Abstract
Hepatic triglyceride lipase (HTGL) and lipoprotein lipase (LPL) are two evolutionarily related enzymes that play key roles in lipoprotein metabolism. Hepatic triglyceride lipase appears to be involved in the hydrolysis of intermediate density lipoprotein (IDL) triglyceride to produce low density lipoprotein (LDL), and that of high density lipoprotein (HDL)-2 triglyceride and phospholipid to produce HDL-3 [1,2]. It may also be required for the uptake of HDL triglyceride and cholesteryl esters by the liver [3–5]. Lipoprotein lipase is essential for the metabolism of the triglyceride-rich lipoproteins, chylomicron and very low density lipoproteins (VLDL). The LPL-mediated hydrolysis of these lipoproteins produces chylomicron remnants and IDL, respectively, releasing necessary components for the production of HDL-2. Thus, both enzymes are involved in HDL metabolism, and HL activity is inversely, whereas LDL activity is directly correlated with plasma HDL levels [6].
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Chan, L., Wölle, J., Lo, JY., Zsigmond, E., Smith, L.C. (1994). Hepatic Triglyceride Lipase and Lipoprotein Lipase Action in Vitro and in Vivo. In: Mackness, M.I., Clerc, M. (eds) Esterases, Lipases, and Phospholipases. NATO ASI Series, vol 266. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0993-0_14
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