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Gastric Lipolysis and Fatty Acid Utilization in Preterm Infants

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Human Lactation 3

Abstract

Development of the newborn infant is greatly dependent upon the capability to utilize dietary fat. In human milk and infant formulas, fats provide 50% of the calories. Fat utilization is dependent upon 1) digestion of the dietary lipids by lipases present in the gastrointestinal tract, and 2) absorption of the hydrolyzed lipid products facilitated by bile salts (1). In the newborn, and especially in the premature infant, because of insufficient maturation, pancreatic lipase activity and bile salt levels are low (2). Consequently intragastric lipolysis by lingual and gastric (3) lipases may play an important role in fat digestion. This is especially critical for the premature or low-birth-weight infant.

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References

  1. Watkins JB. Mechanism of fat absorption and the development of gastrointestinal function. Pediatr Clin N Am 22:721–730 (1975).

    CAS  Google Scholar 

  2. Hamosh M. A Review, Fat digestion in the newborn: role of lingual lipase and preduodenal digestion. Pediatr Res 13:615–622 (1975).

    Article  Google Scholar 

  3. DeNigris SJ, Hamosh M, Kasbekar DK, Fink CK, Lee TC and Hamosh P. Human gastric lipases: secretion from dispersed gastric glands. Biochim Biophys Acta 836:67–72 (1985).

    Article  CAS  Google Scholar 

  4. Roy CC, Ste-Marie M, Chartrand L, Weber A, Bard H, Doray B. Correction of the malabsorption of the preterm infants with a medium-chain triglyceride formula. J Pediatr 86:446–450 (1975).

    Article  CAS  Google Scholar 

  5. Tantibhendyangkul P, Hashim SA. Medium-chain triglyceride feeding in premature infants. Effects on fat and nitrogen absorption. Pediatrics 55:359–370 (1975).

    Google Scholar 

  6. Shenai PJ, Reynolds JW, Babson SG. Nutritional balance studies in very-low-birth-weight infants: Enhanced nutrient retention rates by an experimental formula. Pediatrics 66:233–238 (1980).

    CAS  Google Scholar 

  7. Okamoto E, Muttart CR, Zucker CL, Heird WC. Use of medium-chain triglycerides in feeding the low birth weight infant. Am J Dis Child 136:428–431 (1982).

    CAS  Google Scholar 

  8. Dubowitz LM, Dubowitz V, Goldberg C. Clinical assessment of gestational age in the newborn infant. J Pediatr 77:1–10 (1970).

    Article  CAS  Google Scholar 

  9. Alemi B, Hamosh M, Scanlon JW, Salzman-Mann C, Hamosh P. Fat digestion in very low birth weight infants: effect of addition of human milk to LBW formula. Pediatrics 68:484–489 (1981).

    CAS  Google Scholar 

  10. Liao TH, Hamosh P, Hamosh M. Fat digestion by lingual lipase: Mechanism of lipolysis in the stomach and upper small intestine. Pediatr Res 18:402–409 (1984).

    Article  CAS  Google Scholar 

  11. Folch J, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497–509 (1957).

    CAS  Google Scholar 

  12. Liao TH, Hamosh P, Hamosh M. Gastric lipolysis in the developing rat: Ontogeny of the lipases active in the stomach. Biochim Biophys Acta 754:1–9 (1983).

    Article  CAS  Google Scholar 

  13. Bitman J, Wood DL, Hamosh M, Hamosh P, Mehta NR. Comparison of the lipid composition of breast milk from mothers of term and preterm infants. Am J Clin Nutr 38:300–12 (1983).

    CAS  Google Scholar 

  14. Jeejeebhoy KN, Ahmad S, Kozak G. Determination of fecal fats containing both medium and long chain triglycerides and fatty acids. Clin Biochem 3:157–163 (1970).

    CAS  Google Scholar 

  15. Chew V. Comparisons among treatment means in an analysis of variance. USDA Agricultural Research Publication. ARS/H/6, Beltsville, MD (1977).

    Google Scholar 

  16. Bitman J, Wood DL, Liao TH, Fink CS, Hamosh P, Hamosh M. Gastric lipolysis of milk lipids in suckling rats. Biochim Biophys Acta 834:58–64 (1985).

    Article  CAS  Google Scholar 

  17. Carey MC, Small DM, Bliss CM. Lipid digestion and absorption. Ann Rev Physiol 45:651–677 (1983).

    Article  CAS  Google Scholar 

  18. Abrams CK, Hamosh M, Hubbard VS, Dutta SK, Hamosh P. Lingual lipase in cystic fibrosis. Quantitation of enzyme activity in the upper small intestine of patients with exocrine pancreatic insufficiency. J Clin Invest 73:374–382 (1984).

    Article  CAS  Google Scholar 

  19. Abrams CK, Hamosh M, Dutta SK, Hubbard VS, Hamosh P. The role of non-pancreatic lipolytic activity in exocrine pancreatic insufficiency. Gastroenterology 1987; In Press.

    Google Scholar 

  20. Huston RK, Reynolds JW, Jensen C, Buist NRM. Nutrient and mineral retention and vitamin D absorption in low birth weight infants: effect of medium-chain triglyceride. Pediatrics 72:44–48 (1983).

    CAS  Google Scholar 

  21. Whyte RK, Campbell D, Stanhope R, Bayley HS, Sinclair JC. Energy balance in low birth weight infants fed formula of high or low medium-chain triglyceride content. J Pediatr 108:946–71 (1986).

    Google Scholar 

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© 1987 Springer Science+Business Media New York

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Bitman, J. et al. (1987). Gastric Lipolysis and Fatty Acid Utilization in Preterm Infants. In: Goldman, A.S., Atkinson, S.A., Hanson, L.Ã…. (eds) Human Lactation 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0837-7_17

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  • DOI: https://doi.org/10.1007/978-1-4899-0837-7_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0839-1

  • Online ISBN: 978-1-4899-0837-7

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