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The Modern Hospital pp 357–366Cite as

Wound Healing: Proof-of-Principle Model for the Modern Hospital: Patient Stratification, Prediction, Prevention and Personalisation of Treatment

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Abstract

For many acute and chronic pathologies, poor individual outcomes and overall statistics reflect the current unsatisfactory state of healthcare. Severe chronic pathologies such as cardiovascular disorders, diabetes, and cancer are treated after onset of the disease, frequently at near end stages. Replacing the current paradigm of reactive medical treatment with an innovative approach incorporating predictive, preventive and personalised medicine (PPPM) is crucial for modern healthcare. Cost-effective disease management and the central role of PPPM have been acknowledged as a priority by global and regional health-related organisations such as the United Nations, the European Union and the National Institutes of Health.

The prevalence and economic burden of the wound healing (WH) are not minor issues: in the USA alone, over $25 billion US are spent annually treating chronic wounds in 6.5 million patients. Problematic WH and chronic wounds may result from a broad spectrum of suboptimal health conditions and severe pathologies. Deficient WH reflects pathological processes and predicts severe diseases before their clinical manifestation. Both modifiable and non-modifiable risk factors make WH highly individual. Individualised patient profiling utilises systems medicine, predictive diagnostics, prevention and treatment tailored to the individual person, i.e. the innovative approaches of PPPM. Multilevel diagnostics employ comprehensive biomarker panels. Potential applications are multi-faceted: early diagnostics of related pathologies and disease predisposition, effective prevention and treatment of collateral pathologies, prediction and prognosis of postsurgical complications, improved individual outcomes in plastic surgery, etc.

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References

  1. Duarte AA, Mohsin S, Golubnitschaja O. Diabetes care in figures: current pitfalls and future scenario. EPMA J. 2018;9(2). 10.1007/s13167-018-0133-y.

    Google Scholar 

  2. Golubnitschaja O, Debald M, Yeghiazaryan K, Kuhn W, Pešta M, Costigliola V, Grech G. Breast cancer epidemic in the early 21st century: evaluation of risk factors, cumulative questionnaires and recommendations for preventive measures. Tumor Biol. 2016;37(10):12941–57. https://doi.org/10.1007/s13277-016-5168-x.

    Article  Google Scholar 

  3. Golubnitschaja O. Three levels of prediction, prevention and individualised treatment algorithms to advance diabetes care: integrative approach. In: Mozaffari M, editor. The book “new strategies to advance pre/diabetes care: integrative approach by PPPM”. Dordrecht/Heidelberg/New York/London: Springer; 2013. p. 15–28. ISBN 978-94-007-5970-1.

    Chapter  Google Scholar 

  4. Polivka J Jr, Altun I, Golubnitschaja O. Pregnancy associated breast cancer: the risky status quo and new concepts of predictive medicine. EPMA J. 2018;9(1):1–13. https://doi.org/10.1007/s13167-018-0129-7.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Vaz-Luis I, Lin NU, Keating NL, Barry WT, Winer EP, Freedman RA. Factors associated with early mortality among patients with de novo metastatic breast cancer: a population-based study. Oncologist. 2017;22:386. https://doi.org/10.1634/theoncologist.2016-0369.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Polivka J, Kralickova M, Polivka J, Kaiser C, Kuhn W, Golubnitschaja O. Mystery of the brain metastatic disease in breast cancer patients: improved patient stratification, disease prediction and targeted prevention on the horizon? EPMA J. 2017;8(2):119–27. https://doi.org/10.1007/s13167-017-0087-5.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Golubnitschaja O. Foreword, book series “advances in predictive, preventive and personalised medicine”. Dordrecht/Heidelberg/New York/London: Springer. http://www.springer.com/series/10051.

  8. Sen CK, Gordillo GM, Roy S, Kirsner R, Lambert L, Hunt TK, et al. Human skin wounds: a major and snowballing threat to public health and economy. Wound Repair Regen. 2009;17(6):763–71.

    Article  Google Scholar 

  9. Kunin A, Polivka J Jr, Moiseeva N, Golubnitschaja O. “Dry Mouth” and “Flammer” Syndromes - Neglected Risks in Adolescents and New Concepts by Predictive, Preventive and Personalised Approach. EPMA J. 2018;9(3):307–317. https://doi:10.1007/s13167-018-0145-7.

    Google Scholar 

  10. Avishai E, Yeghiazaryan K, Golubnitschaja O. Impaired wound healing: facts and hypotheses for multi-professional considerations in predictive, preventive and personalised medicine. EPMA J. 2017;8(1):23–33. https://doi.org/10.1007/s13167-017-0081-y.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Golubnitschaja O, Costigliola V, Grech G. EPMA World Congress: traditional forum in predictive, preventive and personalised medicine for multi-professional consideration and consolidation. EPMA J. 2017;8(Suppl):1–54. https://doi.org/10.1007/s13167-017-0108-4.

    Article  Google Scholar 

  12. Bayat A, McGrouther DA, Ferguson MW. Skin scarring. BMJ. 2003;326(7380):88–92.

    Article  CAS  Google Scholar 

  13. Bentov I, Reed MJ. Anesthesia, microcirculation, and wound repair in aging. Anesthesiology. 2014;120(3):760–72. https://doi.org/10.1097/ALN.0000000000000036.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Bhargava M, Viken KJ, Dey S, Steinbach MS, Wu B, Jagtap PD, Higgins L, Panoskaltsis-Mortari A, Weisdorf DJ, Kumar V, Arora M, Bitterman PB, Ingbar DH, Wendt CH. Proteome profiling in lung injury after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2016;22(8):1383–90. https://doi.org/10.1016/j.bbmt.2016.04.021.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Al-Shaqsi S, Al-Bulushi T. Cutaneous scar prevention and management: overview of current therapies. Sultan Qaboos Univ Med J. 2016;16(1):e3–8. https://doi.org/10.18295/squmj.2016.16.01.002.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Bhattacharya S, Aggarwal R, Singh VP, Ramachandran S, Datta M. Downregulation of miRNAs during delayed wound healing in diabetes: role of dicer. Mol Med. 2015;21(1):847–60. https://doi.org/10.2119/molmed.2014.00186.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Brady NJ, Chuntova P, Schwertfeger KL. Macrophages: regulators of the inflammatory microenvironment during mammary gland development and breast cancer. Mediat Inflamm. 2016;2016:4549676. https://doi.org/10.1155/2016/4549676.

    Article  CAS  Google Scholar 

  18. Zubor P, Gondova A, Polivka J Jr, Kasajova P, Konieczka K, Danko J, Golubnitschaja O. Breast cancer and Flammer syndrome: any symptoms in common for prediction, prevention and personalised medical approach? EPMA J. 2017;8(2):129–40. https://doi.org/10.1007/s13167-017-0089-3.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Bubnov R, Polivka J Jr, Zubor P, Koniczka K, Golubnitschaja O. Pre-metastatic niches in breast cancer: are they created by or prior to the tumour onset? Flammer Syndrome relevance to address the question. EPMA J. 2017;8(2):141–57. https://doi.org/10.1007/s13167-017-0092-8.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Kunin A, Polivka J Jr, Moiseeva N, Golubnitschaja O. “Dry Mouth” and “Flammer” Syndromes - Neglected Risks in Adolescents and New Concepts by Predictive, Preventive and Personalised Approach. EPMA J. 2018;9(3):307–317. https://doi:10.1007/s13167-018-0145-7].

    Google Scholar 

  21. Golubnitschaja O, Jaksche A, Moenkemann H, Yeghiazaryan K, Karl SE, Schild HH, Löffler KU. Molecular imaging system for possible prediction of active retinopathy in patients with Diabetes mellitus. Amino Acids. 2005;28:229–37.

    Article  CAS  Google Scholar 

  22. Yeghiazaryan K, Flammer J, Orgül S, Wunderlich K, Golubnitschaja O. Vasospastic individuals demonstrate significant similarity to glaucoma patients as revealed by gene expression profiling in circulating leukocytes. Mol Vis. 2009;15:2339–48.

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Stolzenburg-Veeser L and Golubnitschaja O. Mini-encyclopaedia of the wound healing - Opportunities for integrating multi-omic approaches into medical practice. Journal of Proteomics. 2018;188:71-84. https://doi:10.1016/j.jprot.2017.07.017.

    Google Scholar 

  24. Eming SA, Martin P, Tomic-Canic M. Wound repair and regeneration: mechanisms, signaling, and translation. Sci Transl Med. 2014;6(265):265sr6. https://doi.org/10.1126/scitranslmed.3009337.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Luan A, Hu MS, Leavitt T, Brett EA, Wang KC, Longaker MT, Wan DC. Noncoding RNAs in wound healing: a new and vast frontier. Adv Wound Care (New Rochelle). 2018;7(1):19–27. https://doi.org/10.1089/wound.2017.0765.

    Article  Google Scholar 

  26. Lindley LE, Stojadinovic O, Pastar I, Tomic-Canic M. Biology and biomarkers for wound healing. Plast Reconstr Surg. 2016;138(3 Suppl):18S–28S. https://doi.org/10.1097/PRS.0000000000002682.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Csősz É, Deák E, Kalló G, Csutak A, Tőzsér J. Diabetic retinopathy: proteomic approaches to help the differential diagnosis and to understand the underlying molecular mechanisms. J Proteome. 2017;150:351–8. https://doi.org/10.1016/j.jprot.2016.06.034.

    Article  CAS  Google Scholar 

  28. Darby IA, Laverdet B, Bonté F, Desmoulière A. Fibroblasts and myofibroblasts in wound healing. Clin Cosmet Investig Dermatol. 2014;7:301–11. https://doi.org/10.2147/CCID.S50046.

    Article  PubMed  PubMed Central  Google Scholar 

  29. MacLeod AS, Mansbridge JN. The innate immune system in acute and chronic wounds. Adv Wound Care. 2016;5(2):65–78. https://doi.org/10.1089/wound.2014.0608.

    Article  Google Scholar 

  30. Martin P, Nunan R. Cellular and molecular mechanisms of repair in acute and chronic wound healing. Br J Dermatol. 2015;173(2):370–8. https://doi.org/10.1111/bjd.13954.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Leonardi GC, Accardi G, Monastero R, Nicoletti F, Libra M. Ageing: from inflammation to cancer. Immun Ageing. 2018;15(1):1. https://doi.org/10.1186/s12979-017-0112-5.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Mikesh LM, Aramadhaka LR, Moskaluk C, Zigrino P, Mauch C, Fox JW. Proteomic anatomy of human skin. J Proteome. 2013;84:190–200. https://doi.org/10.1016/j.jprot.2013.03.019.

    Article  CAS  Google Scholar 

  33. Golubnitschaja O, Yeghiazaryan K, Stricker H, Trog D, Schild HH, Berliner L. Patients with hepatic breast cancer metastases demonstrate highly specific profiles of matrix metalloproteinases MMP-2 and MMP-9 after SIRT treatment as compared to other primary and secondary liver tumours. BMC Cancer. 2016;16:357. https://doi.org/10.1186/s12885-016-2382-2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Molnar JA, Underdown MJ, Clark WA. Nutrition and chronic wounds. Adv Wound Care. 2014;3(11):663–81. https://doi.org/10.1089/wound.2014.0530.

    Article  Google Scholar 

  35. Nauta TD, van Hinsbergh VW, Koolwijk P. Hypoxic signaling during tissue repair and regenerative medicine. Int J Mol Sci. 2014;15(11):19791–815. https://doi.org/10.3390/ijms151119791.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Cazander G, Jukema GN, Nibbering PH. Complement activation and inhibition in wound healing. Clin Dev Immunol. 2012;2012:534291. https://doi.org/10.1155/2012/534291.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. George AL, Bangalore-Prakash P, Rajoria S, et al. Endothelial progenitor cell biology in disease and tissue regeneration. J Hematol Oncol. 2011;4:24. https://doi.org/10.1186/1756-8722-4-24.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Falanga V. Wound healing and its impairment in the diabetic foot. Lancet. 2005;366(9498):1736–43.

    Article  Google Scholar 

  39. Ren Y, Gu G, Yao M, Driver VR. Role of matrix metalloproteinases in chronic wound healing: diagnostic and therapeutic implications. Chin Med J. 2014;127(8):1572–81.

    CAS  PubMed  Google Scholar 

  40. Franco C, Hess S. Recent proteomic advances in developmental, regeneration, and cancer governing signaling pathways. Proteomics. 2015;15(5–6):1014–25. https://doi.org/10.1002/pmic.201400368.

    Article  CAS  PubMed  Google Scholar 

  41. Cebioglu M, Schild HH, Golubnitschaja O. Cancer predisposition in diabetics: risk factors considered for predictive diagnostics and targeted preventive measures. EPMA J. 2010;1(1):130–7. https://doi.org/10.1007/s13167-010-0015-4.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Rieger S, Zhao H, Martin P, Abe K, Lisse TS. The role of nuclear hormone receptors in cutaneous wound repair. Cell Biochem Funct. 2015;33(1):1–13. https://doi.org/10.1002/cbf.3086.

    Article  CAS  PubMed  Google Scholar 

  43. Jiang M, Qiu J, Zhang L, et al. Changes in tension regulates proliferation and migration of fibroblasts by remodeling expression of ECM proteins. Exp Ther Med. 2016;12(3):1542–50. https://doi.org/10.3892/etm.2016.3497.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Kunin A, Polivka J Jr, Moiseeva N, Golubnitschaja O. “Dry Mouth” and “Flammer” Syndromes - Neglected Risks in Adolescents and New Concepts by Predictive, Preventive and Personalised Approach. EPMA J. 2018;9(3):307–317. https://doi:10.1007/s13167-018-0145-7].

    Google Scholar 

  45. Ahn C, Mulligan P, Salcido RS. Smoking-the bane of wound healing: biomedical interventions and social influences. Adv Skin Wound Care. 2008;21(5):227–36. quiz 237–8.

    Article  Google Scholar 

  46. Szabo G, Mandrekar P. A recent perspective on alcohol, immunity, and host defense. Alcohol Clin Exp Res. 2009;33(2):220–32.

    Article  CAS  Google Scholar 

  47. Kiecolt-Glaser JK, Marucha PT, Mercado AM, Malarkey WB, Glaser R. Slowing of wound healing by psychological stress. Lancet. 1995;346(8984):1194–6.

    Article  CAS  Google Scholar 

  48. Demling RH. Nutrition, anabolism, and the wound healing process: an overview. Eplasty. 2009;9:e9.

    PubMed  PubMed Central  Google Scholar 

  49. Konieczka K, Ritch R, Traverso CE, Kim DM, Kook MS, Gallino A, Golubnitschaja O, Erb C, Reitsamer HA, Kida T, Kurysheva N, Yao K. Flammer syndrome. EPMA J. 2014;5(1):11. https://doi.org/10.1186/1878-5085-5-11.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Golubnitschaja O. Feeling cold and other underestimated symptoms in breast cancer: anecdotes or individual profiles for advanced patient stratification? EPMA J. 2017;8(1):17–22. https://doi.org/10.1007/s13167-017-0086-6.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Golubnitschaja O, Filep N, Yeghiazaryan K, Blom HJ, Hofmann-Apitius M, Kuhn W. Multi-omic approach decodes paradoxes of the triple-negative breast cancer: lessons for predictive, preventive and personalised medicine. Amino Acids. 2018;50:383. https://doi.org/10.1007/s00726-017-2524-0.

    Article  CAS  PubMed  Google Scholar 

  52. Kapinova A, Kubatka P, Zubor P, Golubnitschaja O, Dankova Z, Uramova S, Pilchova I, Caprnde M, Opatrilova R, Richnavsky J, Kruzliak P, Danko J. The hypoxia-responsive long non-coding RNAs may impact on the tumor biology and subsequent management of breast cancer. Biomed Pharmacother. 2018;99:51–8. https://doi.org/10.1016/j.biopha.2017.12.104.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Radiological Clinic, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany

    Olga Golubnitschaja

  2. Breast Cancer Research Centre, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany

    Olga Golubnitschaja

  3. Centre for Integrated Oncology, Cologne-Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany

    Olga Golubnitschaja

  4. European Association for Predictive, Preventive and Personalised Medicine, EPMA, Brussels, Belgium

    Olga Golubnitschaja & Vincenzo Costigliola

  5. Department of Business Administration, Carlos III University, Getafe, Madrid, Spain

    Lara Stolzenburg Veeser

  6. Department of Immunology, Department of Neuroscience, The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

    Eden Avishai

Authors
  1. Olga Golubnitschaja
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  2. Lara Stolzenburg Veeser
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  3. Eden Avishai
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  4. Vincenzo Costigliola
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Corresponding author

Correspondence to Olga Golubnitschaja .

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Editors and Affiliations

  1. New York Medical College, School of Medicine, Department of Surgery and Westchester Medical Center, Valhalla, NY, USA

    Rifat Latifi

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Golubnitschaja, O., Veeser, L.S., Avishai, E., Costigliola, V. (2019). Wound Healing: Proof-of-Principle Model for the Modern Hospital: Patient Stratification, Prediction, Prevention and Personalisation of Treatment. In: Latifi, R. (eds) The Modern Hospital. Springer, Cham. https://doi.org/10.1007/978-3-030-01394-3_33

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  • DOI: https://doi.org/10.1007/978-3-030-01394-3_33

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