Abstract
The majority of excitatory synapses in the mammalian forebrain and the hippocampus terminate onto dendritic spines. Even though their intricate molecular composition remains obscure in many aspects, available evidence suggests that these structures are highly specialized to support the short- and long-term plasticity crucial for flexible information processing. One concept that is extensively used to describe synaptic function is the Hebb’s postulate. However, the knowledge accumulated throughout following decades advocate for a broader scale in intercellular connection functions. Synaptic activity depends on interactions among sets of proteins (synaptic interactome) that assemble into complex supramolecular machines. Molecular biology, electrophysiology, and live-cell imaging studies have provided tantalizing glimpses into the inner workings of the synapse, yet fundamental questions regarding the functional organization of these “molecular nanomachines” remain to be answered. The presence of accessory receptors for secondary messengers in synapses along with receptors for primary mediator gave us the idea that these molecular constructs could be responsible for initial processing of the incoming signals. The purpose of this initial processing could be determined by analyzing and reconstructing this molecular informational machine that is essentially dendritic spine of hippocampal pyramidal neurons.
In this paper the data obtained during the implementation of RAS IV.35.2.6 and the RFBR 17-04-01440a projects are used.
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References
Turgut, Y.B., Turgut, M.: A mysterious term hippocampus involved in learning and memory. Childs Nerv. Syst. 27(12), 2023–2025 (2011). https://doi.org/10.1007/s00381-011-1513-y
Proskura, A.L., Ratushnyak, A.S., Vechkapova, S.O., Zapara, T.A.: Synapse as a multi-component and multi-level information system. In: Kryzhanovsky, B., Dunin-Barkowski, W., Redko, V. (eds.) Advances in Neural Computation, Machine Learning, and Cognitive Research, NEUROINFORMATICS 2017. Studies in Computational Intelligence, vol. 736, pp. 186–192. Springer, Cham (2018)
Proskura, A.L., Vechkapova, S.O., Zapara, T.A., Ratushnyak, A.S.: Reconstruction of the molecular interactome of glutamatergic synapses. Russ. J. Genet. Appl. Res. 5(6), 616–625 (2015)
Harvey, J.: Leptin regulation of neuronal morphology and hippocampal synaptic function. Front. Synaptic Neurosci. 5(3), 1–7 (2013). https://doi.org/10.3389/fnsyn.2013.00003
Li, S., Cullen, W.K., Anwyl, R., Rowan, M.J.: Dopamine-dependent facilitation of LTP induction in hippocampal CA1 by exposure to spatial novelty. Nat. Neurosci. 6(5), 526–531 (2003). https://doi.org/10.1038/nn1049
Pastalkova, E., Serrano, P., Pinkhasova, D., Wallace, E., Fenton, A.A., Sacktor, T.C.: Storage of spatial information by the maintenance mechanism of LTP. Science 313(5790), 1141–1144 (2006). https://doi.org/10.1126/science.1128657
Ananko, E.A., Podkolodny, N.L., Stepanenko, I.L., Podkolodnaya, O.A., Rasskazov, D.A., Miginsky, D.S., Likhoshvai, V.A., Ratushny, A.V., Podkolodnaya, N.N., Kolchanov, N.A.: GeneNet in 2005. Nucl. Acids Res. 33, 425–427 (2005). https://doi.org/10.1093/nar/gki077
Proskura, A.L., Malakhin, I.A., Zapara, T.A., Turnaev, I.I., Suslov, V.V., Ratushnyak, A.S.: Intermolecular interactions in neuronal functional systems. Russ. J. Genet. Appl. Res. 17, 620–628 (2013)
Proskura, A.L., Ratushnyak, A.S., Zapara, T.A.: The protein-protein interaction networks of dendritic spines in the early phase of long-term potentiation. J. Comput. Sci. Syst. Biol. 7, 40–44 (2014). https://doi.org/10.4172/jcsb.1000136
Raghuram, V., Sharma, Y., Kreutz, M.R.: Ca2+ sensor proteins in dendritic spines: a race for Ca2+. Front. Mol. Neurosci. 5, 61 (2012). https://doi.org/10.3389/fnmol.2012.00061
Newpher, T.M., Ehlers, M.D.: Glutamate receptor dynamics in dendritic microdomains. Neuron 58(4), 472–497 (2008). https://doi.org/10.1016/j.neuron.2008.04.030
Petrini, E.M., Lu, J., Cognet, L., Lounis, B., Ehlers, M.D., Choquet, D.: Endocytic trafficking and recycling maintain a pool of mobile surface AMPA receptors required for synaptic potentiation. Neuron 63(1), 92–105 (2009). https://doi.org/10.1016/j.neuron.2009.05.025
Lee, H.K., Barbarosie, M., Kameyama, K., Bear, M.F., Huganir, R.L.: Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity. Nature 405(6789), 955–959 (2000). https://doi.org/10.1038/35016089
Kim, M., Park, A.J., Havekes, R., Chay, A., Guercio, L.A., Oliveira, R.F., Abel, T., Blackwell, K.T.: Colocalization of protein kinase A with adenylyl cyclase enhances protein kinase A activity during induction of long-lasting long-term-potentiation. PLoS Comput. Biol. 7(6), e1002084 (2011). https://doi.org/10.1371/journal.pcbi.1002084
He, K., Song, L., Cummings, L.W., Goldman, J., Huganir, R.L., Lee, H.K.: Stabilization of Ca2+-permeable AMPA receptors at perisynaptic sites by GluR1-S845 phosphorylation. Proc. Natl. Acad. Sci. USA 106(47), 20033–20038 (2009). https://doi.org/10.1073/pnas.0910338106
Zapara, T.A., Proskura, A.L., Malakhin, I.A., Vechkapova, S.O., Ratushnyak, A.S.: The mobility of AMPA-type glutamate receptors as a key factor in the expression and maintenance of synaptic potentiation. Neurosci. Behav. Physiol. 47(5), 528–533 (2017). https://doi.org/10.1007/s11055-017-0430-2
Lemon, N., Manahan-Vaughan, D.: Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression. J. Neurosci. 26(29), 7723–7729 (2006). https://doi.org/10.1523/JNEUROSCI.1454-06.2006
Moult, P.R., Cross, A., Santos, S.D., Carvalho, A.L., Lindsay, Y., Connolly, C.N., Irving, A.J., Leslie, N.R., Harvey, J.: Leptin regulates AMPA receptor trafficking via PTEN inhibition. J. Neurosci. 30(11), 4088–4101 (2010). https://doi.org/10.1523/JNEUROSCI.3614-09.2010
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Proskura, A.L., Zapara, T.A. (2019). Function and Molecular Design of the Synapse. In: Kryzhanovsky, B., Dunin-Barkowski, W., Redko, V., Tiumentsev, Y. (eds) Advances in Neural Computation, Machine Learning, and Cognitive Research II. NEUROINFORMATICS 2018. Studies in Computational Intelligence, vol 799. Springer, Cham. https://doi.org/10.1007/978-3-030-01328-8_41
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