-associated membrane protein (LAMP) type 2A. The decrease in CMA leads to cells to be more prone to oxidative stresses and pathogenes. Furthermore, the decreased CMA in aging is stem from reduced LAMP-2A in the lysosomal membrane. Here, we describe the evidence in support of the contribution of chaperokines and CMA in viral infections.

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Abbreviations

CHIP:

Hsc70-interacting protein

CMA:

Chaperone-mediated autophagy

HCV:

Hepatitis C virus

HSP:

Heat shock proteins

IFNLR1:

Interferon α receptor 1

LAMP-2A:

Lysosome-Associated Membrane Protein type 2A

PERK:

PKR-like ER kinase

UPR:

Unfolded protein response

VSV:

Vesicular stomatitis virus

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Acknowledgments

We would like to thank all members of virology department of Tarbiat Modares University and Hepatitis and AIDS department of Pasteur Institute for kind assistant and support.

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Authors and Affiliations

  1. Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

    Hoorieh Soleimanjahi

  2. Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran

    Asghar Abdoli

Authors
  1. Hoorieh Soleimanjahi
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  2. Asghar Abdoli
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Corresponding author

Correspondence to Hoorieh Soleimanjahi .

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Editors and Affiliations

  1. Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Soleimanjahi, H., Abdoli, A. (2019). Role of Chaperone Mediated Autophagy in Viral Infections. In: Asea, A., Kaur, P. (eds) Chaperokine Activity of Heat Shock Proteins . Heat Shock Proteins, vol 16. Springer, Cham. https://doi.org/10.1007/978-3-030-02254-9_7

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