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Biological Correlates of Suicide across the Life Span

  • Chapter
Life Span Perspectives of Suicide

Abstract

Much has been said about the psychological implications of the various stages of life as regards suicide. The life span is generally depicted as involving a dynamic, ever-changing interplay of both internal and external forces that largely determine the nature and stability of a person’s emotional experience. A major focus has been on developmental tasks and goals that, if incompletely or tardily accomplished, become an obstacle to subsequent growth, and a source of psychic pain conducive to self-destructive activity.

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References

  • Arato, M., Banki, C., Bissette, G., & Nemeroff, C. (1989a). Elevated CSF CRF in suicide victims. Biological Psychiatry, 25, 355–359.

    Article  PubMed  CAS  Google Scholar 

  • Arato, M., Banki, C., Tothfulusi, L., Bissette, G., Nemeroff, C., & Akil, H. (1989b, May). CSF neuropeptide changes in depression and suicide. Presented at the American Psychiatric Association Annual Meeting, San Francisco, CA.

    Google Scholar 

  • Agren, H. (1983). Life at risk: Markers of suicidality in depression. Psychiatric Developments, 1, 87–103.

    PubMed  CAS  Google Scholar 

  • Arora, R., & Meltzer, H. (1989). Serotonergic measures in the brains of suicide victims: 5HT2 binding sites in the frontal cortex of suicide victims and control subjects. American Journal of Psychiatry, 146, 730–736.

    PubMed  CAS  Google Scholar 

  • Asberg, M., Traskman, L., & Thoren, P (1976). 5-HIAA in the cerebrospinal fluid: A biochemical suicide predictor? Archives of General Psychiatry, 33, 1193–1197.

    Article  PubMed  CAS  Google Scholar 

  • Ash, K., Clark, S., Sandberg, L., Hunter, E., & Woodward, S. (1983). The influences of sample distribution and age on reference intervals for adult males. American Journal of Clinical Pathology, 79, 574–581.

    PubMed  CAS  Google Scholar 

  • Baldessarini, R. (1975). An overview of the basis for amine hypothesis in affective illness. In J. Mendels (Ed.), The psychobiology of depression. New York: Spectrum.

    Google Scholar 

  • Banki, C. (1985). Biochemical markers for suicidal behavior. American Journal of Psychiatry, 142, 147–148.

    PubMed  CAS  Google Scholar 

  • Banki, C., & Arato, M. (1983a). Amine metabolites and neuroendocrine responses related to depression and suicide. Journal of Affective Disorders, 5, 223–232.

    Article  PubMed  CAS  Google Scholar 

  • Banki, C., & Arato, M. (1983b). Amine metabolites, neuroendocrine findings, and personality dimensions as correlates of suicidal behavior. Psychiatry Research, 10, 253–261.

    Article  PubMed  CAS  Google Scholar 

  • Banki, C., Arato, M., & Kiltz, C. (1986). Aminergic studies and cerebrospinal fluid cations in suicide. In J. Mann, & M. Stanley (Eds.), Psychobiology of suicidal behavior. New York: New York Academy of Sciences.

    Google Scholar 

  • Banki, C., Arato, M., Papp, Z., & Kurca, M. (1984). Biochemical markers in suicidal patients. Journal of Affective Disorder, 6, 341–350.

    Article  CAS  Google Scholar 

  • Banki, C., Vojnik, M., Papp, Z., Balla, K. Z., & Arato, M. (1985). Cerebrospinal fluid magnesium and calcium related to amine metabolites, diagnosis, and suicide attempts. Biological Psychiatry, 20, 163–171.

    Article  PubMed  CAS  Google Scholar 

  • Berger, M., Krieg, C., Bossert, S., Schreiber, W., & von Zerssen D. (1988). Past and present strategies of research on the HPA-axis in psychiatry. Acta Psychiatrica Scandinavica, 341, 112–125.

    Article  PubMed  CAS  Google Scholar 

  • Brown, G., Ebert, M., Goyer, P., Jimerson, D. C., Klein, W. J., Bunney, W. E., & Goodwin, F. K. (1982). Aggression, suicide, and serotonin: Relationships to CSF amine metabolites. American Journal of Psychiatry, 139, 741–746.

    PubMed  CAS  Google Scholar 

  • Bunney, W. (1984, October). The future of biologic psychiatry. Paper presented at the San Diego Psychiatric Symposium. San Diego, CA.

    Google Scholar 

  • Bunney, W., & Fawcett, J. (1965). Possibility of a biochemical test for suicide potential. Archives of General Psychiatry, 13, 232–239.

    Article  PubMed  CAS  Google Scholar 

  • Bunney, W., Fawcett, J., Davis, J., & Gifford, S. (1969). Further evaluation of urinary 17-hydroxycorticosteroids in suicidal patients. Archives of General Psychiatry, 21, 138–150.

    Article  PubMed  Google Scholar 

  • Carroll, B. (1983). Neurobiologic dimensions of depression and mania. In J. Angst (Ed.), The origins of depression: Current concepts and approaches (Dahlem Conference). New York: Springer.

    Google Scholar 

  • Chabrol, H., Claverie, J., & Moron, P. (1983). DST, TRH test, and adolescent suicide attempts. American Journal of Psychiatry, 140, 265.

    PubMed  CAS  Google Scholar 

  • Cochran, E., Robins, E., & Grote, S. (1976). Regional serotonin levels in brain: A comparison of depressive suicides and alcoholic suicides with controls. Biological Psychiatry, 11, 283–294.

    PubMed  CAS  Google Scholar 

  • Coryell, W., & Schlesser, M. (1981). Suicide and the DST in unipolar depression. American Journal of Psychiatry, 138, 1120–1121.

    PubMed  CAS  Google Scholar 

  • Cross, J., Cheetham, S., Crompton, M., Katona, C., & Horton, R. (1988). Brain GABA B binding sites in depressed suicide victims. Psychiatry Research, 26, 119–129.

    Article  PubMed  CAS  Google Scholar 

  • Crumley, F. (1983). The dexamethasone suppression test and adolescent suicide attempts. Paper presented at the 16th Annual Meeting of the American Association of Suicidology, Dallas, TX.

    Google Scholar 

  • Davis, B., Bishop, M., & Mass, D. (1989). Clinical laboratory science: Strategies for practice. Philadelphia: Lippincott.

    Google Scholar 

  • Davis, K., Davis, B., Mathe, A., Mohs, R., Rothpearl, M., Levy, M., Gorman, L., & Berger, P. (1984). Age and the dexamethasone suppression test. American Journal of Psychiatry, 141, 872–874.

    PubMed  CAS  Google Scholar 

  • Dilman, V., Ostrovmova, M., & Tsyrlina, E. (1979). Hypothalamic mechanisms of aging and of specific age pathology H. On the sensitivity threshold of the hypothalamic-pituitary complex to homeostatic stimuli in adaptive homeostasis. Experimental Gerontology, 14, 175–181.

    Article  PubMed  CAS  Google Scholar 

  • Fawcett, J. (1988). Predictors of early suicide: Identification and appropriate intervention. Journal of Clinical Psychiatry, 49, 7–8.

    PubMed  Google Scholar 

  • Fink, E., & Carpenter, W. (1976). Further examination of a biochemical test for suicide potential. Diseases of the Nervous System, 37, 341–343.

    PubMed  CAS  Google Scholar 

  • Funkenstein, D., King, S., & Drolette, M. (1954). The direction of anger during a laboratory stress-inducing situation. Psychosomatic Medicine, 16, 404–413.

    PubMed  CAS  Google Scholar 

  • Gross-Isseroff, R., Israeli, M., & Biegon, A. (1989). Autoradiographic analysis of tritiated imipramine binding in the human brain post mortem: Effects of suicide. Archives of General Psychiatry, 46, 237–241.

    Article  PubMed  CAS  Google Scholar 

  • Hershman, J. (1978). Use of thyrotropin-release hormone in clinical medicine. Medical Clinics of North America, 62, 313–325.

    PubMed  CAS  Google Scholar 

  • Jenner, D., Harrison, G., Prior, I., Leonetti, D., & Fujimoto, W. (1987). Twenty-four-hour catecholamine excretion: Relationships with age and weight. Clinica Chimica Acta, 164, 17–25.

    Article  CAS  Google Scholar 

  • Kierkegaard, C., & Carroll, B. (1980). Disturbances of TSH and adrenocortical disturbances in endogenous depression. Psychiatry Research, 3, 253–264.

    Article  Google Scholar 

  • Kocsis, J., Davis, J., Katz, M., Koslow, S., Stokes, P., Casper, R., & Redmond, D. (1985). Depressive behavior and hyperactive adrenocortical function. American Journal of Psychiatry, 142, 1291–1298.

    PubMed  CAS  Google Scholar 

  • Korpi, E., Kleinman, J., Goodman, S., Phillips, I., Delisi, L., Linnoila, M., & Wyatt, R. (1986). Serotonin and 5-hydroxyindoleacetic acid in brains of suicide victims: Comparison in chronic schizophrenic patients with suicide as cause of death. Archives of General Psychiatry, 43, 594–600.

    Article  PubMed  CAS  Google Scholar 

  • Krieger, G. (1974). The plasma level of cortisol as a predictor of suicide. Diseases of the Nervous System, 35, 237–240.

    PubMed  CAS  Google Scholar 

  • Krieger, G. (1975). Is there a biochemical predictor of suicide? Suicide and Life-Threatening behavior, 5, 228–231.

    CAS  Google Scholar 

  • Levy, B., & Hansen, E. (1969). Failure of the urinary test for suicide. Archives of General Psychiatry, 20, 415–418.

    Article  PubMed  CAS  Google Scholar 

  • Lidberg, L., Tuck, J., Asberg, M., Scalia-Tomba, G., & Bertilsson, L. (1985). Homicide, suicide and CSF 5-HIAA. Acta Psychiatrica Scandinavica, 71, 230–236.

    Article  PubMed  CAS  Google Scholar 

  • Linkowski, P., van Wettere, J., Kerkhofs, M., Brauman, H., & Mendlewicz, J. (1983). Thyrotrophin response to thyreostimulin in affectively ill women: Relationship to suicidal behavior. British Journal of Psychiatry, 143, 401–405.

    Article  PubMed  CAS  Google Scholar 

  • Linkowski, P., van Wettere, J., Kerkhofs, M., Gregoire, F., & Brauman, H. (1984). Violent suicidal behavior and the thrytropin releasing hormone-thyroid stimulating hormone test: A clinical outcome study. Neuropsychobiology, 12, 19–22.

    Article  PubMed  CAS  Google Scholar 

  • Loosen, P., Prange, A., & Wilson, I. (1978). Influence of cortisol on TRH-induced TSH response in depression. American Journal of Psychiatry, 135, 244–246.

    PubMed  CAS  Google Scholar 

  • Manchon, M., Kopp, N., Rovzioux, J., Lecestre, D., Deluermoz, S., & Miachon, S. (1987). Benzodiazepine receptor and neurotransmitter studies in the brain of suicides. Life Sciences, 24, 2623–2630.

    Article  Google Scholar 

  • McGeer, E. (1978). Aging and neurotransmitter metabolism in the human brain. In R. Katzman, R. Terry, & K. Bick (Eds.), Alzheimer’s disease: Senile dementia and related disorders. New York: Raven Press.

    Google Scholar 

  • Meltzer, H., & Arora, R. (1986). Platelet markers of suicidality. In J. Mann & M. Stanley (Eds.), Psychobiology of suicidal behavior. New York: New York Academy of Sciences.

    Google Scholar 

  • Nemeroff, C. (1988). The neurobiology of aging and the neurobiology of depression: Is there a relationship? Neurobiology of Aging, 9, 122–124.

    Article  Google Scholar 

  • Ninan, P., van Kammen, D., Scheinen, M., Linnoila, M., Bunney, W. E., & Goodwin, F. K. (1984). CSF 5-hydroxyindoleacetic acid levels in suicidal schizophrenia patients. American Journal of Psychiatry, 141, 566–569.

    PubMed  CAS  Google Scholar 

  • Oreland, L., Widberg, A., Asberg, M., Traskman, L., Sjostrand, L., Thoren, P., Bertilsson, L., & Tybring, G. (1981). Platelet MAO activity and monoamine metabolites in CSF in depressed and suicidal patients and in healthy controls. Psychiatry Research, 4, 21–29.

    Article  PubMed  CAS  Google Scholar 

  • Ostroff, R., Giller, E., Bonese, K., Ebersole, E., Harkness, L., & Mason, J. (1982). Neuroendocrine risk factors of suicidal behavior. American Journal of Psychiatry, 139, 1323–1325.

    PubMed  CAS  Google Scholar 

  • Pickar, D., Roy, A., Breier, A., Doran, A., Wolkowitz, O., Colison, J., & Agren, H. (1986). Suicide and aggression in schizophrenia. Neurobiologic correlates. Annual of New York Academy of Science, 487, 189–196.

    Article  CAS  Google Scholar 

  • Puig-Antich, J., Duhl, R., Ryan, N., Novacenko, H., Goetz, D., Goetz, R., Iwomey, J., & Klepper, T. (1989). Cortisol secretion in prepubertal children with major depressive disorders. Archives of General Psychiatry, 46, 801–809.

    Article  PubMed  CAS  Google Scholar 

  • Robbins, D., & Alessi, N. (1985). Suicide and the dexamethasone suppression test in adolescence. Biological Psychiatry, 20, 107–110.

    Article  PubMed  CAS  Google Scholar 

  • Roy, A., Agren, H., Pickar, D., Linnoila, M., Doran, A., Cutler, N., & Paul S. (1986). Reduced CSF concentrations of homovanillic acid and HVA to 5-HIAA ratios in depressed patients: Relationship to suicidal behavior and dexamethasone nonsuppression. American Journal of Psychiatry, 143, 1539–1545.

    PubMed  CAS  Google Scholar 

  • Roy, A., Ninan, P., Mazonson, A., Pickar, D., van Kammen, D., Linnoila, M., & Paul, S. (1985). CSF monoamine metabolites in chronic schizophrenic patients who attempt suicide. Psychological Medicine, 15, 335–340.

    Article  PubMed  CAS  Google Scholar 

  • Roy, A., Pickar, D., DeJong, I., Karoum, E., & Linnoila, M. (1989). Suicidal behavior in depression: Relation to noradrenergic function. Biological Psychiatry, 25, 341–350.

    Article  PubMed  CAS  Google Scholar 

  • Sachar, E., Asnis, G., Nathan, S., Halbreich, U., Tabrizi, A., & Halpern, F. (1980). Dextroamphetamine and cortisol in depression. Archives of General Psychiatry, 37, 755–757.

    Article  PubMed  CAS  Google Scholar 

  • Shaw, D., Camps, E., & Eccleston, E. (1967). 5-Hydroxytryptamine in the hindbrain of depressed suicides. British Journal of Psychiatry, 113, 1407–1411.

    Article  PubMed  CAS  Google Scholar 

  • Simpkins, J. (1983). Changes in hypothalamic hypophysiotropic hormones and neurotransmitters during aging. In J. Meites (Ed.), Neuroendocrinology of aging. New York: Plenum Press.

    Google Scholar 

  • Snyder, P., & Utiger, R. (1972a). Response to thyrotropin releasing hormone (TRH) in normal men. Journal of Clinical Endocrinology & Metabolism, 34, 380–385.

    Article  CAS  Google Scholar 

  • Snyder, P., & Utiger, R. (1972b). Thyrotropin response to thyrotropin releasing hormone in normal females over forty. Journal of Clinical Endocrinology & Metabolism, 34, 1096–1098.

    Article  CAS  Google Scholar 

  • Stanley, M., & Stanley, B. (1989). Biochemical studies in suicide victims: Current findings and future implications. Suicide and Life-Threatening Behavior, 19, 30–42.

    PubMed  CAS  Google Scholar 

  • Stanley, M., Virgilio, J., & Gershon, S. (1982). Tritiated imipramine binding sites are decreased in the frontal cortex of suicides. Science, 216, 1337–1339.

    Article  PubMed  CAS  Google Scholar 

  • Struve, F. (1979). Clinical encephalography. In L. Hankoff & B. Einsidler (Eds.), Suicide: Theory and clinical aspects. Littleton, MA: PSG.

    Google Scholar 

  • Struve, F., Saraf, K., Arko, R., Klein, D., & Becka D. (1977). Relationship between paroxysmal electroencephalographic dysrhythmia and suicide ideation and attempts in psychiatric patients. In C. Shogass, S. Gershon, & A. Friedhof (Eds.), Psychopathology and brain dysfunction. New York: Raven Press.

    Google Scholar 

  • Traskman, L., Asberg, M. Bertilsson, L., & Sjostrand, L. (1981). Monoamine metabolites in CSF and suicidal behavior. Archives of General Psychiatry, 38, 631–636.

    Article  PubMed  CAS  Google Scholar 

  • Traskman, L., Tybring, G., Asberg, M., Bertilsson, L., Lantto, O., & Schalling, G. (1980). Cortisol in the CSF of depressed and suicidal patients. Archives of General Psychiatry, 37, 761–767.

    Article  PubMed  CAS  Google Scholar 

  • van Praag, H. (1983). CSF 5-HIAA and suicide in nondepressed schizophrenics. Lancet, 2, 1256.

    Google Scholar 

  • van Praag, H. (1986). Biological suicide research: Outcome and limitations. Biological Psychiatry, 21, 1305–1323.

    Article  PubMed  Google Scholar 

  • Veith, R., & Raskind, M. (1988). The neurobiology of aging: Does it predispose to depression? Neurobiology of Aging, 9, 101–117.

    Article  PubMed  CAS  Google Scholar 

  • Woodman, D. (1979). Evidence of a permanent imbalance in catecholamine secretions in violent social deviants. Journal of Psychosomatic Research, 23, 155–157.

    Article  PubMed  CAS  Google Scholar 

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Motto, J.A., Reus, V.I. (1991). Biological Correlates of Suicide across the Life Span. In: Leenaars, A.A. (eds) Life Span Perspectives of Suicide. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0724-0_13

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  • DOI: https://doi.org/10.1007/978-1-4899-0724-0_13

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