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Progress in the Chemistry of Organic Natural Products 108 pp 207–296Cite as

Secondary Metabolites of Endophytic Actinomycetes: Isolation, Synthesis, Biosynthesis, and Biological Activities

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Part of the book series: Progress in the Chemistry of Organic Natural Products ((POGRCHEM,volume 108))

Abstract

Endophytic Actinobacteria are a microbial group that is still poorly investigated. Their association with plants constitutes a unique trait conferring specific biological and chemical features to endophytic Actinobacteria. This contribution discusses aspects of endophytic actinobacterial biology and chemistry comprehensively, including the biosynthesis and total synthesis of secondary metabolites produced in culture. It also presents perspectives for the future of microbial bioactive natural products discovery, with emphasis on the secondary metabolism of endophytic Actinobacteria.

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Acknowledgments

The authors thank Professor Heinz Falk (Johannes Kepler Universität Linz) for many suggestions that improved the manuscript. Financial support was provided by Fundação de Amparo à Pesquisa do Estado de São Paulo to RGSB (2013/50228-8), as well as a Ph.D. scholarship awarded to DIB (2016/21341-9). The Brazilian funding agency Conselho Nacional de Desenvolvimento Científico e Tecnológico is also gratefully acknowledged for postdoctoral fellowships awarded to AFM and GFS.

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Authors and Affiliations

  1. Instituto de Química de São Carlos, Universidade de São Paulo, São Carlos, São Paulo, Brazil

    Darlon Irineu Bernardi, Afif Felix Monteiro, Gabriel Franco dos Santos & Roberto Gomes de Souza Berlinck

  2. Instituto de Pesquisa de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    Fernanda Oliveira das Chagas

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  1. Darlon Irineu Bernardi
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  2. Fernanda Oliveira das Chagas
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  3. Afif Felix Monteiro
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  4. Gabriel Franco dos Santos
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  5. Roberto Gomes de Souza Berlinck
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Correspondence to Roberto Gomes de Souza Berlinck .

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Editors and Affiliations

  1. College of Pharmacy, The Ohio State University, Columbus, OH, USA

    A. Douglas Kinghorn

  2. Institute of Organic Chemistry, Johannes Kepler University, Linz, Austria

    Heinz Falk

  3. UCL School of Pharmacy, University College London, Research, London, UK

    Simon Gibbons

  4. Grad. School of Pharmaceutical Science, Hokkaido University, Fukuoka, Japan

    Jun'ichi Kobayashi

  5. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan

    Yoshinori Asakawa

  6. School of Pharmaceutical Sciences, South-Central Univ. for Nationalities, Wuhan, China

    Ji-Kai Liu

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Bernardi, D.I., das Chagas, F.O., Monteiro, A.F., dos Santos, G.F., de Souza Berlinck, R.G. (2019). Secondary Metabolites of Endophytic Actinomycetes: Isolation, Synthesis, Biosynthesis, and Biological Activities. In: Kinghorn, A., Falk, H., Gibbons, S., Kobayashi, J., Asakawa, Y., Liu, JK. (eds) Progress in the Chemistry of Organic Natural Products 108. Progress in the Chemistry of Organic Natural Products, vol 108. Springer, Cham. https://doi.org/10.1007/978-3-030-01099-7_3

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