Abstract
Phosphatidylinositol (PI) and phosphatidylcholine (PC), two major membrane phospholipids (PLs), participate in cell signaling. Their hydrolysis by activated phospholipases produces second messengers, one of which is diacylglycerol (DAG), an activator of protein kinase C which is involved in a variety of cellular responses (1–5).
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References
A. Kishimoto, Y. Takai, T. Mori, U. Kikkawa, and Y. Nishizuka, Activation of calcium and phospholipiddependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover, J Biol Chem 255: 2273 (1980)
R. H. Michell, Inositol phospholipids in membrane function, Trends Biochem Sci 4: 128 (1979)
M. J. Berridge, Inositol trisphosphate and diacylglycerol as second messengers, Biochem J 220: 345 (1984)
J. H. Exton, Signaling through phosphatidylcholine breakdown, J Biol Chem 265: 1 (1990)
Y. Nishizuka, Studies and perspectives of protein kinase C, Science 233: 305 (1986)
J. Turk, R. L. Maas, A. R. Brash, L. J. Roberts, II, and J. A. Oates, Arachidonic acid 15-lipoxygenase products from human eosinophils, J Biol Chem 257: 7068 (1982)
J. A. Hunter, W. E. Finkbeiner, J. A. Nadel, E. J. Goetzl, and M. J. Holtzman, Predominant generation of 15lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea, Proc Natl Acad Sci USA 82: 4633 (1985)
M. Hamberg and B. Samuelsson, Prostaglandin endoperoxides: novel transformations of arachidonic acid in human platelets, Proc Natl Acad Sci USA 721: 3400 (1974)
A. A. Spector, J. A. Gordon, and S. A. Moore, Hydroxyeicosatetraenoic acids (HETEs), Prog Lipid Res 27: 271 (1988)
A. B. Legrand, J. A. Lawson, B. O. Meyrick, I. A. Blair, and J. A. Oates, Substitution of 15hydroxyeicosatetraenoic acid in the phosphoinositide signaling pathway, J Biol Chem 266: 7570 (1991)
J. Preiss, C. R. Loomis, W. R. Bishop, R. Stein, J. E. Niedel, and R. M. Bell, Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras-and sis-transformed normal rat kidney cells, J Biol Chem 261: 8597 (1986)
L. Wang, T. L. Kaduce, and A. A. Spector, Localization of 12-hydroxyeicosatetraenoic in endothelial cells, J Lipid Res 31: 2265 (1990)
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Legrand, A.B., Lawson, J.A., Oates, J.A. (1991). Incorporation of Hydroxyeicosatetraenoic Acids into Phospholipid Signaling Pathways. In: Bailey, J.M. (eds) Prostaglandins, Leukotrienes, Lipoxins, and PAF. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0727-1_17
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DOI: https://doi.org/10.1007/978-1-4899-0727-1_17
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