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Abstract

The use of drugs for the treatment of child and adolescent behavioral problems in a residential setting dates from 1937, with Bradley’s report on the beneficial effects of the stimulant drug benzedrine on the school performance and conduct of a group of 30 boys and girls, ages 5 to 14 years. Since that time, psychopharmacotherapy has become an accepted and useful treatment modality in residential and hospital settings for children and adolescents.

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References

  • Aman, M. G. (1984. Drugs and learning in mentally retarded persons. In G. D. Burrows & J. S. Werry (Eds.), Advances in human psychopharmacology (pp. 121–163). Greenwich: JAI Press.

    Google Scholar 

  • Anderson, L. T., Campbell, M., Grega, D. M., Perry, R., Small, A. M., & Green, W. H. (1984). Haloperidol in the treatment of infantile autism: Effects on learning and behavioral symptoms. American Journal of Psychiatry, 141, 1195–1202.

    PubMed  CAS  Google Scholar 

  • Bartunkova, Z., Cerny, L. Ortilova, J., & Sturma, J. (1972). Propericiazin, diazepam, chlorpromazine and placebo in a double-blind trial in pedopsychiatric therapy. Activitas Nervosa Superior (Praha), 14, 83–84.

    CAS  Google Scholar 

  • Bennett, W. G., Korein, J., Kalmijn, M., Grega, D. M., & Campbell, M. (1983). EEG and treatment of hospitalized aggressive children with haloperidol or lithium. Biological Psychiatry, 18, 1427–1440.

    PubMed  CAS  Google Scholar 

  • Bradley, C. (1937). The behavior of children receiving benzedrine. American Journal of Psychiatry, 94, 577–585.

    Google Scholar 

  • Cade, J. F. J. (1949). Lithium salts in the treatment of psychotic excitement. Medical Journal of Australia, 36, 349–352.

    Google Scholar 

  • Campbell, M., Adams, P., Small, A. M., Tesch, L. M., & Curren, E. L. (1988). Naltrexone in infantile autism. Psychopharmacology Bulletin, 24, 135–139.

    PubMed  CAS  Google Scholar 

  • Campbell, M., Anderson, L. T., Cohen, I. L., Perry, R., Small, A. M., Green, W. H., Anderson, L., & McCandless, W. (1982). Haloperidol in autistic children: Effects on learning, behavior and abnormal involuntary movements. Psychopharmacology Bulletin, 18, 110–112.

    Google Scholar 

  • Campbell, M., Anderson, L. T., Small, A. M., Perry, R., Green, W. H., & Caplan, R. (1982). The effects of haloperidol on learning and behavior in autistic children. Journal of Autism and Developmental Disorders, 12, 167–175.

    Article  PubMed  CAS  Google Scholar 

  • Campbell, M., Cohen, I., & Perry, R. (1983. Psychopharmacological treatment. In T. H. Ollendick & M. Hersen (Eds.), Handbook of child psychopathology (pp. 461–484). New York: Plenum Press.

    Chapter  Google Scholar 

  • Campbell, M., Cohen, I. L., Perry, R., & Small, A. M. (in press). Psychopharmacological treatment. In T. H. Ollendick & M. Hersen (Eds.), Handbook of child psychopathology. New York: Plenum Press.

    Google Scholar 

  • Campbell, M., Cohen, I. L., & Small, A. M. (1982). Drugs in aggressive behavior. Journal of the American Academy of Child Psychiatry, 21, 107–117.

    Article  PubMed  CAS  Google Scholar 

  • Campbell, M., Geller, B., & Cohen, I. L. (1977). Current status of drug research and treatment with autistic children. Journal of Pediatric Psychology, 2, 153–161.

    Article  Google Scholar 

  • Campbell, M., Green, W. H., & Deutsch, S. I. (1985). Child and adolescent psychopharmacology. Beverly Hills: Sage.

    Google Scholar 

  • Campbell, M., Grega, D. M., Green, W. H., & Bennett, W. G. (1983). Neuroleptic-induced dyskinesias in children. Clinical Neuropharmacology, 6, 207–222.

    Article  PubMed  CAS  Google Scholar 

  • Campbell, M., Perry, R., & Green, W. H. (1984). Use of lithium in children and adolescents. Psychosomatics, 25, 95–106.

    Article  PubMed  CAS  Google Scholar 

  • Campbell, M., Small, A. M., Green, W. H., Jennings, S. J., Perry, R., Bennett, W. G., & Anderson, L. (1984). Behavioral efficacy of haloperidol and lithium carbonate: A comparison in hospitalized aggressive children with conduct disorder. Archives of General Psychiatry, 41, 650–656.

    Article  PubMed  CAS  Google Scholar 

  • Campbell, M., Small, A. M., Palij, M., Perry, R., Polonsky, B. B., Lakashok, D., & Anderson, L. T. (1987). The efficacy and safety of fenfluramine in autistic children: Preliminary analysis of a double-blind study. Psychopharmacology Bulletin, 23, 123–127.

    PubMed  CAS  Google Scholar 

  • Cohen, D. J., Shaywitz, B. A., Young, J. G., Carbonari, C.M., Nathanson, J. A., Lieberman, D., Bowers, M. B., & Mass, J. W. (1979). Central biogenic amine metabolism in children with the syndrome of chronic multiple tics of Gilles de la Tourette. Journal of the American Academy of Child Psychiatry, 18, 320–341.

    Article  PubMed  CAS  Google Scholar 

  • Comings, D. E., & Comings, B. G. (1984). Tourette’s syndrome and attention deficit with hyperactivity: Are they genetically related? Journal of the American Academy of Child Psychiatry, 23, 138–146.

    Article  PubMed  CAS  Google Scholar 

  • Connell, P. H., Corbett, J. A., Home, D. J., & Mathews, A. M. (1967). Drug treatment of adolescent tiguers: A double-blind trial of diazepam and haloperidol. British Journal of Psychiatry, 113, 375–381.

    Article  PubMed  CAS  Google Scholar 

  • Conners, C. K. (1969). A teacher rating scale for use in drug studies with children. American Journal of Psychiatry, 126, 152–156.

    Google Scholar 

  • Conners, C. K. (1985). Issues in the study of adolescent ADD-H/hyperactivity. Psychopharmacology Bulletin, 21, 243–250.

    PubMed  CAS  Google Scholar 

  • Conners, C. K., Kramer, R., Rothschild, G. H., Schwartz, L., & Stone, A. (1971). Treatment of young delinquent boys with diphenylhydantoin sodium and methylphenidate: A controlled comparison. Archives of General Psychiatry, 24, 156–162.

    Article  PubMed  CAS  Google Scholar 

  • Conners, C. K., & Taylor, E. (1980). Pemoline, methylphenidate, and placebo in children with minimal brain dysfunction. Archives of General Psychiatry, 21, 182–190.

    Article  Google Scholar 

  • Cunningham, M. A., Pillai, V., & Rogers, W. J. B. (1968). Haloperidol in the treatment of children with severe behavior disorders. British Journal of Psychiatry, 114, 845–854.

    Article  PubMed  CAS  Google Scholar 

  • D’Amato, G. (1962). Chlordiazepoxide in management of school phobia. Diseases of the Nervous System, 23, 292–295.

    PubMed  Google Scholar 

  • DeLong, G. R., & Aldershof, A. L. (1987). Long-term experience with lithium treatment in childhood: Correlation with clinical diagnosis. Journal of the American Academy of Child and Adolescent Psychiatry, 26, 389–394.

    Article  PubMed  CAS  Google Scholar 

  • DeLong, G. R., & Nieman, G. W. (1983). Lithium-induced behavior changes in children with symptoms suggesting manic-depressive illness. Psychopharmacology Bulletin, 19, 258–265.

    PubMed  CAS  Google Scholar 

  • Denckla, M. B., Bemporad, J. R., & MacKay, M. C. (1976). Tics following methylphenidate administration: A report of 20 cases. Journal of the American Medical Association, 235, 1349–1351.

    Article  PubMed  CAS  Google Scholar 

  • Deutsch, S.I. (1986a). Managing behavior in mentally retarded residential populations. Hospital and Community Psychiatry, 37, 221–222.

    PubMed  CAS  Google Scholar 

  • Deutsch, S.I. (1986b). Rationale for the administration of opiate antagonists in treating infantile autism. American Journal of Mental Deficiency, 90, 631–635.

    PubMed  CAS  Google Scholar 

  • Evans, B. W., Clay, T. H., & Gualtieri, T. (1987). Carbamazepine in pediatric psychiatry. Journal of the American Academy of Child and Adolescent Psychiatry, 26, 2–8.

    Article  PubMed  CAS  Google Scholar 

  • Geller, B., & Greydanus, B. E. (1979). Haloperidol-induced comatose state with hyperthermia and rigidity in adolescence: Two case reports and a literature review. Journal of Clinical Psychiatry, 40, 102–103.

    PubMed  CAS  Google Scholar 

  • Gittelman, R., & Mannuzza, S. (1985). Diagnosing ADD-H in adolescents. Psychopharmacology Bulletin, 21, 237–242.

    PubMed  CAS  Google Scholar 

  • Gittelman-Klein, R., & Klein, D. F. (1973). School phobia: Diagnostic considerations in the light of imipramine effects. Journal of Nervous and Mental Disease, 156, 199–215.

    Article  PubMed  CAS  Google Scholar 

  • Gittelman-Klein, R., Klein, D. F., Katz, S., Saraf, K. R., & Pollack, E. (1976). Comparative effects of methylphenidate and thioridazine in hyperkinetic children: I. Clinical results. Archives of General Psychiatry, 33, 1217–1231.

    Article  PubMed  CAS  Google Scholar 

  • Glick, B. S., Schulman, D., & Turecki, S. (1971). Diazepam (Valium) treatment in childhood sleep disorders. Diseases of the Nervous System, 32, 565–566.

    PubMed  CAS  Google Scholar 

  • Green, W. H., Campbell, M., Wolsky, B. B., Deutsch, S. I., Golden, R. R., & Cicero, S. D. (October, 1984). Effects of short and long term haloperidol administration on growth in young autistic children. Paper presented at the 31st Annual Meeting of the American Academy of Child Psychiatry, Toronto.

    Google Scholar 

  • Greenblatt, D. J., & Shader, B. I. (1974). Benzodiazepines in clinical practice. New York: Raven Press.

    Google Scholar 

  • Greenhill, L. L., Rieder, R. O., Wender, P. H., Buchsbaum, M., & Zahn, T. P. (1973). Lithium carbonate in the treatment of hyperactive children. Archives of General Psychiatry, 28, 636–640.

    Article  PubMed  CAS  Google Scholar 

  • Gualtieri, C. T., Quade, D., Hicks, R. E., Mayo, J. P., & Schroeder, S. R. (1984). Tardive dyskinesia and other clinical consequences of neuroleptics treatment in children and adolescents. American Journal of Psychiatry, 141, 20–23.

    PubMed  CAS  Google Scholar 

  • Herman, B. H., Hammock, M. K., Arthur-Smith, A., Egan, J., Chatoor, I., Zelnick, N., Appelgate, K., Beockx, R. L. (1986). Effects of naltrexone in autism: Correlation with plasma opioid concentrations. Scientific Proceedings for the Annual Meeting of the American Academy of Child and Adolescent Psychiatry, 2, 11–12.

    Google Scholar 

  • Kline, A. H. (1968). Diazepam and the management of nocturnal enuresis. Clinical Medicine, 75, 20–22.

    Google Scholar 

  • Kraft, I. A., Ardali, C., Duffy, J. H., Hart, J. T., & Pearce, P. (1965). A clinical study of chlordiazepoxide used in psychiatric disorders of children. International Journal of Neuropsychiatry, 1, 433–437.

    PubMed  CAS  Google Scholar 

  • Krakowski, A. J. (1963). Chlordiazepoxide in treatment of children with emotional disturbances. New York State Journal of Medicine, 63, 3388–3392.

    PubMed  CAS  Google Scholar 

  • Lefkowitz, M. M. (1969). Effects of diphenylhydantoin on disruptive behavior. Archives of General Psychiatry, 20, 643–651.

    Article  PubMed  CAS  Google Scholar 

  • Levenson, J. L. (1985). Neuroleptic malignant syndrome. American Journal of Psychiatry, 142, 1137–1145.

    PubMed  CAS  Google Scholar 

  • Lowe, T. L., Cohen, D. J., Detlor, J., Kremenitzer, M. W., & Shaywitz, B. A. (1982). Stimulant medications precipitate Tourette’s syndrome. Journal of the American Medical Association, 247, 1729–1731.

    Article  PubMed  CAS  Google Scholar 

  • Lucas, A. R., & Pasley, F. C. (1969). Psychoactive drugs in treatment of emotionally disturbed children: Haloperidol and diazepam. Comprehensive Psychiatry, 10, 376–386.

    Article  PubMed  CAS  Google Scholar 

  • Mattes, J., & Gittelman, R. (1983). Growth of hyperactive children on maintenance methylphenidate. Archives of General Psychiatry, 40, 317–321.

    Article  PubMed  CAS  Google Scholar 

  • McNutt, B. A., Boileau, R. A., Cohen, M. N., Sprague, R. L., & von Neumann, A. (May, 1976). The effects of long term stimulant medication on the growth and body composition of hyperactive children: II. Report on 2 years. Paper presented at the Annual Early Clinical Drug Evaluation Unit Meeting, Psychopharmacology Research Branch, National Institute of Mental Health, Key Biscayne, FL.

    Google Scholar 

  • Panksepp, J., & Sahley, T. L. (1987. Possible brain opioid involvement in disrupted social intent and language development in autism. In E. Schopler & G. B. Mesibov (Eds.), Neurobiological issues in autism (pp. 357–372). New York: Plenum Press.

    Google Scholar 

  • Perry, R., Campbell, M., Adams, P., Lynch, N., Spencer, E. K., Curren, E. L., & Overall, S. E. (1989). Long-term haloperidol in autistic children: Continuous vs. discontinuous drug administration. Journal of the American Academy of Child and Adolescent Psychiatry, 28, 87–92.

    Article  PubMed  CAS  Google Scholar 

  • Perry, R., Campbell, M., Green, W. H., Small, A. M., Die Trill, M. L., Meiselas, K., Golden, R. R., & Deutsch, S. I. (1985). Neuroleptic-related dyskinesias in autistic children: A prospective study. Psychopharmacology Bulletin, 21, 140–143.

    PubMed  CAS  Google Scholar 

  • Pesikoff, R. B., & Davis, P. C. (1971). Treatment of pavor nocturnus and somnambulism in children. American Journal of Psychiatry, 128, 778–781.

    PubMed  CAS  Google Scholar 

  • Petti, T. A., & Campbell, M. (1975). Imipramine and seizures. American Journal of Psychiatry, 132, 538–540.

    PubMed  CAS  Google Scholar 

  • Petti, T. A., Fish, B., Shapiro, T., Cohen, I. L., & Campbell, M. (1982). Effects of chlordiazepoxide in disturbed children: A pilot study. Journal of Clinical Psychopharmacology, 2, 270–273.

    PubMed  CAS  Google Scholar 

  • Physicians Desk Reference. (1989). Oradell, NJ: Medical Economics Company.

    Google Scholar 

  • Platt, J. E., Campbell, M., Green, W. H., & Grega, D. M. (1984). Cognitive effects of lithium carbonate and haloperidol in treatment-resistant aggressive children. Archives of General Psychiatry, 41, 657–662.

    Article  PubMed  CAS  Google Scholar 

  • Pliszka, S. (1987). Tricyclic antidepressants in the treatment of children with attention deficit disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 26, Mini.

    Google Scholar 

  • Polakoff, S. A., Sorgi, P. J., & Ratey, J. J. (1986). The treatment of impulsive and aggressive behavior with nadolol. Journal of Clinical Psychopharmacology, 6, 125–126.

    Article  PubMed  CAS  Google Scholar 

  • Pool, D., Bloom, W., Mielke, D. H., Roniger, J. J., & Gallant, D. M. (1976). A controlled evaluation of loxitane in seventy-five adolescent schizophrenic patients. Current Therapeutic Research, 19, 99–104.

    PubMed  CAS  Google Scholar 

  • Pouissant, A. F., & Ditman, K. S. (1965). A controlled study of imipramine (Tofranil) in the treatment of childhood enuresis. Journal of Pediatrics, 67, 283–290.

    Article  Google Scholar 

  • Puig-Antich, J., Perel, J. M., Lupatkin, W., Chambers, W. J., Tabrizi, M. A., King, J., Goetz, R., Davies, M., & Stiller, R. L. (1987). Imipramine in prepubertal major depressive disorders. Archives of General Psychiatry, 44, 81–89.

    Article  PubMed  CAS  Google Scholar 

  • Rapoport, J. L., Buchsbaum, M. S., Weingartner, H., Zahn, T. P., Ludlow, C., & Mikkelsen, E. J. (1980). Dextroamphetamine: Its cognitive and behavioral effects in normal and hyperactive boys and normal men. Archives of General Psychiatry, 37, 933–943.

    Article  PubMed  CAS  Google Scholar 

  • Rapoport, J. L., Mikkelsen, E. J., & Werry, J. S. (1978). Antimanic, antianxiety, hallucinogenic and miscellaneous drugs. In J. S. Werry (Ed.), Pediatric psychopharmacology: The use of behavioral modifying drugs in children (pp. 316–355). New York; Brunner/Mazel.

    Google Scholar 

  • Rapoport, J. L., Mikkelsen, E. J., Zavadil, A., Nee, L., Gruenau, C., Mendelson, W., & Gillin, J. C. (1980). Childhood enuresis: II. Psychopathology, tricyclic concentration in plasma and antienuretic effect. Archives of General Psychiatry, 37, 1146–1152.

    Article  PubMed  CAS  Google Scholar 

  • Ratey, J. J., Mikkelson, E., Sorgi, P., Zuckerman, S., Polakoff, S., Bemporad, J., Bick, P., & Kadish, W. (1987). Autism: The treatment of aggressive behaviors. Journal of Clinical Psychopharmacology, 7, 35–41.

    PubMed  CAS  Google Scholar 

  • Realmuto, G. M., Erickson, W. D., Yellin, A. M., Hopwood, J. H., & Greenberg, L. M. (1984). Clinical comparison of thiothixene and thioridazine in schizophrenic adolescents. American Journal of Psychiatry, 14, 440–442.

    Google Scholar 

  • Ritvo, E. R., Freeman, B. J., Yuwiler, A., Geller, E., Schroth, P., Yokota, A., Mason-Brothers, A., August, G. J., Klykylo, W., Leventhal, B., Lewis, K., Piggott, L., Realmuto, G., Stubbs, E. G., & Umansky, R. (1986). Fenfluramine treatment of autism: UCLA collaborative study of 81 patients at nine medical centers. Psychopharmacology Bulletin, 22, 133–140.

    PubMed  CAS  Google Scholar 

  • Rogers, W. J. B. (1965). Use of haloperidol in children’s psychiatric disorders. Clinical Trials Journal, 2, 162–165.

    Google Scholar 

  • Satterfield, J. H., Cantwell, D. P., Schell, A., & Blaschke, T. (1979). Growth of hyperactive children treated with methylphenidate. Archives of General Psychiatry, 36, 212–217.

    Article  PubMed  CAS  Google Scholar 

  • Shapiro, A. K., Shapiro, E., & Wayne, H. (1973). Treatment of Tourette’s syndrome. Archives of General Psychiatry, 28, 92.

    Article  PubMed  CAS  Google Scholar 

  • Sheard, M. H. (1975). Lithium in the treatment of aggression. Journal of Nervous and Mental Disease, 160, 108–118.

    Article  PubMed  CAS  Google Scholar 

  • Sheard, M. H., Marini, J. L., Bridges, C. I., & Wagner, E. (1976). The effects of lithium on impulsive, aggressive behavior in man. American Journal of Psychiatry, 133, 1409–1413.

    PubMed  CAS  Google Scholar 

  • Siassi, I. (1982). Lithium treatment of impulsive behavior in children. Journal of Clinical Psychiatry, 32, 34–42.

    Google Scholar 

  • Simpson, G. M., Lee, J. H., Zoubok, B., & Gardos, G. (1979). A rating scale of tardive dyskinesia. Psychopharmacology (Berlin), 64, 171–179.

    Article  CAS  Google Scholar 

  • Wender, P. H., Wood, D. R., & Reimirer, F. W. (1985). Pharmacological treatment of attention deficit disorder, residual type (ADD, RT, “minimal brain dysfunction,” “hyperactivity”) in adults. Psychopharmacology Bulletin, 21, 222–227.

    PubMed  CAS  Google Scholar 

  • Werry, J. S., & Aman, M. G. (1975). Methylphenidate and haloperidol in children: Effects on attention, memory and activity. Archives of General Psychiatry, 32, 790–795.

    Article  PubMed  CAS  Google Scholar 

  • Werry, J. S., Weiss, G., Douglas, V., & Martin J. (1966). Studies on the hyperactive child: III. The effects of chlorpromazine upon behavior and learning ability. Journal of the American Academy of Child Psychiatry, 5, 292–312.

    Article  PubMed  CAS  Google Scholar 

  • Williams, D. T., Mehl, R., Yudofsky, S., Adams, D., & Roseman, B. (1982). The effects of propranolol on uncontrolled rage outbursts in children and adolescents with organic brain dysfunction. Journal of the American Academy of Child Psychiatry, 21, 129–135.

    Article  PubMed  CAS  Google Scholar 

  • Wong, G. H., & Cock, P. J. (1971). Long-term effects of haloperidol on severely emotionally disturbed children. Australian and New Zealand Journal of Psychiatry, 5, 296–300.

    Article  PubMed  CAS  Google Scholar 

  • Zesiewicz, M. F., Natta, M. B., & Kupst, M. J. (1987). Effects of psychiatric hospitalization and psychotropic medications on weight in children. Journal of the American Academy of Child and Adolescent Psychiatry, 26, 854–857.

    Article  PubMed  CAS  Google Scholar 

  • Zrull, J. P., Westman, J. C., Arthur, B., & Bell, W. A. (1963). A comparison of chlordiazepoxide, d-amphetamine, and placebo in the treatment of the hyperkinetic syndrome in children. American Journal of Psychiatry, 120, 590–591.

    PubMed  CAS  Google Scholar 

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Small, A.M., Perry, R. (1989). Pharmacotherapy. In: Lyman, R.D., Prentice-Dunn, S., Gabel, S. (eds) Residential and Inpatient Treatment of Children and Adolescents. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0927-5_9

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