Abstract
Sequential or double immunostaining studies revealed the coexistence of substance P and CGRP in perivascular nerve fibers in mesenteric arteries (Uddman et al., 1986) and veins (Warthon et al., 1986). The potential role of capsaicin-sensitive primary afferents in the physiological regulation of dog intestinal blood flow was first suggested by Rozsa et al. (1984, 1985). Later on, it was shown that intraluminal capsaicin administration in isolated perfused rat mesenteric bed elicits remarkable vasodilation which is unaffected by cholinergic or adrenergic blockade, hexamethonium and tetrodotoxin (Manzini and Perretti, 1988). This relaxation was markedly reduced or even abolished after “in vivo” or “in vitro” capsaicin pretreatment suggesting desensitization, a typical feature of a certain subset of primary sensory nerves (Maggi and Meli, 1988). Kawasaki et al. (1988) have presented functional evidence that in mesenteric resistance vessels calcitonin gene-related peptide (CGRP) released from capsaicin-sensitive nonadrenergic-noncholinergic (NANC) fibers may act as a potent endogenous vasodilator.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Furchgott, R.F., and Zawadzki J.U., 1980, The obligatory role of endothelial cells in relaxation of arterial smooth muscle by acethylcholine, Nature, 288:373.
Furchgott, R.F., Carvalho, M.H., Khan, M.T., and Matsunaga, K. 1987, Evidence for endothelium-dependent vasodilation of resistance vessels by acethylcholine, Blood Vessels, 24:145.
Grace, G.C., Dusting, G.J., Kemp, B.E., and Martin, T.J., 1987, Endothelium and the vasodilator action of rat calcitonin gene-related peptide (CGRP), Br. J. Pharmacol., 91:729.
Greenberg, B., Rhoden, K., and Barnes, P., 1987, Calcitonin gene-related peptide (CGRP) is a potent non-endothelium-dependent inhibitor of coronary vasomotor tone, Br. J. Pharmacol., 92:789.
Holzer, P., 1988, Local effector functions of capsaicin-sensi-tive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides, Neuroscience, 24:739.
Kawasaki, H., Takasaki, K., Saito, A., and Goto, K., 1988, Calcitonin gene-related peptide acts as a novel vasodilator neurotransmitter in mesenteric resistance vessels of the rat, Nature, 335:164.
Maggi, C.A., and Meli, A., 1988, The sensory-efferent function of capsaicin-sensitive sensory neurons, Gen. Pharmacol., 19:1.
Maggi, C.A., Santicioli, P., Del Bianco, E., Geppetti, P., Barbanti, G., Turini, D., and Meli, A., 1989, Release of VIP but not CGRP-LI by capsaicin from the human isolated small intestine, Neurosci. Lett., 98: 317.
Manzini, S., and Perretti, F., 1988, Vascular effects of capsaicin in isolated perfused rat mesenteric bed, Eur. J. Pharmacol., 148:153.
Manzini S., Perretti, F., De Benedetti, L., Pradelles, P., Maggi C.A., and Geppetti, P., 1989, A comparison of bradykinin-and capsaicin-induced myocardial and coronary effects in isolated perfused heart of guinea-pig: involvement of substance P and calcitonin gene-related peptide, Br. J. Pharmacol., 97:303.
Marsh, S.J., Stanfeld, C.E., Brown, D.A., Davey, R., and McCarthy, D., 1987, The mechanism of action of capsaicin on sensory C-type neurons and their axons in vitro, Neuroscience, 23:275.
Marshall, I., Al-Kazwini, S.J., Holman, J.J., and Craig, R.K., 1986, Human and rat a-CGRP but not calcitonin cause mesenteric vasodilatation in rats, Eur. J. Pharmacol. 123:217.
Perretti F., Geppetti, P., and Manzini, S., 1988, Stimulation of capsaicin-sensitive sensory fibers induces vasodilation in rat mesenteric bed, Reg. Peptides 22:145.
Rozsa, Z., Jancsò, G., and Varrò, V., 1984, Possible involvement of capsaicin-sensitive sensory nerves in the regulation of intestinal blood flow in the dog, Naunyn-Schmiedeb. Arch. Pharmacol. 326:352.
Rozsa, Z., Varrò, A., and Jancsò, G., 1985, Use of immuno-blockade to study the involvement of peptidergic afferent nerves in the intestinal vasodilatory response to capsaicin in the dog, Eur. J. Pharmacol. 115:59.
Rozsa, Z., Sharkey, K.A., Jancsò, G., and Varrò, A., 1985, Evidence for a role of capsaicin-sensitive mucosal afferent nerves in the regulation of mesenteric blood flow in the dog, Gastroenterology 90:906.
Rozsa, Z., and Jacobson, E.D., 1989, Capsaicin-sensitive nerves are involved in bile-oleate-induced intestinal hyperemia, Am. J. Physiol. 256:G476.
Stewart-Lee, A., and Burnstock, G., 1989, Actions of tachykinins on the rabbit mesenteric artery: substance P and (Glp6,L-Pro9) SP6–11 are potent agonists for endothelial neurokinin-1 receptors, Br. J. Pharmacol. 97:1218
Uddman R., Edvinsson, L., Ekblad, E., Hakanson, R., and Sundler, F., 1986, Calcitonin gene-related peptide (CGRP): perivascular distribution and vasodilatory effects, Reg. Peptides 15:1.
Wharton, J., Gulbenkian, S., Mulderry, P.K., Ghatei, M.A., McGregor, G.P., Bloom, S.R., and Polak, J.M., 1986, Capsaicin induces a depletion of calcitonin gene-related peptide (CGRP)-immunoreactive nerves in the cardiovascular system of the guinea pig and rat, J. Aut. Nerv. Syst. 16:289.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
Manzini, S., Tramontana, M., Perretti, F. (1991). Efferent Function of Capsaicin-Sensitive Nerves and Neurogenic Vasodilation in Rat Mesenteric Circulation. In: Costa, M., Surrenti, C., Gorini, S., Maggi, C.A., Meli, A. (eds) Sensory Nerves and Neuropeptides in Gastroenterology. Advances in Experimental Medicine and Biology, vol 298. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0744-8_22
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0744-8_22
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0746-2
Online ISBN: 978-1-4899-0744-8
eBook Packages: Springer Book Archive