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Membrane Domains Under Cellular Recycling

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Physics of Biological Membranes

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Abstract

Living cells are bounded by sac-like membranes that play a crucial role in almost every cellular process. These membranes are highly dynamic, two-dimensional systems, with components that are continuously exchanged with rest of the living cell by the secretion and absorption of small vesicles with sizes of the order of tens or hundreds of nanometers in diameter. This constant recycling of the cell membranes leads to a complete turnover of its constituents on the order of tens of minutes. The presence of distinct nano-scale microphase separated domains in biomembranes has been confirmed by numerous experiments. In this chapter we address recent advances in our understanding of the role of recycling in the control of membrane microdomain formation. These results relate to both the steady-state distribution of domain sizes and the transient response of this distribution following perturbation of cellular synthesis, transport, or recycling pathways. This gives a route to testing and calibrating theoretical models from experiments that measure the domain size distribution.

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Acknowledgements

We acknowledge longstanding collaboration with Dr. P. Sens (Paris), and funding from UK EPSRC under Grant No. EP/I005439/1 (M.S.T.) and Simons Foundation (S.A.R).

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Authors and Affiliations

  1. Department of Physics, University of Warwick, Coventry, UK

    S. Alex Rautu & Matthew S. Turner

  2. National Centre for Biological Sciences, UAS-GKVK Campus, Bangalore, India

    S. Alex Rautu

  3. Centre for Complexity Science, University of Warwick, Coventry, UK

    Matthew S. Turner

Authors
  1. S. Alex Rautu
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  2. Matthew S. Turner
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Correspondence to Matthew S. Turner .

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Editors and Affiliations

  1. PhysicoChimie Curie (UMR CNRS 168), Institut Curie, Paris, France

    Patricia Bassereau

  2. PhysicoChimie Curie (UMR CNRS 168), Institut Curie, Paris, France

    Pierre Sens

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Rautu, S.A., Turner, M.S. (2018). Membrane Domains Under Cellular Recycling. In: Bassereau, P., Sens, P. (eds) Physics of Biological Membranes. Springer, Cham. https://doi.org/10.1007/978-3-030-00630-3_9

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