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Computerized Tomography-Guided Surgical Decision-Making in Primary Squamous Cell Carcinoma of the Oral Cavity

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Craniomaxillofacial Reconstructive and Corrective Bone Surgery

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Abstract

Head and neck cancer is the sixth most common cancer worldwide [1]. One third of it comprises the oral cavity, while squamous cell carcinoma (SCC) represents approximately 95% of the dominating histopathology [2, 3]. In contrast to oropharyngeal squamous cell carcinoma, in which HPV-induced etiology is currently discussed to be associated with a better prognosis, OSCC still remains to be based on tobacco and alcohol as major risk factors [4–6]. Even though great emphasis is placed on early detection and optimized surgical and radio-oncologic techniques, the prognosis remains poor with overall 5-year survival beneath 50%, mainly due to a high rate of locoregional recurrences [1, 2, 7]. Furthermore organ-sparing concepts in terms of induction chemotherapy, currently under investigation in laryngeal malignancies, are not in focus in OSCC [8, 9]. Therefore two main therapeutic strategies remain: [1] upfront surgery followed by adjuvant radiotherapy (RT) or radiochemotherapy (RCT) if necessary, according to histopathologic risk factors, and [2] primary RCT followed by salvage surgery in case of residual disease. The aim of this chapter is to discuss the influence of findings by computed tomography, the worldwide most common imaging modality in head and neck cancer, on therapeutic strategies.

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Author information

Authors and Affiliations

  1. Clinic for Oral- and Maxillofacial Surgery, Navigation and Robotics, Charité Campus Virchow, Charité Universitätsmedizin Berlin, Berlin, Germany

    Jan-Dirk Raguse

  2. Oral and Maxillofacial Surgery, Private Practice, Zürich, Switzerland

    Bodo Hoffmeister

  3. Department of Oral and Maxillofacial Surgery/Regional Plastic Surgery, Center for Dental Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Rainer Schmelzeisen

  4. Department of Oral and Maxillofacial Surgery/Translational Implantology, Center for Dental Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Katja Nelson

  5. Institute for Radiology Charité Campus Virchow/Charité Campus Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany

    Beat Hamm & Nadine Thieme

Authors
  1. Jan-Dirk Raguse
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  2. Bodo Hoffmeister
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  3. Rainer Schmelzeisen
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  4. Katja Nelson
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  5. Beat Hamm
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  6. Nadine Thieme
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Corresponding author

Correspondence to Rainer Schmelzeisen .

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Editors and Affiliations

  1. Division of Oral and Maxillofacial Surgery, Columbia University College of Dental Medicine and New York Presbyterian Hospital, New York, NY, USA

    Alex M. Greenberg

  2. Department of Oral and Maxillofacial Surgery, Regional Plastic Surgery, Center for Dental Medicine, Medical Center – University of Freiburg Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Rainer Schmelzeisen

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Raguse, JD., Hoffmeister, B., Schmelzeisen, R., Nelson, K., Hamm, B., Thieme, N. (2019). Computerized Tomography-Guided Surgical Decision-Making in Primary Squamous Cell Carcinoma of the Oral Cavity. In: Greenberg, A., Schmelzeisen, R. (eds) Craniomaxillofacial Reconstructive and Corrective Bone Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1529-3_19

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  • DOI: https://doi.org/10.1007/978-1-4939-1529-3_19

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