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Omics Approaches to Understanding Muscle Biology pp 193–217Cite as

Skeletal Muscle Metabolomics for Metabolic Phenotyping and Biomarker Discovery

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Part of the book series: Methods in Physiology ((METHPHYS))

Abstract

Metabolism is the process of chemical transformation within a biological context. Metabolites comprise all the small-molecule (<1 kDa) substrates and end products of metabolism, including sugars, nucleotides, lipids, amino acids, organic acids, ketones, aldehydes, amines, alkaloids, phenols, steroids, small peptides, xenobiotics, and drugs. Similar in scope to other high-throughput “omics” technologies, the aim of metabolomics is to comprehensively and unbiasedly detect, identify, and quantify the metabolome, i.e., the full complement of small molecules found in cells, biological fluids, or tissues. Here we present a brief introduction of how skeletal muscle metabolomics can be used for metabolic phenotyping and biomarker discovery.

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Authors and Affiliations

  1. Division of Molecular Endocrinology, Institute for Diabetes and Cancer, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany

    Kenneth Allen Dyar

  2. German Center for Diabetes Research (DZD), Neuherberg, Germany

    Kenneth Allen Dyar & Jerzy Adamski

  3. Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany

    Anna Artati, Alexander Cecil & Jerzy Adamski

  4. Lehrstuhl für Experimentelle Genetik, Technische Universität München, Freising-Weihenstephan, Germany

    Jerzy Adamski

  5. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

    Jerzy Adamski

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Correspondence to Kenneth Allen Dyar .

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  1. Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, Merseyside, UK

    Jatin George Burniston

  2. Children’s National Health System, George Washington University, Washington, DC, USA

    Yi-Wen Chen

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Dyar, K.A., Artati, A., Cecil, A., Adamski, J. (2019). Skeletal Muscle Metabolomics for Metabolic Phenotyping and Biomarker Discovery. In: Burniston, J., Chen, YW. (eds) Omics Approaches to Understanding Muscle Biology. Methods in Physiology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-9802-9_10

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