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Intracellular Calcium Dynamics: Biophysical and Simplified Models

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Computational Glioscience

Part of the book series: Springer Series in Computational Neuroscience ((NEUROSCI))

Abstract

Calcium ions are an important second messenger in living cells. A fundamental approach for studying calcium signalling is the combination of state-of-the-art experimental techniques with spatiotemporal mathematical models of calcium regulation. Extensive modelling work on calcium oscillations and waves consists of a variety of theoretical/computational methods and models of different complexity. Some models can be assigned to a category of biologically realistic, detailed models, analysis of which is restricted to numerical methods. Other models can be placed in a category of simplified, minimal models susceptible to mathematical analysis. In this chapter, we provide an overview of a number of models for intracellular calcium dynamics belonging to both categories. Both types of models complement each other nicely and are vital for a better understanding of the complex mechanisms involved in cellular calcium signalling.

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Authors and Affiliations

  1. Department of Computer Science and Centre for Complexity Science, University of Warwick, Coventry, CV4 7AL, UK

    Yulia Timofeeva

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  1. Yulia Timofeeva
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Correspondence to Yulia Timofeeva .

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Editors and Affiliations

  1. Group of Mathematical, Computational and Experimental Neuroscience, Basque Center for Applied Mathematics, Bilbao, Biscay, Spain

    Maurizio De Pittà

  2. INRIA Rhône-Alpes, Université de Lyon, Villeurbanne, Lyon, France

    Hugues Berry

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Timofeeva, Y. (2019). Intracellular Calcium Dynamics: Biophysical and Simplified Models. In: De Pittà, M., Berry, H. (eds) Computational Glioscience. Springer Series in Computational Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-030-00817-8_3

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