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Role of Heat Shock Protein 90 in Autoimmune Inflammatory Rheumatic Diseases

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Chaperokine Activity of Heat Shock Proteins

Part of the book series: Heat Shock Proteins ((HESP,volume 16))

Abstract

Hsp90 is the most studied member of the heat shock proteins family (HSP), which are characterized by induction by increased temperature and various other types of stress. It is a highly conserved molecular chaperone that plays a significant role in many cellular processes. Hsp90 is required for the proper conformation and activation of a number of client cellular proteins, including protein kinases, transcription factors and steroid receptors that play an important role in signal transduction. It also regulates activation of innate immunity, antigen presentation, and the induction of proinflammatory cytokines and chemokines by macrophages and dendritic cells. These properties predispose Hsp90 to a potential role in the pathogenesis of autoimmune inflammatory rheumatic diseases. This article provides an overview of the available knowledge about the potential role of Hsp90 in currently studied rheumatic diseases as a promising candidate for targeted therapy or biomarker of disease activity and severity or a predictor of therapeutic response.

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Abbreviations

17-DMAG:

17-dimethylaminoethylamino-17-demethoxygeldanamycin

AAV:

Adeno-associated virus

APC:

Antigen presenting cells

AS:

Ankylosing spondylitis

ATP:

Adenosine triphosphate

CD:

Cluster of differentiation

Cdc37:

Cell division cycle 37

CK2:

Casein kinase 2

CRP:

C-reactive protein

DAMP:

Danger activated molecular pattern

DAS-28:

Disease activity score-28

DC:

Dendritic cell

DM:

Dermatomyositis

ERK:

Extracellular signal-regulated kinase

GM-CSF:

Granulocyte-macrophage colony-stimulating factor

HLA-B27:

Human leukocyte antigen B27

HSP:

Heat shock protein family

Hsp:

Heat shock proteins

IBM:

Inclusion body myositis

ICAM-1:

Intracellular adhesion molecule-1

Ig:

Immunoglobulin

IIM:

Idiopathic inflammatory myopathies

IKK:

I-κB kinase

IL:

Interleukin

ILD:

Interstitial lung disease

IMNM:

Immune-mediated necrotizing myopathy

iNOS:

Inducible nitric oxide synthase

kDa:

KiloDalton

LOX-1:

Lectin-like oxidized low-density lipoprotein receptor-1

MAPK:

Mitogen-activated protein kinase

MCP-1:

Monocyte chemoattractant protein-1

MHC:

Major histocompatibility complex

MIP-1:

Macrophage inflammatory protein-1

MyoD:

Myogenic regulatory protein

NF-κB:

Nucelar factor κB

NK:

Natural killer cells

nr-axSpA:

Non-radiographic axial spondyloarthritis

OA:

Osteoarthritis

p23:

Prostaglandin E synthase 3

PBMC:

Peripheral blood mononuclear cells

PM:

Polymyositis

PRR:

Pattern recognition receptors

PsA:

Psoriatic arthritis

RA:

Rheumatoid arthritis

RANTES:

Regulated on activation, normal T cell expressed and secreted

SLE:

Systemic lupus erythematosus

SpA:

Spondyloarthritis

SS:

Sjögren’s syndrome

SSc:

Systemic sclerosis

TGF:

Transforming growth factor

TLR:

Toll-like receptor

TNF:

Tumor necrosis factor

TRAP1:

TNF receptor-associated protein 1

TβRI:

TGF-β type I receptor

VCAM-1:

Vascular cell adhesion molecule

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Acknowledgements

This chapter was supported by grant projects AZV 16-33542A, AZV 16-33574A, SVV 260263, PRVOUK, UNCE 204022, and the Ministry of Health of the Czech Republic [Research Project No. 00023728].

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Authors and Affiliations

  1. Institute of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

    Hana Storkanova

  2. Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

    Hana Storkanova

  3. Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

    Michal Tomcik

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  1. Hana Storkanova
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Correspondence to Michal Tomcik .

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Editors and Affiliations

  1. Department of Medicine and Director, Precision Therapeutics Proteogenomics Diagnostic Center, Eleanor N. Dana Cancer Center, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA

    Alexzander A. A. Asea

  2. Department of Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

    Punit Kaur

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Storkanova, H., Tomcik, M. (2019). Role of Heat Shock Protein 90 in Autoimmune Inflammatory Rheumatic Diseases. In: Asea, A., Kaur, P. (eds) Chaperokine Activity of Heat Shock Proteins . Heat Shock Proteins, vol 16. Springer, Cham. https://doi.org/10.1007/978-3-030-02254-9_5

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