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The Role of Astrocytes in Neurotransmitter Uptake and Brain Metabolism

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Computational Glioscience

Part of the book series: Springer Series in Computational Neuroscience ((NEUROSCI))

Abstract

Termination of synaptic transmission relies on neurotransmitter diffusion and removal from the extracellular space by specific molecules called transporters, abundantly expressed in astrocytes. Here we describe the biophysical mechanisms of neurotransmitter transport across the astrocyte membrane and the biochemical pathways that supply energy to these cells. These findings indicate that astrocytes are crucial regulators of brain activity, due to their ability to shape synaptic transmission and control the energy budget of the entire brain.

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  1. Department of Biology, SUNY Albany, 1400 Washington Avenue, Albany, NY, 12222-0100, USA

    Annalisa Scimemi

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  1. Group of Mathematical, Computational and Experimental Neuroscience, Basque Center for Applied Mathematics, Bilbao, Biscay, Spain

    Maurizio De Pittà

  2. INRIA Rhône-Alpes, Université de Lyon, Villeurbanne, Lyon, France

    Hugues Berry

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Scimemi, A. (2019). The Role of Astrocytes in Neurotransmitter Uptake and Brain Metabolism. In: De Pittà, M., Berry, H. (eds) Computational Glioscience. Springer Series in Computational Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-030-00817-8_12

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