Abstract
Prostaglandin E2 (PGE2) appears to be an important factor in calcium handling by the kidney (1) and has been forwarded as a determinant of hypercalciuria (2, 3). Thiazide diuretics are known to lower Ca excretion, and are widely used to prevent recurrent renal stone formation (4). However, the mechanism(s) by which thiazides lower urinary Ca is unclear. The purpose of this study was to search for a possible link between thiazides and PGE2 in the control of urinary Ca excretion.
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© 1989 Springer Science+Business Media New York
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Calò, L. et al. (1989). Prostaglandin E2 and Hydrochlorothiazide-Mediated Hypocalciuria: A Hypothesis. In: Walker, V.R., Sutton, R.A.L., Cameron, E.C.B., Pak, C.Y.C., Robertson, W.G. (eds) Urolithiasis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0873-5_113
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DOI: https://doi.org/10.1007/978-1-4899-0873-5_113
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