Abstract
The evaluation of sulfur-containing amino acids in urine is of interest in cystinuric subjects since the abnormally-high excretion of cystine, a disulfur amino acid, is responsible for the disease. Furthermore, sulfur drugs such as d-penicillamine (PEN) and 2-mercapto-propionyl-glycine (MPG) are often used in the treatment of cystinuric patients on the basis of a thiol-exchange reaction. Some of the resulting compounds appear in urine and their identification is necessary for a full comprehension of urine chromatograms. This study was designed to identify and determine such compounds in the urine of normal subjects and cystine stone patients.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
JA Harbar, DC Cusworth, LC Lawes, and OM Wrong, Comparison of 2-mercapto-propionylglycine and d-penicillamine in the treatment of cystinuria, J. Urol. 136: 146 (1986).
JS King, Jr., Treatment of cystinuria with α-mercaptopropionyl-glycine: a preliminary report with some notes on column chromatography of mercaptans, Proc. Soc. Exptl. Med. 129: 927 (1968).
GW Frimpter, The disulfide of 1-cysteine and 1-homocysteine in urine of patients with cystinuria, J. Biol. Chem. 236-.PC 51 (1961).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer Science+Business Media New York
About this chapter
Cite this chapter
Martini, C., Bruno, M., Petrarulo, M., Cosseddu, D., Linari, F. (1989). Sulfur Amino Acids, Thiol Drugs, and Related Mixed Disulfides from Urine Samples of Cystine Stone Patients. In: Walker, V.R., Sutton, R.A.L., Cameron, E.C.B., Pak, C.Y.C., Robertson, W.G. (eds) Urolithiasis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0873-5_174
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0873-5_174
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0875-9
Online ISBN: 978-1-4899-0873-5
eBook Packages: Springer Book Archive