Abstract
Myosin, a major component of skeletal muscle, is encoded by a multigene family. Three major isoforms of the heavy chain subunits, one slow twitch and two fast twitch, have been distinguished in adult skeletal muscles of mammals (Whalen, 1985). These isoforms are related to specific, physiologically defined fiber types and their expression is clearly nerve-dependent. In chicken and amphibia, there is also another slow myosin heavy chain isoform — slow tonic myosin, present in multiply innervated, slow contracting fibers (Pierobon-Bormioli et al., 1980). This isoform is also expressed in mammalian skeletal muscle, but only in extraocular muscles and in some intrafusal fibers of muscle spindles (Pierobon-Bormioli et al., 1980; Rowlerson et al., 1985).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Barker, D., and Banks, R. W., 1986, The muscle spindle, in: “Myology”, A. G. Engel and B. Q Barker, eds., Mc Graw-Hill Co, New York, pp. 309–340.
Bowden, R. E. M., 1963, Muscle spindles in the human foetus, Acta Biol. Univ. Szeged IX, 35-59.
Butler-Browne, G. S., and Whalen, R. G., 1984, Myosin isozyme transitions occurring during the post-natal development of the rat soleus muscle. Dev. Biol., 102:324–334.
Colling-Saltin, A.-S., 1978, Enzyme histochemistry on skeletal muscle of the human foetus, J. Neurol. Sci., 39, 169–185.
Cuajunco, F., 1940, Development of the neuro-muscular spindle in human fetuses, Carnegie Inst. Wash. Pub. No 173 Contrib. to Embryology, 28, 95–128.
Dhoot, G. K., 1986, Selective synthesis and degradation of slow skeletal myosin heavy chains in developing muscle fibers, Muscle & Nerve, 9, 155–164.
Dubowitz, V., 1965, Enzyme histochemistry of skeletal muscle, Part 2: Developing human muscle, J. Neurol. Neurosurg. Psychiat., 28, 519–524.
Fenichel, G. M., 1966, A histochemical study of developing human skeletal muscle, Neurology (Minneap.), 16, 741–745.
Grove, B. K., Kurer, V., Lehner, C., Doetschman, T. C., Perriard, J.-C., and Eppenberger, H. M., 1984, A new 185,000-dalton muscle protein detected by monoclonal antibodies, J. Cell Biol., 98, 518–524.
Milburn, A., 1984, Stages in the development of cat muscle spindles, J. Embryol. exp. Morph., 82, 177–216.
Miller, J. B., and Stockdale, F. E., 1986, Developmental regulation of the multiple myogenic cell lineages of the avian embryo, J. Cell Biol., 103, 2197–2208.
Narusawa, M., Fitzsimons, R. B., Izumo, S., Nadal-Ginard, B., Rubinstein, N. A., and Kelly, A. M., 1987, Slow myosin in developing rat skeletal muscle, J. Cell Biol., 104, 447–459.
Pierobon-Bormioli, S., Sartore, S., Vitadello, M., and Schiaffino, S., 1980, “Slow” myosins in vertebrate skeletal muscle. An immuno-fluorescence study, J. Cell Biol., 85, 672–681.
Pons, F., Léger, J. O. C, Chevallay, M., Tomé, F. M. S., Fardeau, M., and Léger, J. J., 1986, Immunocytochemical analysis of myosin heavy chains in human fetal skeletal muscles, J. Neurol. Sci., 76, 151–163.
Przedpelska-Ober, E. 1982, The development of muscle spindles in human fetuses. Anat. Anz. (Jena), 152:371–382.
Rowlerson, A., Gorza, L., and Schiaffino, S, Immunohistochemical identification of spindle fibre types in mammalian muscle using type-specific antibodies to isoforms of myosin, in: “The Muscle Spindle,” I. A. Boyd, and M. H. Gladden, eds., Stockton Press, Glasgow (1985).
Sawchak, J. A., Leung, B., and Shafiq, S. A., 1985, Characterization of a monoclonal antibody to myosin specific for mammalian and human type II muscle fibers, J. Neurol. Sci., 69, 247–254.
Thornell, L.-E., Billeter, R., Butler-Browne, G. S., Eriksson, P. O., Ringqvist, M., and Whalen R. G., 1984, Development of fiber types in human fetal muscle, An immunocytochemical study, J. Neurol. Sci., 66, 107–115.
Whalen, R. G., 1985, Myosin isoenzymes as molecular markers for muscle physiology, J. exp. Biol., 115, 43–53.
Whalen, R. G., Sell, S. M., Butler-Browne, G. S., Schwartz, K., Bouveret, P., and Pinset-Hänström, I., 1981, Three myosin heavy-chain isozymes appear sequentially in rat muscle development, Nature (Lond.), 292, 805–809.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer Science+Business Media New York
About this chapter
Cite this chapter
Thornell, LE., Eriksson, PO., Fischman, D.A., Grove, B.K., Butler-Browne, G.S., Virtanen, I. (1988). Human Muscle Spindle Development. In: Hník, P., Soukup, T., Vejsada, R., Zelená, J. (eds) Mechanoreceptors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0812-4_7
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0812-4_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0814-8
Online ISBN: 978-1-4899-0812-4
eBook Packages: Springer Book Archive