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The Role of Intracellular Acidosis in Muscle Fatigue

  • Chapter
Fatigue

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 384))

Abstract

Muscle fatigue is often accompanied by an intracellular acidosis of variable size. The variability reflects the involvement of different metabolic pathways, the presence or absence of blood flow and the effectiveness of pH-regulating pathways. Intracellular acidosis affects many aspects of muscle cell function; for instance it reduces maximal Ca2+-activated force and Ca2+ sensitivity, slows the maximal shortening velocity and prolongs relaxation. However, acidosis is not the only metabolic change in fatigue which causes each of the above, and there are important aspects of muscle fatigue (e.g., the failure of Ca2+ release) which do not appear to be caused by acidosis.

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Author information

Authors and Affiliations

  1. Department of Physiology, University of Sydney, New South Wales, 2006, Australia

    D. G. Allen

  2. Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77, Stockholm, Sweden

    H. Westerblad & J. Lännergren

Authors
  1. D. G. Allen
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  2. H. Westerblad
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  3. J. Lännergren
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Editor information

Editors and Affiliations

  1. Prince of Wales Medical Research Institute, Sydney, New South Wales, Australia

    Simon C. Gandevia

  2. The Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Roger M. Enoka

  3. McMaster University, Hamilton, Ontario, Canada

    Alan J. McComas

  4. The University of Arizona, Tucson, Arizona, USA

    Douglas G. Stuart  & Patricia A. Pierce  & 

  5. University of Miami, Miami, Florida, USA

    Christine K. Thomas

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© 1995 Springer Science+Business Media New York

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Allen, D.G., Westerblad, H., Lännergren, J. (1995). The Role of Intracellular Acidosis in Muscle Fatigue. In: Gandevia, S.C., Enoka, R.M., McComas, A.J., Stuart, D.G., Thomas, C.K., Pierce, P.A. (eds) Fatigue. Advances in Experimental Medicine and Biology, vol 384. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1016-5_5

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  • DOI: https://doi.org/10.1007/978-1-4899-1016-5_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1018-9

  • Online ISBN: 978-1-4899-1016-5

  • eBook Packages: Springer Book Archive

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