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Mechanisms of Lymphocyte Activation and Immune Regulation V pp 91–102Cite as

Properties of Ca Currents Activated by T Cell Receptor Signaling

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 365))

Abstract

Influx of extracellular Ca is one of the early biochemical events associated with signaling through the T cell receptor (TCR) complex1–4. The influx of Ca is a critical component of the signaling pathway because it helps to drive the cytoplasmic Ca from resting levels of around 100 nM up to several μM, the concentration required for activation of many intracellular Ca binding proteins and enzymes5. Recently there has been a great deal of progress in understanding the molecular basis of the very earliest events in TCR signaling which precede Ca mobilization as well as those later Ca-dependent processes leading to transcription of the IL-2 gene6–9. Unfortunately, the molecules involved in initiation, maintenance, and termination of Ca influx remain elusive despite the combined efforts of researchers using molecular, biochemical and electrophysiological approaches. However, during the last year a number of important discoveries have generated an unprecedented interest in the nature of the Ca influx pathway10,11.

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Authors and Affiliations

  1. Departments of Molecular Pharmacology and Medicine, Stanford University Medical Center, Stanford, CA, 94305, USA

    Brett A. Premack & Phyllis Gardner

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  1. Brett A. Premack
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  2. Phyllis Gardner
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Editor information

Editors and Affiliations

  1. Department of Medicine, University of California, Irvine, CA, 92717-4069, USA

    Sudhir Gupta

  2. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892-0001, USA

    William E. Paul

  3. Department of Microbiology and Immunology, University of California, San Francisco, CA, 94143-0552, USA

    Anthony DeFranco

  4. Department of Immunology, University of Washington, Seattle, WA, 98915, USA

    Roger M. Perlmutter

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© 1994 Springer Science+Business Media New York

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Premack, B.A., Gardner, P. (1994). Properties of Ca Currents Activated by T Cell Receptor Signaling. In: Gupta, S., Paul, W.E., DeFranco, A., Perlmutter, R.M. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation V. Advances in Experimental Medicine and Biology, vol 365. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0987-9_10

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  • DOI: https://doi.org/10.1007/978-1-4899-0987-9_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0989-3

  • Online ISBN: 978-1-4899-0987-9

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