Abstract
Much has been said about the psychological implications of the various stages of life as regards suicide. The life span is generally depicted as involving a dynamic, ever-changing interplay of both internal and external forces that largely determine the nature and stability of a person’s emotional experience. A major focus has been on developmental tasks and goals that, if incompletely or tardily accomplished, become an obstacle to subsequent growth, and a source of psychic pain conducive to self-destructive activity.
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References
Arato, M., Banki, C., Bissette, G., & Nemeroff, C. (1989a). Elevated CSF CRF in suicide victims. Biological Psychiatry, 25, 355–359.
Arato, M., Banki, C., Tothfulusi, L., Bissette, G., Nemeroff, C., & Akil, H. (1989b, May). CSF neuropeptide changes in depression and suicide. Presented at the American Psychiatric Association Annual Meeting, San Francisco, CA.
Agren, H. (1983). Life at risk: Markers of suicidality in depression. Psychiatric Developments, 1, 87–103.
Arora, R., & Meltzer, H. (1989). Serotonergic measures in the brains of suicide victims: 5HT2 binding sites in the frontal cortex of suicide victims and control subjects. American Journal of Psychiatry, 146, 730–736.
Asberg, M., Traskman, L., & Thoren, P (1976). 5-HIAA in the cerebrospinal fluid: A biochemical suicide predictor? Archives of General Psychiatry, 33, 1193–1197.
Ash, K., Clark, S., Sandberg, L., Hunter, E., & Woodward, S. (1983). The influences of sample distribution and age on reference intervals for adult males. American Journal of Clinical Pathology, 79, 574–581.
Baldessarini, R. (1975). An overview of the basis for amine hypothesis in affective illness. In J. Mendels (Ed.), The psychobiology of depression. New York: Spectrum.
Banki, C. (1985). Biochemical markers for suicidal behavior. American Journal of Psychiatry, 142, 147–148.
Banki, C., & Arato, M. (1983a). Amine metabolites and neuroendocrine responses related to depression and suicide. Journal of Affective Disorders, 5, 223–232.
Banki, C., & Arato, M. (1983b). Amine metabolites, neuroendocrine findings, and personality dimensions as correlates of suicidal behavior. Psychiatry Research, 10, 253–261.
Banki, C., Arato, M., & Kiltz, C. (1986). Aminergic studies and cerebrospinal fluid cations in suicide. In J. Mann, & M. Stanley (Eds.), Psychobiology of suicidal behavior. New York: New York Academy of Sciences.
Banki, C., Arato, M., Papp, Z., & Kurca, M. (1984). Biochemical markers in suicidal patients. Journal of Affective Disorder, 6, 341–350.
Banki, C., Vojnik, M., Papp, Z., Balla, K. Z., & Arato, M. (1985). Cerebrospinal fluid magnesium and calcium related to amine metabolites, diagnosis, and suicide attempts. Biological Psychiatry, 20, 163–171.
Berger, M., Krieg, C., Bossert, S., Schreiber, W., & von Zerssen D. (1988). Past and present strategies of research on the HPA-axis in psychiatry. Acta Psychiatrica Scandinavica, 341, 112–125.
Brown, G., Ebert, M., Goyer, P., Jimerson, D. C., Klein, W. J., Bunney, W. E., & Goodwin, F. K. (1982). Aggression, suicide, and serotonin: Relationships to CSF amine metabolites. American Journal of Psychiatry, 139, 741–746.
Bunney, W. (1984, October). The future of biologic psychiatry. Paper presented at the San Diego Psychiatric Symposium. San Diego, CA.
Bunney, W., & Fawcett, J. (1965). Possibility of a biochemical test for suicide potential. Archives of General Psychiatry, 13, 232–239.
Bunney, W., Fawcett, J., Davis, J., & Gifford, S. (1969). Further evaluation of urinary 17-hydroxycorticosteroids in suicidal patients. Archives of General Psychiatry, 21, 138–150.
Carroll, B. (1983). Neurobiologic dimensions of depression and mania. In J. Angst (Ed.), The origins of depression: Current concepts and approaches (Dahlem Conference). New York: Springer.
Chabrol, H., Claverie, J., & Moron, P. (1983). DST, TRH test, and adolescent suicide attempts. American Journal of Psychiatry, 140, 265.
Cochran, E., Robins, E., & Grote, S. (1976). Regional serotonin levels in brain: A comparison of depressive suicides and alcoholic suicides with controls. Biological Psychiatry, 11, 283–294.
Coryell, W., & Schlesser, M. (1981). Suicide and the DST in unipolar depression. American Journal of Psychiatry, 138, 1120–1121.
Cross, J., Cheetham, S., Crompton, M., Katona, C., & Horton, R. (1988). Brain GABA B binding sites in depressed suicide victims. Psychiatry Research, 26, 119–129.
Crumley, F. (1983). The dexamethasone suppression test and adolescent suicide attempts. Paper presented at the 16th Annual Meeting of the American Association of Suicidology, Dallas, TX.
Davis, B., Bishop, M., & Mass, D. (1989). Clinical laboratory science: Strategies for practice. Philadelphia: Lippincott.
Davis, K., Davis, B., Mathe, A., Mohs, R., Rothpearl, M., Levy, M., Gorman, L., & Berger, P. (1984). Age and the dexamethasone suppression test. American Journal of Psychiatry, 141, 872–874.
Dilman, V., Ostrovmova, M., & Tsyrlina, E. (1979). Hypothalamic mechanisms of aging and of specific age pathology H. On the sensitivity threshold of the hypothalamic-pituitary complex to homeostatic stimuli in adaptive homeostasis. Experimental Gerontology, 14, 175–181.
Fawcett, J. (1988). Predictors of early suicide: Identification and appropriate intervention. Journal of Clinical Psychiatry, 49, 7–8.
Fink, E., & Carpenter, W. (1976). Further examination of a biochemical test for suicide potential. Diseases of the Nervous System, 37, 341–343.
Funkenstein, D., King, S., & Drolette, M. (1954). The direction of anger during a laboratory stress-inducing situation. Psychosomatic Medicine, 16, 404–413.
Gross-Isseroff, R., Israeli, M., & Biegon, A. (1989). Autoradiographic analysis of tritiated imipramine binding in the human brain post mortem: Effects of suicide. Archives of General Psychiatry, 46, 237–241.
Hershman, J. (1978). Use of thyrotropin-release hormone in clinical medicine. Medical Clinics of North America, 62, 313–325.
Jenner, D., Harrison, G., Prior, I., Leonetti, D., & Fujimoto, W. (1987). Twenty-four-hour catecholamine excretion: Relationships with age and weight. Clinica Chimica Acta, 164, 17–25.
Kierkegaard, C., & Carroll, B. (1980). Disturbances of TSH and adrenocortical disturbances in endogenous depression. Psychiatry Research, 3, 253–264.
Kocsis, J., Davis, J., Katz, M., Koslow, S., Stokes, P., Casper, R., & Redmond, D. (1985). Depressive behavior and hyperactive adrenocortical function. American Journal of Psychiatry, 142, 1291–1298.
Korpi, E., Kleinman, J., Goodman, S., Phillips, I., Delisi, L., Linnoila, M., & Wyatt, R. (1986). Serotonin and 5-hydroxyindoleacetic acid in brains of suicide victims: Comparison in chronic schizophrenic patients with suicide as cause of death. Archives of General Psychiatry, 43, 594–600.
Krieger, G. (1974). The plasma level of cortisol as a predictor of suicide. Diseases of the Nervous System, 35, 237–240.
Krieger, G. (1975). Is there a biochemical predictor of suicide? Suicide and Life-Threatening behavior, 5, 228–231.
Levy, B., & Hansen, E. (1969). Failure of the urinary test for suicide. Archives of General Psychiatry, 20, 415–418.
Lidberg, L., Tuck, J., Asberg, M., Scalia-Tomba, G., & Bertilsson, L. (1985). Homicide, suicide and CSF 5-HIAA. Acta Psychiatrica Scandinavica, 71, 230–236.
Linkowski, P., van Wettere, J., Kerkhofs, M., Brauman, H., & Mendlewicz, J. (1983). Thyrotrophin response to thyreostimulin in affectively ill women: Relationship to suicidal behavior. British Journal of Psychiatry, 143, 401–405.
Linkowski, P., van Wettere, J., Kerkhofs, M., Gregoire, F., & Brauman, H. (1984). Violent suicidal behavior and the thrytropin releasing hormone-thyroid stimulating hormone test: A clinical outcome study. Neuropsychobiology, 12, 19–22.
Loosen, P., Prange, A., & Wilson, I. (1978). Influence of cortisol on TRH-induced TSH response in depression. American Journal of Psychiatry, 135, 244–246.
Manchon, M., Kopp, N., Rovzioux, J., Lecestre, D., Deluermoz, S., & Miachon, S. (1987). Benzodiazepine receptor and neurotransmitter studies in the brain of suicides. Life Sciences, 24, 2623–2630.
McGeer, E. (1978). Aging and neurotransmitter metabolism in the human brain. In R. Katzman, R. Terry, & K. Bick (Eds.), Alzheimer’s disease: Senile dementia and related disorders. New York: Raven Press.
Meltzer, H., & Arora, R. (1986). Platelet markers of suicidality. In J. Mann & M. Stanley (Eds.), Psychobiology of suicidal behavior. New York: New York Academy of Sciences.
Nemeroff, C. (1988). The neurobiology of aging and the neurobiology of depression: Is there a relationship? Neurobiology of Aging, 9, 122–124.
Ninan, P., van Kammen, D., Scheinen, M., Linnoila, M., Bunney, W. E., & Goodwin, F. K. (1984). CSF 5-hydroxyindoleacetic acid levels in suicidal schizophrenia patients. American Journal of Psychiatry, 141, 566–569.
Oreland, L., Widberg, A., Asberg, M., Traskman, L., Sjostrand, L., Thoren, P., Bertilsson, L., & Tybring, G. (1981). Platelet MAO activity and monoamine metabolites in CSF in depressed and suicidal patients and in healthy controls. Psychiatry Research, 4, 21–29.
Ostroff, R., Giller, E., Bonese, K., Ebersole, E., Harkness, L., & Mason, J. (1982). Neuroendocrine risk factors of suicidal behavior. American Journal of Psychiatry, 139, 1323–1325.
Pickar, D., Roy, A., Breier, A., Doran, A., Wolkowitz, O., Colison, J., & Agren, H. (1986). Suicide and aggression in schizophrenia. Neurobiologic correlates. Annual of New York Academy of Science, 487, 189–196.
Puig-Antich, J., Duhl, R., Ryan, N., Novacenko, H., Goetz, D., Goetz, R., Iwomey, J., & Klepper, T. (1989). Cortisol secretion in prepubertal children with major depressive disorders. Archives of General Psychiatry, 46, 801–809.
Robbins, D., & Alessi, N. (1985). Suicide and the dexamethasone suppression test in adolescence. Biological Psychiatry, 20, 107–110.
Roy, A., Agren, H., Pickar, D., Linnoila, M., Doran, A., Cutler, N., & Paul S. (1986). Reduced CSF concentrations of homovanillic acid and HVA to 5-HIAA ratios in depressed patients: Relationship to suicidal behavior and dexamethasone nonsuppression. American Journal of Psychiatry, 143, 1539–1545.
Roy, A., Ninan, P., Mazonson, A., Pickar, D., van Kammen, D., Linnoila, M., & Paul, S. (1985). CSF monoamine metabolites in chronic schizophrenic patients who attempt suicide. Psychological Medicine, 15, 335–340.
Roy, A., Pickar, D., DeJong, I., Karoum, E., & Linnoila, M. (1989). Suicidal behavior in depression: Relation to noradrenergic function. Biological Psychiatry, 25, 341–350.
Sachar, E., Asnis, G., Nathan, S., Halbreich, U., Tabrizi, A., & Halpern, F. (1980). Dextroamphetamine and cortisol in depression. Archives of General Psychiatry, 37, 755–757.
Shaw, D., Camps, E., & Eccleston, E. (1967). 5-Hydroxytryptamine in the hindbrain of depressed suicides. British Journal of Psychiatry, 113, 1407–1411.
Simpkins, J. (1983). Changes in hypothalamic hypophysiotropic hormones and neurotransmitters during aging. In J. Meites (Ed.), Neuroendocrinology of aging. New York: Plenum Press.
Snyder, P., & Utiger, R. (1972a). Response to thyrotropin releasing hormone (TRH) in normal men. Journal of Clinical Endocrinology & Metabolism, 34, 380–385.
Snyder, P., & Utiger, R. (1972b). Thyrotropin response to thyrotropin releasing hormone in normal females over forty. Journal of Clinical Endocrinology & Metabolism, 34, 1096–1098.
Stanley, M., & Stanley, B. (1989). Biochemical studies in suicide victims: Current findings and future implications. Suicide and Life-Threatening Behavior, 19, 30–42.
Stanley, M., Virgilio, J., & Gershon, S. (1982). Tritiated imipramine binding sites are decreased in the frontal cortex of suicides. Science, 216, 1337–1339.
Struve, F. (1979). Clinical encephalography. In L. Hankoff & B. Einsidler (Eds.), Suicide: Theory and clinical aspects. Littleton, MA: PSG.
Struve, F., Saraf, K., Arko, R., Klein, D., & Becka D. (1977). Relationship between paroxysmal electroencephalographic dysrhythmia and suicide ideation and attempts in psychiatric patients. In C. Shogass, S. Gershon, & A. Friedhof (Eds.), Psychopathology and brain dysfunction. New York: Raven Press.
Traskman, L., Asberg, M. Bertilsson, L., & Sjostrand, L. (1981). Monoamine metabolites in CSF and suicidal behavior. Archives of General Psychiatry, 38, 631–636.
Traskman, L., Tybring, G., Asberg, M., Bertilsson, L., Lantto, O., & Schalling, G. (1980). Cortisol in the CSF of depressed and suicidal patients. Archives of General Psychiatry, 37, 761–767.
van Praag, H. (1983). CSF 5-HIAA and suicide in nondepressed schizophrenics. Lancet, 2, 1256.
van Praag, H. (1986). Biological suicide research: Outcome and limitations. Biological Psychiatry, 21, 1305–1323.
Veith, R., & Raskind, M. (1988). The neurobiology of aging: Does it predispose to depression? Neurobiology of Aging, 9, 101–117.
Woodman, D. (1979). Evidence of a permanent imbalance in catecholamine secretions in violent social deviants. Journal of Psychosomatic Research, 23, 155–157.
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Motto, J.A., Reus, V.I. (1991). Biological Correlates of Suicide across the Life Span. In: Leenaars, A.A. (eds) Life Span Perspectives of Suicide. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0724-0_13
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DOI: https://doi.org/10.1007/978-1-4899-0724-0_13
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