Abstract
Vascular injury and inflammation are the most important features of a heterogeneous group of disorders commonly referred to as the systemic necrotizing vasculitides.1 Previous studies have established two pathogenetic mechanisms for vasculitis2,3: deposition of circulating immune complexes with subsequent complement activation and inflammation; and interactions between circulating antibodies with blood vessel wall antigens in situ, such as occurs in Goodpasture’s syndrome, in which autoantibodies interact with glomerular and pulmonary capillary basement membranes. These mechanisms, however, cannot account for many forms of inflammatory vasculitis and several additional or alternative pathways have recently been explored. In this chapter we will review three settings of vascular injury which may shed light on the pathogenesis of vasculitis. First, we will examine the role of cytokine-induced activation4 of endothelial cells in causing endothelial and vascular injury and the possible role of these effects in one form of vasculitis—Kawasaki’s disease; second, we will describe the details of vascular injury occurring during transplantation reactions, and how these may be relevant to other forms of vasculitis; and third, we will review recent work associating the presence of antineutrophil cytoplasmic antibodies with certain forms of vasculitis, such as Wegener’s granulomatosis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Cupps, T. R., and Fauci, A. S., 1981, The Vasculitides, Saunders, Philadelphia.
Savage, C. O. S., and Ng, Y. C., 1986, The etiology and pathogenesis of major systemic vasculitis, Postgrad. Med. J. 62:623.
Wilson, C.B., 1990, The renal response to immunological injury, in: The Kidney, 4th ed. (B. M. Brenner and R. C. Rector, eds.), Saunders, Philadelphia.
Pober, J. S., and Cotran, R. S., 1990, Cytokines and endothelial cell biology, Physiol. Rev. 70:427.
Pober, J. S., Gimbrone, M. A., Jr., Cotran, R. S., Reiss, C. S., Burakoff, S. J., Fiers, W., and Ault, K. A., 1983, Ia expression by vascular endothelium is inducible by activated T-cells and by human γ interferon, J. Exp. Med. 157:1339.
Cotran, R. S., and Pober, J. S., 1990, Cytokine-endothelial interactions in inflammation, immunity and vascular injury, J. Am. Soc. Nephrol. 1:225–235.
Osborn, J., 1990, Leukocyte adhesion to endothelium in inflammation, Cell 62:3.
Thornhill, M. H., Kyan-Aung, U., and Haskard, D. O., 1990, IL-4 increases human endothelial cell adhesiveness for T-cells but not for neutrophils, J. Immunol. 144:3060.
Stolpen, A. H., Guinan, E. C., Fiers, W., and Pober, J. S., 1986, Recombinant tumor necrosis factor and immune interferon act singly and in combination to reorganize human vascular endothelial cell monolayers, Am. J. Pathol. 123:16.
Brett, J., Gerlack, H., Nawroth, P., Steinberg, S., Godman, G., and Stern, D., 1989, Tumor necrosis factor/cachectin increases permeability of endothelial cell monolayers by a mechanism involving regulatory G-proteins, J. Exp. Med. 169:1977.
Ward, P. A., and Varani, J., 1990, Mechanisms of neutrophil-mediated killing of endothelial cells, J. Leukocyte Biol. 48:97.
Cotran, R. S., 1990, Pathogenesis of vasculitis: An update, in: Advances in Pathology, Vol. III, pp. 301–310.
Brasile, L., Kremer, J. M., Clarke, J. L., and Cerilli, J., 1989, Identification of an autoantibody to vascular endothelial cell-specific antigens in systemic vasculitis, Am. J. Med. 87:74.
Leung, D. Y. M., Geha, R. S., Newburger, J. W., Burns, J. C., Fiers, W., Lapierre, L. A., and Pober, J. S., 1986, Two monokines, interleukin a and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome, J. Exp. Med. 164:1958.
Leung, D. Y. M., Collins, T., Lapierre, L. A., Geha, R. S., and Pober, J. S., 1986, Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by γ-interferon, J. Clin. Invest. 77:1428.
Maury, C. P. J., Salo, E., and Pelkonen, P., 1988, Circulating interleukin-1 in patients with Kawasaki disease, N. Engl. J. Med. 319:1670.
Kurukawa, S., Matsubara, T., Jujoh, K., Yone, K., Sugawara, T., Sasai, K., Kato, H., and Yabuta, K., 1988, Peripheral blood monocyte/macrophage and serum tumor necrosis factor in Kawasaki disease, Clin. Immunol. Immunopathol. 48:247.
Rowley, A. H., Shulman, S. T., Preble, O. T., Poiesz, B. J., Ehrlich, G. D., and Sullivan, J. R., 1988, Serum interferon concentrations and retroviral serology in Kawasaki syndrome, Pediatr. Inf. Dis. J. 7:663.
Leung, D. Y. M., Cotran, R. S., Kurt-Jones, E. A., Burns, J. C., Newburger, J. W., and Pober, J. S., 1989, Endothelial activation and high interleukin-1 secretion in the pathogenesis of acute Kawasaki disease, Lancet 2:1298.
Esmon, C., 1987, The regulation of natural anticoagulant pathways, Science 235:1348.
Platt, J. L., Vercellotti, G. M., Lindman, B. J., Oegema, T. R. Jr., Bach, F. H., and Dalmasso, A. P., 1990, Release of heparan sulfate from endothelial cells: Implications for pathogenesis of hyperacute rejection, J. Exp. Med. 171;1363.
Hamilton, K. K., Hattori, R., Esmon, C. T., and Sims, P. J., 1990, Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrom-binase enzyme complex, J. Biol. Chem. 265:3809.
Hattori, R., Hamilton, K. K., McEver, R. P., and Sims, P. J., 1989, Complement proteins C5b-9 induce secretion of high molecular weight multimers of endothelial von Willebrand factor and translocation of granule membrane protein GMP-140 to one cell surface, J. Biol. Chem. 264:9053.
Cerilli, J., and Brasile, L., 1988, Endothelial cell alloantigens, Transplant. Proc. 12:37.
Yowell, R. L., Hammond, E. H., Brislow, M., Watson, F. S., Renlund, D. G., and O’Connell, J. B., 1988, Acute vascular rejection involving the major coronary arteries of cardiac allograft, Heart Transplant. 7:191.
Feogh, M. L., 1990, Chronic rejection-graft arteriosclerosis, Transplant. Proc. 22:119.
Salomon, R. N., Hughes, C. C. W., Schoen, F. J., Payne, D. D., Pober, J. S., Libby, P., 1991, Human coronary transplantation-associated arteriosclerosis: Evidence for a chronic immune reaction to activated graft endothelial cells, Am. J. Path. 138:791–798.
Libby, P., Salomon, R. N., Payne, D. D., Schoen, F. J., and Pober, J. S., 1989, Functions of vascular wall cells related to development of transplantation-associated coronary arteriosclerosis, Transplant. Proc. 21:3677.
Grattan, M. T., Moreno-Cabral, C. E., Starnes, V. A., Oyer, P. E., Stinson, E. B., and Shumway, N. E., 1989, Cytomegalovirus infection is associated with cardiac allograft rejection and atherosclerosis, J. Am. Med. Assoc. 261:3651.
Nölle, B., Specks, U., Ludemann, J., Rohrbach, M. S., DeRemee, R. A., and Gross, W. L., 1989, Anticytoplasmic autoantibodies: Their immunodiagnostic value in Wegener’s granulomatosis, Ann. Intern. Med. 111:28.
Feinberg, R., 1989, Morphologic and immunohistologic study of the evolution of necrotizing palisading granuloma of pathergic granulomatosis, Semin. Respir. Med. 10:126.
Falk, R. J., and Jennette, J. C., 1988, Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis, N. Engl. J. Med. 318:1651.
Jennette, J. C., Wilkman, A. S., and Falk, R. J., 1989, Anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis and vasculitis, Am. J. Pathol. 135:921.
Goldschmeding, R., van der Schoot, C. E., Ten Bokkel Huinick, D., Hack, C. E., Van den Ende, M. E., Kallenberg, C. G., and Von dem Borne, A. E., 1989, Wegener’s granulomatosis autoantibodies identify a novel DFP-binding protein in the lysosomes of normal human neutrophils, J. Clin. Invest. 84:1577.
Niles, J. L., McCluskey, R. T., Ahmad, M. F., and Arnaout, M. A., 1989, Wegener’s granulomatosis autoantigen is a novel neutrophil serine protease, Blood 74:1988.
Ludemann, B. U., Utecht, B., and Gross, W. L., 1990, Antineutrophil cytoplasmic antibodies in Wegener’s granulomatosis recognize an elastic enzyme, J. Exp. Med. 171:357.
Kao, R. C., Wehner, N. G., Skubitz, K. M., Gray, B. H., and Hoidal, J. R., 1988, Proteinase 3: A distinct polymorphonuclear leukocyte proteinase that produces emphysema in hamsters, J. Clin. Invest. 82:1963.
Falk, R. J., Terrell, R. S., Charles, L. A., and Jennette, J. C., 1990, Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro, Proc. Natl. Acad. Sci. USA 87:4115.
Jenne Tshopp, J., Ludemann, J., Uthatb, and Gross, W. L., 1990, Wegener’s autoantigen decoded, Nature 346:520.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Cotran, R.S., Pober, J.S. (1992). Recent Insights into the Mechanisms of Vascular Injury. In: Simionescu, N., Simionescu, M. (eds) Endothelial Cell Dysfunctions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0721-9_11
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0721-9_11
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0723-3
Online ISBN: 978-1-4899-0721-9
eBook Packages: Springer Book Archive