Abstract
It is well known that the most common manifestation of alcohol hepatotoxicty is the occurrence of a fatty liver, that is to say, an increase in the hepatic triacylglycerol level. Such an increase can be reproduced experimentally even by a single ethanol administration. It is still subject to debate whether the fatty liver induced by such administration is due to ethanol metabolism, resulting in an enhanced production of reducing equivalents in the hepatocyte and thereby inhibiting fatty acid oxidation. However other experimental data, such as those of Kalant, Khanna, Seymour, and Loth (1975), have brought arguments in favor of the role of ethanol per se, acting through an unspecific stress action, independent from ethanol metabolism.
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References
Abrams, M. A., and Cooper, C. “Quantitative analysis of metabolism of hepatic triglyceride in ethanol-treated rats.” Biochem. J., 1976, 156: 33–46.
Beaugé, F., Clément, M., Nordmann, J., and Nordmann, R. “Comparative effects of ethanol, n-propanol and isopropanol on lipid disposal by rat liver.” Chem. Biol. Interactions, 1979, 26: 155–166.
Brindley, D. N., Cooling, J., Burditt, S. L., Pritchard, P. H., Pawson, S., and Sturton, R. G. “The involvement of glucocorticoids in regulating the activity of phosphatidate phosphohydrolase and the synthesis of triacylglycerols in the liver. Effects of feeding rats with glucose, sorbitol, fructose, glycerol and ethanol.” Biochem J., 1979, 180: 195–199.
Cederbaum, A. I., and Cohen, G. “Oxidative demethylation of t-butyl alcohol by rat liver microsomes.” Biochem. Biophys. Res. Comm., 1980, 97: 730–736.
Kalant, H., Khanna, J. M., Seymour, F., and Loth, J. “Acute alcoholic fatty liver. Metabolism or stress.” Biochem. Pharmacol., 1975, 24: 431–434.
Lieber, C. S., and De Carli, L. M. “Metabolic effects of alcohol on the liver.” In C. S. Lieber (Ed.), Metabolic Aspects of Alcoholism. Lancaster: MTP Press, 1977.
Mc Comb, J. A., and Goldstein, D. B. “Quantitative comparison of physical dependence on tertiary butanol and ethanol in mice: correlation with lipid solubility.” J. Pharmacol. Exp. Ther., 1979, 208: 113–117.
Nordmann, R. “Metabolism of some higher alcohols.” In C. Stock and H. Sarles (Eds.) Alcohol and the Gastrointestinal Tract. Paris: INSERM -Editions, 1980, Vol. 95, pp. 187–206.
Thurman, R. G., and Pathman, D. E. “Withdrawal symptoms from ethanol: evidence against the involvement of acetaldehyde.” in K. O. Lindros and C. J. P. Eriksson (eds.), The Role of Acetaldehyde in the Action of Ethanol. Helsinki: Finnish Found. Alcohol Stud., 1975, pp. 217–231.
von Wartburg, J. P. “The metabolism of alcohol in normals and alcoholics: Enzymes.” In: B. Kissin and H. Begleiter (Eds.) The Biology of Alcoholism, Vol 1: Biochemistry. New York, Plenum Press, 1971, pp. 63–102.
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Nordmann, R., Beaugé, F., Clément, M., Nordmann, J. (1989). Metabolism Through Alcohol Dehydrogenase is Not a Prerequisite for Fatty Liver Induction by Alcohols. In: Einstein, S. (eds) Drug and Alcohol Use. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0888-9_32
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DOI: https://doi.org/10.1007/978-1-4899-0888-9_32
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