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CMR Assessment of Cardiac Masses

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Cardiovascular Magnetic Resonance Imaging

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Cardiac masses are rare entities; however, they can cause significant morbidity and mortality. The management of cardiac masses varies based on patient’s clinical symptoms, type, and extension of the mass. Clinical symptoms are nonspecific, and usually these masses are great masqueraders of common cardiac and systemic diseases. Therefore, cardiac imaging plays a substantial role in the management of cardiac masses. Multiple imaging modalities are available, including echocardiography, cardiac computed tomography (CT), cardiac F-18 fluoro-2-deoxy-D-glucose (FDG), positron emission tomography (PET)/CT, and cardiac magnetic resonance (CMR) imaging. Evaluation of patients with clinical suspicion for cardiac masses begins with echocardiography; however, CMR imaging is usually considered as the next step in comprehensive assessment. In addition to the tissue and blood flow characterization within the mass, CMR imaging can assess cardiac function as well as extracardiac involvement. This chapter provides a detailed review of cardiac masses including CMR imaging findings and an overview of the optimal CMR imaging techniques.

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References

  1. Travis WD, World Health Organization, International Agency for Research on Cancer, International Association for the Study of Lung Cancer, International Academy of Pathology. Pathology and genetics of tumours of the lung, pleura, thymus and heart. Lyon/Oxford: IARC Press/Oxford University Press (distributor); 2004. 344 pgs.

    Google Scholar 

  2. Reynen K. Frequency of primary tumors of the heart. Am J Cardiol. 1996;77(1):107.

    Article  CAS  PubMed  Google Scholar 

  3. Sutsch G, Jenni R, von Segesser L, Schneider J. Heart tumors: incidence, distribution, diagnosis. Exemplified by 20,305 echocardiographies. Schweizerische Medizinische Wochenschrift. 1991;121(17):621–9.

    CAS  PubMed  Google Scholar 

  4. Lam KY, Dickens P, Chan AC. Tumors of the heart. A 20-year experience with a review of 12,485 consecutive autopsies. Arch Pathol Lab Med. 1993;117(10):1027–31.

    CAS  PubMed  Google Scholar 

  5. Abraham KP, Reddy V, Gattuso P. Neoplasms metastatic to the heart: review of 3314 consecutive autopsies. Am J Cardiovasc Pathol. 1990;3(3):195–8.

    CAS  PubMed  Google Scholar 

  6. Klatt EC, Heitz DR. Cardiac metastases. Cancer. 1990;65(6):1456–9.

    Article  CAS  PubMed  Google Scholar 

  7. McManus B. Primary tumors of the heart. In: Bonow RO, Mann DL, Zipes DP, et al., editors. Braunwald’s heart disease. 9th ed. Philadelphia: Elsevier Saunders; 2012. p. 1638–50.

    Google Scholar 

  8. McAllister HA Jr. Primary tumors and cysts of the heart and pericardium. Curr Probl Cardiol. 1979;4(2):1–51.

    Article  PubMed  Google Scholar 

  9. Elbardissi AW, Dearani JA, Daly RC, Mullany CJ, Orszulak TA, Puga FJ, et al. Survival after resection of primary cardiac tumors: a 48-year experience. Circulation. 2008;118(14 Suppl):S7–15.

    Article  PubMed  Google Scholar 

  10. Burke A, Virmani R. Tumors of the heart and great vessels: atlas of tumor pathology. 3rd ed. Washington, DC: Armed Forces Institute of Pathology; 1996.

    Google Scholar 

  11. Roberts WC. Primary and secondary neoplasms of the heart. Am J Cardiol. 1997;80(5):671–82.

    Article  CAS  PubMed  Google Scholar 

  12. Burazor I, Aviel-Ronen S, Imazio M, Markel G, Grossman Y, Yosepovich A, et al. Primary malignancies of the heart and pericardium. Clin Cardiol. 2014;37(9):582–8.

    PubMed  PubMed Central  Google Scholar 

  13. Butany J, Nair V, Naseemuddin A, Nair GM, Catton C, Yau T. Cardiac tumours: diagnosis and management. Lancet Oncol. 2005;6(4):219–28.

    Article  PubMed  Google Scholar 

  14. Bruce CJ. Cardiac tumours: diagnosis and management. Heart. 2011;97(2):151–60.

    Article  PubMed  Google Scholar 

  15. Grebenc ML, Rosado-de-Christenson ML, Green CE, Burke AP, Galvin JR. Cardiac myxoma: imaging features in 83 patients. Radiographics. 2002;22(3):673–89.

    Article  PubMed  Google Scholar 

  16. Pinede L, Duhaut P, Loire R. Clinical presentation of left atrial cardiac myxoma. A series of 112 consecutive cases. Medicine. 2001;80(3):159–72.

    Article  CAS  PubMed  Google Scholar 

  17. Mendoza CE, Rosado MF, Bernal L. The role of interleukin-6 in cases of cardiac myxoma. Clinical features, immunologic abnormalities, and a possible role in recurrence. Tex Heart Inst J. 2001;28(1):3–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Elbardissi AW, Dearani JA, Daly RC, Mullany CJ, Orszulak TA, Puga FJ, et al. Embolic potential of cardiac tumors and outcome after resection: a case-control study. Stroke. 2009;40(1):156–62.

    Article  PubMed  Google Scholar 

  19. Ekinci EI, Donnan GA. Neurological manifestations of cardiac myxoma: a review of the literature and report of cases. Intern Med J. 2004;34(5):243–9.

    Article  CAS  PubMed  Google Scholar 

  20. Sabolek M, Bachus-Banaschak K, Bachus R, Arnold G, Storch A. Multiple cerebral aneurysms as delayed complication of left cardiac myxoma: a case report and review. Acta Neurol Scand. 2005;111(6):345–50.

    Article  CAS  PubMed  Google Scholar 

  21. Acebo E, Val-Bernal JF, Gomez-Roman JJ, Revuelta JM. Clinicopathologic study and DNA analysis of 37 cardiac myxomas: a 28-year experience. Chest. 2003;123(5):1379–85.

    Article  PubMed  Google Scholar 

  22. Kocak H, Ozyazicioglu A, Gundogdu C, Sevimli S. Cardiac hemangioma complicated with cerebral and coronary embolization. Heart Vessel. 2005;20(6):296–7.

    Article  Google Scholar 

  23. Fox E, Brunson C, Campbell W, Aru G. Cardiac papillary fibroelastoma presents as an acute embolic stroke in a 35-year-old African American male. Am J Med Sci. 2006;331(2):91–4.

    Article  PubMed  Google Scholar 

  24. Pomper GJ, Gianani R, Johnston RJ, Rizeq MN. Cardiac angiosarcoma: an unusual presentation with cutaneous metastases. Arch Pathol Lab Med. 1998;122(3):273–6.

    CAS  PubMed  Google Scholar 

  25. Sinatra R, Brancaccio G, di Gioia CRT, De Santis M, Sbraga F, Gallo P. Integrated approach for cardiac angiosarcoma. Int J Cardiol. 2003;88(2–3):301–4.

    Article  PubMed  Google Scholar 

  26. Motwani M, Kidambi A, Herzog BA, Uddin A, Greenwood JP, Plein S. MR imaging of cardiac tumors and masses: a review of methods and clinical applications. Radiology. 2013;268(1):26–43.

    Article  PubMed  Google Scholar 

  27. Meng Q, Lai H, Lima J, Tong W, Qian Y, Lai S. Echocardiographic and pathologic characteristics of primary cardiac tumors: a study of 149 cases. Int J Cardiol. 2002;84(1):69–75.

    Article  PubMed  Google Scholar 

  28. Hendel RC, Patel MR, Kramer CM, Poon M, Hendel RC, Carr JC, et al. ACCF/ACR/SCCT/SCMR/ASNC/NASCI/SCAI/SIR 2006 appropriateness criteria for cardiac computed tomography and cardiac magnetic resonance imaging: a report of the American College of Cardiology Foundation Quality Strategic Directions Committee Appropriateness Criteria Working Group, American College of Radiology, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, American Society of Nuclear Cardiology, North American Society for Cardiac Imaging, Society for Cardiovascular Angiography and Interventions, and Society of Interventional Radiology. J Am Coll Cardiol. 2006;48(7):1475–97.

    Article  PubMed  Google Scholar 

  29. O’Donnell DH, Abbara S, Chaithiraphan V, Yared K, Killeen RP, Cury RC, et al. Cardiac tumors: optimal cardiac MR sequences and spectrum of imaging appearances. AJR Am J Roentgenol. 2009;193(2):377–87.

    Article  PubMed  Google Scholar 

  30. Altbach MI, Squire SW, Kudithipudi V, Castellano L, Sorrell VL. Cardiac MRI is complementary to echocardiography in the assessment of cardiac masses. Echocardiography. 2007;24(3):286–300.

    Article  PubMed  Google Scholar 

  31. Hundley WG, Bluemke DA, Finn JP, Flamm SD, Fogel MA, Friedrich MG, et al. ACCF/ACR/AHA/NASCI/SCMR 2010 expert consensus document on cardiovascular magnetic resonance: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. Circulation. 2010;121(22):2462–508.

    Article  PubMed  Google Scholar 

  32. Pennell D, Sechtem U, Higgins C, Manning W, Pohost G, Rademakers F, et al. Clinical indications for cardiovascular magnetic resonance (CMR): Consensus Panel report. J Cardiovasc Magn Reson. 2004;6(4):727–65.

    Article  PubMed  Google Scholar 

  33. Fussen S, De Boeck BW, Zellweger MJ, Bremerich J, Goetschalckx K, Zuber M, et al. Cardiovascular magnetic resonance imaging for diagnosis and clinical management of suspected cardiac masses and tumours. Eur Heart J. 2011;32(12):1551–60.

    Article  PubMed  Google Scholar 

  34. Hoffmann U, Globits S, Schima W, Loewe C, Puig S, Oberhuber G, et al. Usefulness of magnetic resonance imaging of cardiac and paracardiac masses. Am J Cardiol. 2003;92(7):890–5.

    Article  PubMed  Google Scholar 

  35. Kramer CM, Barkhausen J, Flamm SD, Kim RJ, Nagel E, Society for Cardiovascular Magnetic Resonance Board of Trustees Task Force on Standardized P. Standardized cardiovascular magnetic resonance (CMR) protocols 2013 update. J Cardiovasc Magn Reson. 2013;15:91.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Sparrow PJ, Kurian JB, Jones TR, Sivananthan MU. MR imaging of cardiac tumors. Radiographics. 2005;25(5):1255–76.

    Article  PubMed  Google Scholar 

  37. Bouton S, Yang A, McCrindle BW, Kidd L, McVeigh ER, Zerhouni EA. Differentiation of tumor from viable myocardium using cardiac tagging with MR imaging. J Comput Assist Tomogr. 1991;15(4):676–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Simonetti OP, Finn JP, White RD, Laub G, Henry DA. “Black blood” T2-weighted inversion-recovery MR imaging of the heart. Radiology. 1996;199(1):49–57.

    Article  CAS  PubMed  Google Scholar 

  39. Reynen K. Cardiac myxomas. N Engl J Med. 1995;333(24):1610–7.

    Article  CAS  PubMed  Google Scholar 

  40. Kuon E, Kreplin M, Weiss W, Dahm JB. The challenge presented by right atrial myxoma. Herz. 2004;29(7):702–9.

    Article  PubMed  Google Scholar 

  41. Bjessmo S, Ivert T. Cardiac myxoma: 40 years’ experience in 63 patients. Ann Thorac Surg. 1997;63(3):697–700.

    Article  CAS  PubMed  Google Scholar 

  42. Premaratne S, Hasaniya NW, Arakaki HY, Mugiishi MM, Mamiya RT, McNamara JJ. Atrial myxomas: experiences with 35 patients in Hawaii. Am J Surg. 1995;169(6):600–3.

    Article  CAS  PubMed  Google Scholar 

  43. Carney JA, Gordon H, Carpenter PC, Shenoy BV, Go VL. The complex of myxomas, spotty pigmentation, and endocrine overactivity. Medicine. 1985;64(4):270–83.

    Article  CAS  PubMed  Google Scholar 

  44. Farah MG. Familial cardiac myxoma. A study of relatives of patients with myxoma. Chest. 1994;105(1):65–8.

    Article  CAS  PubMed  Google Scholar 

  45. Pucci A, Gagliardotto P, Zanini C, Pansini S, di Summa M, Mollo F. Histopathologic and clinical characterization of cardiac myxoma: review of 53 cases from a single institution. Am Heart J. 2000;140(1):134–8.

    Article  CAS  PubMed  Google Scholar 

  46. Orlandi A, Ferlosio A, Dell’Anna V, Quitadamo R, Pellegrino A, Spagnoli LG. Undifferentiated sarcoma of the heart: a rare clinicopathologic presentation. J Thorac Cardiovasc Surg. 2002;124(1):192–3.

    Article  PubMed  Google Scholar 

  47. Tazelaar HD, Locke TJ, McGregor CG. Pathology of surgically excised primary cardiac tumors. Mayo Clin Proc. 1992;67(10):957–65.

    Article  CAS  PubMed  Google Scholar 

  48. McCarthy PM, Piehler JM, Schaff HV, Pluth JR, Orszulak TA, Vidaillet HJ Jr, et al. The significance of multiple, recurrent, and “complex” cardiac myxomas. J Thorac Cardiovasc Surg. 1986;91(3):389–96.

    CAS  PubMed  Google Scholar 

  49. Kaminaga T, Takeshita T, Kimura I. Role of magnetic resonance imaging for evaluation of tumors in the cardiac region. Eur Radiol. 2003;13(Suppl 6):L1–L10.

    Article  PubMed  Google Scholar 

  50. Syed IS, Feng D, Harris SR, Martinez MW, Misselt AJ, Breen JF, et al. MR imaging of cardiac masses. Magn Reson Imaging Clin N Am. 2008;16(2):137–64, vii.

    Article  PubMed  Google Scholar 

  51. Masui T, Takahashi M, Miura K, Naito M, Tawarahara K. Cardiac myxoma: identification of intratumoral hemorrhage and calcification on MR images. AJR Am J Roentgenol. 1995;164(4):850–2.

    Article  CAS  PubMed  Google Scholar 

  52. Larsson S, Lepore V, Kennergren C. Atrial myxomas: results of 25 years’ experience and review of the literature. Surgery. 1989;105(6):695–8.

    CAS  PubMed  Google Scholar 

  53. Castells E, Ferran V, Octavio de Toledo MC, Calbet JM, Benito M, Fontanillas C, et al. Cardiac myxomas: surgical treatment, long-term results and recurrence. J Cardiovasc Surg. 1993;34(1):49–53.

    CAS  Google Scholar 

  54. Salanitri JC, Pereles FS. Cardiac lipoma and lipomatous hypertrophy of the interatrial septum: cardiac magnetic resonance imaging findings. J Comput Assist Tomogr. 2004;28(6):852–6.

    Article  PubMed  Google Scholar 

  55. Hananouchi GI, Goff WB 2nd. Cardiac lipoma: six-year follow-up with MRI characteristics, and a review of the literature. Magn Reson Imaging. 1990;8(6):825–8.

    Article  CAS  PubMed  Google Scholar 

  56. Kamiya H, Ohno M, Iwata H, Ohsugi S, Sawada K, Koike A, et al. Cardiac lipoma in the interventricular septum: evaluation by computed tomography and magnetic resonance imaging. Am Heart J. 1990;119(5):1215–7.

    Article  CAS  PubMed  Google Scholar 

  57. King SJ, Smallhorn JF, Burrows PE. Epicardial lipoma: imaging findings. AJR Am J Roentgenol. 1993;160(2):261–2.

    Article  CAS  PubMed  Google Scholar 

  58. Mullen JC, Schipper SA, Sett SS, Trusler GA. Right atrial lipoma. Ann Thorac Surg. 1995;59(5):1239–41.

    Article  CAS  PubMed  Google Scholar 

  59. Doshi S, Halim M, Singh H, Patel R. Massive intrapericardial lipoma, a rare cause of breathlessness. Investigations and management. Int J Cardiol. 1998;66(2):211–5.

    Article  CAS  PubMed  Google Scholar 

  60. Akram K, Hill C, Neelagaru N, Parker M. A left ventricular lipoma presenting as heart failure in a septuagenarian: a first case report. Int J Cardiol. 2007;114(3):386–7.

    Article  PubMed  Google Scholar 

  61. Grande AM, Minzioni G, Pederzolli C, Rinaldi M, Pederzolli N, Arbustini E, et al. Cardiac lipomas. Description of 3 cases. J Cardiovasc Surg. 1998;39(6):813–5.

    CAS  Google Scholar 

  62. Vanderheyden M, De Sutter J, Wellens F, Andries E. Left atrial lipoma: case report and review of the literature. Acta Cardiol. 1998;53(1):31–2.

    CAS  PubMed  Google Scholar 

  63. Burke AP, Litovsky S, Virmani R. Lipomatous hypertrophy of the atrial septum presenting as a right atrial mass. Am J Surg Pathol. 1996;20(6):678–85.

    Article  CAS  PubMed  Google Scholar 

  64. Araoz PA, Mulvagh SL, Tazelaar HD, Julsrud PR, Breen JF. CT and MR imaging of benign primary cardiac neoplasms with echocardiographic correlation. Radiographics. 2000;20(5):1303–19.

    Article  CAS  PubMed  Google Scholar 

  65. Sankar NM, Thiruchelvam T, Thirunavukkaarasu K, Pang K, Hanna WM. Symptomatic lipoma in the right atrial free wall. A case report. Tex Heart Inst J. 1998;25(2):152–4.

    CAS  PubMed  PubMed Central  Google Scholar 

  66. Ashar K, van Hoeven KH. Fatal lipoma of the heart. Am J Cardiovasc Pathol. 1992;4(1):85–90.

    CAS  PubMed  Google Scholar 

  67. Howard RA, Aldea GS, Shapira OM, Kasznica JM, Davidoff R. Papillary fibroelastoma: increasing recognition of a surgical disease. Ann Thorac Surg. 1999;68(5):1881–5.

    Article  CAS  PubMed  Google Scholar 

  68. Gowda RM, Khan IA, Nair CK, Mehta NJ, Vasavada BC, Sacchi TJ. Cardiac papillary fibroelastoma: a comprehensive analysis of 725 cases. Am Heart J. 2003;146(3):404–10.

    Article  PubMed  Google Scholar 

  69. Roberts WC. Papillary fibroelastomas of the heart. Am J Cardiol. 1997;80(7):973–5.

    Article  CAS  PubMed  Google Scholar 

  70. Kumar G, Macdonald RJ, Sorajja P, Edwards WD, Ommen SR, Klarich KW. Papillary fibroelastomas in 19 patients with hypertrophic cardiomyopathy undergoing septal myectomy. J Am Soc Echocardiogr. 2010;23(6):595–8.

    Article  PubMed  Google Scholar 

  71. Scalia D, Basso C, Rizzoli G, Lupia M, Budano S, Thiene G, et al. Should right-sided fibroelastomas be operated upon? J Heart Valve Dis. 1997;6(6):647–50.

    CAS  PubMed  Google Scholar 

  72. Aggarwal A, Leavitt BJ. Images in clinical medicine. Giant Lambl’s excrescences. N Engl J Med. 2003;349(25):e24.

    Article  PubMed  Google Scholar 

  73. Matsumoto N, Sato Y, Kusama J, Matsuo S, Kinukawa N, Kunimasa T, et al. Multiple papillary fibroelastomas of the aortic valve: case report. Int J Cardiol. 2007;122(1):e1–3.

    Article  PubMed  Google Scholar 

  74. Edwards FH, Hale D, Cohen A, Thompson L, Pezzella AT, Virmani R. Primary cardiac valve tumors. Ann Thorac Surg. 1991;52(5):1127–31.

    Article  CAS  PubMed  Google Scholar 

  75. Sun JP, Asher CR, Yang XS, Cheng GG, Scalia GM, Massed AG, et al. Clinical and echocardiographic characteristics of papillary fibroelastomas : a retrospective and prospective study in 162 patients. Circulation. 2001;103(22):2687–93.

    Article  CAS  PubMed  Google Scholar 

  76. Wintersperger BJ, Becker CR, Gulbins H, Knez A, Bruening R, Heuck A, et al. Tumors of the cardiac valves: imaging findings in magnetic resonance imaging, electron beam computed tomography, and echocardiography. Eur Radiol. 2000;10(3):443–9.

    Article  CAS  PubMed  Google Scholar 

  77. Kondruweit M, Schmid M, Strecker T. Papillary fibroelastoma of the mitral valve: appearance in 64-slice spiral computed tomography, magnetic resonance imaging, and echocardiography. Eur Heart J. 2008;29(6):831.

    Article  PubMed  Google Scholar 

  78. Kelle S, Chiribiri A, Meyer R, Fleck E, Nagel E. Images in cardiovascular medicine. Papillary fibroelastoma of the tricuspid valve seen on magnetic resonance imaging. Circulation. 2008;117(11):e190–1.

    Article  PubMed  Google Scholar 

  79. Klarich KW, Enriquez-Sarano M, Gura GM, Edwards WD, Tajik AJ, Seward JB. Papillary fibroelastoma: echocardiographic characteristics for diagnosis and pathologic correlation. J Am Coll Cardiol. 1997;30(3):784–90.

    Article  CAS  PubMed  Google Scholar 

  80. Shahian DM, Labib SB, Chang G. Cardiac papillary fibroelastoma. Ann Thorac Surg. 1995;59(2):538–41.

    Article  CAS  PubMed  Google Scholar 

  81. Eftychiou C, Antoniades L. Cardiac hemangioma in the left ventricle and brief review of the literature. J Cardiovasc Med. 2009;10(7):565–7.

    Article  Google Scholar 

  82. Kipfer B, Englberger L, Stauffer E, Carrel T. Rare presentation of cardiac hemangiomas. Ann Thorac Surg. 2000;70(3):977–9.

    Article  CAS  PubMed  Google Scholar 

  83. Zanati SG, Hueb JC, Cogni AL, de Morais MG, de Almeida Prado Franceschi LE, et al. Cardiac hemangioma of the right atrium. Eur J Echocardiogr. 2008;9(1):52–3.

    PubMed  Google Scholar 

  84. Oshima H, Hara M, Kono T, Shibamoto Y, Mishima A, Akita S. Cardiac hemangioma of the left atrial appendage: CT and MR findings. J Thorac Imaging. 2003;18(3):204–6.

    Article  PubMed  Google Scholar 

  85. Kojima S, Sumiyoshi M, Suwa S, Tamura H, Sasaki A, Kojima T, et al. Cardiac hemangioma: a report of two cases and review of the literature. Heart Vessels. 2003;18(3):153–6.

    Article  PubMed  Google Scholar 

  86. Palmer TE, Tresch DD, Bonchek LI. Spontaneous resolution of a large, cavernous hemangioma of the heart. Am J Cardiol. 1986;58(1):184–5.

    Article  CAS  PubMed  Google Scholar 

  87. Beroukhim RS, Prakash A, Buechel ER, Cava JR, Dorfman AL, Festa P, et al. Characterization of cardiac tumors in children by cardiovascular magnetic resonance imaging: a multicenter experience. J Am Coll Cardiol. 2011;58(10):1044–54.

    Article  PubMed  Google Scholar 

  88. Herman TE, Siegel MJ, McAlister WH. Cardiac tumor in Gorlin syndrome. Nevoid basal cell carcinoma syndrome. Pediatr Radiol. 1991;21(3):234–5.

    Article  CAS  PubMed  Google Scholar 

  89. Walpot J, Shivalkar B, Bogers JP, Salgado R, Rodrigus I, Van Marck E, et al. A patient with cardiac fibroma and a subvalvular aortic stenosis caused by a subvalvular membrane. J Am Soc Echocardiogr. 2007;20(7):906 e1-4.

    Article  PubMed  Google Scholar 

  90. Cina SJ, Smialek JE, Burke AP, Virmani R, Hutchins GM. Primary cardiac tumors causing sudden death: a review of the literature. Am J Forensic Med Pathol. 1996;17(4):271–81.

    Article  CAS  PubMed  Google Scholar 

  91. Patel J, Patel S, Sheppard MN. Benign cardiac tumours associated with sudden death. Europace. 2014;16(6):855–60.

    Article  PubMed  Google Scholar 

  92. Burke AP, Rosado-de-Christenson M, Templeton PA, Virmani R. Cardiac fibroma: clinicopathologic correlates and surgical treatment. J Thorac Cardiovasc Surg. 1994;108(5):862–70.

    CAS  PubMed  Google Scholar 

  93. Goel S, Chen O, Brichkov I, Lipton J, Seemanthini L, Shani J. Asymptomatic giant cardiac fibroma presenting as mitral valve prolapse in an adult patient. Int J Cardiovasc Imaging. 2015;31(2):315–7.

    Article  PubMed  Google Scholar 

  94. Luna A, Ribes R, Caro P, Vida J, Erasmus JJ. Evaluation of cardiac tumors with magnetic resonance imaging. Eur Radiol. 2005;15(7):1446–55.

    Article  PubMed  Google Scholar 

  95. Kiaffas MG, Powell AJ, Geva T. Magnetic resonance imaging evaluation of cardiac tumor characteristics in infants and children. Am J Cardiol. 2002;89(10):1229–33.

    Article  PubMed  Google Scholar 

  96. Beghetti M, Gow RM, Haney I, Mawson J, Williams WG, Freedom RM. Pediatric primary benign cardiac tumors: a 15-year review. Am Heart J. 1997;134(6):1107–14.

    Article  CAS  PubMed  Google Scholar 

  97. Grebenc ML, Rosado de Christenson ML, Burke AP, Green CE, Galvin JR. Primary cardiac and pericardial neoplasms: radiologic-pathologic correlation. Radiographics. 2000;20(4):1073–103; Quiz 110-1, 112.

    Article  CAS  PubMed  Google Scholar 

  98. Burke AP, Gatto-Weis C, Griego JE, Ellington KS, Virmani R. Adult cellular rhabdomyoma of the heart: a report of 3 cases. Hum Pathol. 2002;33(11):1092–7.

    Article  PubMed  Google Scholar 

  99. Krasuski RA, Hesselson AB, Landolfo KP, Ellington KJ, Bashore TM. Cardiac rhabdomyoma in an adult patient presenting with ventricular arrhythmia. Chest. 2000;118(4):1217–21.

    Article  CAS  PubMed  Google Scholar 

  100. Chen X, Hoda SA, Edgar MA. Cardiac rhabdomyoma. Arch Pathol Lab Med. 2002;126(12):1559.

    PubMed  Google Scholar 

  101. Berkenblit R, Spindola-Franco H, Frater RW, Fish BB, Glickstein JS. MRI in the evaluation and management of a newborn infant with cardiac rhabdomyoma. Ann Thorac Surg. 1997;63(5):1475–7.

    Article  CAS  PubMed  Google Scholar 

  102. Fieno DS, Saouaf R, Thomson LE, Abidov A, Friedman JD, Berman DS. Cardiovascular magnetic resonance of primary tumors of the heart: A review. J Cardiovasc Magn Reson. 2006;8(6):839–53.

    Article  PubMed  Google Scholar 

  103. Bosi G, Lintermans JP, Pellegrino PA, Svaluto-Moreolo G, Vliers A. The natural history of cardiac rhabdomyoma with and without tuberous sclerosis. Acta Paediatr. 1996;85(8):928–31.

    Article  CAS  PubMed  Google Scholar 

  104. Burke A, Virmani R. Pediatric heart tumors. Cardiovasc Pathol. 2008;17(4):193–8.

    Article  PubMed  Google Scholar 

  105. Nir A, Tajik AJ, Freeman WK, Seward JB, Offord KP, Edwards WD, et al. Tuberous sclerosis and cardiac rhabdomyoma. Am J Cardiol. 1995;76(5):419–21.

    Article  CAS  PubMed  Google Scholar 

  106. Lin JC, Palafox BA, Jackson HA, Cohen AJ, Gazzaniga AB. Cardiac pheochromocytoma: resection after diagnosis by 111-indium octreotide scan. Ann Thorac Surg. 1999;67(2):555–8.

    Article  CAS  PubMed  Google Scholar 

  107. Jeevanandam V, Oz MC, Shapiro B, Barr ML, Marboe C, Rose EA. Surgical management of cardiac pheochromocytoma. Resection versus transplantation. Ann Surg. 1995;221(4):415–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  108. Schirpenbach C, Hoppert T, Aleksic I, Neumann HP, Hahner S, Fassnacht M, et al. A 47-year-old patient with paroxysmal arterial hypertension and gastric tumors. Internist. 2012;53(9):1119–24.

    Article  CAS  PubMed  Google Scholar 

  109. Heufelder AE, Hofbauer LC. Greetings from below the aortic arch! The paradigm of cardiac paraganglioma. J Clin Endocrinol Metab. 1996;81(3):891–5.

    CAS  PubMed  Google Scholar 

  110. Hamilton BH, Francis IR, Gross BH, Korobkin M, Shapiro B, Shulkin BL, et al. Intrapericardial paragangliomas (pheochromocytomas): imaging features. AJR Am J Roentgenol. 1997;168(1):109–13.

    Article  CAS  PubMed  Google Scholar 

  111. Rana O, Gonda P, Addis B, Greaves K. Image in cardiovascular medicine. Intrapericardial paraganglioma presenting as chest pain. Circulation. 2009;119(12):e373–5.

    Article  PubMed  Google Scholar 

  112. Cane ME, Berrizbeitia LD, Yang SS, Mahapatro D, McGrath LB. Paraganglioma of the interatrial septum. Ann Thorac Surg. 1996;61(6):1845–7.

    Article  CAS  PubMed  Google Scholar 

  113. Goldstein DJ, Oz MC, Rose EA, Fisher P, Michler RE. Experience with heart transplantation for cardiac tumors. J Heart Lung Transplant. 1995;14(2):382–6.

    CAS  PubMed  Google Scholar 

  114. Orenstein HH, Green GE, Kancherla PL. Aortocoronary paraganglioma. Anatomic relationship of left coronary artery to paraganglia of aorta. New York State J Med. 1984;84(1):33–6.

    CAS  Google Scholar 

  115. Lee HH, Brenner WI, Vardhan I, Hyatt J, Terlecki M. Cardiac pheochromocytoma originating in the interatrial septum. Chest. 1990;97(3):760–2.

    Article  CAS  PubMed  Google Scholar 

  116. Stowers SA, Gilmore P, Stirling M, Morantz JM, Miller AB, Meyer LJ, et al. Cardiac pheochromocytoma involving the left main coronary artery presenting with exertional angina. Am Heart J. 1987;114(2):423–7.

    Article  CAS  PubMed  Google Scholar 

  117. Buckley O, Madan R, Kwong R, Rybicki FJ, Hunsaker A. Cardiac masses, part 2: key imaging features for diagnosis and surgical planning. AJR Am J Roentgenol. 2011;197(5):W842–51.

    Article  PubMed  PubMed Central  Google Scholar 

  118. Tomasian A, Lai C, Ruehm S, Krishnam MS. Cardiovascular magnetic resonance and PET-CT of left atrial paraganglioma. J Cardiovasc Magn Reson. 2010;12:1.

    Article  PubMed  PubMed Central  Google Scholar 

  119. Yendamuri S, Elfar M, Walkes JC, Reardon MJ. Aortic paraganglioma requiring resection and replacement of the aortic root. Interact Cardiovasc Thorac Surg. 2007;6(6):830–1.

    Article  PubMed  Google Scholar 

  120. Rakovich G, Ferraro P, Therasse E, Duranceau A. Preoperative embolization in the management of a mediastinal paraganglioma. Ann Thorac Surg. 2001;72(2):601–3.

    Article  CAS  PubMed  Google Scholar 

  121. Burke AP, Anderson PG, Virmani R, James TN, Herrera GA, Ceballos R. Tumor of the atrioventricular nodal region. A clinical and immunohistochemical study. Arch Pathol Lab Med. 1990;114(10):1057–62.

    CAS  PubMed  Google Scholar 

  122. Sharma G, Linden MD, Schultz DS, Inamdar KV. Cystic tumor of the atrioventricular node: an unexpected finding in an explanted heart. Cardiovasc Pathol. 2010;19(3):e75–8.

    Article  PubMed  Google Scholar 

  123. Monma N, Satodate R, Tashiro A, Segawa I. Origin of so-called mesothelioma of the atrioventricular node. An immunohistochemical study. Arch Pathol Lab Med. 1991;115(10):1026–9.

    CAS  PubMed  Google Scholar 

  124. Wolf PL, Bing R. The smallest tumor which causes sudden death. JAMA. 1965;194(6):674–5.

    Article  CAS  PubMed  Google Scholar 

  125. Guo J, Zuo S, Lin C, Ji Y. Surgical treatment of a giant cystic tumor of the atrioventricular nodal region. Interact Cardiovasc Thorac Surg. 2009;8(5):592–3.

    Article  PubMed  Google Scholar 

  126. Strom EH, Skjorten F, Stokke ES. Polycystic tumor of the atrioventricular nodal region in a man with Emery-Dreifuss muscular dystrophy. Pathol Res Pract. 1993;189(8):960–4; Discussion 5–7.

    Article  CAS  PubMed  Google Scholar 

  127. Law KB, Feng T, Nair V, Cusimano RJ, Butany J. Cystic tumor of the atrioventricular node: rare antemortem diagnosis. Cardiovasc Pathol. 2012;21(2):120–7.

    Article  PubMed  Google Scholar 

  128. Randhawa K, Ganeshan A, Hoey ET. Magnetic resonance imaging of cardiac tumors: part 1, sequences, protocols, and benign tumors. Curr Probl Diagn Radiol. 2011;40(4):158–68.

    Article  PubMed  Google Scholar 

  129. Tran TT, Starnes V, Wang X, Getzen J, Ross BD. Cardiovascular magnetics resonance diagnosis of cystic tumor of the atrioventricular node. J Cardiovasc Magn Reson. 2009;11:13.

    Article  PubMed  PubMed Central  Google Scholar 

  130. Balasundaram S, Halees SA, Duran C. Mesothelioma of the atrioventricular node: first successful follow-up after excision. Eur Heart J. 1992;13(5):718–9.

    Article  CAS  PubMed  Google Scholar 

  131. Saito S, Kobayashi J, Tagusari O, Bando K, Niwaya K, Nakajima H, et al. Successful excision of a cystic tumor of the atrioventricular nodal region. Circ J. 2005;69(10):1293–4.

    Article  PubMed  Google Scholar 

  132. Kaji T, Takamatsu H, Noguchi H, Tahara H, Matsuda H, Nomura Y, et al. Cardiac lymphangioma: case report and review of the literature. J Pediatr Surg. 2002;37(10):1–3.

    Article  Google Scholar 

  133. Huang Z. Lymphangioma of the left ventricle. J Cardiac Surg. 2013;28(1):24–6.

    Article  Google Scholar 

  134. Jougon J, Laborde MN, Parrens M, MacBride T. Cystic lymphangioma of the heart mimicking a mediastinal tumor. Eur J Cardiothorac Surg. 2002;22(3):476–8.

    Article  PubMed  Google Scholar 

  135. Pennec PY, Blanc JJ. Cardiac lymphangioma: a benign cardiac tumour. Eur Heart J. 2006;27(24):2913.

    Article  PubMed  Google Scholar 

  136. Look Hong NJ, Pandalai PK, Hornick JL, Shekar PS, Harmon DC, Chen YL, et al. Cardiac angiosarcoma management and outcomes: 20-year single-institution experience. Ann Surg Oncol. 2012;19(8):2707–15.

    Article  PubMed  Google Scholar 

  137. Casha AR, Davidson LA, Roberts P, Nair RU. Familial angiosarcoma of the heart. J Thorac Cardiovasc Surg. 2002;124(2):392–4.

    Article  PubMed  Google Scholar 

  138. Best AK, Dobson RL, Ahmad AR. Best cases from the AFIP: cardiac angiosarcoma. Radiographics. 2003;23 Spec No:S141–5.

    Article  PubMed  Google Scholar 

  139. Afzal MN, Alguacil-Garcia A. Primary cardiac angiosarcoma: clinical and pathological diagnostic problems. Can J Cardiol. 1997;13(3):293–6.

    CAS  PubMed  Google Scholar 

  140. van Beek EJ, Stolpen AH, Khanna G, Thompson BH. CT and MRI of pericardial and cardiac neoplastic disease. Cancer Imaging. 2007;7:19–26.

    Article  PubMed  PubMed Central  Google Scholar 

  141. Herrmann MA, Shankerman RA, Edwards WD, Shub C, Schaff HV. Primary cardiac angiosarcoma: a clinicopathologic study of six cases. J Thorac Cardiovasc Surg. 1992;103(4):655–64.

    CAS  PubMed  Google Scholar 

  142. Araoz PA, Eklund HE, Welch TJ, Breen JF. CT and MR imaging of primary cardiac malignancies. Radiographics. 1999;19(6):1421–34.

    Article  CAS  PubMed  Google Scholar 

  143. Khanji M, Lee E, Ionescu A. Blushing primary cardiac angiosarcoma. Heart. 2014;100(3):266.

    Article  PubMed  Google Scholar 

  144. Puppala S, Hoey ET, Mankad K, Wood AM. Primary cardiac angiosarcoma arising from the interatrial septum: magnetic resonance imaging appearances. Br J Radiol. 2010;83(995):e230–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  145. Rodrigues AG, Tardif JC, Petitclerc R, Mercier LA, Paquet E, Leung TK, et al. Angiosarcomas of the interatrial septum mimicking atrial myxomas. J Am Soc Echocardiogr. 1996;9(2):209–12.

    Article  CAS  PubMed  Google Scholar 

  146. Chaturvedi A, Vummidi D, Shuman WP, Dubinsky TJ, Maki JH. Cardiac angiosarcoma: an unusual cause of coronary artery pseudoaneurysm. J Thorac Imaging. 2012;27(1):W8–9.

    Article  PubMed  Google Scholar 

  147. Berry MF, Williams M, Welsby I, Lin S. Cardiac angiosarcoma presenting with right coronary artery pseudoaneurysm. J Cardiothorac Vasc Anesth. 2010;24(4):633–5.

    Article  PubMed  Google Scholar 

  148. Kakizaki S, Takagi H, Hosaka Y. Cardiac angiosarcoma responding to multidisciplinary treatment. Int J Cardiol. 1997;62(3):273–5.

    Article  CAS  PubMed  Google Scholar 

  149. Valeviciene N, Mataciunas M, Tamosiunas A, Petrulioniene Z, Briediene R. Primary heart angiosarcoma detected by magnetic resonance imaging. Acta Radiol. 2006;47(7):675–9.

    Article  CAS  PubMed  Google Scholar 

  150. Kim EE, Wallace S, Abello R, Coan JD, Ewer MS, Salem PA, et al. Malignant cardiac fibrous histiocytomas and angiosarcomas: MR features. J Comput Assist Tomogr. 1989;13(4):627–32.

    Article  CAS  PubMed  Google Scholar 

  151. Deetjen AG, Conradi G, Mollmann S, Hamm CW, Dill T. Cardiac angiosarcoma diagnosed and characterized by cardiac magnetic resonance imaging. Cardiol Rev. 2006;14(2):101–3.

    Article  PubMed  Google Scholar 

  152. Yahata S, Endo T, Honma H, Ino T, Hayakawa H, Ogawa M, et al. Sunray appearance on enhanced magnetic resonance image of cardiac angiosarcoma with pericardial obliteration. Am Heart J. 1994;127(2):468–71.

    Article  CAS  PubMed  Google Scholar 

  153. Akkaya Z, Gursoy A, Erden A. The disastrous “sun ray” sign in cardiac magnetic resonance: an indicator of angiosarcoma. Cardiol Young. 2014;24(5):929–31.

    Article  PubMed  Google Scholar 

  154. Kurian KC, Weisshaar D, Parekh H, Berry GJ, Reitz B. Primary cardiac angiosarcoma: case report and review of the literature. Cardiovasc Pathol. 2006;15(2):110–2.

    Article  PubMed  Google Scholar 

  155. Brandt RR, Arnold R, Bohle RM, Dill T, Hamm CW. Cardiac angiosarcoma: case report and review of the literature. Zeitschrift fur Kardiologie. 2005;94(12):824–8.

    Article  CAS  PubMed  Google Scholar 

  156. Burke AP, Cowan D, Virmani R. Primary sarcomas of the heart. Cancer. 1992;69(2):387–95.

    Article  CAS  PubMed  Google Scholar 

  157. Donsbeck AV, Ranchere D, Coindre JM, Le Gall F, Cordier JF, Loire R. Primary cardiac sarcomas: an immunohistochemical and grading study with long-term follow-up of 24 cases. Histopathology. 1999;34(4):295–304.

    Article  CAS  PubMed  Google Scholar 

  158. Itoh K, Matsumura T, Egawa Y, Watanabe M, Ohshio T, Ohta A, et al. Primary mitral valve sarcoma in infancy. Pediatr Cardiol. 1998;19(2):174–7.

    Article  CAS  PubMed  Google Scholar 

  159. Bi W, Qu R, Ren W. A primary pericardial undifferentiated sarcoma invading the right atrium and superior vena cava. Echocardiography. 2012;29(8):E182–5.

    Article  PubMed  Google Scholar 

  160. Turhan N, Ozguler Z, Cagli K, Cagli K, Golbasi Z. Primary cardiac undifferentiated sarcoma: role of intraoperative imprint cytology and frozen section of two cases. Cardiovasc Pathol. 2011;20(4):232–7.

    Article  PubMed  Google Scholar 

  161. Furukawa N, Gummert J, Borgermann J. Complete resection of undifferentiated cardiac sarcoma and reconstruction of the atria and the superior vena cava: case report. J Cardiothorac Surg. 2012;7:96.

    Article  PubMed  PubMed Central  Google Scholar 

  162. Bakaeen FG, Jaroszewski DE, Rice DC, Walsh GL, Vaporciyan AA, Swisher SS, et al. Outcomes after surgical resection of cardiac sarcoma in the multimodality treatment era. J Thorac Cardiovasc Surg. 2009;137(6):1454–60.

    Article  PubMed  Google Scholar 

  163. Doty DB, Doty JR, Reid BB, Anderson JL. Left atrial sarcoma: resection and repair by cardiac autotransplant and in situ pericardial patch. Ann Thorac Surg. 2006;82(4):1514–7.

    Article  PubMed  Google Scholar 

  164. Hui KS, Green LK, Schmidt WA. Primary cardiac rhabdomyosarcoma: definition of a rare entity. Am J Cardiovasc Path. 1988;2(1):19–29.

    CAS  Google Scholar 

  165. Castorino F, Masiello P, Quattrocchi E, Di Benedetto G. Primary cardiac rhabdomyosarcoma of the left atrium: an unusual presentation. Tex Heart Inst J. 2000;27(2):206–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  166. Lo Re V 3rd, Fox KR, Ferrari VA, Scott CH, Kossev PM, Kostman JR. Hypereosinophilia associated with cardiac rhabdomyosarcoma. Am J Hematol. 2003;74(1):64–7.

    Article  PubMed  Google Scholar 

  167. Raaf HN, Raaf JH. Sarcomas related to the heart and vasculature. Semin Surg Oncol. 1994;10(5):374–82.

    Article  CAS  PubMed  Google Scholar 

  168. Geyer SJ. Rhabdomyosarcoma of the heart with cerebral metastases. West J Med. 1987;147(5):596–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  169. Schvartzman PR, White RD. Imaging of cardiac and paracardiac masses. J Thorac Imaging. 2000;15(4):265–73.

    Article  CAS  PubMed  Google Scholar 

  170. Villacampa VM, Villarreal M, Ros LH, Alvarez R, Cozar M, Fuertes MI. Cardiac rhabdomyosarcoma: diagnosis by MR imaging. Eur Radiol. 1999;9(4):634–7.

    Article  CAS  PubMed  Google Scholar 

  171. Vujin B, Benc D, Srdic S, Bikicki M, Vuckovic D, Dodic S. Rhabdomyosarcoma of the heart. Herz. 2006;31(8):798–800.

    Article  PubMed  Google Scholar 

  172. Dirican A, Kucukzeybek Y, Erten C, Somali I, Can A, Bayoglu IV, et al. Cardiac rhabdomyosarcoma of the left atrium. Contemp Oncol. 2014;18(1):73–5.

    Google Scholar 

  173. Ye Z, Shi H, Peng T, Han A. Clinical and pathological features of high grade primary cardiac osteosarcoma. Interact Cardiovasc Thorac Surg. 2011;12(1):94–5.

    Article  PubMed  Google Scholar 

  174. Burke AP, Virmani R. Osteosarcomas of the heart. Am J Surg Pathol. 1991;15(3):289–95.

    Article  CAS  PubMed  Google Scholar 

  175. Dohi T, Ohmura H, Daida H, Amano A. Primary right atrial cardiac osteosarcoma with congestive heart failure. Eur J Cardiothorac Surg. 2009;35(3):544–6.

    Article  PubMed  Google Scholar 

  176. Sogabe O, Ohya T. Right ventricular failure due to primary right ventricle osteosarcoma. Gen Thorac Cardiovasc Surg. 2007;55(1):19–22.

    Article  PubMed  Google Scholar 

  177. Hashimoto W, Hashizume K, Ariyoshi T, Taniguchi S, Miura T, Kinoshita N, et al. Primary cardiac osteosarcoma with imaging that revealed no calcification. Gen Thorac Cardiovasc Surg. 2011;59(3):184–6.

    Article  PubMed  Google Scholar 

  178. Bradford WT, Arora H, Sheridan BC, Sileshi B, Kumar PA. A left atrial mass in a middle-aged woman: just another myxoma? J Cardiothorac Vasc Anesth. 2013;27(4):816–8.

    Article  PubMed  Google Scholar 

  179. Takeuchi I, Kawaguchi T, Kimura Y, Kojima J, Shimamura H, Shimizu N, et al. Primary cardiac osteosarcoma in a young man with severe congestive heart failure. Intern Med. 2007;46(10):649–52.

    Article  PubMed  Google Scholar 

  180. Gomez-Rubin MC, Rios JC, Dobarro D, Sanchez-Recalde A, Bret-Zurita M, Filgueiras D, et al. A recidivant primary cardiac osteosarcoma: the role of bone scans. Cardiovasc Pathol. 2010;19(1):55–8.

    Article  PubMed  Google Scholar 

  181. Yamagishi M, Yamada N, Kuribayashi S. Images in cardiology: magnetic resonance imaging of cardiac osteosarcoma. Heart. 2001;85(3):311.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  182. Ahn S, Choi JA, Chung JH, Choi H, Chun EJ, Choi SI, et al. MR imaging findings of a primary cardiac osteosarcoma and its bone metastasis with histopathologic correlation. Korean J Radiol. 2011;12(1):135–9.

    Article  PubMed  PubMed Central  Google Scholar 

  183. Neragi-Miandoab S, Kim J, Vlahakes GJ. Malignant tumours of the heart: a review of tumour type, diagnosis and therapy. Clin Oncol. 2007;19(10):748–56.

    Article  CAS  Google Scholar 

  184. Clarke NR, Mohiaddin RH, Westaby S, Banning AP. Multifocal cardiac leiomyosarcoma. Diagnosis and surveillance by transoesophageal echocardiography and contrast enhanced cardiovascular magnetic resonance. Postgrad Med J. 2002;78(922):492–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  185. Willaert W. Leiomyosarcoma of the right ventricle extending into the pulmonary trunk. Heart. 2001;86(1):e2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  186. Lo FL, Chou YH, Tiu CM, Lan GY, Hwang JH, Chern MS, et al. Primary cardiac leiomyosarcoma: imaging with 2-D echocardiography, electron beam CT and 1.5-Tesla MR. Eur J Radiol. 1998;27(1):72–6.

    Article  CAS  PubMed  Google Scholar 

  187. Durand E, Vanel D, Mousseaux E, Meingan P, Fornes P, Bittoun J. A recurrent left atrium leiomyosarcoma. Eur Radiol. 1998;8(1):97–9.

    Article  CAS  PubMed  Google Scholar 

  188. Jellis C, Doyle J, Sutherland T, Gutman J, Macisaac A. Cardiac epithelioid leiomyosarcoma and the role of cardiac imaging in the differentiation of intracardiac masses. Clin Cardiol. 2010;33(6):E6–9.

    Article  PubMed  PubMed Central  Google Scholar 

  189. Antunes MJ, Vanderdonck KM, Andrade CM, Rebelo LS. Primary cardiac leiomyosarcomas. Ann Thorac Surg. 1991;51(6):999–1001.

    Article  CAS  PubMed  Google Scholar 

  190. Panday VR, Cramer MJ, Elbers HR, de la Riviere AB, Ernst SM, Plokker HW. Primary leiomyosarcoma of the heart presenting as obstruction to the pulmonary trunk. Am Heart J. 1997;133(4):465–6.

    Article  CAS  PubMed  Google Scholar 

  191. Knobel B, Rosman P, Kishon Y, Husar M. Intracardiac primary fibrosarcoma. Case report and literature review. Thorac Cardiovasc Surg. 1992;40(4):227–30.

    Article  CAS  PubMed  Google Scholar 

  192. Kim DG, Lee SY, Chung SK, Park SK, Chun YK, Chi JG. Brain metastasis from myxofibrosarcoma of the heart. Acta Neurochir. 1997;139(1):88–9.

    Article  CAS  PubMed  Google Scholar 

  193. Coskun H, Bozkurt AK, Ozbay G, Demirkesen C, Kaynak K, Vural FS. Primary fibrosarcoma of the heart. Aus N Z J Surg. 1995;65(1):66–8.

    Article  CAS  Google Scholar 

  194. Hoffstetter P, Djavidani B, Feuerbach S, Hofstadter F, Seitz J. Myxoid fibrosarcoma of a pulmonary vein with extension into the left atrium. AJR Am J Roentgenol. 2006;186(2):365–7.

    Article  PubMed  Google Scholar 

  195. Putnam JB Jr, Sweeney MS, Colon R, Lanza LA, Frazier OH, Cooley DA. Primary cardiac sarcomas. Ann Thorac Surg. 1991;51(6):906–10.

    Article  PubMed  Google Scholar 

  196. Can C, Arpaci F, Celasun B, Gunhan O, Finci R. Primary pericardial liposarcoma presenting with cardiac tamponade and multiple organ metastases. Chest. 1993;103(1):328.

    Article  CAS  PubMed  Google Scholar 

  197. Nzayinambaho K, Noel H, Brohet C, Cosyns J, Reding R, Sonnet J, et al. Primary cardiac liposarcoma simulating a left atrial myxoma. Thorac Cardiovasc Surg. 1985;33(3):193–5.

    Article  CAS  PubMed  Google Scholar 

  198. Paraf F, Bruneval P, Balaton A, Deloche A, Mikol J, Maitre F, et al. Primary liposarcoma of the heart. Am J Cardiovasc Path. 1990;3(2):175–80.

    CAS  Google Scholar 

  199. Murtra M, Mestres CA, Igual A, Cubells J, Espinosa M, Benasco C, et al. Primary liposarcoma of the right ventricle and pulmonary artery: surgical excision and replacement of the pulmonic valve by a Bjork-Shiley tilting disc valve. Thorac Cardiovasc Surg. 1983;31(3):172–4.

    Article  CAS  PubMed  Google Scholar 

  200. Pino PG, Zampi G, Pergolini A, Pero G, Polizzi V, Sbaraglia F, et al. Metastatic liposarcoma of the heart. Case series and brief literature review. Herz. 2013;38(8):938–42.

    Article  CAS  PubMed  Google Scholar 

  201. Wu TP, Zhou F, DeAnda A Jr, Melamed J, Lim RP, Balsam LB. Surgical management of cardiac liposarcomas. J Card Surg. 2012;27(2):192–5.

    Article  PubMed  Google Scholar 

  202. Hoey ET, Mankad K, Puppala S, Gopalan D, Sivananthan MU. MRI and CT appearances of cardiac tumours in adults. Clin Radiol. 2009;64(12):1214–30.

    Article  CAS  PubMed  Google Scholar 

  203. Schrem SS, Colvin SB, Weinreb JC, Glassman E, Kronzon I. Metastatic cardiac liposarcoma: diagnosis by transesophageal echocardiography and magnetic resonance imaging. J Am Soc Echocardiogr. 1990;3(2):149–53.

    Article  CAS  PubMed  Google Scholar 

  204. Wang JG, Li NN. Primary cardiac synovial sarcoma. Ann Thorac Surg. 2013;95(6):2202–9.

    Article  PubMed  Google Scholar 

  205. Bittira B, Tsang J, Huynh T, Morin JF, Huttner I. Primary right atrial synovial sarcoma manifesting as transient ischemic attacks. Ann Thorac Surg. 2000;69(6):1949–51.

    Article  CAS  PubMed  Google Scholar 

  206. Kim CH, Dancer JY, Coffey D, Zhai QJ, Reardon M, Ayala AG, et al. Clinicopathologic study of 24 patients with primary cardiac sarcomas: a 10-year single institution experience. Hum Pathol. 2008;39(6):933–8.

    Article  PubMed  Google Scholar 

  207. Hannachi Sassi S, Zargouni N, Saadi Dakhlia M, Mrad K, Cammoun M, Ben Romdhane K. Primary synovial sarcoma of the heart. A clinicopathologic study of one case and review of the literature. Pathologica. 2004;96(1):29–34.

    CAS  PubMed  Google Scholar 

  208. Lv X, Guo X, Chen X, He Z, Shen J, Jin T, et al. Primary cardiac synovial sarcoma. J Cardiac Surg. 2010;25(3):288–90.

    Article  Google Scholar 

  209. Provenzano SC, Con R, Jones OD, Grant PW. Synovial sarcoma of the heart. Heart Lung Circ. 2006;15(4):278–9.

    Article  PubMed  Google Scholar 

  210. Wolf M, Van den Brande J, Rodrigus I, Paelinck BP. Giant primary right ventricular synovial sarcoma. Eur Heart J. 2014;35(37):2509.

    Article  PubMed  Google Scholar 

  211. Sakai M, Takami H, Joyama S, Tomita Y, Yamamoto T, Araki N, et al. Cardiac synovial sarcoma swinging through the aortic valve. Ann Thorac Surg. 2011;92(3):1129.

    Article  PubMed  Google Scholar 

  212. Kumar N, Agarwal S, Ahuja A, Das P, Airon B, Ray R. Spectrum of cardiac tumors excluding myxoma: Experience of a tertiary center with review of the literature. Pathol Res Pract. 2011;207(12):769–74.

    Article  CAS  PubMed  Google Scholar 

  213. Siebenmann R, Jenni R, Makek M, Oelz O, Turina M. Primary synovial sarcoma of the heart treated by heart transplantation. J Thorac Cardiovasc Surg. 1990;99(3):567–8.

    CAS  PubMed  Google Scholar 

  214. Ceresoli GL, Ferreri AJ, Bucci E, Ripa C, Ponzoni M, Villa E. Primary cardiac lymphoma in immunocompetent patients: diagnostic and therapeutic management. Cancer. 1997;80(8):1497–506.

    Article  CAS  PubMed  Google Scholar 

  215. Anghel G, Zoli V, Petti N, Remotti D, Feccia M, Pino P, et al. Primary cardiac lymphoma: report of two cases occurring in immunocompetent subjects. Leuk Lymphoma. 2004;45(4):781–8.

    Article  PubMed  Google Scholar 

  216. Chalabreysse L, Berger F, Loire R, Devouassoux G, Cordier JF, Thivolet-Bejui F. Primary cardiac lymphoma in immunocompetent patients: a report of three cases and review of the literature. Virchows Arch. 2002;441(5):456–61.

    Article  PubMed  Google Scholar 

  217. Rockwell L, Hetzel P, Freeman JK, Fereshetian A. Cardiac involvement in malignancies. Case 3. Primary cardiac lymphoma. J Clin Oncol. 2004;22(13):2744–5.

    Article  PubMed  Google Scholar 

  218. Engelen MA, Juergens KU, Breithardt G, Eckardt L. Interatrial conduction delay and atrioventricular block due to primary cardiac lymphoma. J Cardiovasc Electrophysiol. 2005;16(8):926.

    Article  PubMed  Google Scholar 

  219. Nelson KH, Chatzizisis YS, Steigner ML, Mitchell RN, Blankstein R, Givertz MM. Cardiac allograft involvement by post-transplantation lymphoproliferative disorder. J Am Coll Cardiol. 2013;62(10):937.

    Article  PubMed  Google Scholar 

  220. Nart D, Nalbantgil S, Yagdi T, Yilmaz F, Hekimgil M, Yuce G, et al. Primary cardiac lymphoma in a heart transplant recipient. Transplant Proc. 2005;37(2):1362–4.

    Article  CAS  PubMed  Google Scholar 

  221. Chim CS, Chan AC, Kwong YL, Liang R. Primary cardiac lymphoma. Am J Hematol. 1997;54(1):79–83.

    Article  CAS  PubMed  Google Scholar 

  222. Dawson MA, Mariani J, Taylor A, Koulouris G, Avery S. The successful treatment of primary cardiac lymphoma with a dose-dense schedule of rituximab plus CHOP. Ann Oncol. 2006;17(1):176–7.

    Article  CAS  PubMed  Google Scholar 

  223. Tas F, Mudun A, Kirma C. Cardiac involvement in melanoma: a case report and review of the literature. J Cancer Res Ther. 2010;6(3):359–61.

    Article  PubMed  Google Scholar 

  224. Bussani R, De-Giorgio F, Abbate A, Silvestri F. Cardiac metastases. J Clin Pathol. 2007;60(1):27–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  225. Hancock EW. Neoplastic pericardial disease. Cardiol Clin. 1990;8(4):673–82.

    Article  CAS  PubMed  Google Scholar 

  226. Weiss L. An analysis of the incidence of myocardial metastasis from solid cancers. Br Heart J. 1992;68(5):501–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  227. Petersen CD, Robinson WA, Kurnick JE. Involvement of the heart and pericardium in the malignant lymphomas. Am J Med Sci. 1976;272(2):161–5.

    Article  CAS  PubMed  Google Scholar 

  228. Schoen FJ, Berger BM, Guerina NG. Cardiac effects of noncardiac neoplasms. Cardiol Clin. 1984;2(4):657–70.

    Article  CAS  PubMed  Google Scholar 

  229. Thurber DL, Edwards JE, Achor RWP. Secondary malignant tumors of the pericardium. Circulation. 1962;26(2):228–41.

    Article  CAS  PubMed  Google Scholar 

  230. El Allaf D, et al. Cardiac tamponade as the first manifestation of cardiothoracic malignancy: a study of 10 cases. Eur Heart J. 1986;7:247–53.

    Article  PubMed  Google Scholar 

  231. Sheldon R, Isaac D. Metastatic melanoma to the heart presenting with ventricular tachycardia. Chest. 1991;99(5):1296–8.

    Article  CAS  PubMed  Google Scholar 

  232. Mousseaux E, Meunier P, Azancott S, Dubayle P, Gaux JC. Cardiac metastatic melanoma investigated by magnetic resonance imaging. Magn Reson Imaging. 1998;16(1):91–5.

    Article  CAS  PubMed  Google Scholar 

  233. Vogel-Claussen J, Rochitte CE, Wu KC, Kamel IR, Foo TK, Lima JA, et al. Delayed enhancement MR imaging: utility in myocardial assessment. Radiographics. 2006;26(3):795–810.

    Article  PubMed  Google Scholar 

  234. Shepherd FA. Malignant pericardial effusion. Curr Opin Oncol. 1997;9(2):170–4.

    Article  CAS  PubMed  Google Scholar 

  235. Sacco RL, Adams R, Albers G, Alberts MJ, Benavente O, Furie K, et al. Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline. Stroke. 2006;37(2):577–617.

    Article  PubMed  Google Scholar 

  236. Weinsaft JW, Kim HW, Shah DJ, Klem I, Crowley AL, Brosnan R, et al. Detection of left ventricular thrombus by delayed-enhancement cardiovascular magnetic resonance prevalence and markers in patients with systolic dysfunction. J Am Coll Cardiol. 2008;52(2):148–57.

    Article  PubMed  Google Scholar 

  237. Pazos-Lopez P, Pozo E, Siqueira ME, Garcia-Lunar I, Cham M, Jacobi A, et al. Value of CMR for the differential diagnosis of cardiac masses. JACC Cardiovasc Imaging. 2014;7(9):896–905.

    Article  PubMed  Google Scholar 

  238. Paydarfar D, Krieger D, Dib N, Blair RH, Pastore JO, Stetz JJ Jr, et al. In vivo magnetic resonance imaging and surgical histopathology of intracardiac masses: distinct features of subacute thrombi. Cardiology. 2001;95(1):40–7.

    Article  CAS  PubMed  Google Scholar 

  239. Corti R, Osende JI, Fayad ZA, Fallon JT, Fuster V, Mizsei G, et al. In vivo noninvasive detection and age definition of arterial thrombus by MRI. J Am Coll Cardiol. 2002;39(8):1366–73.

    Article  PubMed  Google Scholar 

  240. Barkhausen J, Hunold P, Eggebrecht H, Schuler WO, Sabin GV, Erbel R, et al. Detection and characterization of intracardiac thrombi on MR imaging. AJR Am J Roentgenol. 2002;179(6):1539–44.

    Article  PubMed  Google Scholar 

  241. Mollet NR. Visualization of Ventricular Thrombi With Contrast-Enhanced Magnetic Resonance Imaging in Patients With Ischemic Heart Disease. Circulation. 2002;106(23):2873–6.

    Article  PubMed  Google Scholar 

  242. Gay JD, Guileyardo JM, Townsend-Parchman JK, Ross K. Clinical and morphologic features of lipomatous hypertrophy (“massive fatty deposits”) of the interatrial septum. Am J Forensic Med Pathol. 1996;17(1):43–8.

    Article  CAS  PubMed  Google Scholar 

  243. Pochis WT, Saeian K, Sagar KB. Usefulness of transesophageal echocardiography in diagnosing lipomatous hypertrophy of the atrial septum with comparison to transthoracic echocardiography. Am J Cardiol. 1992;70(3):396–8.

    Article  CAS  PubMed  Google Scholar 

  244. Heyer CM, Kagel T, Lemburg SP, Bauer TT, Nicolas V. Lipomatous hypertrophy of the interatrial septum: a prospective study of incidence, imaging findings, and clinical symptoms. Chest. 2003;124(6):2068–73.

    Article  PubMed  Google Scholar 

  245. Shirani J, Roberts WC. Clinical, electrocardiographic and morphologic features of massive fatty deposits (“lipomatous hypertrophy”) in the atrial septum. J Am Coll Cardiol. 1993;22(1):226–38.

    Article  CAS  PubMed  Google Scholar 

  246. Beau P, Michel P, Coisne D, Morichau-Beauchant M. Lipomatous hypertrophy of the cardiac interatrial septum: an unusual complication in long-term home parenteral nutrition in adult patients. J Parenter Enter Nutr. 1991;15(6):659–62.

    Article  CAS  Google Scholar 

  247. Dotti MT, Mondillo S, Plewnia K, Agricola E, Federico A. Cerebrotendinous xanthomatosis: evidence of lipomatous hypertrophy of the atrial septum. J Neurol. 1998;245(11):723–6.

    Article  CAS  PubMed  Google Scholar 

  248. Enzi G, Busetto L, Ceschin E, Coin A, Digito M, Pigozzo S. Multiple symmetric lipomatosis: clinical aspects and outcome in a long-term longitudinal study. Int J Obesity Rel Metabol Dis. 2002;26(2):253–61.

    Article  CAS  Google Scholar 

  249. Cheezum MK, Jezior MR, Carbonaro S, Villines TC. Lipomatous hypertrophy presenting as superior vena cava syndrome. J Cardiovasc Comput Tomogr. 2014;8(3):250–1.

    Article  PubMed  Google Scholar 

  250. Hutter AM Jr, Page DL. Atrial arrhythmias and lipomatous hypertrophy of the cardiac interatrial septum. Am Heart J. 1971;82(1):16–21.

    Article  PubMed  Google Scholar 

  251. Nadra I, Dawson D, Schmitz SA, Punjabi PP, Nihoyannopoulos P. Lipomatous hypertrophy of the interatrial septum: a commonly misdiagnosed mass often leading to unnecessary cardiac surgery. Heart. 2004;90(12):e66.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  252. Bajaj RR, Deva D, Kirpalani A, Yan RT, Chow CM, Lo V, et al. Cardiac magnetic resonance imaging for non-invasive diagnosis of lipomatous hypertrophy of inter-atrial septum. Indian Heart J. 2014;66(2):244–6.

    Article  PubMed  PubMed Central  Google Scholar 

  253. Christiansen S, Stypmann J, Baba HA, Hammel D, Scheld HH. Surgical management of extensive lipomatous hypertrophy of the right atrium. Cardiovasc Surg. 2000;8(1):88–90.

    Article  CAS  PubMed  Google Scholar 

  254. Patel J, Park C, Michaels J, Rosen S, Kort S. Pericardial cyst: case reports and a literature review. Echocardiography. 2004;21(3):269–72.

    Article  PubMed  Google Scholar 

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Aghayev, A., Steigner, M.L. (2019). CMR Assessment of Cardiac Masses. In: Kwong, R., Jerosch-Herold, M., Heydari, B. (eds) Cardiovascular Magnetic Resonance Imaging. Contemporary Cardiology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-8841-9_16

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