Abstract
This chapter will summarize the evidence supporting the clinical use of FDG-PET brain imaging in the evaluation of patients with pharmaco-resistant epilepsy considered for surgical treatment. We will discuss the clinical indications, the main patterns of hypometabolism observed, and the main advantages and limitations associated with its use.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Scheffer IE, Berkovic S, et al. ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58(4):512–21.
Gschwind M, Seeck M. Modern management of seizures and epilepsy. Swiss Med Wkly. 2016;146:w14310.
Kwan P, Arzimanoglou A, et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia. 2010;51(6):1069–77.
de Tisi J, Bell GS, et al. The long-term outcome of adult epilepsy surgery, patterns of seizure remission, and relapse: a cohort study. Lancet. 2011;378(9800):1388–95.
Duncan JS. Imaging in the surgical treatment of epilepsy. Nat Rev Neurol. 2010;6(10):537–50.
Mouthaan BE, Rados M, et al. Current use of imaging and electromagnetic source localization procedures in epilepsy surgery centers across Europe. Epilepsia. 2016;57(5):770–6.
ILAE. ILAE Neuroimaging Commission recommendations for neuroimaging of patients with epilepsy. Epilepsia. 2005;38(s10):1–2.
Lascano AM, Perneger T, et al. Yield of MRI, high-density electric source imaging (HD-ESI), SPECT and PET in epilepsy surgery candidates. Clin Neurophysiol. 2016;127(1):150–5.
Von Oertzen J, Urbach H, et al. Standard magnetic resonance imaging is inadequate for patients with refractory focal epilepsy. J Neurol Neurosurg Psychiatry. 2002;73(6):643–7.
Kumar A, Chugani HT. The role of radionuclide imaging in epilepsy, Part 1: Sporadic temporal and extratemporal lobe epilepsy. J Nucl Med. 2013a;54(10):1775–81.
Kumar A, Chugani HT. The role of radionuclide imaging in epilepsy, Part 2: Epilepsy syndromes. J Nucl Med. 2013b;54(11):1924–30.
Chassoux F, Rodrigo S, et al. FDG-PET improves surgical outcome in negative MRI Taylor-type focal cortical dysplasias. Neurology. 2010;75(24):2168–75.
Carne RP, O’Brien TJ, et al. MRI-negative PET-positive temporal lobe epilepsy: a distinct surgically remediable syndrome. Brain. 2004;127.(Pt 10:2276–85.
Li LM, Cendes F, et al. Surgical outcome in patients with epilepsy and dual pathology. Brain. 1999;122. (Pt 5:799–805.
la Fougere C, Rominger A, et al. PET and SPECT in epilepsy: a critical review. Epilepsy Behav. 2009;15(1):50–5.
Wieser HG. The role of PET in the diagnosis of epilepsies. Epileptologie. 2004;21:109–16.
Guedj E, Bonini F, et al. 18FDG-PET in different subtypes of temporal lobe epilepsy: SEEG validation and predictive value. Epilepsia. 2015;56(3):414–21.
Juhasz C, Nagy F, et al. Glucose and [11C]flumazenil positron emission tomography abnormalities of thalamic nuclei in temporal lobe epilepsy. Neurology. 1999;53(9):2037–45.
Semah F. PET imaging in epilepsy: basal ganglia and thalamic involvement. Epileptic Disord. 2002;4(Suppl 3):S55–60.
Chang CP, Yen DJ, et al. Unilateral thalamic hypometabolism in patients with temporal lobe epilepsy. J Formos Med Assoc. 2008;107(7):567–71.
Kim YK, Lee DS, et al. (18)F-FDG PET in localization of frontal lobe epilepsy: comparison of visual and SPM analysis. J Nucl Med. 2002;43(9):1167–74.
Wang K, Liu T, et al. Comparative study of voxel-based epileptic foci localization accuracy between statistical parametric mapping and three-dimensional stereotactic surface projection. Front Neurol. 2016;7:164.
Mendes Coelho VC, Morita ME, et al. Automated online quantification method for (18)F-FDG positron emission tomography/CT improves detection of the epileptogenic zone in patients with pharmacoresistant epilepsy. Front Neurol. 2017;8:453.
Savic I, Altshuler L, et al. Localized cerebellar hypometabolism in patients with complex partial seizures. Epilepsia. 1996;37(8):781–7.
Conrad GR, Sinha P. FDG PET imaging of subependymal gray matter heterotopia. Clin Nucl Med. 2005;30(1):35–6.
Morioka T, Nishio S, et al. Functional imaging in periventricular nodular heterotopia with the use of FDG-PET and HMPAO-SPECT. Neurosurg Rev. 1999;22(1):41–4.
Chugani HT, Conti JR. Etiologic classification of infantile spasms in 140 cases: role of positron emission tomography. J Child Neurol. 1996;11(1):44–8.
Chandra PS, Salamon N, et al. FDG-PET/MRI coregistration and diffusion-tensor imaging distinguish epileptogenic tubers and cortex in patients with tuberous sclerosis complex: a preliminary report. Epilepsia. 2006;47(9):1543–9.
Chugani HT, Mazziotta JC, et al. The Lennox-Gastaut syndrome: metabolic subtypes determined by 2-deoxy-2[18F]fluoro-D-glucose positron emission tomography. Ann Neurol. 1987;21(1):4–13.
You SJ, Lee JK, et al. Epilepsy surgery in a patient with Lennox-Gastaut syndrome and cortical dysplasia. Brain and Development. 2007;29(3):167–70.
Sarikaya I. PET studies in epilepsy. Am J Nucl Med Mol Imaging. 2015;5(5):416–30.
Chassoux F, Artiges E, et al. (18)F-FDG-PET patterns of surgical success and failure in mesial temporal lobe epilepsy. Neurology. 2017;88(11):1045–53.
Wong CH, Bleasel A, et al. The topography and significance of extratemporal hypometabolism in refractory mesial temporal lobe epilepsy examined by FDG-PET. Epilepsia. 2010;51(8):1365–73.
Wong CH, Bleasel A, et al. Relationship between preoperative hypometabolism and surgical outcome in neocortical epilepsy surgery. Epilepsia. 2012;53(8):1333–40.
Hinde S, Soares M, et al. The added clinical and economic value of diagnostic testing for epilepsy surgery. Epilepsy Res. 2014;108(4):775–81.
Desarnaud S, Mellerio C, et al. (18)F-FDG PET in drug-resistant epilepsy due to focal cortical dysplasia type 2: additional value of electroclinical data and coregistration with MRI. Eur J Nucl Med Mol Imaging. 2018;45(8):1449–60.
Salamon N, Kung J, et al. FDG-PET/MRI coregistration improves detection of cortical dysplasia in patients with epilepsy. Neurology. 2008;71(20):1594–601.
Hodolic M, Topakian R, et al. (18)F-fluorodeoxyglucose and (18)F-flumazenil positron emission tomography in patients with refractory epilepsy. Radiol Oncol. 2016;50(3):247–53.
Meltzer CC, Adelson PD, et al. Planned ictal FDG PET imaging for localization of extratemporal epileptic foci. Epilepsia. 2000;41(2):193–200.
Garibotto V, Heinzer S, et al. Clinical applications of hybrid PET/MRI in neuroimaging. Clin Nucl Med. 2013;38(1):e13–8.
Grouiller F, Delattre BM, et al. All-in-one interictal presurgical imaging in patients with epilepsy: single-session EEG/PET/(f)MRI. Eur J Nucl Med Mol Imaging. 2015;42(7):1133–43.
Paldino MJ, Yang E, et al. Comparison of the diagnostic accuracy of PET/MRI to PET/CT-acquired FDG brain exams for seizure focus detection: a prospective study. Pediatr Radiol. 2017;47(11):1500–7.
Shin HW, Jewells V, et al. Initial experience in hybrid PET-MRI for evaluation of refractory focal onset epilepsy. Seizure. 2015;31:1–4.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Mainta, I.C., Picard, F., Garibotto, V. (2019). 18F-FDG PET in Epilepsy. In: Fraioli, F. (eds) PET/CT in Brain Disorders. Clinicians’ Guides to Radionuclide Hybrid Imaging(). Springer, Cham. https://doi.org/10.1007/978-3-030-01523-7_7
Download citation
DOI: https://doi.org/10.1007/978-3-030-01523-7_7
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-01522-0
Online ISBN: 978-3-030-01523-7
eBook Packages: MedicineMedicine (R0)