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Fat Transplantation

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Abstract

The changes that happen as an intrinsic part of aging occur deeper in the subcutaneous tissues and are atrophic in nature (Donofrio, Dermatol Surg 26:1129–1134, 2000). This volume loss can be corrected through several means, including tissue repositioning, implants, synthetic fillers, or autologous tissue (Modarressi, World J Plast Surg 2(1):6–13, 2013). More recently, autologous fat grafting has come to be considered an ideal filler, as fat grafts are biocompatible, nonallergenic, nontoxic, easy to obtain, and synergistic with natural skin (Sinno et al. Plast Reconstr Surg 137:818–824, 2016). Neuber first reported the technique in 1893, followed by Illouz who then pioneered liposuction in the 1980s. In the modern day, Coleman demonstrated techniques for long-term fat graft stability (Sinno et al. Plast Reconstr Surg 137:818–824, 2016). Its first indications were for aesthetic surgery of the face, and more recently in hands (Modarressi, World J Plast Surg 2(1):6–13, 2013). Fat grafting is also useful for tissue loss due to an accident, operation, congenital disease, or lipodystrophy. In addition to a volumizing effect, the injected fat leads to neoangiogenesis, thereby improving the cutaneous elasticity. This technique is also used for wound healing, scar reduction, treatment of radiodermatitis, correction of acne scars, and breast reconstruction and augmentation in plastic surgery (Modarressi, World J Plast Surg 2(1):6–13, 2013).

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References

  1. Donofrio LM. Structural autologous lipoaugmentation: a pan-facial technique. Dermatol Surg. 2000;26:1129–34.

    Article  CAS  Google Scholar 

  2. Modarressi A. Platlet rich plasma (PRP) improves fat grafting outcomes. World J Plast Surg. 2013;2(1):6–13.

    PubMed  PubMed Central  Google Scholar 

  3. Sinno S, Wilson S, Brownstone N, Levine SM. Current thoughts on fat grafting: using the evidence to determine fact or fiction. Plast Reconstr Surg. 2016;137:818–24.

    Article  CAS  Google Scholar 

  4. Kim WS, Park BS, Sung JH. Protective role of adipose-derived stem cells and their soluble factors in photoaging. Arch Der- matol Res. 2009;301:329–36.

    Google Scholar 

  5. Meier JD, Glasgold RA, Glasgold MJ. Autologous fat grafting: long-term evidence of its efficacy in midfacial rejuvenation. Arch Facial Plast Surg. 2009;11:24–8.

    Article  Google Scholar 

  6. Lilleth H, Boberg J. The lipoprotein-lipase activity of adipose tissue from different sites in obese women and relationship to cell size. Int J Obes. 1978;2:47–52.

    Google Scholar 

  7. Rohrich RJ, Sorokin ES, Brown SA. In search of improved fat transfer viability: a quantitative analysis of the role of centrif- ugation and harvest site. Plast Reconstr Surg. 2004;113:391–5. discussion 396

    Article  Google Scholar 

  8. Small K, Choi M, Petruolo O, Lee C, Karp N. Is there an ideal donor site of fat for secondary breast reconstruction? Aesthet Surg J. 2014;34:545–50.

    Article  Google Scholar 

  9. Klein JA. The tumescent technique. Anesthesia and modified liposuction technique. Dermatol Clin. 1990;8:425–37.

    Article  CAS  Google Scholar 

  10. Moore JH, Kolaczynski JW, Morales LM, et al. Viability of fat obtained by syringe suction lipectomy: effects of local anesthesia with lidocaine. Aesthet Plast Surg. 1995;19:335–9.

    Article  Google Scholar 

  11. Moore JH Jr, Kolaczynski JW, Morales LM, et al. Viability of fat obtained by syringe suction lipectomy: effects of local anes- thesia with lidocaine. Aesthet Plast Surg. 1995;19:335–9.

    Article  Google Scholar 

  12. Kim IH, Yang JD, Lee DG, Chung HY, Cho BC. Evaluation of centrifugation technique and effect of epinephrine on fat cell viability in autologous fat injection. Aesthet Surg J. 2009;29:35–9.

    Article  Google Scholar 

  13. Smith P, Adams WP Jr, Lipschitz AH, et al. Autologous human fat grafting: effect of harvesting and preparation techniques on adipocyte graft survival. Plast Reconstr Surg. 2006;117:1836–44.

    Article  CAS  Google Scholar 

  14. Kurita M, Matsumoto D, Shigeura T, Sato K, Harii K, Yoshimura K. Influences of centrifugation on cells and tissues in lipo- suction aspirates: optimized centrifugation for lipotransfer and cell isolation. Plast Reconstr Surg. 2008;121:1033–41.

    Article  CAS  Google Scholar 

  15. Condé-Greena A, Ferreira N, de Amorima G, Pitanguya I. Influence of decantation, washing and centrifugation on adipocyte and mesenchymal stem cell content of aspirated adipose tissue: a comparative study. J Plast Reconstr Aesthet Surg. 2010;63:1375–81.

    Article  Google Scholar 

  16. Coleman WP. Autologous fat transplantation. Plast Reconstr Surg. 1991;88:736.

    Article  Google Scholar 

  17. Matsumoto D, Shigeura T, Sato K, et al. Influences of preser- vation at various temperatures on liposuction aspirates. Plast Reconstr Surg. 2007;120:1510–7.

    Article  CAS  Google Scholar 

  18. Chung MT, Paik KJ, Atashroo DA, et al. Studies in fat graft- ing: part I effects of injection technique on in vitro fat viability and in vivo volume retention. Plast Reconstr Surg. 2014;134:29–38.

    Article  CAS  Google Scholar 

  19. Fournier PF. Liposculpture: the syringe technique. Paris: Arnette Blackwell; 1991.

    Google Scholar 

  20. Erdim M, Tezel E, Numanoglu A, Sav A. The effects of the size of liposuction cannula on adipocyte survival and the optimum temperature for fat graft storage: an experimental study. J Plast Reconstr Aesthet Surg. 2009;62:1210–4.

    Article  Google Scholar 

  21. Piasecki JH, Gutowski KA, Moreno KM, Lahvis GL. Purified viable fat suspended in matrigel improves volume longevity. Aesthet Surg J. 2008;28:24–32.

    Article  CAS  Google Scholar 

  22. Kleinman HK, Martin GR. Matrigel: basement mem- brane matrix with biological activity. Semin Cancer Biol. 2005;15:378–86.

    Article  CAS  Google Scholar 

  23. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgefff KR. Platelet-rich plasma: Growth factor en- hancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85:638–46.

    Article  CAS  Google Scholar 

  24. Garg AK. The use of platelet-rich plasma to enhance the success of bone grafts around dental implants. Dent Implantol Updat. 2000;11:17–21.

    CAS  Google Scholar 

  25. Mooren RECM, Merkx MAW, Bronk- horst EM, Jansen JA, Stoelinga PJW. The effect of platelet-rich plasma on early and late bone healing using a mixture of par- ticulate autogenous cancellous bone and bio-Oss: an experimental study in goats. Int J Oral Maxillofac Surg. 2010;39:371–8.

    Article  CAS  Google Scholar 

  26. Villela DL, Vera Lucia C, Santos G. Evi- dence on the use of platelet-rich plasma for diabetic ulcer: a systematic review. Growth Factors. 2010;28:111–6.

    Article  CAS  Google Scholar 

  27. Pallua N, Wolter T, Markowicz M. Platelet- rich plasma in burns. Burns. 2010;36:4–8.

    Article  Google Scholar 

  28. Lacci KM, Dardik A. Platelet-rich plasma: support for its use in wound healing. Yale J Biol Med. 2010;83:1–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Lubowitz JH, Poehling GG. Shoulder, hip, knee, and PRP. Arthroscopy. 2010;26:141–2.

    Article  Google Scholar 

  30. Peerbooms JC, Sluimer J, Bruijn DJ. Go- Sens T. positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticos- teroid injection with a 1-year follow-up. Am J Sports Med. 2010;38:255–62.

    Article  Google Scholar 

  31. Creaney L. Platelet-rich plasma for treat- ment of Achilles tendinopathy. JAMA. 2010;303:1696–8.

    Article  CAS  Google Scholar 

  32. Tayfun TS, Altintas YN, Yildiz O, Kursat D, Ender S, Yusuf C. The effect of sub- conjunctival platelet-rich plasma on cor- neal epithelial wound healing. Cornea. 2010;29:664–9.

    Article  Google Scholar 

  33. Kau E, Kagami H, Kato R, Yamada Y, Ueda M. Regenerative medicine for anti-aging. Nippon Rinsho. 2009;67:1402–6.

    Google Scholar 

  34. Cervelli V, Gentile P, Scioli MG, Gri- maldy M, Casciani CU, Spagnoli LG, Or- landi A. Application of platelet-rich plasma in plastic surgery: clinical and in vitro evaluation. Tissue Eng Part C Methods. 2009;15:625–34.

    Article  CAS  Google Scholar 

  35. Adler SC, Kent KJ. Enhancing wound healing with growth factors. Facial Plast Surg Clin North Am. 2002;10:129–46.

    Article  Google Scholar 

  36. Man D, Plosker H, Winland-Brown JE. The use of autologous platelet-rich plasma (platelet gel) and autologous platelet-poor plasma (fibrin glue) in cosmetic surgery. Plast Reconstr Surg. 2001;107:229–37.

    Article  CAS  Google Scholar 

  37. Natsuko K, Tatsuya M, Toshihito M, Sato- shi K, Zefanya NF, Kenji K. Proliferation- promoting effect of platelet-rich plasma on human adipose-derived stem cells and hu- man dermal fibroblasts. Plast Reconstr Surg. 2008;122:1352–60.

    Article  Google Scholar 

  38. Shinichiro N, Masayuki I, Megumi T, Kaoru M, Satoko K, Shingo N, Satoshi Y, Sa- toshi K, Naoto Y, Tomoharu K. Platelet- rich plasma (PRP) promotes survival of fat-grafts in rats. Ann Plast Surg. 2010;65:101–6.

    Article  Google Scholar 

  39. Cervelli V, Gentile P. Use of cell fat mixed with platelet gel in progressive hemifacial atrophy. Aesthet Plast Surg. 2009;33:22–7.

    Article  CAS  Google Scholar 

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Ellis, D.L., Donofrio, L.M. (2019). Fat Transplantation. In: Alam, M. (eds) Evidence-Based Procedural Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-030-02023-1_37

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  • DOI: https://doi.org/10.1007/978-3-030-02023-1_37

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-02022-4

  • Online ISBN: 978-3-030-02023-1

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