Abstract
Sepsis is the clinical syndrome denoting systemic inflammatory response to an infection. There is some confusion over the use of the terms “bacteremia” and “septicemia.” Most studies in the United States used the term bacteremia to denote a positive blood culture with evidence of infection. Septicemia was used to denote a state of microbial invasion from a portal of entry into the bloodstream that causes signs of illness. Sepsis syndrome was initially described by Bone et al. to identify a population of patients at risk for adult respiratory distress syndrome (ARDS) and death (1).
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References
Bone, R.C., Fisher, C.J., Clemmer, T.P., et al. (1989) Sepsis syndrome: a valid clinical entity. Crit. Care Med. 17, 389–393.
Bone, R.C., Balk, R.A., Cerra, F.B., et al. (1992) American College of Chest Physicians/ Society of Critical Care Medicine Consensus Conference: definitions for sepsis and multiple-organ failure and guidelines for the use of innovative therapies in sepsis. Chest 101, 1644–1655.
Rangel-Frausto, M.S., Pittet, D., Costigan, M., et al. (1996) The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA 273, 117–123.
Bernard, R.B. (1997) Issues in the design of clinical trials for sepsis. Cytokines and pulmonary infection. Part 2; the role of cytokines in systemic and pulmonary medicine. ATS Continuing Education Monograph Series (Pratter, M.R., ed. ), American Thoracic Society New York, pp 1–6.
Centers for Disease Control and Prevention. Increase in national hospital discharge survey rates for septicemia, United States 1979–1987. (1990) M.M.W.R. 39, 31–34.
CDC National Center for Health Statistics. Mortality patterns-United States, 1990. (1993) Monthly Vital Stat. Rep. 41, 45.
Sands, K.E., Bates, D.W., Lanken, P.N,. et al. (1997) Epidemiology of sepsis syndrome in 8 academic medical centers. JAMA 278, 234–240.
Brun-Buisson, C., Doyon, F., Carlet, J., et al. (1995) Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. JAMA 274, 968–974.
Knaus, W.A., Harrell, F.E., Fisher, C.J., et al. (1993) The clinical evaluation of new drugs for sepsis. A prospective study design based on survival analysis. JAMA 270, 1233–1241.
Geerdes, H.F., Ziegler, D., Lode H., et al. (1992) Septicemia in 980 patients at a university hospital in Berlin: prospective studies during 4 selected years between 1979 and 1989. Clin. Infect. Dis. 15, 991–1002.
Niederman, M.S. and Fein, A.M. (1990) Sepsis syndrome, the adult respiratory distress syndrome, and nosocomial pneumonia: a common clinical sequence. Clin. Chest Med. 11, 663–665.
Friedman, G., Silva, E., and Vincent, J.L. (1998) Has the mortality of septic shock changed with time? Crit. Care Med. 26, 2078–2086.
Pinner, R.W., Tutsch, S.M., Simonsen, L., et al. (1996) Trends in infectious diseases mortality in the United States JAMA 275, 189–193.
Winn, T., Tayback, M., and Israel, E. (1991) Mortality due to septicemia in the elderly: factors accounting for a rapid rise. Maryland Med. J. 40, 803–807.
McCue, J.D. (1987) Gram-negative bacillary bacteremia in the elderly: incidence, ecology, etiology and mortality. J. Am. Geriatr. Soc. 35, 213–218.
Sonnenblick, M., Carmon, M., Rudenski, B., et al. (1990) Septicemia in the elderly: incidence, etiology and prognostic factors. Isr. J. Med. Sci. 26, 195–199.
Parker, M.M. and Parrillo, J.E. (1983) Septic shock. Hemodynamics and pathogenesis. JAMA 250, 3324–3327.
Bone, R.C. (1991) The pathogenesis of sepsis. Ann. Intern. Med. 115, 457–469.
Boldt, J., Muller, M., Heesen, M., et al. (1997) Does age influence circulating adhesion molecules in the critically ill? Crit. Care Med. 25, 95–100.
Rink, L., Cakman, I., and Kirchner, H. (1998) Altered cytokine production in the elderly. Mech. Ageing Dey. 102(2–3), 199–209.
Chassagne, P., Perol, M.B., Trivalle, C., et al. (1996) Is presentation of bacteremia in the elderly the same as in younger patients. Am. J. Med. 100, 65–70.
Van Dijk, J.M., Rosin, A.J., and Rudenski, B. (1982) in the elderly. Practitioner 226, 1439–1443.
Windsor, A.C.M. (1983) Bacteraemia in a geriatric unit. Gerontology 29, 125–130.
Finkelstein, M.S., Petkun, W.M., Freedman, M.L., et al. (1983) Pneumococcal bacteremia in adults: Age-dependent differences in presentation and in outcome. J. Am. Geriatr. Soc. 31, 19–27.
Gleckman, R. and Hibert, D. (1982) Afebrile bacteremia. A phenomenon in geriatric patients. JAMA 248, 1478–1481.
Miller, D., Yoshikawa, T., Castle, S.C., et al. (1991) Effect of age on fever response to recombinant tumor necrosis factor alpha in a murine model. J. Gerontol. 46, M176–179.
Norman, D.C. and Yoshikawa, T.T. (1983) Intraabdominal infections in the elderly. J. Am. Geriatr. Soc. 31, 677–684.
Weinstein, M.P., Towns, M.L., Quartey, S.M., et al. (1997) The clinical significance of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults. Clin. Infect. Dis. 24, 584–602.
Gransden, W.R. (1994) Septicemia in the newborn and elderly. J. Antimicrob. Chemother. 34(Suppl. A), 101–119.
Muder, R.R., Brennen, C., Wagener, M.M., et al (1992) Bacteremia in a long-term-care facility: five-year prospective study of 163 consecutive episodes. Clin. Infect. Dis. 14, 647–654.
Kreger, B.E., Craven, D.E., Carling, P.C., et al. (1980) Gram-negative bacteremia. III. Reassessment of etiology, epidemiology and ecology in 612 patients. Am. J. Med. 68, 332–343.
Howell, T.H. (1948) Normal temperatures in old age. Lancet 1, 517–520.
Castle, S.C., Norman, D.C., Yeh, M., et al. (1991) Fever response in elderly nursing home residents. Are the older truly colder? J. Am. Geriatr. Soc. 39, 853–857.
Bender, B. (1992) Sepsis. Clin. Geriatr. Med. 8, 913–924.
Iberti, T.J., Bone, R.C., Fein, A., et al. (1993) Are the criteria used to determine sepsis applicable for patients >75 years of age? Crit. Care Med. 21, S130.
Esposito, A.L.M., Gleckman, R.A., Cram, S. et al. (1980) Community-acquired bacteremia in the elderly: analysis of one hundred consecutive episodes. J. Am. Geriatr. Soc. 28, 315–319.
Centers for Disease Control and Prevention. (1990) Increase in national hospital discharge survey rates for septicemia: United States, 1979–1987. (1990) M.M.W.R. 39, 31–34.
Leibovici, L., Pitlik, S.D., Konisberger, H., et al. (1993) Bloodstream infections in patients older than eighty years. Age Ageing 22, 431–442.
Setia, U., Serventi, I., and Lorenz, P. (1984) Bacteremia in a long-term care facility. Arch. Intern. Med. 144, 1633–1635.
Meyers, B.R., Sherman, E., Mendelson, M.H., et al. (1989) Bloodstream infections in the elderly. Am. J. Med. 86, 379–386.
Madden, J.W., Croker, J.R., and Beynon, C.P.J. (1981) Septicemia in the elderly. Postgrad. Med. J. 57, 502–509.
Rudman, D., Hontanosas, A., Cohen, Z., et al. (1988) Clinical correlates of bacteremia in a Veterans Administration extended care facility. J. Am. Geriatr. Soc. 36, 726–732.
Saviteer, S.M., Samsa, G.P., and Rutala, W.A. (1998) Nosocomial infections in the elderly. Increased risk per hospital day. Am. J. Med. 84, 661–666.
Whitelaw, D.A., Rayner, B.L., and Willcox, P.A. (1992) Community-acquired bacteremia in the elderly: A prospective study of 121 cases. J. Am. Geriatr. Soc. 40, 996–1000.
Arbo, M.D.J. and Snydman, D.R. (1994) Influence of blood culture results on antibiotic choice in the treatment of bacteremia. Arch. Intern. Med. 154, 2641–2644.
Levy, M., Dremer, F., and Brion, N. (1998) Community-acquired pneumonia: importance of initial noninvasive bacteriologic investigations. Chest 92, 43–48.
Caldwell, A., Glauser, F.L., Smith, W.R., et al. (1975) The effects of dehydration on the radiologic and pathologic appearance of experimental canine segmental pneumonia. Am. Rev. Respir. Dis. 112, 651–656.
Hall, F.M., Simon, B. (1987) Occult pneumonia associated with dehydration: myth or reality. Am. J. Roentgenol. 148, 853–854.
Mueller, P.R. and Simeonne, J.F. (1983) Intraabdominal abcesses diagnosis by sonography and computed tomography. Radiol. Clin. North Am. 21, 425–448.
Van Dissel, J.T., van Langevelde, P., Westendorp, R.G., et al. (1998) Anti-inflammatory cytokine profile and mortality in febrile patients. Lancet 28, 950–953.
Cunha, B.A. (1992) Sepsis and its mimics. Intern. Med. 13, 48–52.
Lundberg, J.S., Perl, T.M., Wiblin, T., et al. (1998) Septic shock: An analysis of outcomes for patients with onset on hospital wards versus intensive care units. Crit. Care Med. 26, 1020–1024.
Diep, D., Tran, A., Johan, B., et al. (1990) Age, chronic disease, sepsis, organ system failure, and mortality in a medical intensive care unit. Crit. Care Med. 18, 474–479.
Deulofeu, F., Cervello., B, Capell, S., et al. (1998) Predictors of mortality in patients with bacteremia: The importance of functional status. J. Am. Geriatr. Soc. 46, 14–18.
Leibovici, L., Paul, M., Poznanski, O., et al. (1997) Monotherapy versus beta-lactam aminoglycoside combination treatment for gram-negative bacteremia: a prospective, observational study. Antimicrob. Agents Chemother. 41, 1127–1138.
Kollef, M.H., Sherman, G., Ward, S., et al. (1999) Inadequate antimicrobial treatment of infections:A risk factor for hospital mortality among critically ill patients. Chest 115, 462–474.
Cunha, BA. (1995) Antibiotic treatment of sepsis. Med. Clin. North Am. 79, 551–558.
Ognibene, F.P. (1996) Hemodynamic support during sepsis. Clin. Chest Med. 17, 279–287.
Connors, A.F. Jr, Speroff, T., Dawson, N.V., et al (1998) The effectiveness of right heart catheterization in the initial care of critically ill patients. JAMA 18, 889–897.
Parker, M.M. and Peruzzi, W. (1997) Pulmonary artery catheters in sepsis/septic shock. New Horiz. 5, 228–232.
Alia, I., Esteban, A., Gordo, F., et al. (1999) A randomized and controlled trial of the effect of treatment aimed at maximizing oxygen delivery in patients with severe sepsis or septic shock. Chest 115, 453–461.
Maynard, N.D., Bihari, D.J., Dalton, R.N., et al. (1995) Increasing splanchnic blood flow in the critically ill. Chest 108, 1648–1654.
Meadows, D., Edwards, J.D., Wilkins, R.G., et al. (1998) Reversal of intractable septic shock with norepinephrine therapy. Crit. Care Med. 16, 663–666.
Vincent, J.L., Roman, A., and Kahn, R.J. (1990) Dobutamine administration in septic shock: addition to a standard protocol. Crit. Care Med. 18, 689–693.
Rudis, M.I., Basha, M.A., and Zarowitz, B.J. (1996) Is it time to reposition vasopressors and inotropes in sepsis? Cuit. Care Med. 24, 525–537.
Hamel, M.B., Teno, J.M., Goldman, L., et al. (1999) Patient age and decisions to withhold life-sustaining treatments from seriously ill, hospitalized adults. SUPPORT Investigators. Study to understand prognoses and preferences for outcomes and risks of treatment. Ann. Intern. Med. 130, 116–125.
Marik, P.E. and Sibbald, W.J. (1993) Effect of stored-blood transfusion on oxygen delivery in patients with sepsis. JAMA 269, 3024–3029.
Mullin, T.J. and Kirkpatrick, J.R. (1981) The effect of nutritional support on immune competency in patients suffering form trauma, sepsis, or malignant disease. Surgery 90, 610–615.
Navab, F., Steingrub, J. (1995) Stress ulcer: is routine prophylaxis necessary? Am. J. Gastroenterol. 90, 708–712. -
Cook, D., Guyatt, G., and Marshall, J. (1998) A comparison between sucralfate and ranitidine for the prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials. N. Engl. J. Med. 398, 791–807.
Prod’hom, G., Leuenberger, P., Koerfer, J., et al. (1997) Nosocomial pneumonia in mechanically ventilated patients receiving antacid, ranitidine, or sucralfate as prophylaxis for stress ulcer. Ann. Intern. Med. 120, 653–662.
Centers for Disease Control and Prevention. (1997) Guideline for prevention of nosocomial pneumonia. M.M.W.R. 46(RR-1), 1–79.
Walsh, C.J., Sugerman, H.J., Mullen, P.G., et al. (1992) Monoclonal antibody to tumor necrosis factor alpha attenuates cardiopulmonary dysfunction in porcine Gram-negative sepsis. Arch. Surg. 127, 138–144.
Fisher, C.J. Jr., Opal, S.M., Lowry, S.F, et al. (1994) Role of IL-1 and the therapeutic potential of IL-1 receptor antagonist in sepsis. Circ. Shock 44, 1–8.
Abraham, E., Wunderink, R., Silverman, H., et al. (1995) Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome: a randomized, controlled, double-blind, multicenter clinical trial. JAMA 273, 934–941.
Cohen, J. and Carlet, J. (1996) INTERSEPT: an international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. Crit. Care Med. 24, 1431–1440.
Abraham, E., Anzueto, A., Gutierrez, G., et al. (1998) Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. NORASEPT II Study Group. Lancet 28, 929–933.
Greenman, R.L., Schein, R.M.H, and Martin, M.A. (1991) A controlled clinical trial of-E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. JAMA 266, 1097–1102.
Bone, R.C., Balk, R.A., and Fein, A.M. (1995) A second randomized large controlled clinical study of E 5, a monoclonal antibody to endotoxin, multicenter, randomized, controlled trial. Crit. Care Med. 23, 994–1006.
Lefering, R. and Neugebauer, E.A.M. (1995) Steroid controversy in sepsis and septic shock: a meta-analysis. Crit. Care Med. 23, 1294–1303.
Haupt, M.T., Jastremski, M.S., Clemmer, T.P., et al. (1991) Effects of ibuprofen in patients with severe sepsis: a randomized double-blind, multicenter study. Crit. Care Med. 19, 1339–1347
King, D.W., Pushparaj, N., and O’Toole, K. (1992) Morbidity and mortality in the aged. Hosp. Pract. 17(2), 97–109.
Bolton, C.F., Young, G.B., and Zochodne, D.W. (1993) The neurological complications of sepsis. Ann. Neurol. 33, 94–100.
Schlag, G., Krosl, P., and Redl, H. (1988) Cardiopulmonary response of the elderly to traumatic and septic shock. Prog. Clin. Biol. Res. 264, 233–242.
Chan, E.D. and Welsh, C.H. (1998) Geriatric respiratory medicine. Chest 114, 1704–1733.
Dematte, J.E., Barnard, M.L., and Sznajder, J.I. (1997) Acute respiratory failure in sepsis, in Sepsis and Multiorgan Failure ( Fein, A.M., ed.), Williams and Wilkins, MD, pp. 155–167.
Hussain, S.N. (1998) Respiratory muscle dysfunction in sepsis. Mol. Cell Biochem. 179, 125–134.
Xu, D., Lu, Q., Guillory, D., et al. (1993) Mechanisms of endotoxin-induced intestinal injury in a hyperdynamic model of sepsis. J. Trauma 34, 676–683.
Van Lanschot, J.J.B., Mealy, K., and Wilmore, D.W. (1990) The effects of tumor necrosis factor on intestinal structure and metabolism. Ann. Surg. 212, 663–670.
Doig, C.J., Sutherland, L.R., Snadham, J.D., et al. (1998) Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients. Am. J. Respir. Crit. Care Med. 158, 444.
Matuschak, G.M. (1997) Liver dysfunction in sepsis, in Sepsis and Multiorgan Failure ( Fein, A.M., ed.), Williams and Wilkins, MD, pp. 168–180.
Neveu, H., Kleinknecht D., Brivet F., et al. (1996) Prognostic factors in acute renal failure due to sepsis. Results of a prospective multicenter study. The French study group on acute renal failure. Nephrol. Dial. Transplant 11, 293–299.
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Chintanadilok, J., Bender, B.S. (2001). Sepsis. In: Yoshikawa, T.T., Norman, D.C. (eds) Infectious Disease in the Aging. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-026-1_5
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