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Genital Mesenchymal Tumors

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Book cover Soft Tissue Tumors of the Skin

Abstract

A variety of mesenchymal tumors can arise in the cervix, vulvovaginal, and inguinoscrotal regions including lipomatous neoplasms, peripheral nerve sheath tumors, and sarcomas such as rhabdomyosarcoma. Consequently, this chapter will focus on lesions that solely or predominantly affect the soft tissues of the distal genital tract, beginning with the genital stromal tumors. This group includes fibroepithelial stromal polyp, cellular angiofibroma, mammary-type myofibroblastoma, angiomyofibroblastoma, and aggressive angiomyxoma. As genital stromal tumors are notorious for significant morphologic and immunophenotypic overlap, key histologic features of each entity will be emphasized. Two rare lesions involving the vulva, prepubertal vulval fibroma and massive vulval edema, will also be reviewed. Finally, the chapter ends with a discussion of smooth muscle tumors of the external genitalia. Even though the morphology of smooth muscle tumors of the vulva, vagina, and scrotum is similar to those at other sites, each of these locations has unique criteria for distinguishing leiomyomas from leiomyosarcomas.

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Authors and Affiliations

  1. Mayo Clinic, Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Rochester, MN, USA

    Karen J. Fritchie

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  1. Karen J. Fritchie
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Correspondence to Karen J. Fritchie .

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Editors and Affiliations

  1. Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA

    Steven D. Billings

  2. Departments of Pathology and Dermatology, University of Michigan Medical Center, Ann Arbor, MI, USA

    Rajiv M. Patel

  3. Department of Pathology and Laboratory Medicine, University of Wisconsin–Madison, Madison, WI, USA

    Darya Buehler

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Fritchie, K.J. (2019). Genital Mesenchymal Tumors. In: Billings, S., Patel, R., Buehler, D. (eds) Soft Tissue Tumors of the Skin. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-8812-9_11

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  • DOI: https://doi.org/10.1007/978-1-4939-8812-9_11

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-8810-5

  • Online ISBN: 978-1-4939-8812-9

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