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Targeted MR Imaging in Cardiovascular Disease

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Cardiovascular Magnetic Resonance Imaging

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Molecular imaging refers to the use of targeted imaging agents to detect molecular and cellular processes in the body. Some of these processes are associated with highly expressed targets, which can be imaged with only slight modifications to conventional small gadolinium chelates. However, many biological processes of interest occur in the low nanomolar range and require larger constructs with higher sensitivity to be developed. A large number of probes have been developed for preclinical imaging, targeting processes in both the vessel wall and myocardium. Several of these probes have been used in the clinical setting too, with excellent results and no adverse effects. The development of 19F (fluorine)-based imaging agents and integrated positron emission tomography magnetic resonance (PET-MR) scanners offers further opportunities. While the clinical translation of radiolabeled probes is in some ways easier, molecular MR agents have several conceptual advantages and could play an important role in the development of personalized therapies for cardiovascular disease.

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Authors and Affiliations

  1. Massachusetts General Hospital, Harvard Medical School, Martinos Center for Biomedical Imaging, Charlestown, MA, USA

    David E. Sosnovik & Peter Caravan

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  1. David E. Sosnovik
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  2. Peter Caravan
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Correspondence to David E. Sosnovik .

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Editors and Affiliations

  1. Cardiovascular Division, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, USA

    Raymond Y. Kwong

  2. Department of Radiology, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, USA

    Michael Jerosch-Herold

  3. Department of Cardiac Sciences, University of Calgary, Calgary, AB, Canada

    Bobak Heydari

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Sosnovik, D.E., Caravan, P. (2019). Targeted MR Imaging in Cardiovascular Disease. In: Kwong, R., Jerosch-Herold, M., Heydari, B. (eds) Cardiovascular Magnetic Resonance Imaging. Contemporary Cardiology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-8841-9_24

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