Abstract
Iron is an essential growth factor for microorganisms, Its unique redox qualities makes it an important cofactor in many biological processes, including such fundamental functions as respiratory electron transport, energy metabolism and DNA biosynthesis, As such, a continuous supply of iron is crucial in the establishment and maintenance of a microorganism in its environment, Despite its abundance in nature, free Fe3+ is not readily available in aqueous solutions due to the presence of chelating anions and to the formation of insoluble ferric complexes at neutral pH in the presence of oxygen, In the vertebrate host, most iron is intracellular, in the form of ferritin or heme-compounds, making it unavailable to invading pathogens in the extracellular milieu (Otto et al., 1992), Although small amounts of intracellular iron are released in the host in the form of hemoglobin, heme or other complexes as a result of cell lysis, these are readily eliminated by an efficient host hepatocyte scavenging mechanism, In the extracellular compartment, the small amount of iron that is available is complexed by the host glycoproteins, transferrin and lactoferrin.
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References
Alcantara, J., Yu, R-H., and Schryvers A.B., 1993, The region of human transferrin involved in binding to bacterial transferrin receptors is localized in the C-lobe, Mol, Microbiol, 8: 1135–1143.
Alcantara, J., 1994, Identifying the binding domains of transferrin to its bacterial transferrin receptor, Thesis, University of Calgary, Calgary, Alberta, Canada.
Anderson, J.A., Spading, P.F., and Cornelissen, C.N., 1994, Gonococcal transferrin-binding protein 2 facilitates but is not essential for transferrin utilization, I, Bart, 176: 3162–3170.
Aneerer, A., Gaisser, S., and Braun, V., 1990, Nucleotide sequences of the sfitA, sfiuB, and sfiuC genes of Serratia marcescens suggest a periplasmic binding protein dependant iron transport mechanism, J, Bact, 172: 572–578.
Baker, E.N., Rumball, S.V., and Anderson, B.F., 1987, Transferrins: insights into structure and function from studies on lactofearin, Trends Biochem, Sci, 12: 350–355.
Baker, E.N., and Lindley, P.F., 1992, New perspectives on the structure and function of transferrins, J, Inorg, Biochem, 47: 147–160.
Bezkorovainy, A., 1987, Iron proteins, in:“Iron and infection, Molecular, Physiological and Clinical Aspects,” Bullen, J.J., and Griffiths, E., eds., John Wiley and Sons, Chichester.
Brock, J.H., 1985, Transferrins, in:“Metalloproteins (Part il),” Harrison, P.M., ed., MacMillan, London.
Chen, C-Y., Berish, S.A., Morse, S.A., and Mictzner T.A., 1993, The ferric iron-binding protein of pathogenic Neisseria spp, functions as a periplasmic transport in iron-acquisition from human transferrin, Mol, Mierobiol, 10: 311–318.
Cornelissen, C.N., Biswas, G.D., Tsai, J., Paruchuri, D.K., Thompson, S.A., and Sparling, P.F., 1992, Gonococcal transferrin-binding protein 1 is required for transferrin utilization and is homologous to TonB-dependant outer membrane receptors, J, Bact, 174: 5788–5797.
Crosa, J.H., 1989, Genetics and molecular biology of siderophore-mediated iron transport in bacteria, Microbiol, Lett, 53: 517–530.
Deneer, H.G., and Potter, A.A., 1989, Iron-repressible outer-membrane proteins of Pasteurel!a haemolytica, J, Gen, Microbiol, 135: 435–443.
Donachie, W., and Gilmour, N.J.L., 1988, Sheep antibody response to cell wall antigens expressed in vivo by Pasteurella haemolytica serotype A2, FEMS Microhiol, Lett, 56: 271–276.
Funk, W.D., and MacGillivray, R.T.A., 1989, Molecular biology of transferrins, in,“Iron Transport and Storage,” Ponka, P., Schulman, H.M., and Woodworth, R.C., eds., CRC Press, Boston.
Genco, C.A., Berish, S.A., Chen, C-Y., Morse, S., and Trees, D.L., 1994, Genetic diversity of the iron-binding protein (Fbp) gene of the pathogenic and commensal Neisseria, FEMS Microbiol, Lett, 116: 123–130.
Gerlach, G.F., Klashinsky, S., Anderson, C., Potter, A.A., and Willson, P.J., 1992a, Characterization of two genes encoding distinct transferrin-binding proteins in different Actinobacillus pleuropneumoniae isolates, Infect, Inunun, 60: 3253–3261.
Gerlach, G.F., Anderson, C., Potter, A.A., Klashinsky, S., and Willson, P.J., 19926, Cloning and expression of a transferrin-binding protein from Actinobacillus pleuropneumoniae, Infect, Immun, 60: 892–898.
Gonzalez, G.C., Caamano, D.L., and Schryvers, A.B., 1990, Identification and characterization of a porcine-specific transferrin receptor in Actinobacillus pleuropneumoniae, Mol, Microbiol, 4: 1173–1179.
Gonzalez, G.C., Yu, R-H., Rosteck, P., and Schryvers, A.B., 1994, Cloning, expression and analysis of the transferrin binding protein genes from Actinobacillus pleuropneumoniae, Manuscript in preparation.
Gray-Owen, S.D., Loosemore, S., and Schryvers, A.B., 1994, identification and characterization of genes encoding the human transferrin binding proteins from Haemophibts influenzae, infect, Immun, Submitted for publication.
Gray-Owen, S.D., and Schryvers, A.B., 1993, The interaction of primate transferrins with receptors on bacteria pathogenic to humans, Microb, Pathog, 14: 389–398.
Harkness, R.E., Chong, P., and Klein, M.H., 1992, Identification of two iron-repressed periplasmic proteins in Haemophilus influenzae, J, Bact, 174: 2425–2430.
Hennecke, H., 1990, Regulation of bacterial gene expression by metal-protein complexes, Mol, Micro, 4: 1621–1628.
Holland, J., Langford, P.R., Towner, K.J., and Williams, P., 1992, Evidence for in vivo expression of transferrin-binding proteins in Haemophilia influenzae type h, Infect, Immun, 60: 2986–2991.
Irwin, S.W., Averill, N., Cheng, C.Y., and Schryvers, A.B., 1993, Preparation and analysis of isogenic mutants in the transferrin receptor protein genes, tbpl and tbp2, from Neisseria meningitidis, Mol, Microbiol, 8: 1125–1133.
Jarosik, G.P., Sanders, J.D., Cope, L.D., Muller-Eberhard, U., and Hansen, E.J., 1994, A functional tonB gene is required for both utilization of heme and virulence expression by Haemophilus influenzae type b, infect, Immun, 62: 2470–2477.
Kabani, A.M., Button, L.L., and Schryvers, A.B., 1994, Identification of binding domains for bacterial transferrin receptors using chimeric transferrins, Manuscript in preparation.
Klebba, P.E., Rutz, J.M., Liu, J., and Murphy, C.K., 1993, Mechanisms of TonB-catalyzed iron transport through the enteric bacterial cell envelope, J, Bioenerg, Biomemb, 25: 603–611.
Krek-Staples, J.A., Kew, R.R., and Webster, R.O., 1992, Ceruloplasmin and transferrin levels are altered in serum and brochoalveolar lavage fluid of patients with adult respiratory distress syndrome, Am, Rev, Respir, Dis, 145: 1009–1015.
Lainson, F.A., Harkins, D.C., Wilson, C.F., Sutherland, A.D., Murray, J.E., Donachie, W, and Baird, G.D, 1991, Identification and localization of an iron-regulated 35 kDa protein of Pasteurella haemolytica serotype A2, J, Gen, Microbiol, 137: 219–226.
Maciver, I., and Hansen, E.J., 1994, Identification of a positive regulatory factor involved in expression of transferrin-binding activity by Haemophilus influenzae, Mol, Microhiol, Submitted for publication.
Morton, D.J., Musser, J.M., and Stull, T.L., 1993, Expression of the Haemophilus influenzae transferring receptor is repressible by hemin but not elemental iron alone, Infect, Immun, 61: 4033–4037.
Morton, D.J., and Williams, P., 1989, Utilization of transferrin-hound iron by Haemophilus species of human and porcine origins, FEMS Microhiol, Lett, 65: 123–128.
Morton, D.J., and Williams, P., 1990, Siderophore-independent acquisition of transferrin-hound iron by Haemophilus influenzae type b„ I, Gen, Microhiol, 136:927–933.
Neilands, J.B., 1981, Microbial iron compounds, Ann, Rev, Microhiol, 50: 715–731.
Niven, D.F., Donga, J., and Archibald, F.S., 1989, Responses of Haemophilus pleuropneumoniae to iron restriction: changes in the outer membrane protein profile and the removal of iron from porcine transferrin, Mol, Microbiol, 3: 1083–1089.
Ogunnariwo, J.A., Cheng, C.Y., Ford, J.A., and Schryvers, A.B., 1990, Response of Haemophilus somnus to iron limitation: Expression and identification of a bovine-specific transferrin receptor, Microb, Pathog, 9: 397–406.
Ogunnariwo, J.A., Alcantara, J., and Schryvers, A.B., 1991, Evidence for non-siderophore-mediated acquisition of transferrin-bound iron by Pasteurella multocida, Microbial Pathogenesis, 11: 47–56.
Ogunnariwo, J.A., and Schryvers, A.B., 1990, Iron acquisition in Pasteurella haemolytica:: expression and identification of a bovine-specific transferrin receptor, Infect, Immun, 58: 2091–2097.
Ogunnariwo, J.A., and Schryvers, A.B., 1992, Correlation between the ability of Haemophilus paragallinarum to acquire ovotransferrin-bound iron and the expression of ovotransferrin-specific receptors, Avian Dis, 36: 655–663.
Ogunnariwo, J.A., and Schryvers, A.B., 1994, Antigenic and genetic analysis of transferrin receptors in ruminant isolates of Pasteurella haemolytica, Manuscript in preparation.
Otto, B.R., Verweij-Van Vught, A.M.J.J., and Maclaren, D.M., 1992, Transferrins and heme-compounds as iron sources for pathogenic bacteria, CRC Crit, Rev, Microbiol, 18: 217–233.
Padda, J.S., and Schryvers, A.B., 1990, N-linked oligosaccharides of human transferrin are not required for binding to bacterial transferrin receptors, Infect, Immun, 58: 2972–2976.
Postle, K., 1993, TonB protein and energy transduction between membranes, J, Bioenerg, Biomemb, 25: 591–601.
Rossi-Campos, A., Anderson, C., Gerlach, G-F., Klashinsky, S., Potter, A.A., and Willson, P.J., 1992, Immunization of pigs against Actinobacillus pleuropneumoniae with two recombinant protein preparations, Vaccine, 10: 512–518.
Rutz, J.M., Lui, J., Lyons, J.A., Goranson, J., Armstrong, S.K., McIntosh, M.A., Feix, J.B., and Klebba, P.E., 1992, Formation of gated channel by a ligand-specific transport protein in the bacterial outer membrane, Science, 258: 471–475.
Schryvers, A.B., 1988, Characterization of the human transferrin and lactoferrin receptors in Haemophilus influenaae, Mol, Microbiol, 2: 467–472.
Schryvers, A.B., 1989, Identification of the transferrin and lactoferrin binding proteins in Haemophilus influen_ae, J, Med, Microbiol, 29.: 121–130.
Schryvers, A.B., and Gonzalez, G.C., 1990, Receptors for transferrin in pathogenic bacteria are specific for the host’s protein, Can, J, Microbiol, 36: 145–147.
Schryvers, A.B., and Lee, B.C., 1993., Analysis of bacterial receptors for host iron binding proteins, J, Microbial, Methods, 18: 255–266.
Schryvers, A.B., and Morris, L.J., 1988a, identification and characterization of the transferrin receptor from Neisseria meningitidis, Mol, Microbiol, 2: 281–288.
Schryvers, A.B., and Morris, L.J., 1988b, identification and characterization of the human lactoferrin-binding protein from Neisseria meningitidis, Infect, Immun, 56: 1144–1149.
Stevenson, P., Williams, P., and Griffiths, E., 1992, Common antigenic domains in transferrin binding protein 2 of Neisseria meningitidis, Neisseria gonorrhoeae and Haemophilus influenzae type b, infect, Immun, 60: 2391–2396.
Sutherland, A.D., Jones, G.E., and Poxton, I.R., 1990, The susceptibility of in vivo grown Pasteurella haemolytica to ovine defence mechanisms in vitro, FEMS Microbial, Im unol, 64: 269–278.
Tam, R., and Saier Jr., MH., 1993, Structural, Functional and Evolutionary Relationships among Extracellular Solute-Binding Receptors of Bacteria, Microbiol, Rev, 57: 320–346.
Weinberg, E.D., 1978, Iron and infection, Microbiol, Rev, 42: 45–66.
Williams, P., and Griffiths, E., 1992, Bacterial transferrin receptors–structure, function and contribution to virulence, Med, Microbiol, Immunol, 181: 301–322.
Yu, R-H., Gray-Owen, S.D., Ogunnariwo, J., and Schryvers, A.B., 1992, Interaction of ruminant transferrin receptors in bovine isolates of Pasteurella haemolytica and Haemophilus somnus, Infect, Immun, 60: 2992–2994.
Yu, R-H., and Schryvers, A.B., 1994, Transferrin receptors on ruminant pathogens vary in their interaction with the C-lobe and N-lobe of ruminant transferrins, Can, J, Microbiol, 40: 532–540.
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Kirby, S.D..., Ogunnariwo, J.A., Schryvers, A.B. (1995). Receptor-Mediated Iron Acquisition from Transferrin in the Pasteurellaceae . In: Donachie, W., Lainson, F.A., Hodgson, J.C. (eds) Haemophilus, Actinobacillus, and Pasteurella. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0978-7_10
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DOI: https://doi.org/10.1007/978-1-4899-0978-7_10
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