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Immunobiology and Immunotherapy of Multiple Myeloma

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Myeloma Therapy

Part of the book series: Contemporary Hematology ((CH))

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References

  1. Mitsiades CS, Mitsiades N, Munshi NC, Anderson KC. Focus on multiple myeloma. Cancer Cell 2004;6(5):439–44.

    PubMed  CAS  Google Scholar 

  2. Kyle RA, Therneau TM, Rajkumar SV, et al. A long-term study of prognosis in monoclonal gammopathy of undetermined significance. N Engl J Med 2002;346(8):564–9.

    PubMed  Google Scholar 

  3. Kyle RA, Remstein ED, Therneau TM, et al. Clinical course and prognosis of smoldering (asymptomatic) multiple myeloma. N Engl J Med 2007;356(25):2582–90.

    PubMed  CAS  Google Scholar 

  4. Zhan F, Hardin J, Kordsmeier B, et al. Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells. Blood 2002;99(5):1745–57.

    PubMed  CAS  Google Scholar 

  5. Fonseca R, Barlogie B, Bataille R, et al. Genetics and cytogenetics of multiple myeloma: a workshop report. Cancer Res 2004;64(4):1546–58.

    PubMed  CAS  Google Scholar 

  6. Munshi NC. Immunoregulatory mechanisms in multiple myeloma. Hematol Oncol Clin North Am 1997;11(1):51–69.

    PubMed  CAS  Google Scholar 

  7. Boon T, Van Der Bruggen P. Human tumor antigens recognized by T lymphocytes. J Exp Med 1996;183:725–9.

    PubMed  CAS  Google Scholar 

  8. Gilboa E. The makings of a tumor rejection antigen. Immunity 1999;11(3):263–70.

    PubMed  CAS  Google Scholar 

  9. Pardoll D. Does the immune system see tumors as foreign or self? Annu Rev Immunol 2003;21:807–39.

    PubMed  CAS  Google Scholar 

  10. Houghton AN, Gold JS, Blachere NE. Immunity against cancer: lessons learned from melanoma. Curr Opin Immunol 2001;13(2):134–40.

    PubMed  CAS  Google Scholar 

  11. Houghton AN. Cancer antigens: immune recognition of self and altered self. J Exp Med 1994;180:1–4.

    PubMed  CAS  Google Scholar 

  12. Sjoblom T, Jones S, Wood LD, et al. The consensus coding sequences of human breast and colorectal cancers. Science 2006;314(5797):268–74.

    PubMed  Google Scholar 

  13. Sogn JA. Tumor immunology: the glass is half full. Immunity 1998;9(6):757–63.

    PubMed  CAS  Google Scholar 

  14. Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD. Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol 2002;3(11):991–8.

    PubMed  CAS  Google Scholar 

  15. Bui JD, Schreiber RD. Cancer immunosurveillance, immunoediting and inflammation: independent or interdependent processes?. Curr Opin Immunol 2007;19(2):203–8.

    PubMed  CAS  Google Scholar 

  16. Marincola FM, Jaffee EM, Hicklin DJ, Ferrone S. Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance. Adv Immunol 2000;74:181–273.

    PubMed  CAS  Google Scholar 

  17. Zinkernagel RM. Immunity against solid tumors?. Int J Cancer 2001;93(1):1–5.

    PubMed  CAS  Google Scholar 

  18. Pardoll D. T cells and tumors. Nature 2001;411:1010–2.

    PubMed  CAS  Google Scholar 

  19. Huang AYC, Golumbek P, Ahmadzadeh M, Jaffee E, Pardoll D, Levitsky H. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science 1994;264:961–5.

    PubMed  CAS  Google Scholar 

  20. Heath WR, Carbone FR. Cross-presentation, dendritic cells, tolerance and immunity. Annu Rev Immunol 2001;19:47–64.

    PubMed  CAS  Google Scholar 

  21. Ochsenbein A, Sierro S, Odermatt B, et al. Roles of tumor localization, second signals and cross priming in cytotoxic T cell induction. Nature 2001;411:1058–64.

    PubMed  CAS  Google Scholar 

  22. Mellman I, Steinman RM. Dendritic cells: specialized and regulated antigen processing machines. Cell 2001;106(3):255–8.

    PubMed  CAS  Google Scholar 

  23. Hawiger D, Inaba K, Dorsett Y, et al. Dendritic cells induce peripheral T cell unrespon-siveness under steady state conditions in vivo. J Exp Med 2001;194(6):769–79.

    PubMed  CAS  Google Scholar 

  24. Liu K, Iyoda T, Saternus M, Kimura Y, Inaba K, Steinman RM. Immune tolerance after delivery of dying cells to dendritic cells in situ. J Exp Med 2002;196(8):1091–7.

    PubMed  CAS  Google Scholar 

  25. Sotomayor EM, Borrello I, Rattis FM, et al. Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression. Blood 2001;98(4):1070–7.

    PubMed  CAS  Google Scholar 

  26. Staveley-O'Carroll K, Sotomayor E, Montgomery J, et al. Induction of antigen-specific T cell anergy: an early event in the course of tumor progression. Proc Natl Acad Sci 1998;95:1178–93.

    PubMed  Google Scholar 

  27. Hanson HL, Donermeyer DL, Ikeda H, et al. Eradication of established tumors by CD8 + T cell adoptive immunotherapy. Immunity 2000;13(2):265–76.

    PubMed  CAS  Google Scholar 

  28. Gilboa E. How tumors escape immune destruction and what we can do about it. Cancer Immunol Immunother 1999;48(7):382–5.

    PubMed  CAS  Google Scholar 

  29. Herber DL, Nagaraj S, Djeu JY, Gabrilovich DI. Mechanism and therapeutic reversal of immune suppression in cancer. Cancer Res 2007;67(11):5067–9.

    PubMed  CAS  Google Scholar 

  30. Terabe M, Berzofsky JA. Immunoregulatory T cells in tumor immunity. Curr Opin Immunol 2004;16(2):157–62.

    PubMed  CAS  Google Scholar 

  31. Bissell MJ, Radisky D. Putting tumours in context. Nat Rev Cancer 2001;1(1):46–54.

    PubMed  CAS  Google Scholar 

  32. Dhodapkar MV. Harnessing host immune responses to preneoplasia: promise and challenges. Cancer Immunol Immunother 2005;54(5):409–13.

    PubMed  Google Scholar 

  33. Serra HM, Mant MJ, Ruether BA, Ledbetter JA, Pilarski LM. Selective loss of CD4 + CD45R + T cells in peripheral blood of multiple myeloma patients. J Clin Immunol 1988;8(4):259–65.

    PubMed  CAS  Google Scholar 

  34. San Miguel JF, Garcia-Sanchez R, Gonzales A. Lymphoid subsets and prognostic factors in multiple myeloma. Br J Hem 1992;80:305–9.

    CAS  Google Scholar 

  35. Kay N, Leong T, Kyle RA, et al. Altered T cell repertoire usage in CD4 and CD8 subsets of multiple myeloma patients, a Study of the Eastern Cooperative Oncology Group (E9487). Leuk Lymphoma 1999;33(1–2):127–33.

    PubMed  CAS  Google Scholar 

  36. Kay NE, Leong TL, Bone N, et al. Blood levels of immune cells predict survival in myeloma patients: results of an Eastern Cooperative Oncology Group phase 3 trial for newly diagnosed multiple myeloma patients. Blood 2001;98(1):23–8.

    PubMed  CAS  Google Scholar 

  37. Kay NE, Leong T, Bone N, et al. T-helper phenotypes in the blood of myeloma patients on ECOG phase III trials E9486/E3A93. Br J Haematol 1998;100(3):459–63.

    PubMed  CAS  Google Scholar 

  38. Brown R, Murray A, Pope B, et al. B7 + T cells in myeloma: an acquired marker of prior chronic antigen presentation. Leuk Lymphoma 2004;45(2):363–71.

    PubMed  CAS  Google Scholar 

  39. Yi Q, Dabadgao S, Osterborg A, Bergenbrant S, Holm G. Myeloma bone marrow plasma cells: evidence for their capacity as antigen presenting cells. Blood 1997;5:1960–7.

    Google Scholar 

  40. Dhodapkar MV, Krasovsky J, Olson K. T cells from the tumor microenvironment of patients with progressive myeloma can generate strong tumor specific cyto-lytic responses to autologous tumor loaded dendritic cells. Proc Natl Acad Sci 2002;99:13009–13.

    PubMed  CAS  Google Scholar 

  41. Brander C, Raje N, O'Connor PG, et al. Absence of biologically important Kaposi sarcoma-associated herpesvirus gene products and virus-specific cellular immune responses in multiple myeloma. Blood 2002;100(2):698–700.

    PubMed  CAS  Google Scholar 

  42. Maecker B, Anderson KS, von Bergwelt-Baildon MS, et al. Viral antigen-specific CD8 + T-cell responses are impaired in multiple myeloma. Br J Haematol 2003;121(6):842–8.

    PubMed  Google Scholar 

  43. Massaia M, Attisano C, Peola S, et al. Rapid generation of antiplasma cell activity in the bone marrow of myeloma patients by CD3-activated T cells. Blood 1993;82(6):1787–97.

    PubMed  CAS  Google Scholar 

  44. Paglieroni TG, MacKenzie MR. In vitro cytotoxic response to human myeloma plasma cells by peripheral blood leukocytes from patients with multiple myeloma and benign monoclonal gammopathy. Blood 1979;54:226–37.

    PubMed  CAS  Google Scholar 

  45. Bianchi A, Mariani S, Beggiato E, et al. Distribution of T-cell signalling molecules in human myeloma. Br J Haematol 1997;97(4):815–20.

    PubMed  CAS  Google Scholar 

  46. Massaia M, Borrione P, Attisano C, et al. Dysregulated Fas and Bcl-2 expression leading to enhanced apoptosis in T cells of multiple myeloma patients. Blood 1995;85(12):3679–87.

    PubMed  CAS  Google Scholar 

  47. Osterborg A, Henriksson L, Mellstedt H. Idiotype immunity (natural and vaccine-induced) in early stage multiple myeloma. Acta Oncol 2000;39(7):797–800.

    PubMed  CAS  Google Scholar 

  48. Osterborg A, Yi Q, Bergenbrant S, Holm G, Lefvert AK, Mellstedt H. Idiotype-specific T cells in multiple myeloma stage I:an evaluation by four different functional tests. Br J Haematol 1995;89(1):110–6.

    PubMed  CAS  Google Scholar 

  49. 49 Wen T Mellstedt H, Jondal M. Presence of clonal T cell populations in chronic B lymphocytic leukemia and smoldering myeloma. J Exp Med 1990;171(3):659–66.

    Google Scholar 

  50. Wen YJ, Barlogie B, Yi Q. Idiotype-specific cytotoxic T lymphocytes in multiple myeloma:evidence for their capacity to lyse autologous primary tumor cells. Blood 2001;97(6):1750–5.

    PubMed  CAS  Google Scholar 

  51. Osterborg A, Masucci M, Bergenbrant S, Holm G, Lefvert AK, Mellstedt H. Generation of T cell clones binding F(ab')2 fragments of the idiotypic immu-noglobulin in patients with monoclonal gammopathy. Cancer Immunol Immunother 1991;34(3):157–62.

    PubMed  CAS  Google Scholar 

  52. Yi Q, Osterborg A, Bergenbrant S, Mellstedt H, Holm G, Lefvert AK. Idiotype-reactive T-cell subsets and tumor load in monoclonal gammopathies. Blood 1995;86 (8):3043–9.

    PubMed  CAS  Google Scholar 

  53. Li Y, Bendandi M, Deng Y, et al. Tumor-specific recognition of human myeloma cells by idiotype-induced CD8(+) T cells. Blood 2000;96(8):2828–33.

    PubMed  CAS  Google Scholar 

  54. Lim SH, Badros A, Lue C, Barlogie B. Distinct T-cell clonal expansion in the vicinity of tumor cells in plasmacytoma. Cancer 2001;91(5):900–8.

    PubMed  CAS  Google Scholar 

  55. Halapi E, Werner A, Wahlstrom J, et al. T cell repertoire in patients with multiple myeloma and monoclonal gammopathy of undetermined significance:clonal CD8 + T cell expansions are found preferentially in patients with a low tumor burden. Eur J Immunol 1997;27(9):2245–52.

    PubMed  CAS  Google Scholar 

  56. Yi Q, Eriksson I, He W, Holm G, Mellstedt H, Osterborg A. Idiotype-specific T lymphocytes in monoclonal gammopathies:evidence for the presence of CD4 + and CD8 + subsets. Br J Haematol 1997;96(2):338–45.

    PubMed  CAS  Google Scholar 

  57. Romero P, Cerottini JC, Waanders GA. Novel methods to monitor antigen-specific cytotoxic T-cell responses in cancer immunotherapy. Mol Med Today 1998;4(7):305–12.

    PubMed  CAS  Google Scholar 

  58. Noonan K, Matsui W, Serafini P, et al. Activated marrow-infiltrating lymphocytes effectively target plasma cells and their clonogenic precursors. Cancer Res 2005;65(5):2026–34.

    PubMed  CAS  Google Scholar 

  59. Wen YJ, Min R, Tricot G, Barlogie B, Yi Q. Tumor lysate-specific cytotoxic T lymphocytes in multiple myeloma:promising effector cells for immunotherapy. Blood 2002;99(9):3280–5.

    PubMed  CAS  Google Scholar 

  60. Dhodapkar MV, Krasovsky J, Osman K, Geller MD. Vigorous premalignancy specific effector T cell response in the bone marrow of patients with preneoplastic gammopathy. J Exp Med 2003;198:1753–7.

    PubMed  CAS  Google Scholar 

  61. Spisek R, Kukreja A, Chen LC, et al. Frequent and specific immunity to the embryonal stem cell-associated antigen SOX2 in patients with monoclonal gammopathy. J Exp Med 2007;204(4):831–40.

    PubMed  CAS  Google Scholar 

  62. Pilarski LM, Andrews EJ, Mant MJ, Ruether BA. Humoral immune deficiency in multiple myeloma patients due to compromised B-cell function. J Clin Immunol 1986;6(6):491–501.

    PubMed  CAS  Google Scholar 

  63. Hargreaves RM, Lea JR, Griffiths H. Immunologic factors and risk of infection in plateau phase myeloma. J Clin Path 1995;48:260–9.

    PubMed  CAS  Google Scholar 

  64. Pilarski LM, Mant MJ, Ruether BA. Pre-B cells in peripheral blood of multiple myeloma patients. Blood 1985;66(2):416–22.

    PubMed  CAS  Google Scholar 

  65. Pilarski LM, Mant MJ, Ruether BA, Belch A. Severe deficiency of B lymphocytes in peripheral blood from multiple myeloma patients. J Clin Invest 1984;74(4):1301–6.

    PubMed  CAS  Google Scholar 

  66. Paglieroni T, MacKenzie MR, Caggiano V. Abnormalities in immunoregulatory CD5 + B cells precede the diagnosis of multiple myeloma. Ann N Y Acad Sci 1992;651:486–7.

    PubMed  CAS  Google Scholar 

  67. Broder S, Humphrey R, Durm M, et al. Impaired synthesis of polyclonal (non-para-protein) immunoglobulins by circulating lymphocytes from patients with multiple myeloma. Role of suppressor cells. N Engl J Med 1975;293(18):887–92.

    PubMed  CAS  Google Scholar 

  68. Ullrich S, Zolla-Pazner S. Immunoregulatory circuits in myeloma. Clin Haematol 1982;11(1):87–111.

    PubMed  CAS  Google Scholar 

  69. Bellucci R, Wu CJ, Chiaretti S, et al. Complete response to donor lymphocyte infusion in multiple myeloma is associated with antibody responses to highly expressed antigens. Blood 2004;103(2):656–63.

    PubMed  CAS  Google Scholar 

  70. Smyth MJ, Crowe NY, Hayakawa Y, Takeda K, Yagita H, Godfrey DI. NKT cells—conductors of tumor immunity?. Curr Opin Immunol 2002;14(2):165–71.

    PubMed  CAS  Google Scholar 

  71. Girardi M, Oppenheim DE, Steele CR, et al. Regulation of cutaneous malignancy by gammadelta T cells. Science 2001;294(5542):605–9.

    PubMed  CAS  Google Scholar 

  72. Coughlin CM, Salhany KE, Gee MS,. Tumor cell responses to IFNgamma affect tumorigenicity and response to IL-12 therapy and antiangiogenesis. Immunity 1998;9(1):25–34.

    PubMed  CAS  Google Scholar 

  73. Catlett-Falcone R, Landowski TH, Oshiro MM, et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 1999;10(1):105–15.

    PubMed  CAS  Google Scholar 

  74. Takayanagi H, Ogasawara K, Hida S, et al. T-cell-mediated regulation of osteo-clastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature 2000;408(6812):600–5.

    PubMed  CAS  Google Scholar 

  75. Wilhelm M, Kunzmann V, Eckstein S, et al. Gammadelta T cells for immune therapy of patients with lymphoid malignancies. Blood 2003;102(1):200–6.

    PubMed  CAS  Google Scholar 

  76. Kunzmann V, Bauer E, Feurle J, Weissinger F, Tony HP, Wilhelm M. Stimulation of gammadelta T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma. Blood 2000;96(2):384–92.

    PubMed  CAS  Google Scholar 

  77. Dhodapkar MV, Geller MD, Chang DH, et al. A reversible defect in natural killer T cell function characterizes the progression of premalignant to malignant multiple myeloma. J Exp Med 2003;197(12):1667–76.

    PubMed  CAS  Google Scholar 

  78. Hoover RG, Lary C, Page R, et al. Autoregulatory circuits in myeloma. Tumor cell cytotoxicity mediated by soluble CD16. J Clin Invest 1995;95(1):241–7.

    PubMed  CAS  Google Scholar 

  79. Mathiot C, Galon J, Tartour E, et al. Soluble CD16 in plasma cell dyscrasias. Leuk Lymphoma 1999;32(5–6):467–74.

    PubMed  CAS  Google Scholar 

  80. Nielsen H, Nielsen HJ, Tvede N, et al. Immune dysfunction in multiple myeloma. Reduced natural killer cell activity and increased levels of soluble interleukin-2 receptors. APMIS 1991;99(4):340–6.

    PubMed  CAS  Google Scholar 

  81. Uchida A, Yagita M, Sugiyama H. Strong natural killer (NK) cell activity in bone marrow of myeloma patients:accelerated maturation of bone marrow NK cells and their interaction with other NK cells. Int J Cancer 1984;34:375–81.

    PubMed  CAS  Google Scholar 

  82. Osterborg A, Nilsson B, Bjorkholm M, Holm G, Mellstedt H. Natural killer cell activity in monoclonal gammopathies:relation to disease activity. Eur J Haematol 1990;45(3):153–7.

    PubMed  CAS  Google Scholar 

  83. Garcia-Sanz R, Gonzalez M, Orfao A. Analysis of natural killer associated antigens in the peripheral blood and bone marrow of multiple myeloma patients:prognostic implications. Br J Hematology 1996;93:81–9.

    CAS  Google Scholar 

  84. Carbone E, Neri P, Mesuraca M, et al. HLA class I, NKG2D, and natural cytotox-icity receptors regulate multiple myeloma cell recognition by natural killer cells. Blood 2005;105(1):251–8.

    PubMed  CAS  Google Scholar 

  85. Said JW, Rettig MR, Heppner K, et al. Localization of Kaposi's sarcoma-associated herpesvirus in bone marrow biopsy samples from patients with multiple myeloma. Blood 1997;90(11):4278–82.

    PubMed  CAS  Google Scholar 

  86. Bahlis NJ, King AM, Kolonias D, et al. CD28-mediated regulation of multiple myeloma cell proliferation and survival. Blood 2007;109(11):5002–10.

    PubMed  CAS  Google Scholar 

  87. Brown RD, Pope B, Murray A, et al. Dendritic cells from patients with myeloma are numerically normal but functionally defective as they fail to up-regulate CD80 (B7—1) expression after huCD40LT stimulation because of inhibition by transforming growth factor-beta1 and interleukin-10. Blood 2001;98(10):2992–8.

    PubMed  CAS  Google Scholar 

  88. Ratta M, Fagnoni F, Curti A, et al. Dendritic cells are functionally defective in multiple myeloma:the role of interleukin-6. Blood 2002;100(1):230–7.

    PubMed  CAS  Google Scholar 

  89. Podar K, Anderson KC. The pathophysiological role of VEGF in hematological malignancies:therapeutic implications. Blood 2005;105(4):1383–1395.

    PubMed  CAS  Google Scholar 

  90. Brown R, Murray A, Pope B, et al. Either interleukin-12 or interferon-gamma can correct the dendritic cell defect induced by transforming growth factor beta in patients with myeloma. Br J Haematol 2004;125(6):743–8.

    PubMed  CAS  Google Scholar 

  91. Rettig MB, Ma HJ, Vescio RA, et al. Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients. Science 1997;276(5320):1851–4.

    PubMed  CAS  Google Scholar 

  92. Yi Q, Ekman M, Anton D, et al. Blood dendritic cells from myeloma patients are not infected with Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8). Blood 1998;92(2):402–4.

    PubMed  CAS  Google Scholar 

  93. Raje N, Kica G, Chauhan D, et al. Kaposi's sarcoma-associated herpesvirus gene sequences are detectable at low copy number in primary amyloidosis. Amyloid 2000;7(2):126–32.

    PubMed  CAS  Google Scholar 

  94. Raje N, Gong J, Chauhan D, et al. Bone marrow and peripheral blood dendritic cells from patients with multiple myeloma are phenotypically and functionally normal despite the detection of Kaposi's sarcoma herpesvirus gene sequences. Blood 1999;93(5):1487–95.

    PubMed  CAS  Google Scholar 

  95. Kukreja A, Hutchinson A, Dhodapkar K, et al. Enhancement of clonogenic-ity of human multiple myeloma by dendritic cells. J Exp Med 2006;203(8):1859–65.

    PubMed  CAS  Google Scholar 

  96. Prabhala RH, Neri P, Bae JE, et al. Dysfunctional T regulatory cells in multiple myeloma. Blood 2006;107(1):301–4.

    PubMed  CAS  Google Scholar 

  97. Beyer M, Kochanek M, Giese T, et al. In vivo peripheral expansion of naive CD4 +CD25high FOXP3 +regulatory T cells in patients with multiple myeloma. Blood 2006;107(10):3940–9.

    PubMed  CAS  Google Scholar 

  98. Banerjee D, Dhodapkar MV, Matayeva E, Steinman RM, Dhodapkar K. Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after DC injection of cytokine matured DCs in myeloma patients. Blood 2006;108(8):2655–2661.

    PubMed  CAS  Google Scholar 

  99. Zhou G, Drake CG, Levitsky HI. Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines. Blood 2006;107(2):628–36.

    PubMed  CAS  Google Scholar 

  100. Lynch RG, Graff RJ, Sirisinha S, Simms ES, Eisen HN. Myeloma proteins as tumor-specific transplantation antigens. Proc Natl Acad Sci USA 1972;69(6):1540–4.

    PubMed  CAS  Google Scholar 

  101. Kwak LW, Thielemans K, Massaia M. Idiotypic vaccination as therapy for multiple myeloma. Semin Hematol 1999;36(1 Suppl 3):34–7.

    PubMed  CAS  Google Scholar 

  102. Milburn GL, Lynch RG. Immunoregulation of murine myeloma in vitro. II. Suppression of MOPC-315 immunoglobulin secretion and synthesis by idiotype-specific suppressor T cells. J Exp Med 1982;155(3):852–62.

    PubMed  CAS  Google Scholar 

  103. Abbas AK. T lymphocyte-mediated suppression of myeloma function in vitro. I. Suppression by allogeneically activated T lymphocytes. J Immunol 1979;123(5):2011–8.

    PubMed  CAS  Google Scholar 

  104. Bogen B, Malissen B, Haas W. Idiotope-specific T cell clones that recognize syngeneic immunoglobulin fragments in the context of class II molecules. Eur J Immunol 1986;16(11):1373–8.

    PubMed  CAS  Google Scholar 

  105. Bogen B. Peripheral T cell tolerance as a tumor escape mechanism:deletion of CD4 +T cells specific for a monoclonal immunoglobulin idiotype secreted by a plasmacytoma. Eur J Immunol 1996;26(11):2671–9.

    PubMed  CAS  Google Scholar 

  106. Lynch RG, Graff RJ, Sirisinha S. Myeloma proteins as tumor specific transplantation antigens. Proc Natl Acad Sci USA 1972;69:1540–4.

    PubMed  CAS  Google Scholar 

  107. Daley MJ, Gebel HM, Lynch RG. Idiotype specific transplantation resist-snce to MOPC315:abrogation by post-immunization thymectomy. J Immunol 1978;120:1620–4.

    PubMed  CAS  Google Scholar 

  108. Lauritzsen GF, Bogen B. The role of idiotype-specific, CD4 +T cells in tumor resistance against major histocompatibility complex class II molecule negative plasmacytoma cells. Cell Immunol 1993;148(1):177–88.

    PubMed  CAS  Google Scholar 

  109. Dembic Z, Schenck K, Bogen B. Dendritic cells purified from myeloma are primed with tumor-specific antigen (idiotype) and activate CD4 +T cells. Proc Natl Acad Sci USA 2000;97(6):2697–702.

    PubMed  CAS  Google Scholar 

  110. Dembic Z, Rottingen JA, Dellacasagrande J, Schenck K, Bogen B. Phagocytic dendritic cells from myelomas activate tumor-specific T cells at a single cell level. Blood 2001;97(9):2808–14.

    PubMed  CAS  Google Scholar 

  111. Wen YJ, Barlogie B, Yi Q. Idiotype-specific cytotoxic T lymphocytes in multiple myeloma:evidence for their capacity to lyse autologous primary tumor cells. Blood 2001;97(6):1750–5.

    PubMed  CAS  Google Scholar 

  112. Yi Q, Desikan R, Barlogie B, Munshi N. Optimizing dendritic cell-based immu-notherapy in multiple myeloma. Br J Haematol 2002;117(2):297–305.

    PubMed  Google Scholar 

  113. Wen YJ, Ling M, Bailey-Wood R, Lim SH. Idiotypic protein-pulsed adherent peripheral blood mononuclear cell-derived dendritic cells prime immune system in multiple myeloma. Clin Cancer Res 1998;4(4):957–62.

    PubMed  CAS  Google Scholar 

  114. Reichardt VL, Milazzo C, Brugger W, Einsele H, Kanz L, Brossart P. Idiotype vaccination of multiple myeloma patients using monocyte-derived dendritic cells. Haematologica 2003;88(10):1139–49.

    PubMed  Google Scholar 

  115. Chen YT, Old LJ. Cancer-testis antigens:targets for cancer immunotherapy. Cancer J Sci Am 1999;5(1):16–7.

    PubMed  CAS  Google Scholar 

  116. van Baren N, Brasseur F, Godelaine D, et al. Genes encoding tumor-specific antigens are expressed in human myeloma cells. Blood 1999;94(4):1156–64.

    PubMed  Google Scholar 

  117. Pellat-Deceunynck C, Mellerin MP, Labarriere N, et al. The cancer germ-line genes MAGE-1, MAGE-3 and PRAME are commonly expressed by human myeloma cells. Eur J Immunol 2000;30(3):803–9.

    PubMed  CAS  Google Scholar 

  118. Dhodapkar K, Krasovsky J, Williamson B, Dhodapkar M. Anti-tumor monoclonal antibodies enhance cross presentation of cellular antigens and the generation of tumor specific killer T cells by dendritic cells. J Exp Med 2002;195:125–33.

    PubMed  CAS  Google Scholar 

  119. Tarte K, Zhan F, De Vos J, Klein B, Shaughnessy J. Gene expression profiling of plasma cells and plasmablasts:toward a better understanding of the late stages of B-cell differentiation. Blood 2003;102(2):592–600.

    PubMed  CAS  Google Scholar 

  120. Dhodapkar MV, Osman K, Teruya-Feldstein J, et al. Expression of cancer/testis (CT) antigens MAGE-A1, MAGE-A3, MAGE-A4, CT-7, and NY-ESO-1 in malignant gammopathies is heterogeneous and correlates with site, stage and risk status of disease. Cancer Immun 2003;3:9.

    PubMed  Google Scholar 

  121. Batchu RB, Moreno AM, Szmania S, et al. High-level expression of cancer/testis antigen NY-ESO-1 and human granulocyte-macrophage colony-stimulating factor in dendritic cells with a bicistronic retroviral vector. Hum Gene Ther 2003;14(14):1333–45.

    PubMed  CAS  Google Scholar 

  122. Dhodapkar MV, Osman K, Feldstein J, et al. Expression of cancer-testis antigens (MAGE-A1, -A3, -A4, CT-7 and NY-ESO-1 in malignant gammopathies is heterogeneous and correlates with site, stage and risk status of disease. Cancer Immun 2003;3:9–16.

    PubMed  Google Scholar 

  123. van Rhee F, Szmania SM, Zhan F, et al. NY-ESO-1 is highly expressed in poor-prognosis multiple myeloma and induces spontaneous humoral and cellular immune responses. Blood 2005;105(10):3939–44.

    PubMed  Google Scholar 

  124. Jungbluth AA, Ely S, Diliberto M, et al. The Cancer-Testis antigens CT7 (MAGE-C1) and MAGE-A3/6 are commonly expressed in multiple myeloma and correlate with plasma cell proliferation. Blood 2005;106(1):167–174.

    PubMed  CAS  Google Scholar 

  125. Sahota SS, Goonewardena CM, Cooper CD, et al. PASD1 is a potential multiple myeloma-associated antigen. Blood 2006;108(12):3953–5.

    PubMed  CAS  Google Scholar 

  126. Brossart P, Schneider A, Dill P, et al. The epithelial tumor antigen MUC1 is expressed in hematological malignancies and is recognized by MUC1-specific cytotoxic T-lymphocytes. Cancer Res 2001;61(18):6846–50.

    PubMed  CAS  Google Scholar 

  127. Treon SP, Mollick JA, Urashima M,. Muc-1 core protein is expressed on multiple myeloma cells and is induced by dexamethasone. Blood 1999;93(4):1287–98.

    PubMed  CAS  Google Scholar 

  128. Mileshkin L, Prince HM, Seymour JF, Biagi JJ. Serum MUC-1 as a marker of disease status in multiple myeloma patients receiving thalidomide. Br J Haematol 2003;123(4):747–8;author reply 8.

    PubMed  Google Scholar 

  129. Choi C, Witzens M, Bucur M, et al. Enrichment of functional CD8 memory T cells specific for MUC1 in bone marrow of multiple myeloma patients. Blood 2005;105(5):2132–2134.

    PubMed  CAS  Google Scholar 

  130. Vonderheide RH, Hahn WC, Schultze JL, Nadler LM. The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes. Immunity 1999;10(6):673–9.

    PubMed  CAS  Google Scholar 

  131. Qian J, Xie J, Hong S, et al. DKK1 is a widely expressed and potent tumor-associated antigen in multiple myeloma. Blood 2007;110(5):1587–1594.

    PubMed  CAS  Google Scholar 

  132. Rew SB, Peggs K, Sanjuan I, et al. Generation of potent antitumor CTL from patients with multiple myeloma directed against HM1. 24. Clin Cancer Res 2005;11(9):3377–84.

    PubMed  CAS  Google Scholar 

  133. Jalili A, Ozaki S, Hara T, et al. Induction of HM1. 24 peptide-specific cytotoxic T lymphocytes by using peripheral-blood stem-cell harvests in patients with multiple myeloma. Blood 2005;106(10):3538–45.

    PubMed  CAS  Google Scholar 

  134. Hundemer M, Schmidt S, Condomines M, et al. Identification of a new HLA-A2-restricted T-cell epitope within HM1. 24 as immunotherapy target for multiple myeloma. Exp Hematol 2006;34(4):486–96.

    PubMed  CAS  Google Scholar 

  135. Dhodapkar MV, Krasovsky J, Osman K, Geller MD. Vigorous premalignancy-specific effector T cell response in the bone marrow of patients with monoclonal gammopathy. J Exp Med 2003;198(11):1753–7.

    PubMed  CAS  Google Scholar 

  136. Milazzo C, Reichardt VL, Muller MR, Grunebach F, Brossart P. Induction of myeloma-specific cytotoxic T cells using dendritic cells transfected with tumor-derived RNA. Blood 2003;101(3):977–82.

    PubMed  CAS  Google Scholar 

  137. Hayashi T, Hideshima T, Akiyama M, et al. Ex vivo induction of multiple myeloma-specific cytotoxic T lymphocytes. Blood 2003;102(4):1435–42.

    PubMed  CAS  Google Scholar 

  138. Raje N, Hideshima T, Davies FE, et al. Tumour cell/dendritic cell fusions as a vaccination strategy for multiple myeloma. Br J Haematol 2004;125(3):343–52.

    PubMed  Google Scholar 

  139. Qian J, Wang S, Yang J, et al. Targeting heat shock proteins for immunotherapy in multiple myeloma:generation of myeloma-specific CTLs using dendritic cells pulsed with tumor-derived gp96. Clin Cancer Res 2005;11(24 Pt 1):8808–15.

    PubMed  CAS  Google Scholar 

  140. Jiang X, Kanai H, Hiromura K, Sawamura M, Yano S. Increased intra-platelet and urinary transforming growth factor-beta in patients with multiple myeloma. Acta Hematol 1995;94:1–6.

    CAS  Google Scholar 

  141. Matthes T, Werner-Farve C, Tang H, Zang X, Kindler V, Zubler RH. Cytokine gene expression during in vitro response of human B lymphocytes:kinetics of B cell tumor necrosis factor alpha, interleukin-6, interleukin-10, and transforming growth factor-beta 1 mRNAs. J Exp Med 1993;178:521–8.

    PubMed  CAS  Google Scholar 

  142. Cook G, Campbell JD, Carr CE, Boyd KS, Franklin IM. Transforming growth factor beta from multiple myeloma cells inhibits proliferation and IL-2 responsiveness in T lymphocytes. J Leukoc Biol 1999;66(6):981–8.

    PubMed  CAS  Google Scholar 

  143. Cook G, Campbell JD. Immune regulation in multiple myeloma:the host-tumour conflict. Blood Rev 1999;13(3):151–62.

    PubMed  CAS  Google Scholar 

  144. Urashima M, Ogata A, Chauhan D, et al. Transforming growth factor-beta1:differential effects on multiple myeloma versus normal B cells. Blood 1996;87 (5):1928–38.

    PubMed  CAS  Google Scholar 

  145. Campbell JD, Cook G, Robertson SE, et al. Suppression of IL-2-induced T cell proliferation and phosphorylation of STAT3 and STAT5 by tumor-derived TGF beta is reversed by IL-15. J Immunol 2001;167(1):553–61.

    PubMed  CAS  Google Scholar 

  146. Ameglio F, Alvino S, Trento E. Serum interleukin-10 levels in patients affected with multiple myeloma:correlation with the monoclonal component and disease progression. Int J Oncol 1995;6:1189–92.

    PubMed  CAS  Google Scholar 

  147. Gabrilovich DI, Chen HI, Girgis KR, et al. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat Med 1996;2:1096–103.

    PubMed  CAS  Google Scholar 

  148. Chomarat P, Banchereau J, Davoust J, Palucka AK. IL-6 switches the differentiation of monocytes from dendritic cells to macrophages. Nat Immunol 2000;1(6):510–4.

    PubMed  CAS  Google Scholar 

  149. Xie J, Wang Y, Freeman ME, 3rd, Barlogie B, Y i Q Beta 2-microglobulin as a negative regulator of the immune system:high concentrations of the protein inhibit in vitro generation of functional dendritic cells. Blood 2003;101(10):4005–12.

    PubMed  CAS  Google Scholar 

  150. Serafini P, Meckel K Kelso M,. Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. J Exp Med 2006;203(12):2691–702.

    PubMed  CAS  Google Scholar 

  151. Villunger A, Egle A, Marschitz I, et al. Constitutive expression of Fas (Apo-1/CD95) ligand on multiple myeloma cells:a potential mechanism of tumor-induced suppression of immune surveillance. Blood 1997;90(1):12–20.

    PubMed  CAS  Google Scholar 

  152. Barlogie B, Shaughnessy J, Tricot G, et al. Treatment of multiple myeloma. Blood 2004;103(1):20–32.

    PubMed  CAS  Google Scholar 

  153. Bruno B, Rotta M, Patriarca F,. A comparison of allografting with autografting for newly diagnosed myeloma. N Engl J Med 2007;356(11):1110–20.

    PubMed  CAS  Google Scholar 

  154. Tricot G, Vesole DH, Jagannath S, Hilton J, Munshi N, Barlogie B. Graft-versus-myeloma effect:proof of principle. Blood 1996;87(3):1196–8.

    PubMed  CAS  Google Scholar 

  155. Lokhorst HM, Schattenberg A, Cornelissen JJ,. Donor lymphocyte infusions for relapsed multiple myeloma after allogeneic stem-cell transplantation:predictive factors for response and long-term outcome. J Clin Oncol 2000;18(16):3031–7.

    PubMed  CAS  Google Scholar 

  156. Kwak LW, Taub DD, Duffey PL, et al. Transfer of myeloma idiotype-specific immunity from an actively immunised marrow donor. Lancet 1995;345(8956):1016–20.

    PubMed  CAS  Google Scholar 

  157. van Bergen CA, Kester MG, Jedema I, et al. Multiple myeloma-reactive T cells recognize an activation-induced minor histocompatibility antigen encoded by the ATP-dependent interferon-responsive (ADIR) gene. Blood 2007;109(9):4089–96.

    PubMed  Google Scholar 

  158. Atanackovic D, Arfsten J, Cao Y,. Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation. Blood 2007;109(3):1103–12.

    PubMed  CAS  Google Scholar 

  159. Singhal S, Mehta J, Desikan R, et al. Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med 1999;341(21):1565–71.

    PubMed  CAS  Google Scholar 

  160. Haslett PA, Corral LG, Albert M, Kaplan G. Thalidomide costimulates primary human T lymphocytes, preferentially inducing proliferation, cytokine production, and cytotoxic responses in the CD8 +subset. J Exp Med 1998;187(11):1885–92.

    PubMed  CAS  Google Scholar 

  161. LeBlanc R, Hideshima T, Catley LP, et al. Immunomodulatory drug costimulates T cells via the B7-CD28 pathway. Blood 2004;103(5):1787–90.

    PubMed  CAS  Google Scholar 

  162. Davies FE, Raje N, Hideshima T, et al. Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma. Blood 2001;98(1):210–6.

    PubMed  CAS  Google Scholar 

  163. Chang DH, Liu N, Klimek V, et al. Enhancement of ligand dependent activation of human natural killer T cells by lenalidomide:therapeutic implications. Blood 2006;108(2):618–621.

    PubMed  CAS  Google Scholar 

  164. Lake RA, Robinson BW. Immunotherapy and chemotherapy—a practical partnership. Nat Rev Cancer 2005;5(5):397–405.

    PubMed  CAS  Google Scholar 

  165. Lake RA, van der Most RG. A better way for a cancer cell to die. N Engl J Med 2006;354(23):2503–4.

    PubMed  CAS  Google Scholar 

  166. Casares N, Pequignot MO, Tesniere A, et al. Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. J Exp Med 2005;202(12):1691–701.

    PubMed  CAS  Google Scholar 

  167. Spisek R, Dhodapkar MV. Towards a better way to die with chemotherapy:role of heat shock proteins on dying tumor cells. Cell Cycle 2007;6(16):1962–1965.

    PubMed  CAS  Google Scholar 

  168. Spisek R, Charalambous A, Mazumder A, Vesole DH, Jagannath S, Dhodapkar MV. Bortezomib enhances dendritic cell (DC) mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells:therapeutic implications. Blood 2007;109(Jun 1):4839–45.

    PubMed  CAS  Google Scholar 

  169. Obeid M, Tesniere A, Ghiringhelli F, et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med 2007;13(1):54–61.

    PubMed  CAS  Google Scholar 

  170. North RJ, Awwad M. T cell suppression as an obstacle to immunologically-mediated tumor regression:elimination of suppression results in regression. Prog Clin Biol Res 1987;244:345–58.

    PubMed  CAS  Google Scholar 

  171. Barker E, Mokyr MB. Importance of Lyt-2 +T-cells in the resistance of melpha-lan-cured MOPC- 315 tumor bearers to a challenge with MOPC-315 tumor cells. Cancer Res 1988;48(17):4834–42.

    PubMed  CAS  Google Scholar 

  172. Barker E, Mokyr MB. Some characteristics of the in vivo antitumor immunity exhibited by mice cured of a large MOPC-315 tumor by a low dose of melphalan. Cancer Immunol Immunother 1987;25(3):215–24.

    PubMed  CAS  Google Scholar 

  173. Maloney DG, Donovan K, Hamblin TJ. Antibody therapy for treatment of multiple myeloma. Semin Hematol 1999;36(1 Suppl 3):30–3.

    PubMed  CAS  Google Scholar 

  174. Ono K, Ohtomo T, Yoshida K, et al. The humanized anti-HM1. 24 antibody effectively kills multiple myeloma cells by human effector cell-mediated cytotoxicity. Mol Immunol 1999;36(6):387–95.

    PubMed  CAS  Google Scholar 

  175. Stevenson GT. CD38 as a therapeutic target. Mol Med 2006;12(11–12):345–6.

    PubMed  CAS  Google Scholar 

  176. Lim SH, Zhang Y, Wang Z, Varadarajan R, Periman P, Esler WV. Rituximab administration following autologous stem cell transplantation for multiple myeloma is associated with severe IgM deficiency. Blood 2004;103(5):1971–2.

    PubMed  CAS  Google Scholar 

  177. Musto P, Carella AM, Jr., Greco MM, et al. Short progression-free survival in myeloma patients receiving rituximab as maintenance therapy after autologous transplantation. Br J Haematol 2003;123(4):746–7.

    PubMed  Google Scholar 

  178. Matsui W, Huff CA, Wang Q, et al. Characterization of clonogenic multiple myeloma cells. Blood 2004;103(6):2332–6.

    PubMed  CAS  Google Scholar 

  179. Clynes R. Antitumor antibodies in the treatment of cancer:Fc receptors link opsonic antibody with cellular immunity. Hematol Oncol Clin North Am 2006;20(3):585–612.

    PubMed  Google Scholar 

  180. Dhodapkar KM, Dhodapkar MV. Recruiting dendritic cells to improve antibody therapy of cancer. Proc Natl Acad Sci USA 2005;102(18):6243–4.

    PubMed  CAS  Google Scholar 

  181. Osterborg A, Yi Q, Henriksson L, et al. Idiotype immunization combined with granulocyte-macrophage colony-stimulating factor in myeloma patients induced type I, major histocompatibility complex-restricted, CD8- and CD4-specific T-cell responses. Blood 1998;91(7):2459–66.

    PubMed  CAS  Google Scholar 

  182. Rasmussen T, Hansson L, Osterborg A, Johnsen HE, Mellstedt H. Idiotype vaccination in multiple myeloma induced a reduction of circulating clonal tumor B cells. Blood 2003;101(11):4607–10.

    PubMed  CAS  Google Scholar 

  183. King CA, Spellerberg MB, Zhu D, et al. DNA vaccines with single-chain Fv fused to fragment C of tetanus toxin induce protective immunity against lymphoma and myeloma. Nat Med 1998;4(11):1281–6.

    PubMed  CAS  Google Scholar 

  184. Stritzke J, Zunkel T, Steinmann J, Schmitz N, Uharek L, Zeis M. Therapeutic effects of idiotype vaccination can be enhanced by the combination of granulo-cyte-macrophage colony-stimulating factor and interleukin 2 in a myeloma model. Br J Haematol 2003;120(1):27–35.

    PubMed  CAS  Google Scholar 

  185. Coscia M, Mariani S, Battaglio S, et al. Long-term follow-up of idiotype vaccination in human myeloma as a maintenance therapy after high-dose chemotherapy. Leukemia 2004;18(1):139–45.

    PubMed  CAS  Google Scholar 

  186. Reichardt VL, Brossart P. Dendritic cells in clinical trials for multiple myeloma. Methods Mol Med 2005;109:127–36.

    PubMed  CAS  Google Scholar 

  187. Liso A, Stockerl-Goldstein KE, Auffermann-Gretzinger S,. Idiotype vaccination using dendritic cells after autologous peripheral blood progenitor cell transplantation for multiple myeloma. Biol Blood Marrow Transplant 2000;6(6):621–7.

    PubMed  CAS  Google Scholar 

  188. Abdalla AO, Hansson L, Eriksson I, et al. Idiotype protein vaccination in combination with adjuvant cytokines in patients with multiple myeloma—evaluation of T-cell responses by different read-out systems. Haematologica 2007;92(1):110–4.

    PubMed  CAS  Google Scholar 

  189. Hansson L, Abdalla AO, Moshfegh A, et al. Long-term idiotype vaccination combined with interleukin-12 (IL-12), or IL-12 and granulocyte macrophage colony-stimulating factor, in early-stage multiple myeloma patients. Clin Cancer Res 2007;13(5):1503–10.

    PubMed  CAS  Google Scholar 

  190. Vasir B, Borges V, Wu Z, et al. Fusion of dendritic cells with multiple myeloma cells results in maturation and enhanced antigen presentation. Br J Haematol 2005;129(5):687–700.

    PubMed  CAS  Google Scholar 

  191. Mariani S, Coscia M, Even J, et al. Severe and long-lasting disruption of T-cell receptor diversity in human myeloma after high-dose chemotherapy and autolo-gous peripheral blood progenitor cell infusion. Br J Haematol 2001;113(4):1051–9.

    PubMed  CAS  Google Scholar 

  192. Brown RD, Yuen E, Nelson M, Gibson J, Joshua D. The prognostic significance of T cell receptor beta gene rearrangements and idiotype-reactive T cells in multiple myeloma. Leukemia 1997;11(8):1312–7.

    PubMed  CAS  Google Scholar 

  193. Rapoport AP, Stadtmauer EA, Aqui N, et al. Restoration of immunity in lympho-penic individuals with cancer by vaccination and adoptive T-cell transfer. Nat Med 2005;11(11):1230–7.

    PubMed  CAS  Google Scholar 

  194. Frohn C, Hoppner M, Schlenke P, Kirchner H, Koritke P, Luhm J. Anti-myeloma activity of natural killer lymphocytes. Br J Haematol 2002;119(3):660–4.

    PubMed  CAS  Google Scholar 

  195. Luhm J, Brand JM, Koritke P, Hoppner M, Kirchner H, Frohn C. Large-scale generation of natural killer lymphocytes for clinical application. J Hematother Stem Cell Res 2002;11(4):651–7.

    PubMed  Google Scholar 

  196. Azuma T, Otsuki T, Kuzushima K, Froelich CJ, Fujita S, Yasukawa M. Myeloma cells are highly sensitive to the granule exocytosis pathway mediated by WT1-specific cytotoxic T lymphocytes. Clin Cancer Res 2004;10(21):7402–12.

    PubMed  CAS  Google Scholar 

  197. Grube M, Moritz S, Obermann EC, et al. CD8 +T cells reactive to survivin antigen in patients with multiple myeloma. Clin Cancer Res 2007;13(3):1053–60.

    PubMed  CAS  Google Scholar 

  198. Dhodapkar KM, Krasovsky J, Williamson B, Dhodapkar MV. Antitumor monoclonal antibodies enhance cross-presentation of cellular antigens and the generation of myeloma-specific killer T cells by dendritic cells. J Exp Med 2002;195(1):125–33.

    PubMed  CAS  Google Scholar 

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Acknowledgments

MVD was supported in part by funds from the National Institutes of Health, Dana Foundation, and Damon Runyon Cancer Research Fund.

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  1. Laboratory of Tumor Immunology and Immunotherapy, The Rockefeller University, New York, NY, USA

    Madhav V. Dhodapkar

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  1. Winship Cancer Institute, Emory University, B3307 Clifton Road, Atlanta, GA, 30322, USA

    Sagar Lonial MD

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Dhodapkar, M.V. (2008). Immunobiology and Immunotherapy of Multiple Myeloma. In: Lonial, S. (eds) Myeloma Therapy. Contemporary Hematology. Humana Press. https://doi.org/10.1007/978-1-59745-564-0_11

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